Development Level

Tbio 33 | 11,445
Tchem 22 | 1,598
Tclin 7 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, incomple... 5 | 499
preweaning lethality, complete... 4 | 979
decreased circulating LDL chol... 3 | 38
increased mean corpuscular hem... 3 | 96
abnormal lens morphology 2 | 81
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
decreased body weight 2 | 161
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased erythrocyte cell num... 2 | 62
decreased mean platelet volume 2 | 25
decreased total body fat amoun... 2 | 207
enlarged spleen 2 | 41
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating choleste... 2 | 66
increased hemoglobin content 2 | 45
increased mean platelet volume 2 | 45
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal glucose homeostasis 1 | 4
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged thymus 1 | 5
hyperactivity 1 | 148
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
improved glucose tolerance 1 | 79
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 24
increased glycosylated hemoglo... 1 | 1
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
short tibia 1 | 97
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 49 | 11,493
ovarian cancer 41 | 8,520
Cancer 32 | 2,499
osteosarcoma 31 | 7,950
medulloblastoma, large-cell 28 | 6,241
lung cancer 27 | 4,740
psoriasis 27 | 6,694
glioblastoma 24 | 5,792
Breast cancer 23 | 3,578
atypical teratoid / rhabdoid tumor 23 | 5,112
diabetes mellitus 20 | 1,728
Kidney cancer 19 | 2,613
Obesity 17 | 678
ependymoma 17 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
invasive ductal carcinoma 16 | 2,951
Autosomal recessive predisposition 15 | 1,442
Schizophrenia 15 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
group 4 medulloblastoma 14 | 1,855
group 3 medulloblastoma 13 | 4,104
interstitial cystitis 13 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
primitive neuroectodermal tumor 13 | 3,035
Alzheimer's disease 12 | 658
Bipolar Disorder 12 | 666
Breast Neoplasms 12 | 445
Epilepsy 12 | 792
Hyperglycemia 12 | 137
Mammary Neoplasms 12 | 425
adult high grade glioma 12 | 3,801
astrocytic glioma 12 | 2,597
breast carcinoma 12 | 1,638
malignant mesothelioma 12 | 3,232
Insulin Resistance 11 | 72
Seizures 11 | 596
lung carcinoma 11 | 2,843
oligodendroglioma 11 | 2,850
Depressive disorder 10 | 409
Diabetes Mellitus, Non-Insulin-Dependent 10 | 145
Parkinson's disease 10 | 392
Prostatic Neoplasms 10 | 495
Stomach Neoplasms 10 | 300
Vascular disease 10 | 319
ductal carcinoma in situ 10 | 1,745
pituitary cancer 10 | 1,972
subependymal giant cell astrocytoma 10 | 2,287
Carcinoma, Squamous Cell 9 | 110
Diabetes Mellitus, Experimental 9 | 108
Diabetes Mellitus, Type 2 9 | 142
Hypertension 9 | 396
Hypertensive disease 9 | 292
Intellectual disability 9 | 1,016
Squamous cell carcinoma 9 | 129
dermatomyositis 9 | 966
juvenile dermatomyositis 9 | 1,187
lung adenocarcinoma 9 | 2,716
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Anemia 8 | 365
Carcinoma, Hepatocellular 8 | 228
Dull intelligence 8 | 645
Endometriosis 8 | 540
Hyperinsulinism 8 | 133
Liver carcinoma 8 | 240
Low intelligence 8 | 645
Mental Depression 8 | 333
Mental Retardation 8 | 645
Mental deficiency 8 | 645
Orbital separation excessive 8 | 244
Poor school performance 8 | 645
astrocytoma 8 | 1,146
cystic fibrosis 8 | 1,696
pancreatic cancer 8 | 2,398
ulcerative colitis 8 | 1,819
Astrocytoma, Pilocytic 7 | 3,081
Atherosclerosis 7 | 291
Cognitive delay 7 | 608
Concave bridge of nose 7 | 195
Delayed bone age 7 | 136
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Endometrial cancer 7 | 311
Global developmental delay 7 | 608
Hypoplastic mandible condyle 7 | 275
Kidney disease 7 | 430
Major Depressive Disorder 7 | 301
Mandibular hypoplasia 7 | 275
Mental and motor retardation 7 | 608
Micrognathism 7 | 275
Pick disease 7 | 1,894
Polycystic ovary syndrome 7 | 360
Rheumatoid arthritis 7 | 1,191
Short stature 7 | 531
Unipolar Depression 7 | 250
Waldenstrons macroglobulinemia 7 | 765
acute quadriplegic myopathy 7 | 1,158
adrenocortical carcinoma 7 | 1,428
non-small cell lung cancer 7 | 2,890
pediatric high grade glioma 7 | 1,064
tuberculosis 7 | 2,010

Tissue

Endocrine System 62 | 18,159
Digestive Tract 61 | 17,369
Female tissues 61 | 17,400
Male tissues 61 | 17,142
Skin and soft tissues 61 | 17,230
Blood and immune system 59 | 16,909
Respiratory system 59 | 16,393
Urinary Tract 59 | 16,678
Cardiovascular System 58 | 15,192
Liver and Pancreas 58 | 16,750
Nervous System 58 | 16,725

Target Family

Enzyme 21 | 4,145
Kinase 19 | 634
Non-IDG 16 | 12,091
Epigenetic 3 | 242
Transcription Factor 3 | 1,400

KEGG Pathway

Longevity regulating pathway -... 62 | 62
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Heat shock-related 70 kDa protein 2 HSPA2 Tbio Non-IDG -1.98655 104.3 162
Eukaryotic translation initiation factor 4E-binding protein 2 EIF4EBP2 Tbio Non-IDG -1.55776 33.4 189
Heat shock 70 kDa protein 1A HSPA1B Tchem Non-IDG -3.10995 0.00000 1174
Heat shock 70 kDa protein 1B HSPA1B Tbio Non-IDG -1.61862 0.00000 60
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328