Development Level

Tchem 127 | 1,890
Tbio 99 | 10,625
Tclin 23 | 602
Tdark 6 | 7,003

Collection

Eligible Ion Channel Proteins 16 | 117
Eligible Kinase Proteins 5 | 134

IMPC Term

preweaning lethality, complete... 17 | 633
decreased lean body mass 9 | 195
abnormal bone structure 8 | 131
decreased body weight 7 | 174
increased blood urea nitrogen ... 6 | 44
abnormal embryo size 5 | 112
abnormal retina morphology 5 | 100
decreased bone mineral content 5 | 157
embryonic lethality prior to t... 5 | 187
abnormal bone mineralization 4 | 55
abnormal startle reflex 4 | 14
decreased circulating sodium l... 4 | 18
decreased grip strength 4 | 123
decreased prepulse inhibition 4 | 52
decreased total body fat amoun... 4 | 186
increased circulating alkaline... 4 | 119
increased circulating sodium l... 4 | 71
limb grasping 4 | 35
abnormal behavior 3 | 226
abnormal cornea morphology 3 | 24
abnormal lens morphology 3 | 73
decreased circulating choleste... 3 | 85
decreased circulating glucose ... 3 | 121
decreased circulating iron lev... 3 | 25
decreased circulating triglyce... 3 | 83
decreased erythrocyte cell num... 3 | 43
decreased fasted circulating g... 3 | 49
decreased hematocrit 3 | 25
increased bone mineral content 3 | 92
increased lean body mass 3 | 107
abnormal coat/hair pigmentatio... 2 | 54
abnormal forebrain development 2 | 18
abnormal gait 2 | 51
abnormal hindbrain development 2 | 24
abnormal locomotor activation 2 | 26
abnormal neural tube closure 2 | 37
abnormal retinal pigmentation 2 | 61
abnormal retinal vasculature m... 2 | 15
cataract 2 | 26
corneal opacity 2 | 25
decreased body length 2 | 108
decreased bone mineral density 2 | 126
decreased caudal vertebrae num... 2 | 49
decreased circulating HDL chol... 2 | 77
decreased circulating alanine ... 2 | 53
decreased circulating creatini... 2 | 31
decreased circulating fructosa... 2 | 31
decreased hemoglobin content 2 | 53
decreased kidney weight 2 | 7
decreased leukocyte cell numbe... 2 | 54
decreased lumbar vertebrae num... 2 | 62
decreased mean corpuscular hem... 2 | 19
decreased rib number 2 | 59
decreased thoracic vertebrae n... 2 | 7
enlarged heart 2 | 111
impaired pupillary reflex 2 | 14
impaired righting response 2 | 19
increased body length 2 | 20
increased circulating HDL chol... 2 | 63
increased circulating amylase ... 2 | 13
increased circulating chloride... 2 | 43
increased circulating choleste... 2 | 53
increased erythrocyte cell num... 2 | 26
increased mean corpuscular vol... 2 | 91
increased or absent threshold ... 2 | 128
increased startle reflex 2 | 38
male infertility 2 | 62
preweaning lethality, incomple... 2 | 260
thrombocytopenia 2 | 46
abnormal body wall morphology 1 | 7
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
decreased CD4-positive, alpha ... 1 | 19
decreased T cell number 1 | 31
decreased circulating chloride... 1 | 32
decreased circulating magnesiu... 1 | 11
decreased circulating potassiu... 1 | 17
decreased eosinophil cell numb... 1 | 41
decreased total retina thickne... 1 | 20
dilated heart left ventricle 1 | 10
enlarged lymph nodes 1 | 27
female infertility 1 | 34
hydrops fetalis 1 | 22
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating glucose ... 1 | 16
increased circulating iron lev... 1 | 25
increased circulating triglyce... 1 | 24
increased grip strength 1 | 83
increased lactate dehydrogenas... 1 | 3
increased rib number 1 | 41
increased sacral vertebrae num... 1 | 62
persistence of hyaloid vascula... 1 | 22
polycystic kidney 1 | 9
prenatal lethality 1 | 16
short tibia 1 | 82
straub tail 1 | 26
vertebral fusion 1 | 23

