Development Level

Tbio 22 | 11,445
Tchem 4 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
impaired glucose tolerance 2 | 75
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
cardiovascular system phenotyp... 1 | 36
decreased bone mineral density 1 | 126
decreased circulating glucose ... 1 | 126
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
increased circulating alkaline... 1 | 122
increased circulating total pr... 1 | 28
increased total retina thickne... 1 | 4
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36

Disease

diabetes mellitus 18 | 1,728
Carcinoma 16 | 11,493
Diabetes Mellitus, Non-Insulin-Dependent 13 | 145
Diabetes Mellitus, Type 2 13 | 142
maturity-onset diabetes of the young 12 | 32
Hyperglycemia 10 | 137
Cancer 9 | 2,499
Diabetes Mellitus, Experimental 8 | 108
glioblastoma 8 | 5,792
medulloblastoma, large-cell 8 | 6,241
Diabetes Mellitus, Noninsulin-Dependent 7 | 31
Maturity onset diabetes mellitus in young 7 | 11
Type 2 diabetes mellitus 7 | 272
intraductal papillary-mucinous adenoma (IPMA) 7 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 7 | 2,989
malignant mesothelioma 7 | 3,232
psoriasis 7 | 6,694
Cognitive delay 6 | 608
Global developmental delay 6 | 608
Glycosuria 6 | 29
Hypoglycemia 6 | 152
Mental and motor retardation 6 | 608
intraductal papillary-mucinous neoplasm (IPMN) 6 | 3,291
Acquired metabolic disease 5 | 336
Astrocytoma, Pilocytic 5 | 3,081
Autosomal recessive predisposition 5 | 1,442
Epilepsy 5 | 792
Failure to gain weight 5 | 365
Hyperinsulinism 5 | 133
Pediatric failure to thrive 5 | 365
Seizures 5 | 596
group 3 medulloblastoma 5 | 4,104
lung cancer 5 | 4,740
osteosarcoma 5 | 7,950
Blepharoptosis 4 | 231
Dehydration 4 | 40
Diarrhea 4 | 253
Dull intelligence 4 | 645
Hyperinsulinemic hypoglycemia 4 | 17
Insulin Resistance 4 | 72
Insulinoma 4 | 24
Intellectual disability 4 | 1,016
Liver Cirrhosis, Experimental 4 | 769
Low intelligence 4 | 645
Mental Retardation 4 | 645
Mental deficiency 4 | 645
Obesity 4 | 678
Poor school performance 4 | 645
Prostatic Neoplasms 4 | 495
adult high grade glioma 4 | 3,801
atypical teratoid / rhabdoid tumor 4 | 5,112
ependymoma 4 | 4,679
ovarian cancer 4 | 8,520
pancreatic cancer 4 | 2,398
pituitary cancer 4 | 1,972
ulcerative colitis 4 | 1,819
Abnormality of the immune system 3 | 18
Adenoma 3 | 167
Anteverted nostril 3 | 191
Arthrogryposis 3 | 54
Axial hypotonia 3 | 46
Breast Neoplasms 3 | 445
Breast cancer 3 | 3,578
Congenital Heart Defects 3 | 58
Congenital heart disease 3 | 93
Elevated hepatic transaminases 3 | 81
Epilepsies, Myoclonic 3 | 32
Generalized myoclonic seizures 3 | 30
Gout 3 | 106
Hepatic enzyme increased 3 | 81
Hypsarrhythmia 3 | 25
Kidney disease 3 | 430
Lipid metabolism disorder 3 | 114
Liver Dysfunction 3 | 99
Liver enzymes abnormal 3 | 81
Liver function test increased 3 | 81
Liver function tests abnormal finding 3 | 81
Long philtrum 3 | 137
Low Birth Weights 3 | 69
Mammary Neoplasms 3 | 425
Melanoma 3 | 711
Motor delay 3 | 147
Muscle Weakness 3 | 170
Myoclonic Epilepsies, Progressive 3 | 44
Neuropathy 3 | 261
No development of motor milestones 3 | 147
Retinal Diseases 3 | 55
Short nose 3 | 132
Small for gestational age (disorder) 3 | 69
Small nose 3 | 132
Subclinical abnormal liver function tests 3 | 81
Tachycardia 3 | 43
Transaminases increased 3 | 81
Vomiting 3 | 116
Weight decreased 3 | 103
colon cancer 3 | 1,478
lung adenocarcinoma 3 | 2,716
non-small cell lung cancer 3 | 2,890
oligodendroglioma 3 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 3 | 1,962

Tissue

Digestive Tract 26 | 17,369
Endocrine System 24 | 18,159
Liver and Pancreas 24 | 16,750
Skin and soft tissues 21 | 17,230
Female tissues 20 | 17,400
Nervous System 19 | 16,725
Urinary Tract 19 | 16,678
Male tissues 18 | 17,142
Blood and immune system 17 | 16,909
Respiratory system 13 | 16,393
Cardiovascular System 7 | 15,192

Target Family

Transcription Factor 18 | 1,400
Nuclear Receptor 3 | 48
Kinase 2 | 634
Non-IDG 2 | 12,091
Transporter 1 | 473

KEGG Pathway

Maturity onset diabetes of the... 26 | 26
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Paired box protein Pax-6 PAX6 Tbio Transcription Factor -3.16650 1458.6 570
Pancreas/duodenum homeobox protein 1 PDX1 Tbio Transcription Factor -2.36445 252.7 605
Motor neuron and pancreas homeobox protein 1 MNX1 Tbio Transcription Factor -2.14902 139.2 126
Transcription factor MafA MAFA Tbio Transcription Factor -1.36099 23.0 195
DNA-binding protein RFX6 RFX6 Tbio Transcription Factor -2.57722 368.8 44
Hepatocyte nuclear factor 1-beta HNF1B Tbio Transcription Factor -2.63510 401.5 403
Hematopoietically-expressed homeobox protein HHEX HHEX Tbio Transcription Factor -3.05655 1150.7 363
Hepatocyte nuclear factor 4-gamma HNF4G Tbio Nuclear Receptor -1.08671 9.11 135
Islet amyloid polypeptide IAPP Tbio Non-IDG -3.20630 1751.6 330