Development Level

Tbio 56 | 11,651
Tchem 26 | 1,388
Tclin 6 | 612
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 7 | 499
embryonic lethality prior to t... 4 | 278
increased circulating alkaline... 4 | 122
decreased circulating LDL chol... 3 | 38
increased mean corpuscular hem... 3 | 96
increased mean platelet volume 3 | 45
abnormal behavior 2 | 298
abnormal retina morphology 2 | 71
abnormal retinal blood vessel ... 2 | 26
abnormal retinal vasculature m... 2 | 27
decreased blood urea nitrogen ... 2 | 51
decreased body weight 2 | 161
decreased circulating amylase ... 2 | 28
decreased circulating chloride... 2 | 30
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased erythrocyte cell num... 2 | 62
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 31
decreased mean platelet volume 2 | 25
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
enlarged spleen 2 | 41
hypoactivity 2 | 132
increased circulating LDL chol... 2 | 13
increased circulating choleste... 2 | 66
increased lean body mass 2 | 172
increased red blood cell distr... 2 | 34
abnormal bone mineralization 1 | 38
abnormal cornea morphology 1 | 31
abnormal embryo size 1 | 220
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal iris morphology 1 | 13
abnormal lens morphology 1 | 81
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal response to new envir... 1 | 10
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
cataract 1 | 92
corneal opacity 1 | 32
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating bilirubi... 1 | 19
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
embryonic lethality prior to o... 1 | 239
enlarged heart 1 | 210
enlarged thymus 1 | 5
hemorrhage 1 | 23
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
impaired pupillary reflex 1 | 26
improved glucose tolerance 1 | 79
increased aggression 1 | 4
increased circulating HDL chol... 1 | 80
increased circulating bilirubi... 1 | 16
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased glycosylated hemoglo... 1 | 1
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
irregularly shaped pupil 1 | 7
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
short tibia 1 | 97
small testis 1 | 58
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 71 | 11,493
ovarian cancer 53 | 8,520
osteosarcoma 48 | 7,950
Cancer 46 | 2,499
psoriasis 42 | 6,694
medulloblastoma, large-cell 41 | 6,241
glioblastoma 39 | 5,792
atypical teratoid / rhabdoid tumor 36 | 5,112
lung cancer 34 | 4,740
diabetes mellitus 31 | 1,728
ependymoma 28 | 4,679
Breast cancer 26 | 3,578
Obesity 25 | 678
adult high grade glioma 24 | 3,801
group 3 medulloblastoma 24 | 4,104
Kidney cancer 23 | 2,613
primitive neuroectodermal tumor 22 | 3,035
Schizophrenia 20 | 1,160
astrocytic glioma 20 | 2,597
invasive ductal carcinoma 20 | 2,951
breast carcinoma 19 | 1,638
group 4 medulloblastoma 19 | 1,855
subependymal giant cell astrocytoma 18 | 2,287
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 17 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
oligodendroglioma 17 | 2,850
Epilepsy 16 | 792
Hyperglycemia 16 | 137
malignant mesothelioma 16 | 3,232
Alzheimer's disease 15 | 658
Autosomal recessive predisposition 15 | 1,442
Breast Neoplasms 15 | 445
Diabetes Mellitus, Non-Insulin-Dependent 15 | 145
Mammary Neoplasms 15 | 425
Astrocytoma, Pilocytic 14 | 3,081
Diabetes Mellitus, Type 2 14 | 142
Hypertension 14 | 396
Intellectual disability 14 | 1,016
Polycystic ovary syndrome 14 | 360
Prostatic Neoplasms 14 | 495
Seizures 14 | 596
ductal carcinoma in situ 14 | 1,745
lung adenocarcinoma 14 | 2,716
non-small cell lung cancer 14 | 2,890
ulcerative colitis 14 | 1,819
Bipolar Disorder 13 | 666
Diabetes Mellitus, Experimental 13 | 108
Hypertensive disease 13 | 292
Insulin Resistance 13 | 72
Depressive disorder 12 | 409
Pick disease 12 | 1,894
Renal Cell Carcinoma 12 | 214
Vascular disease 12 | 319
interstitial cystitis 12 | 2,312
juvenile dermatomyositis 12 | 1,187
lung carcinoma 12 | 2,843
Carcinoma, Hepatocellular 11 | 228
Dull intelligence 11 | 645
Fatty liver disease 11 | 103
Kidney disease 11 | 430
Liver carcinoma 11 | 240
Low intelligence 11 | 645
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
Rheumatoid arthritis 11 | 1,191
Stomach Neoplasms 11 | 300
adrenocortical carcinoma 11 | 1,428
pancreatic cancer 11 | 2,398
tuberculosis 11 | 2,010
Hyperinsulinism 10 | 133
Parkinson's disease 10 | 392
astrocytoma 10 | 1,146
dermatomyositis 10 | 966
pediatric high grade glioma 10 | 1,064
pituitary cancer 10 | 1,972
Anemia 9 | 365
Atherosclerosis 9 | 291
Autistic Disorder 9 | 364
Carcinoma, Squamous Cell 9 | 110
Cell Transformation, Neoplastic 9 | 97
Cognitive delay 9 | 608
Global developmental delay 9 | 608
Mental and motor retardation 9 | 608
Multiple myeloma 9 | 1,332
Neoplastic Cell Transformation 9 | 89
Osteoporosis 9 | 363
Squamous cell carcinoma 9 | 129
acute quadriplegic myopathy 9 | 1,158
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
Adenoma 8 | 167
Endometrial cancer 8 | 311
Heart disease 8 | 306
Mental Depression 8 | 333
Mood Disorders 8 | 184
Orbital separation excessive 8 | 244
colon cancer 8 | 1,478
cystic fibrosis 8 | 1,696
spina bifida 8 | 1,074

Tissue

Endocrine System 89 | 18,159
Digestive Tract 87 | 17,369
Female tissues 87 | 17,400
Male tissues 87 | 17,142
Nervous System 87 | 16,725
Skin and soft tissues 87 | 17,230
Blood and immune system 85 | 16,909
Cardiovascular System 85 | 15,192
Liver and Pancreas 85 | 16,750
Urinary Tract 85 | 16,678
Respiratory system 84 | 16,393

Target Family

Non-IDG 26 | 12,091
Kinase 23 | 634
Enzyme 21 | 4,145
Transcription Factor 15 | 1,400
Epigenetic 3 | 242
Nuclear Receptor 1 | 48

KEGG Pathway

Longevity regulating pathway 89 | 89
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
DCC-interacting protein 13-alpha APPL1 Tbio Non-IDG -2.75344 511.0 230
Cyclic AMP-dependent transcription factor ATF-6 beta ATF6B Tbio Transcription Factor -1.03459 8.22 6
Cyclic AMP-responsive element-binding protein 5 CREB5 Tbio Transcription Factor -0.88055 7.80 164
5'-AMP-activated protein kinase catalytic subunit alpha-2 PRKAA2 Tchem Kinase -1.42705 21.1 603
5'-AMP-activated protein kinase subunit gamma-1 PRKAG1 Tbio Kinase -1.00162 9.02 293
5'-AMP-activated protein kinase subunit beta-1 PRKAB1 Tbio Kinase -1.52519 32.5 532
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.64133 414.7 227
Autophagy-related protein 101 ATG101 Tbio Non-IDG -1.01771 9.13 65