Disease

ovarian cancer 134 | 8,484
glioblastoma 124 | 5,572
osteosarcoma 124 | 7,933
Cancer 116 | 2,346
psoriasis 114 | 6,685
medulloblastoma, large-cell 112 | 6,234
atypical teratoid / rhabdoid tumor 93 | 4,369
lung cancer 93 | 4,466
malignant mesothelioma 78 | 3,162
pilocytic astrocytoma 77 | 3,086
oligodendroglioma 68 | 2,849
pediatric high grade glioma 66 | 2,712
Breast cancer 62 | 3,094
primitive neuroectodermal tumor 62 | 3,031
lung carcinoma 59 | 2,844
ependymoma 57 | 2,514
intraductal papillary-mucinous neoplasm (IPMN) 56 | 3,289
subependymal giant cell astrocytoma 56 | 2,287
Carcinoma 55 | 2,147
invasive ductal carcinoma 51 | 2,950
non-small cell lung cancer 49 | 2,798
ulcerative colitis 47 | 2,087
Pick disease 45 | 1,893
pancreatic cancer 45 | 2,300
astrocytoma 43 | 1,493
lung adenocarcinoma 42 | 2,713
pituitary cancer 42 | 1,972
astrocytic glioma 41 | 2,241
interstitial cystitis 41 | 2,299
intraductal papillary-mucinous adenoma (IPMA) 41 | 2,956
medulloblastoma 41 | 1,524
diabetes mellitus 40 | 1,663
adult high grade glioma 38 | 2,148
cystic fibrosis 38 | 1,665
group 4 medulloblastoma 38 | 1,875
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,988
group 3 medulloblastoma 35 | 2,254
Rheumatoid Arthritis 33 | 1,160
colon cancer 33 | 1,475
posterior fossa group A ependymoma 33 | 1,511
tuberculosis 33 | 1,557
adrenocortical carcinoma 30 | 1,427
primary pancreatic ductal adenocarcinoma 30 | 1,271
Mammary Neoplasms 28 | 410
Vascular disease 28 | 281
ductal carcinoma in situ 28 | 1,745
Parkinson's disease 26 | 364
posterior fossa group B ependymoma 26 | 1,530
Schizophrenia 25 | 501
Lung Neoplasms 24 | 171
Intellectual disability 23 | 573
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,795
sonic hedgehog group medulloblastoma 23 | 1,482
Alzheimer's disease 22 | 644
Multiple myeloma 22 | 1,327
dermatomyositis 22 | 933
juvenile dermatomyositis 22 | 1,189
cutaneous lupus erythematosus 21 | 1,056
breast carcinoma 20 | 1,614
Arthritis 19 | 248
Toxic encephalopathy 19 | 131
Cleft palate 18 | 125
Endometriosis 18 | 535
Prostatic Neoplasms 18 | 471
Waldenstrons macroglobulinemia 18 | 765
acute quadriplegic myopathy 18 | 1,157
spina bifida 18 | 1,064
Epilepsy 17 | 346
Obesity 17 | 616
Stomach Neoplasms 17 | 282
Heart disease 16 | 279
Kidney disease 16 | 396
Liver carcinoma 16 | 217
Lung disease 16 | 132
Osteoporosis 16 | 257
Renal Cell Carcinoma 16 | 199
active Crohn's disease 16 | 918
acute myeloid leukemia 16 | 780
atypical teratoid/rhabdoid tumor 16 | 1,095
hepatocellular carcinoma 16 | 532
nasopharyngeal carcinoma 16 | 1,056
non primary Sjogren syndrome sicca 16 | 840
Amyotrophic Lateral Sclerosis 15 | 431
Brain Ischemia 15 | 87
Colonic Neoplasms 15 | 126
Down syndrome 15 | 548
Myocardial Ischemia 15 | 169
inflammatory breast cancer 15 | 404
non-small cell lung carcinoma 15 | 413
Autistic Disorder 14 | 320
Chronic Lymphocytic Leukemia 14 | 242
Neoplasm Metastasis 14 | 138
Reperfusion Injury 14 | 84
esophageal adenocarcinoma 14 | 737
gastric cancer 14 | 430
gastric carcinoma 14 | 832
Asthma 13 | 349
Neurodegenerative disease 13 | 383
aldosterone-producing adenoma 13 | 664
pancreatic carcinoma 13 | 567

Tissue

Endocrine System 254 | 18,512
Female tissues 254 | 18,647
Nervous System 254 | 18,561
Liver and Pancreas 253 | 18,136
Digestive Tract 252 | 18,473
Urinary Tract 252 | 18,444
Skin and soft tissues 251 | 18,115
Blood and immune system 250 | 17,995
Cardiovascular System 250 | 17,958
Male tissues 247 | 17,969
Respiratory system 244 | 17,484

Target Family

Non-IDG 81 | 11,971
Kinase 80 | 634
Enzyme 47 | 4,146
Ion Channel 26 | 341
Transcription Factor 19 | 1,400
Nuclear Receptor 1 | 48
TF/Epigenetic 1 | 38

KEGG Pathway

MAPK signaling pathway 255 | 255
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Proto-oncogene c-Fos FOS Tchem Transcription Factor -4.11560 13094.7 961
Interleukin-1 beta IL1B Tclin Non-IDG -4.34333 22444.2 1345
Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B Tclin Ion Channel -2.21210 162.9 67
Fibroblast growth factor 5 FGF5 Tbio Non-IDG -2.00731 99.9 143
TNF receptor-associated factor 2 TRAF2 Tbio Non-IDG -1.85843 68.9 516
C-Jun-amino-terminal kinase-interacting protein 3 MAPK8IP3 Tbio Enzyme -1.63360 51.0 128
Interleukin-1 receptor type 2 IL1R2 Tbio Non-IDG -1.85724 72.1 361
Beta-arrestin-1 ARRB1 Tchem Non-IDG -2.54226 366.3 416
Tumor necrosis factor receptor superfamily member 6 FAS Tbio Non-IDG -3.27492 2052.7 1794