Development Level

Tbio 67 | 11,445
Tchem 24 | 1,598
Tclin 11 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 11 | 979
decreased vertical activity 5 | 208
increased startle reflex 5 | 112
abnormal bone structure 4 | 187
abnormal heart morphology 4 | 162
decreased total body fat amoun... 4 | 207
enlarged heart 4 | 210
increased heart weight 4 | 62
decreased startle reflex 3 | 75
preweaning lethality, incomple... 3 | 499
abnormal behavior 2 | 298
abnormal coat-hair pigmentatio... 2 | 64
abnormal gait 2 | 69
abnormal skin morphology 2 | 50
cataract 2 | 92
decreased bone mineral content 2 | 151
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
hydrometra 2 | 53
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
prenatal lethality 2 | 28
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal bone mineralization 1 | 38
abnormal brain morphology 1 | 13
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal forelimb morphology 1 | 2
abnormal gallbladder morpholog... 1 | 1
abnormal head morphology 1 | 10
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal response to tactile s... 1 | 17
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased lymphocyte cell numb... 1 | 83
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased respiratory quotient 1 | 16
edema 1 | 59
enlarged gallbladder 1 | 2
hydroencephaly 1 | 14
hydrops fetalis 1 | 1
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased B cell number 1 | 9
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating insulin ... 1 | 3
increased circulating triglyce... 1 | 42
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
male infertility 1 | 123
mammalian phenotype 1 | 17
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87
small heart 1 | 10
syndactyly 1 | 23

Disease

Carcinoma 83 | 11,493
ovarian cancer 58 | 8,520
psoriasis 54 | 6,694
glioblastoma 45 | 5,792
osteosarcoma 45 | 7,950
ependymoma 44 | 4,679
atypical teratoid / rhabdoid tumor 43 | 5,112
Cancer 42 | 2,499
medulloblastoma, large-cell 41 | 6,241
Breast cancer 37 | 3,578
group 3 medulloblastoma 37 | 4,104
lung cancer 33 | 4,740
Astrocytoma, Pilocytic 28 | 3,081
Kidney cancer 28 | 2,613
adult high grade glioma 28 | 3,801
primitive neuroectodermal tumor 28 | 3,035
oligodendroglioma 26 | 2,850
astrocytic glioma 24 | 2,597
Schizophrenia 23 | 1,160
lung carcinoma 23 | 2,843
malignant mesothelioma 21 | 3,232
non-small cell lung cancer 21 | 2,890
Melanoma 20 | 711
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 19 | 2,955
invasive ductal carcinoma 19 | 2,951
ulcerative colitis 19 | 1,819
Pick disease 18 | 1,894
breast carcinoma 18 | 1,638
interstitial cystitis 18 | 2,312
lung adenocarcinoma 18 | 2,716
pancreatic cancer 18 | 2,398
Autosomal recessive predisposition 17 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
subependymal giant cell astrocytoma 17 | 2,287
Epilepsy 16 | 792
Obesity 16 | 678
Bipolar Disorder 15 | 666
colon cancer 15 | 1,478
diabetes mellitus 15 | 1,728
pituitary cancer 15 | 1,972
Intellectual disability 14 | 1,016
Short stature 14 | 531
Strabismus 14 | 270
tuberculosis 14 | 2,010
Cognitive delay 13 | 608
Cryptorchidism 13 | 296
Depressive disorder 13 | 409
Dull intelligence 13 | 645
Global developmental delay 13 | 608
Hypoplastic mandible condyle 13 | 275
Low intelligence 13 | 645
Mandibular hypoplasia 13 | 275
Mental Retardation 13 | 645
Mental and motor retardation 13 | 608
Mental deficiency 13 | 645
Micrognathism 13 | 275
Poor school performance 13 | 645
Skin cancer 13 | 469
cystic fibrosis 13 | 1,696
ductal carcinoma in situ 13 | 1,745
group 4 medulloblastoma 13 | 1,855
Substance Withdrawal Syndrome 12 | 55
astrocytoma 12 | 1,146
Heart disease 11 | 306
Liver cancer 11 | 604
Major Depressive Disorder 11 | 301
Muscle hypotonia 11 | 571
Osteoporosis 11 | 363
cutaneous lupus erythematosus 11 | 1,057
Breast Neoplasms 10 | 445
Downward slant of palpebral fissure 10 | 158
Frontal bossing 10 | 157
Kidney disease 10 | 430
Low set ears 10 | 181
Mental Depression 10 | 333
Multiple myeloma 10 | 1,332
Nystagmus 10 | 317
Rheumatoid arthritis 10 | 1,191
juvenile dermatomyositis 10 | 1,187
Adenoma 9 | 167
Alzheimer's disease 9 | 658
Byzanthine arch palate 9 | 194
Hypertension 9 | 396
Lung Neoplasms 9 | 232
Mammary Neoplasms 9 | 425
Orbital separation excessive 9 | 244
Pectus excavatum 9 | 100
Seizures 9 | 596
Stomach Neoplasms 9 | 300
esophageal adenocarcinoma 9 | 737
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
pediatric high grade glioma 9 | 1,064
Acquired scoliosis 8 | 281
Broad flat nasal bridge 8 | 236
Congenital Epicanthus 8 | 177
Crohn's disease 8 | 321
Curvature of spine 8 | 282
Delayed bone age 8 | 136
Prostatic Neoplasms 8 | 495

Tissue

Endocrine System 99 | 18,159
Female tissues 99 | 17,400
Skin and soft tissues 97 | 17,230
Blood and immune system 96 | 16,909
Digestive Tract 96 | 17,369
Male tissues 96 | 17,142
Nervous System 96 | 16,725
Liver and Pancreas 93 | 16,750
Urinary Tract 92 | 16,678
Respiratory system 89 | 16,393
Cardiovascular System 83 | 15,192

Target Family

Non-IDG 43 | 12,091
Enzyme 19 | 4,145
Kinase 17 | 634
GPCR 12 | 408
Transcription Factor 11 | 1,400
Epigenetic 2 | 242

KEGG Pathway

Melanogenesis 104 | 104
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Melanocyte-stimulating hormone receptor MC1R Tclin GPCR -2.90014 829.2 194
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
5,6-dihydroxyindole-2-carboxylic acid oxidase TYRP1 Tbio Enzyme -2.95336 876.7 309
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574