Development Level

Tbio 88 | 11,445
Tchem 29 | 1,598
Tdark 4 | 6,588
Tclin 2 | 613

IMPC Phenotype

increased bone mineral content 6 | 108
short tibia 6 | 97
decreased total body fat amoun... 5 | 207
preweaning lethality, incomple... 5 | 499
hypoactivity 4 | 132
increased circulating alkaline... 4 | 122
increased lean body mass 4 | 172
abnormal bone structure 3 | 187
abnormal seminal vesicle morph... 3 | 114
decreased circulating serum al... 3 | 82
enlarged lymph nodes 3 | 37
increased bone mineral density 3 | 72
increased circulating potassiu... 3 | 29
increased or absent threshold ... 3 | 101
preweaning lethality, complete... 3 | 979
thrombocytosis 3 | 27
abnormal behavior 2 | 298
abnormal heart morphology 2 | 162
abnormal kidney morphology 2 | 65
cardiovascular system phenotyp... 2 | 36
decreased bone mineral density 2 | 126
decreased prepulse inhibition 2 | 82
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased circulating phosphat... 2 | 26
increased startle reflex 2 | 112
small adrenal glands 2 | 16
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal coat-hair pigmentatio... 1 | 64
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal hindbrain morphology 1 | 10
abnormal lung morphology 1 | 26
abnormal midbrain morphology 1 | 10
abnormal neural tube closure 1 | 46
abnormal retina morphology 1 | 71
abnormal retinal vasculature m... 1 | 27
abnormal sensory capabilities-... 1 | 8
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal vibrissa morphology 1 | 25
absent adrenal gland 1 | 2
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body weight 1 | 161
decreased cardiac output 1 | 3
decreased cardiac stroke volum... 1 | 6
decreased circulating aspartat... 1 | 34
decreased circulating bilirubi... 1 | 19
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased respiratory quotient 1 | 16
decreased vertical activity 1 | 208
edema 1 | 59
enlarged kidney 1 | 14
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
female infertility 1 | 60
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased B cell number 1 | 9
increased blood urea nitrogen ... 1 | 48
increased body length 1 | 32
increased cardiac muscle contr... 1 | 8
increased circulating aspartat... 1 | 15
increased coping response 1 | 4
increased fasted circulating g... 1 | 76
increased heart rate 1 | 23
increased heart weight 1 | 62
increased kidney weight 1 | 6
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased prepulse inhibition 1 | 32
limb grasping 1 | 41
male infertility 1 | 123
premature death 1 | 5
prenatal lethality 1 | 28
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small superior vagus ganglion 1 | 74

