Development Level

Tbio 31 | 10,625
Tchem 28 | 1,890
Tclin 13 | 602

IMPC Phenotype

preweaning lethality, complete... 7 | 633
abnormal embryo size 4 | 112
cataract 4 | 26
abnormal lens morphology 3 | 73
decreased body weight 3 | 174
embryonic lethality prior to t... 3 | 187
enlarged heart 3 | 111
decreased circulating creatini... 2 | 31
decreased grip strength 2 | 123
decreased kidney weight 2 | 7
decreased lean body mass 2 | 195
impaired pupillary reflex 2 | 14
increased circulating triglyce... 2 | 24
abnormal body wall morphology 1 | 7
abnormal bone mineralization 1 | 55
abnormal bone structure 1 | 131
abnormal cornea morphology 1 | 24
abnormal epididymis morphology 1 | 31
abnormal eye morphology 1 | 38
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal heart morphology 1 | 51
abnormal hindbrain development 1 | 24
abnormal midbrain development 1 | 22
abnormal motor learning 1 | 4
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal response to tactile s... 1 | 16
abnormal retina morphology 1 | 100
abnormal retinal vasculature m... 1 | 15
abnormal seminal vesicle morph... 1 | 47
abnormal spleen morphology 1 | 36
abnormal startle reflex 1 | 14
abnormal tail morphology 1 | 17
abnormal testis morphology 1 | 30
absent startle reflex 1 | 15
cleft palate 1 | 6
corneal opacity 1 | 25
decreased body length 1 | 108
decreased bone mineral content 1 | 157
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 37
decreased circulating alanine ... 1 | 53
decreased circulating choleste... 1 | 85
decreased circulating insulin ... 1 | 75
decreased circulating triglyce... 1 | 83
decreased leukocyte cell numbe... 1 | 54
decreased lumbar vertebrae num... 1 | 62
decreased spleen weight 1 | 13
decreased total body fat amoun... 1 | 186
embryonic lethality prior to o... 1 | 148
enlarged epididymis 1 | 27
enlarged lymph nodes 1 | 27
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
immune system phenotype 1 | 17
impaired righting response 1 | 19
increased blood urea nitrogen ... 1 | 44
increased circulating HDL chol... 1 | 63
increased circulating LDL chol... 1 | 15
increased circulating alkaline... 1 | 119
increased circulating choleste... 1 | 53
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 93
increased mean corpuscular vol... 1 | 91
increased respiratory quotient 1 | 12
increased startle reflex 1 | 38
increased total body fat amoun... 1 | 57
limb grasping 1 | 35
male infertility 1 | 62
microphthalmia 1 | 15
mydriasis 1 | 9
narrow eye opening 1 | 15
no spontaneous movement 1 | 1
preweaning lethality, incomple... 1 | 260
small testis 1 | 37
thrombocytosis 1 | 23

