Development Level

Tbio 85 | 11,178
Tchem 32 | 1,885
Tdark 4 | 6,569
Tclin 2 | 612

IMPC Phenotype

increased bone mineral content 6 | 108
short tibia 6 | 97
decreased total body fat amoun... 5 | 207
preweaning lethality, incomple... 5 | 499
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
increased lean body mass 4 | 172
abnormal bone structure 3 | 187
abnormal seminal vesicle morph... 3 | 114
decreased circulating serum al... 3 | 82
enlarged lymph nodes 3 | 37
increased bone mineral density 3 | 72
increased circulating potassiu... 3 | 29
increased or absent threshold ... 3 | 101
preweaning lethality, complete... 3 | 979
thrombocytosis 3 | 27
abnormal behavior 2 | 298
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
cardiovascular system phenotyp... 2 | 36
decreased bone mineral density 2 | 126
decreased prepulse inhibition 2 | 82
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased circulating phosphat... 2 | 26
increased startle reflex 2 | 112
small adrenal glands 2 | 16
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal hindbrain morphology 1 | 10
abnormal lung morphology 1 | 26
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
absent adrenal gland 1 | 2
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased cardiac output 1 | 3
decreased cardiac stroke volum... 1 | 6
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased respiratory quotient 1 | 16
decreased vertical activity 1 | 208
edema 1 | 59
enlarged kidney 1 | 14
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
female infertility 1 | 60
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased B cell number 1 | 9
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased cardiac muscle contr... 1 | 8
increased circulating aspartat... 1 | 15
increased coping response 1 | 4
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
male infertility 1 | 123
premature death 1 | 5
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small superior vagus ganglion 1 | 74

Disease

ovarian cancer 80 | 8,297
Carcinoma 79 | 11,192
osteosarcoma 58 | 7,766
glioblastoma 57 | 5,635
Autosomal recessive predisposition 49 | 1,407
medulloblastoma, large-cell 49 | 6,086
psoriasis 42 | 6,514
atypical teratoid / rhabdoid tumor 39 | 4,971
malignant mesothelioma 36 | 3,135
ependymoma 35 | 4,559
lung cancer 34 | 4,607
Astrocytoma, Pilocytic 31 | 3,006
Epilepsy 31 | 775
tuberculosis 31 | 1,963
subependymal giant cell astrocytoma 30 | 2,230
Intellectual disability 29 | 998
Multiple myeloma 29 | 1,296
Seizures 29 | 584
diabetes mellitus 28 | 1,683
lung carcinoma 27 | 2,755
Hepatomegaly 25 | 280
adult high grade glioma 24 | 3,701
Coarse facial features 23 | 103
Muscle hypotonia 23 | 562
Splenomegaly 23 | 186
Thickened facial skin with coarse facial features 23 | 103
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,204
Dull intelligence 22 | 634
Low intelligence 22 | 634
Mental Retardation 22 | 634
Mental deficiency 22 | 634
Poor school performance 22 | 634
invasive ductal carcinoma 22 | 2,867
Neurodegenerative disease 21 | 402
astrocytoma 21 | 1,113
group 3 medulloblastoma 21 | 4,002
Cancer 20 | 2,388
Cognitive delay 20 | 596
Global developmental delay 20 | 596
Mental and motor retardation 20 | 596
group 4 medulloblastoma 20 | 1,806
Breast cancer 19 | 3,469
Congenital deafness 18 | 180
Deafness 18 | 193
Hearing Loss, Partial 18 | 180
hearing impairment 18 | 194
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,872
pancreatic cancer 18 | 2,322
pediatric high grade glioma 18 | 1,035
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,902
ulcerative colitis 17 | 1,765
Mucopolysaccharidosis 16 | 26
Pick disease 16 | 1,856
Short stature 16 | 514
dermatomyositis 16 | 941
non-small cell lung cancer 16 | 2,799
primitive neuroectodermal tumor 16 | 2,957
acute quadriplegic myopathy 15 | 1,133
astrocytic glioma 15 | 2,530
juvenile dermatomyositis 15 | 1,147
Kidney cancer 14 | 2,548
Waldenstrons macroglobulinemia 14 | 742
esophageal adenocarcinoma 14 | 696
pancreatic ductal adenocarcinoma liver metastasis 14 | 1,911
inclusion-cell disease 13 | 16
lung adenocarcinoma 13 | 2,627
oligodendroglioma 13 | 2,768
Alzheimer's disease 12 | 640
Cerebellar Ataxia 12 | 302
Cerebral atrophy 12 | 175
Down syndrome 12 | 480
Dysarthria 12 | 190
Gangliosidosis 12 | 20
Hyperreflexia 12 | 208
Liver Cirrhosis, Experimental 12 | 733
Rheumatoid arthritis 12 | 1,156
interstitial cystitis 12 | 2,237
Duchenne muscular dystrophy 11 | 587
Pfaundler-Hurler Syndrome 11 | 11
Recurrent respiratory infections 11 | 138
cystic fibrosis 11 | 1,629
Degenerative brain disorder 10 | 98
Failure to gain weight 10 | 359
Frontal bossing 10 | 154
Hernia, Inguinal 10 | 88
Multiple Sclerosis 10 | 527
Myoclonus 10 | 71
Neuronal ceroid lipofuscinosis 10 | 28
Pediatric failure to thrive 10 | 359
Supratentorial atrophy 10 | 93
breast carcinoma 10 | 1,589
cutaneous lupus erythematosus 10 | 1,016
Acquired scoliosis 9 | 274
Curvature of spine 9 | 275
Hydrocephalus 9 | 148
Muscle Spasticity 9 | 192
colon cancer 9 | 1,428
mucosa-associated lymphoid tissue lymphoma 9 | 473
pituitary cancer 9 | 1,915
primary Sjogren syndrome 9 | 710

Tissue

Blood and immune system 123 | 16,909
Digestive Tract 123 | 17,369
Endocrine System 123 | 18,159
Female tissues 123 | 17,400
Male tissues 123 | 17,142
Nervous System 123 | 16,725
Respiratory system 123 | 16,393
Skin and soft tissues 123 | 17,230
Liver and Pancreas 122 | 16,750
Urinary Tract 122 | 16,678
Cardiovascular System 120 | 15,192

Target Family

Enzyme 68 | 4,145
Non-IDG 48 | 12,091
Transporter 5 | 473
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

KEGG Pathway

Lysosome 123 | 123
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cathepsin D CTSD Tchem Enzyme -3.47061 2866.8 779
Alpha-N-acetylgalactosaminidase NAGA Tbio Enzyme -2.21917 159.3 96
Mucolipin-1 MCOLN1 Tbio Ion Channel -2.43459 272.2 132
Cathepsin Z CTSZ Tchem Enzyme -1.80363 70.2 233
Glucosylceramidase GBA Tchem Enzyme -3.22080 1617.1 299
Sortilin SORT1 Tchem Non-IDG -2.36389 235.8 137
Sialidase-1 NEU1 Tbio Enzyme -2.07548 116.0 278
AP-3 complex subunit beta-2 AP3B2 Tbio Non-IDG -0.76737 5.95 100
Battenin CLN3 Tbio Non-IDG -3.01271 937.3 134
Cathepsin B CTSB Tchem Enzyme -3.72723 5011.5 448