Development Level

Tbio 45 | 10,625
Tchem 43 | 1,890
Tclin 5 | 602
Tdark 1 | 7,003

Collection

Eligible Kinase Proteins 5 | 134

IMPC Term

preweaning lethality, incomple... 5 | 260
decreased total body fat amoun... 4 | 186
increased circulating alkaline... 4 | 119
decreased circulating LDL chol... 3 | 37
decreased lean body mass 3 | 195
embryonic lethality prior to t... 3 | 187
increased mean corpuscular hem... 3 | 93
preweaning lethality, complete... 3 | 633
abnormal retina morphology 2 | 100
decreased body weight 2 | 174
decreased bone mineral density 2 | 126
decreased circulating amylase ... 2 | 24
decreased circulating chloride... 2 | 32
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased erythrocyte cell num... 2 | 43
decreased grip strength 2 | 123
decreased mean corpuscular hem... 2 | 19
enlarged spleen 2 | 26
hypoactivity 2 | 89
increased circulating LDL chol... 2 | 15
increased circulating choleste... 2 | 53
increased mean platelet volume 2 | 19
increased or absent threshold ... 2 | 128
abnormal behavioral response t... 1 | 52
abnormal bone mineralization 1 | 55
abnormal cornea morphology 1 | 24
abnormal embryo size 1 | 112
abnormal forebrain development 1 | 18
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal hindbrain development 1 | 24
abnormal iris morphology 1 | 12
abnormal lens morphology 1 | 73
abnormal locomotor activation 1 | 26
abnormal maxilla morphology 1 | 16
abnormal neural tube closure 1 | 37
abnormal respiratory quotient 1 | 9
abnormal retinal blood vessel ... 1 | 18
abnormal retinal pigmentation 1 | 61
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 63
abnormal snout morphology 1 | 18
abnormal spleen morphology 1 | 36
abnormal tooth morphology 1 | 24
anophthalmia 1 | 20
corneal opacity 1 | 25
decreased CD5-positive Ly6C-po... 1 | 4
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased circulating HDL chol... 1 | 77
decreased circulating calcium ... 1 | 33
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating serum al... 1 | 79
decreased circulating sodium l... 1 | 18
decreased circulating triglyce... 1 | 83
decreased fasted circulating g... 1 | 49
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular vol... 1 | 50
decreased prepulse inhibition 1 | 52
decreased rib number 1 | 59
decreased startle reflex 1 | 48
embryonic lethality prior to o... 1 | 148
enlarged heart 1 | 111
impaired glucose tolerance 1 | 52
increased bone mineral density 1 | 52
increased circulating HDL chol... 1 | 63
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 43
increased circulating creatini... 1 | 29
increased circulating free fat... 1 | 17
increased circulating phosphat... 1 | 24
increased circulating sodium l... 1 | 71
increased effector memory T-he... 1 | 5
increased glycosylated hemoglo... 1 | 1
increased grip strength 1 | 83
increased heart rate 1 | 17
increased hemoglobin content 1 | 45
increased lean body mass 1 | 107
increased leukocyte cell numbe... 1 | 37
increased mean corpuscular vol... 1 | 91
increased memory-marker gamma-... 1 | 2
increased red blood cell distr... 1 | 21
increased spleen weight 1 | 3
increased total body fat amoun... 1 | 57
irregularly shaped pupil 1 | 7
limb grasping 1 | 35
narrow eye opening 1 | 15
shortened RR interval 1 | 19
thrombocytopenia 1 | 46
thrombocytosis 1 | 23