Disease

Cancer 54 | 2,346
ovarian cancer 46 | 8,491
lung cancer 40 | 4,473
osteosarcoma 39 | 7,933
Breast cancer 33 | 3,098
medulloblastoma, large-cell 33 | 6,234
psoriasis 31 | 6,685
glioblastoma 30 | 5,572
atypical teratoid / rhabdoid tumor 28 | 4,369
malignant mesothelioma 27 | 3,163
oligodendroglioma 26 | 2,849
invasive ductal carcinoma 25 | 2,950
Carcinoma 24 | 2,147
Mammary Neoplasms 24 | 410
pilocytic astrocytoma 21 | 3,086
primitive neuroectodermal tumor 20 | 3,031
ependymoma 18 | 2,514
non-small cell lung cancer 18 | 2,798
Liver carcinoma 17 | 217
Lung Neoplasms 17 | 171
subependymal giant cell astrocytoma 17 | 2,287
Prostatic Neoplasms 16 | 471
diabetes mellitus 16 | 1,663
ductal carcinoma in situ 16 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,956
Adenoma 15 | 165
interstitial cystitis 15 | 2,299
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,289
lung adenocarcinoma 15 | 2,714
lung carcinoma 15 | 2,844
non-small cell lung carcinoma 15 | 413
pancreatic cancer 15 | 2,300
Vascular disease 14 | 281
medulloblastoma 14 | 1,524
Squamous cell carcinoma 13 | 96
Stomach Neoplasms 13 | 282
adrenocortical carcinoma 13 | 1,427
astrocytic glioma 13 | 2,241
cystic fibrosis 13 | 1,670
juvenile dermatomyositis 13 | 1,189
Neoplasm Invasiveness 12 | 127
adult high grade glioma 12 | 2,148
astrocytoma 12 | 1,493
group 3 medulloblastoma 12 | 2,254
pediatric high grade glioma 12 | 2,712
pituitary cancer 12 | 1,972
ulcerative colitis 12 | 2,087
Melanoma 11 | 261
Neoplasm Metastasis 11 | 138
Renal Cell Carcinoma 11 | 199
breast carcinoma 11 | 1,614
nasopharyngeal carcinoma 11 | 1,056
tuberculosis 11 | 1,563
Cleft palate 10 | 125
Mammary Neoplasms, Experimental 10 | 149
colon cancer 10 | 1,475
group 4 medulloblastoma 10 | 1,875
Adenocarcinoma 9 | 115
Bladder Neoplasm 9 | 109
Colorectal Neoplasms 9 | 217
Kidney cancer 9 | 121
Kidney disease 9 | 397
Pick disease 9 | 1,893
Rheumatoid Arthritis 9 | 1,170
ovarian neoplasm 9 | 97
Adenoid Cystic Carcinoma 8 | 99
Animal Mammary Neoplasms 8 | 135
Glioma 8 | 66
Intellectual disability 8 | 573
Neoplastic Cell Transformation 8 | 81
Papilloma 8 | 27
Parkinson's disease 8 | 364
Pulmonary Fibrosis 8 | 66
Schizophrenia 8 | 503
Skin cancer 8 | 37
acute quadriplegic myopathy 8 | 1,157
autosomal dominant Emery-Dreifuss muscular dystrophy 8 | 499
pancreatic ductal adenocarcinoma liver metastasis 8 | 1,795
Autistic Disorder 7 | 320
Cleft Lip 7 | 91
Endometriosis 7 | 535
Familial adenomatous polyposis 7 | 33
Heart disease 7 | 279
Liver Neoplasms, Experimental 7 | 48
Liver neoplasms 7 | 108
Lung disease 7 | 136
Mesothelioma 7 | 40
Multiple myeloma 7 | 1,327
Neoplastic Syndromes, Hereditary 7 | 48
Noonan Syndrome 7 | 33
Pancreatic Neoplasm 7 | 79
Stomach cancer 7 | 18
dermatomyositis 7 | 966
pancreatic carcinoma 7 | 567
primary pancreatic ductal adenocarcinoma 7 | 1,271
Alzheimer's disease 6 | 644
gastric carcinoma 6 | 832
hepatocellular carcinoma 6 | 550
spina bifida 6 | 1,064

Tissue

Endocrine System 72 | 18,511
Female tissues 71 | 18,646
Nervous System 71 | 18,560
Skin and soft tissues 71 | 18,114
Digestive Tract 70 | 18,472
Liver and Pancreas 70 | 18,135
Blood and immune system 69 | 17,994
Urinary Tract 69 | 18,443
Cardiovascular System 68 | 17,957
Male tissues 67 | 17,968
Respiratory system 64 | 17,483

Target Family

Non-IDG 33 | 11,969
Kinase 23 | 634
Enzyme 11 | 4,146
Transcription Factor 5 | 1,400

KEGG Pathway

Melanoma 72 | 72
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine/threonine-protein kinase B-raf BRAF Tclin Kinase -2.28702 199.1 1276
Cyclin-dependent kinase inhibitor 2A CDKN2A Tbio Enzyme -3.70375 8561.3 896
GTPase KRas KRAS Tbio Enzyme -3.77389 5694.2 421
Pro-epidermal growth factor EGF Tbio Non-IDG -3.74596 4837.7 851
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.67376 362.2 617
Hepatocyte growth factor HGF Tchem Enzyme -3.29371 2317.3 573
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
GTPase NRas NRAS Tchem Enzyme -2.98048 880.4 265
Platelet-derived growth factor subunit B PDGFB Tchem Non-IDG -3.24522 1684.0 357
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.74106 54.5 120