Development Level

Tbio 143 | 11,651
Tchem 102 | 1,388
Tclin 42 | 612
Tdark 8 | 6,593

Collection

RFA-RM-18-021 19 | 328
Ion Channel: IDG Consortium (T... 14 | 99
Kinase: IDG Consortium (Target... 5 | 125
Kinase: IDG Consortium (Comple... 3 | 37

IMPC Phenotype

preweaning lethality, complete... 22 | 979
abnormal bone structure 10 | 187
abnormal behavior 7 | 298
decreased body weight 7 | 161
embryonic lethality prior to t... 7 | 278
increased startle reflex 6 | 112
preweaning lethality, incomple... 6 | 499
abnormal embryo size 5 | 220
decreased total body fat amoun... 5 | 207
increased circulating alkaline... 5 | 122
increased circulating choleste... 5 | 66
increased total body fat amoun... 5 | 134
limb grasping 5 | 41
abnormal cornea morphology 4 | 31
abnormal lens morphology 4 | 81
cataract 4 | 92
decreased bone mineral content 4 | 151
decreased circulating choleste... 4 | 93
decreased circulating glucose ... 4 | 126
decreased circulating sodium l... 4 | 22
decreased fasted circulating g... 4 | 65
decreased hematocrit 4 | 46
decreased lean body mass 4 | 135
decreased prepulse inhibition 4 | 82
increased circulating sodium l... 4 | 71
increased lean body mass 4 | 172
abnormal gait 3 | 69
abnormal retina morphology 3 | 71
abnormal startle reflex 3 | 15
decreased circulating iron lev... 3 | 32
decreased circulating triglyce... 3 | 79
decreased erythrocyte cell num... 3 | 62
decreased grip strength 3 | 116
decreased neutrophil cell numb... 3 | 42
embryonic lethality prior to o... 3 | 239
impaired pupillary reflex 3 | 26
increased blood urea nitrogen ... 3 | 48
increased bone mineral content 3 | 108
increased circulating HDL chol... 3 | 80
short tibia 3 | 97
abnormal bone mineralization 2 | 38
abnormal coat-hair pigmentatio... 2 | 64
abnormal locomotor activation 2 | 16
abnormal optic disc morphology 2 | 10
abnormal retinal vasculature m... 2 | 27
abnormal rib morphology 2 | 10
abnormal sleep behavior 2 | 70
corneal opacity 2 | 32
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 68
decreased circulating alanine ... 2 | 47
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased hemoglobin content 2 | 68
decreased mean corpuscular vol... 2 | 79
decreased spleen weight 2 | 10
decreased vertical activity 2 | 208
edema 2 | 59
enlarged heart 2 | 210
enlarged kidney 2 | 14
enlarged lymph nodes 2 | 37
hemorrhage 2 | 23
hyperactivity 2 | 148
increased body length 2 | 32
increased bone mineral density 2 | 72
increased circulating amylase ... 2 | 25
increased circulating free fat... 2 | 20
increased circulating glucose ... 2 | 24
increased circulating triglyce... 2 | 42
increased leukocyte cell numbe... 2 | 47
increased or absent threshold ... 2 | 101
male infertility 2 | 123
polycystic kidney 2 | 15
prenatal lethality 2 | 28
thrombocytopenia 2 | 56
abnormal body wall morphology 1 | 9
abnormal cranium morphology 1 | 36
abnormal neural tube closure 1 | 46
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vocalization 1 | 21
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
increased circulating iron lev... 1 | 30
increased circulating phosphat... 1 | 26
increased eosinophil cell numb... 1 | 11
increased heart weight 1 | 62
increased mean corpuscular vol... 1 | 92
iris synechia 1 | 3
persistence of hyaloid vascula... 1 | 33
tremors 1 | 39
vertebral fusion 1 | 23