Disease

ovarian cancer 54 | 8,484
osteosarcoma 49 | 7,933
Cancer 44 | 2,346
medulloblastoma, large-cell 43 | 6,234
psoriasis 41 | 6,685
glioblastoma 38 | 5,572
atypical teratoid / rhabdoid tumor 33 | 4,369
lung cancer 33 | 4,466
diabetes mellitus 29 | 1,663
Carcinoma 24 | 2,147
Obesity 24 | 616
Breast cancer 23 | 3,094
primitive neuroectodermal tumor 23 | 3,031
ependymoma 22 | 2,514
invasive ductal carcinoma 22 | 2,950
pediatric high grade glioma 22 | 2,712
subependymal giant cell astrocytoma 21 | 2,287
oligodendroglioma 18 | 2,849
ulcerative colitis 18 | 2,087
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,289
malignant mesothelioma 17 | 3,162
medulloblastoma 17 | 1,524
pilocytic astrocytoma 17 | 3,086
astrocytic glioma 16 | 2,241
group 4 medulloblastoma 16 | 1,875
Mammary Neoplasms 15 | 410
adult high grade glioma 15 | 2,148
lung adenocarcinoma 15 | 2,713
non-small cell lung cancer 15 | 2,798
Alzheimer's disease 14 | 644
Diabetes Mellitus, Non-Insulin-Dependent 14 | 157
Hyperglycemia 14 | 120
astrocytoma 14 | 1,493
ductal carcinoma in situ 14 | 1,745
interstitial cystitis 14 | 2,299
lung carcinoma 14 | 2,844
Metabolic syndrome X 13 | 155
Schizophrenia 13 | 501
breast carcinoma 13 | 1,614
Diabetes Mellitus, Experimental 12 | 106
Hypertensive disease 12 | 193
Pick disease 12 | 1,893
Prostatic Neoplasms 12 | 471
group 3 medulloblastoma 12 | 2,254
juvenile dermatomyositis 12 | 1,189
Fatty liver disease 11 | 84
Kidney disease 11 | 396
Liver carcinoma 11 | 217
Polycystic Ovary Syndrome 11 | 332
Rheumatoid Arthritis 11 | 1,160
Vascular disease 11 | 281
adrenocortical carcinoma 11 | 1,427
non-small cell lung carcinoma 11 | 413
pituitary cancer 11 | 1,972
Autistic Disorder 10 | 320
Hyperinsulinism 10 | 63
Insulin Resistance 10 | 48
Parkinson's disease 10 | 364
Renal Cell Carcinoma 10 | 199
dermatomyositis 10 | 933
pancreatic cancer 10 | 2,300
spina bifida 10 | 1,064
tuberculosis 10 | 1,557
Multiple myeloma 9 | 1,327
Squamous cell carcinoma 9 | 94
Stomach Neoplasms 9 | 282
acute quadriplegic myopathy 9 | 1,157
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,795
primary Sjogren syndrome 9 | 789
Adenocarcinoma 8 | 115
Adenoma 8 | 165
Atherosclerosis 8 | 275
Epilepsy 8 | 346
Heart disease 8 | 279
Intellectual disability 8 | 573
Neoplastic Cell Transformation 8 | 81
Osteoporosis 8 | 257
colon cancer 8 | 1,475
cystic fibrosis 8 | 1,665
pancreatic carcinoma 8 | 567
posterior fossa group A ependymoma 8 | 1,511
Acquired metabolic disease 7 | 267
Amyotrophic Lateral Sclerosis 7 | 431
Colonic Neoplasms 7 | 126
Colorectal Neoplasms 7 | 217
Diffuse large B-cell lymphoma 7 | 41
Hypertension 7 | 287
Lung Neoplasms 7 | 171
Mouth Neoplasms 7 | 42
Waldenstrons macroglobulinemia 7 | 765
cutaneous lupus erythematosus 7 | 1,056
Atopic dermatitis 6 | 944
Coronary artery disease 6 | 240
Peripheral Neuropathy 6 | 303
aldosterone-producing adenoma 6 | 664
nasopharyngeal carcinoma 6 | 1,056
primary pancreatic ductal adenocarcinoma 6 | 1,271
sonic hedgehog group medulloblastoma 6 | 1,482

Tissue

Blood and immune system 94 | 17,995
Digestive Tract 94 | 18,473
Endocrine System 94 | 18,512
Female tissues 94 | 18,647
Liver and Pancreas 94 | 18,136
Nervous System 94 | 18,561
Cardiovascular System 93 | 17,958
Male tissues 93 | 17,969
Skin and soft tissues 93 | 18,115
Urinary Tract 93 | 18,444
Respiratory system 91 | 17,484

Target Family

Kinase 27 | 634
Non-IDG 26 | 11,971
Enzyme 22 | 4,146
Transcription Factor 15 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 1 | 48

KEGG Pathway

Longevity regulating pathway 94 | 94
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase KRas KRAS Tbio Enzyme -3.75582 5694.2 421
Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 Tchem Kinase -2.48996 301.3 641
Cyclic AMP-responsive element-binding protein 3 CREB3 Tbio Transcription Factor -1.61736 42.0 159
Insulin INS Tbio Non-IDG -5.14691 141255.4 1549
Adenylate cyclase type 1 ADCY1 Tchem Enzyme -1.58202 42.2 123
Sestrin-2 SESN2 Tbio Non-IDG -1.73062 73.0 151
Sestrin-3 SESN3 Tbio Non-IDG -1.01398 10.1 137
Serine/threonine-protein kinase ULK2 ULK2 Tchem Kinase -1.07146 10.6 355
Tuberin TSC2 Tbio Non-IDG -2.94615 933.5 1483
Autophagy-related protein 13 ATG13 Tbio Non-IDG -1.41149 24.1 305