Development Level

Tbio 36 | 11,445
Tchem 23 | 1,598
Tclin 14 | 613

IMPC Phenotype

preweaning lethality, complete... 9 | 979
cataract 5 | 92
abnormal embryo size 4 | 220
abnormal lens morphology 4 | 81
decreased body weight 3 | 161
embryonic lethality prior to t... 3 | 278
enlarged heart 3 | 210
increased circulating choleste... 3 | 66
abnormal retinal vasculature m... 2 | 27
abnormal seminal vesicle morph... 2 | 114
decreased circulating creatini... 2 | 39
impaired pupillary reflex 2 | 26
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal body wall morphology 1 | 9
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal spleen morphology 1 | 55
abnormal tail morphology 1 | 25
abnormal testis morphology 1 | 43
absent startle reflex 1 | 24
cleft palate 1 | 8
corneal opacity 1 | 32
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased spleen weight 1 | 10
decreased total body fat amoun... 1 | 207
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
female infertility 1 | 60
fused cornea and lens 1 | 5
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired righting response 1 | 26
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular hem... 1 | 36
increased startle reflex 1 | 112
iris synechia 1 | 3
limb grasping 1 | 41
male infertility 1 | 123
microphthalmia 1 | 26
narrow eye opening 1 | 12
no spontaneous movement 1 | 1
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
short tibia 1 | 97
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Cancer 59 | 2,499
ovarian cancer 48 | 8,520
Carcinoma 45 | 11,493
lung cancer 42 | 4,740
osteosarcoma 40 | 7,950
Breast cancer 36 | 3,578
glioblastoma 35 | 5,792
psoriasis 34 | 6,694
malignant mesothelioma 33 | 3,232
medulloblastoma, large-cell 32 | 6,241
atypical teratoid / rhabdoid tumor 30 | 5,112
group 3 medulloblastoma 26 | 4,104
Breast Neoplasms 25 | 445
Mammary Neoplasms 25 | 425
oligodendroglioma 23 | 2,850
invasive ductal carcinoma 22 | 2,951
Carcinoma, Hepatocellular 20 | 228
Liver carcinoma 20 | 240
Kidney cancer 19 | 2,613
Lung Neoplasms 19 | 232
Prostatic Neoplasms 19 | 495
ependymoma 19 | 4,679
primitive neuroectodermal tumor 19 | 3,035
Autosomal recessive predisposition 18 | 1,442
breast carcinoma 18 | 1,638
pancreatic cancer 18 | 2,398
Stomach Neoplasms 17 | 300
non-small cell lung cancer 17 | 2,890
Astrocytoma, Pilocytic 16 | 3,081
Dull intelligence 16 | 645
Intellectual disability 16 | 1,016
Low intelligence 16 | 645
Melanoma 16 | 711
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Orbital separation excessive 16 | 244
Poor school performance 16 | 645
Seizures 16 | 596
adult high grade glioma 16 | 3,801
astrocytic glioma 16 | 2,597
diabetes mellitus 16 | 1,728
ductal carcinoma in situ 16 | 1,745
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 16 | 3,291
Adenoma 15 | 167
Epilepsy 15 | 792
Hypoplastic mandible condyle 15 | 275
Mandibular hypoplasia 15 | 275
Micrognathism 15 | 275
Short stature 15 | 531
Squamous cell carcinoma 15 | 129
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
juvenile dermatomyositis 15 | 1,187
lung adenocarcinoma 15 | 2,716
Carcinoma, Squamous Cell 14 | 110
Downward slant of palpebral fissure 14 | 158
Schizophrenia 14 | 1,160
adrenocortical carcinoma 14 | 1,428
subependymal giant cell astrocytoma 14 | 2,287
Blepharoptosis 13 | 231
Cognitive delay 13 | 608
Depressive disorder 13 | 409
Global developmental delay 13 | 608
Mental and motor retardation 13 | 608
Neoplasm Metastasis 13 | 168
Renal Cell Carcinoma 13 | 214
Vascular disease 13 | 319
interstitial cystitis 13 | 2,312
tuberculosis 13 | 2,010
Concave bridge of nose 12 | 195
Delayed bone age 12 | 136
Depressed nasal bridge 12 | 195
Depressed nasal root/bridge 12 | 195
Neoplasm Invasiveness 12 | 161
Skin cancer 12 | 469
Stomach cancer 12 | 30
cystic fibrosis 12 | 1,696
lung carcinoma 12 | 2,843
Byzanthine arch palate 11 | 194
Cleft Palate 11 | 271
Cryptorchidism 11 | 296
DOID:2627 11 | 94
Frontal bossing 11 | 157
Liver Neoplasms, Experimental 11 | 59
Melanocytic nevus 11 | 43
Ovarian Neoplasms 11 | 102
Papilloma 11 | 44
Rheumatoid arthritis 11 | 1,191
Strabismus 11 | 270
Upper respiratory tract disease 11 | 15
astrocytoma 11 | 1,146
nasopharyngeal carcinoma 11 | 1,058
non-small cell lung carcinoma 11 | 317
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
pituitary cancer 11 | 1,972
Endometrial cancer 10 | 311
Intrauterine retardation 10 | 176
Pectus excavatum 10 | 100
colon cancer 10 | 1,478
ulcerative colitis 10 | 1,819

Tissue

Endocrine System 71 | 18,159
Digestive Tract 69 | 17,369
Nervous System 69 | 16,725
Female tissues 68 | 17,400
Liver and Pancreas 68 | 16,750
Male tissues 68 | 17,142
Skin and soft tissues 68 | 17,230
Urinary Tract 68 | 16,678
Blood and immune system 67 | 16,909
Respiratory system 66 | 16,393
Cardiovascular System 62 | 15,192

Target Family

Non-IDG 35 | 12,091
Kinase 22 | 634
Enzyme 11 | 4,145
Transcription Factor 5 | 1,400

KEGG Pathway

Melanoma 73 | 73
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Fibroblast growth factor 16 FGF16 Tbio Non-IDG -1.75464 57.5 162
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Fibroblast growth factor 18 FGF18 Tbio Non-IDG -1.89822 84.6 146
Fibroblast growth factor receptor 1 FGFR1 Tclin Kinase -3.13063 1294.7 1785
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.07061 109.8 192
Insulin-like growth factor 1 receptor IGF1R Tclin Kinase -3.37168 2419.5 1686