Development Level

Tchem 29 | 1,388
Tbio 21 | 11,651
Tclin 15 | 612
Tdark 2 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased total body fat amoun... 3 | 207
abnormal embryo size 2 | 220
abnormal gait 2 | 69
decreased body weight 2 | 161
embryonic lethality prior to t... 2 | 278
increased bone mineral content 2 | 108
male infertility 2 | 123
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal forebrain development 1 | 20
abnormal gallbladder morpholog... 1 | 1
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal vocalization 1 | 21
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating calcium ... 1 | 36
decreased circulating insulin ... 1 | 76
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
embryonic growth retardation 1 | 106
enlarged gallbladder 1 | 2
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased circulating glucose ... 1 | 24
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
short tibia 1 | 97
small epididymis 1 | 3
small superior vagus ganglion 1 | 74

Disease

Carcinoma 49 | 11,493
glioblastoma 39 | 5,792
medulloblastoma, large-cell 39 | 6,241
atypical teratoid / rhabdoid tumor 38 | 5,112
psoriasis 37 | 6,694
ovarian cancer 35 | 8,520
adult high grade glioma 33 | 3,801
ependymoma 32 | 4,679
osteosarcoma 30 | 7,950
Astrocytoma, Pilocytic 28 | 3,081
primitive neuroectodermal tumor 27 | 3,035
Cancer 26 | 2,499
group 3 medulloblastoma 26 | 4,104
Kidney cancer 25 | 2,613
Schizophrenia 25 | 1,160
astrocytic glioma 25 | 2,597
oligodendroglioma 24 | 2,850
Breast cancer 23 | 3,578
lung cancer 23 | 4,740
subependymal giant cell astrocytoma 22 | 2,287
Epilepsy 21 | 792
Intellectual disability 19 | 1,016
Pick disease 18 | 1,894
Bipolar Disorder 16 | 666
Melanoma 16 | 711
lung adenocarcinoma 16 | 2,716
Dull intelligence 15 | 645
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Muscle hypotonia 15 | 571
Poor school performance 15 | 645
Short stature 15 | 531
lung carcinoma 15 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Depressive disorder 13 | 409
Toxic encephalopathy 13 | 141
pancreatic cancer 13 | 2,398
Blepharoptosis 12 | 231
Byzanthine arch palate 12 | 194
Strabismus 12 | 270
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
malignant mesothelioma 12 | 3,232
Acquired scoliosis 11 | 281
Cognitive delay 11 | 608
Curvature of spine 11 | 282
Global developmental delay 11 | 608
Mental and motor retardation 11 | 608
Parkinson's disease 11 | 392
Seizures 11 | 596
Skin cancer 11 | 469
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
tuberculosis 11 | 2,010
Alzheimer's disease 10 | 658
Autistic Disorder 10 | 364
Downward slant of palpebral fissure 10 | 158
Liver cancer 10 | 604
Major Depressive Disorder 10 | 301
Mental Depression 10 | 333
Multiple myeloma 10 | 1,332
colon cancer 10 | 1,478
group 4 medulloblastoma 10 | 1,855
non-small cell lung cancer 10 | 2,890
Autosomal recessive predisposition 9 | 1,442
Cardiac Arrhythmia 9 | 103
Cocaine-Related Disorders 9 | 92
Congenital Epicanthus 9 | 177
Cryptorchidism 9 | 296
Electroencephalogram abnormal 9 | 101
Endometrial cancer 9 | 311
Feeding difficulties in infancy 9 | 175
Frontal bossing 9 | 157
Heart disease 9 | 306
Hyperreflexia 9 | 209
Pectus excavatum 9 | 100
Rheumatoid arthritis 9 | 1,191
pituitary cancer 9 | 1,972
Delayed bone age 8 | 136
Hypoplastic mandible condyle 8 | 275
Joint hyperflexibility 8 | 78
Low posterior hairline 8 | 52
Low set ears 8 | 181
Mandibular hypoplasia 8 | 275
Micrognathism 8 | 275
Noonan syndrome 8 | 34
Orbital separation excessive 8 | 244
Unipolar Depression 8 | 250
Waldenstrons macroglobulinemia 8 | 765
diabetes mellitus 8 | 1,728
invasive ductal carcinoma 8 | 2,951
Attention deficit hyperactivity disorder 7 | 278
Concave bridge of nose 7 | 195
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Failure to gain weight 7 | 365
Pediatric failure to thrive 7 | 365
Vascular disease 7 | 319
cystic fibrosis 7 | 1,696
juvenile dermatomyositis 7 | 1,187
ulcerative colitis 7 | 1,819

Tissue

Endocrine System 67 | 18,159
Female tissues 64 | 17,400
Male tissues 64 | 17,142
Nervous System 64 | 16,725
Skin and soft tissues 64 | 17,230
Digestive Tract 63 | 17,369
Liver and Pancreas 63 | 16,750
Blood and immune system 62 | 16,909
Respiratory system 61 | 16,393
Urinary Tract 60 | 16,678
Cardiovascular System 58 | 15,192

Target Family

Kinase 22 | 634
Enzyme 18 | 4,145
Ion Channel 11 | 344
Non-IDG 11 | 12,091
Epigenetic 2 | 242
GPCR 2 | 408
Transcription Factor 1 | 1,400

KEGG Pathway

Long-term potentiation 67 | 67
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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