Disease

Carcinoma 210 | 11,493
ovarian cancer 163 | 8,520
Cancer 157 | 2,499
glioblastoma 152 | 5,792
osteosarcoma 144 | 7,950
psoriasis 140 | 6,694
lung cancer 126 | 4,740
medulloblastoma, large-cell 126 | 6,241
atypical teratoid / rhabdoid tumor 121 | 5,112
ependymoma 115 | 4,679
malignant mesothelioma 104 | 3,232
Breast cancer 102 | 3,578
adult high grade glioma 93 | 3,801
Astrocytoma, Pilocytic 86 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 81 | 3,291
lung carcinoma 76 | 2,843
oligodendroglioma 75 | 2,850
Kidney cancer 74 | 2,613
group 3 medulloblastoma 74 | 4,104
invasive ductal carcinoma 67 | 2,951
primitive neuroectodermal tumor 66 | 3,035
pancreatic cancer 65 | 2,398
non-small cell lung cancer 64 | 2,890
Schizophrenia 63 | 1,160
subependymal giant cell astrocytoma 63 | 2,287
astrocytic glioma 60 | 2,597
group 4 medulloblastoma 58 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 58 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 56 | 2,989
tuberculosis 55 | 2,010
ulcerative colitis 55 | 1,819
diabetes mellitus 54 | 1,728
interstitial cystitis 54 | 2,312
cystic fibrosis 53 | 1,696
lung adenocarcinoma 53 | 2,716
pituitary cancer 51 | 1,972
Pick disease 48 | 1,894
Breast Neoplasms 42 | 445
Mammary Neoplasms 42 | 425
adrenocortical carcinoma 41 | 1,428
Bipolar Disorder 40 | 666
Depressive disorder 40 | 409
Rheumatoid arthritis 40 | 1,191
astrocytoma 38 | 1,146
colon cancer 38 | 1,478
ductal carcinoma in situ 38 | 1,745
Intellectual disability 35 | 1,016
Epilepsy 34 | 792
Vascular disease 34 | 319
breast carcinoma 34 | 1,638
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,962
Short stature 32 | 531
cutaneous lupus erythematosus 32 | 1,057
primary pancreatic ductal adenocarcinoma 32 | 1,109
Alzheimer's disease 31 | 658
Lung Neoplasms 31 | 232
Autosomal recessive predisposition 30 | 1,442
pediatric high grade glioma 30 | 1,064
Melanoma 29 | 711
Mental Depression 28 | 333
Renal Cell Carcinoma 28 | 214
spina bifida 28 | 1,074
Orbital separation excessive 27 | 244
Parkinson's disease 27 | 392
Prostatic Neoplasms 27 | 495
Seizures 27 | 596
Arthritis 26 | 290
Liver Cirrhosis, Experimental 26 | 769
Multiple myeloma 26 | 1,332
Skin cancer 26 | 469
Stomach Neoplasms 26 | 300
dermatomyositis 26 | 966
Obesity 25 | 678
Osteoporosis 25 | 363
juvenile dermatomyositis 25 | 1,187
Acquired scoliosis 24 | 281
Byzanthine arch palate 24 | 194
Cleft Palate 24 | 271
Cryptorchidism 24 | 296
Curvature of spine 24 | 282
Dull intelligence 24 | 645
Heart disease 24 | 306
Hypoplastic mandible condyle 24 | 275
Low intelligence 24 | 645
Mandibular hypoplasia 24 | 275
Mental Retardation 24 | 645
Mental deficiency 24 | 645
Micrognathism 24 | 275
Poor school performance 24 | 645
Carcinoma, Hepatocellular 23 | 228
Hypertension 23 | 396
Liver carcinoma 23 | 240
acute quadriplegic myopathy 23 | 1,158
Blepharoptosis 22 | 231
Downward slant of palpebral fissure 22 | 158
Hypertensive disease 22 | 292
Lung disease 21 | 142
Myocardial Ischemia 21 | 169
hepatocellular carcinoma 21 | 547
non primary Sjogren syndrome sicca 21 | 891

Tissue

Endocrine System 293 | 18,159
Digestive Tract 287 | 17,369
Nervous System 286 | 16,725
Female tissues 284 | 17,400
Blood and immune system 283 | 16,909
Male tissues 282 | 17,142
Skin and soft tissues 282 | 17,230
Urinary Tract 279 | 16,678
Liver and Pancreas 276 | 16,750
Respiratory system 275 | 16,393
Cardiovascular System 262 | 15,192

Target Family

Non-IDG 102 | 12,091
Kinase 97 | 634
Enzyme 49 | 4,145
Ion Channel 26 | 344
Transcription Factor 19 | 1,400
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

KEGG Pathway

MAPK signaling pathway 295 | 295
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Tyrosine-protein phosphatase non-receptor type 5 PTPN5 Tchem Enzyme -1.85420 70.8 225
Ras GTPase-activating protein 1 RASA1 Tbio Enzyme -2.61637 404.4 402
Serine/threonine-protein kinase PAK 1 PAK1 Tchem Kinase -2.29299 237.8 1060
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Platelet-derived growth factor C PDGFC Tbio Non-IDG -2.03910 120.6 226
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Voltage-dependent calcium channel gamma-2 subunit CACNG2 Tbio Ion Channel -1.92203 89.6 173
Interleukin-1 receptor-associated kinase 4 IRAK4 Tchem Kinase -2.28820 202.2 610