Disease

ovarian cancer 82 | 8,520
Carcinoma 81 | 11,493
glioblastoma 59 | 5,792
osteosarcoma 59 | 7,950
Autosomal recessive predisposition 51 | 1,442
medulloblastoma, large-cell 49 | 6,241
psoriasis 43 | 6,694
atypical teratoid / rhabdoid tumor 40 | 5,112
malignant mesothelioma 38 | 3,232
ependymoma 37 | 4,679
lung cancer 36 | 4,740
Epilepsy 33 | 792
Astrocytoma, Pilocytic 32 | 3,081
subependymal giant cell astrocytoma 32 | 2,287
Intellectual disability 31 | 1,016
tuberculosis 31 | 2,010
Multiple myeloma 30 | 1,332
Seizures 30 | 596
diabetes mellitus 28 | 1,728
Hepatomegaly 27 | 285
lung carcinoma 27 | 2,843
Coarse facial features 24 | 108
Dull intelligence 24 | 645
Low intelligence 24 | 645
Mental Retardation 24 | 645
Mental deficiency 24 | 645
Muscle hypotonia 24 | 571
Poor school performance 24 | 645
Splenomegaly 24 | 190
Thickened facial skin with coarse facial features 24 | 108
adult high grade glioma 24 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
Neurodegenerative disease 22 | 414
astrocytoma 22 | 1,146
invasive ductal carcinoma 22 | 2,951
group 3 medulloblastoma 21 | 4,104
group 4 medulloblastoma 21 | 1,855
Cancer 20 | 2,499
Cognitive delay 20 | 608
Global developmental delay 20 | 608
Mental and motor retardation 20 | 608
Breast cancer 19 | 3,578
pediatric high grade glioma 19 | 1,064
Congenital deafness 18 | 185
Deafness 18 | 198
Hearing Loss, Partial 18 | 185
Short stature 18 | 531
hearing impairment 18 | 199
intraductal papillary-mucinous adenoma (IPMA) 18 | 2,955
pancreatic cancer 18 | 2,398
Pick disease 17 | 1,894
dermatomyositis 17 | 966
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
non-small cell lung cancer 17 | 2,890
primitive neuroectodermal tumor 17 | 3,035
ulcerative colitis 17 | 1,819
Mucopolysaccharidosis 16 | 26
acute quadriplegic myopathy 15 | 1,158
astrocytic glioma 15 | 2,597
juvenile dermatomyositis 15 | 1,187
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
Kidney cancer 14 | 2,613
Waldenstrons macroglobulinemia 14 | 765
esophageal adenocarcinoma 14 | 737
lung adenocarcinoma 14 | 2,716
Cerebral atrophy 13 | 178
Liver Cirrhosis, Experimental 13 | 769
Recurrent respiratory infections 13 | 141
inclusion-cell disease 13 | 16
oligodendroglioma 13 | 2,850
Alzheimer's disease 12 | 658
Cerebellar Ataxia 12 | 304
Down syndrome 12 | 499
Dysarthria 12 | 192
Gangliosidosis 12 | 20
Hyperreflexia 12 | 209
Pfaundler-Hurler Syndrome 12 | 12
Rheumatoid arthritis 12 | 1,191
interstitial cystitis 12 | 2,312
Acquired scoliosis 11 | 281
Curvature of spine 11 | 282
Degenerative brain disorder 11 | 100
Duchenne muscular dystrophy 11 | 601
Failure to gain weight 11 | 365
Myoclonus 11 | 74
Pediatric failure to thrive 11 | 365
Supratentorial atrophy 11 | 94
cystic fibrosis 11 | 1,696
Frontal bossing 10 | 157
Hernia, Inguinal 10 | 89
Hydrocephalus 10 | 152
Hyperkyphosis 10 | 111
Kyphosis deformity of spine 10 | 114
Multiple Sclerosis 10 | 540
Muscle Spasticity 10 | 195
Neuronal ceroid lipofuscinosis 10 | 28
breast carcinoma 10 | 1,638
cutaneous lupus erythematosus 10 | 1,057
Small head 9 | 374
primary Sjogren syndrome 9 | 735

Tissue

Blood and immune system 123 | 16,909
Digestive Tract 123 | 17,369
Endocrine System 123 | 18,159
Female tissues 123 | 17,400
Male tissues 123 | 17,142
Nervous System 123 | 16,725
Respiratory system 123 | 16,393
Skin and soft tissues 123 | 17,230
Liver and Pancreas 122 | 16,750
Urinary Tract 122 | 16,678
Cardiovascular System 120 | 15,192

Target Family

Enzyme 68 | 4,145
Non-IDG 48 | 12,091
Transporter 5 | 473
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

KEGG Pathway

Lysosome 123 | 123
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Galactocerebrosidase GALC Tbio Enzyme -2.56924 363.2 143
Alpha-N-acetylglucosaminidase NAGLU Tbio Enzyme -2.18649 159.9 64
Dipeptidyl peptidase 1 CTSC Tchem Enzyme -3.27566 1855.5 168
Clathrin heavy chain 2 CLTCL1 Tbio Non-IDG -1.29555 21.3 39
Lysosomal-associated transmembrane protein 4B LAPTM4B Tbio Non-IDG -1.90763 86.1 91
Lysosomal-associated transmembrane protein 5 LAPTM5 Tbio Non-IDG -1.07401 14.4 71
V-type proton ATPase 116 kDa subunit a isoform 4 ATP6V0A4 Tbio Enzyme -2.84949 692.2 90
Niemann-Pick C1 protein NPC1 Tbio Non-IDG -2.71962 551.3 284
Clathrin heavy chain 1 CLTC Tbio Non-IDG -1.66258 38.8 231
Sulfatase-modifying factor 1 SUMF1 Tbio Enzyme -2.21118 157.7 145