Development Level

Tbio 157 | 11,445
Tchem 59 | 1,598
Tclin 27 | 613
Tdark 9 | 6,588

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 9 | 499
decreased body weight 5 | 161
increased total body fat amoun... 4 | 134
abnormal bone mineralization 3 | 38
abnormal bone structure 3 | 187
abnormal embryo size 3 | 220
abnormal gait 3 | 69
decreased bone mineral density 3 | 126
decreased circulating creatini... 3 | 39
small superior vagus ganglion 3 | 74
abnormal behavior 2 | 298
decreased bone mineral content 2 | 151
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
decreased lean body mass 2 | 135
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
embryonic growth retardation 2 | 106
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
enlarged spleen 2 | 41
hyperactivity 2 | 148
increased bone mineral density 2 | 72
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased circulating glucose ... 2 | 24
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased startle reflex 2 | 112
male infertility 2 | 123
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
female infertility 1 | 60
hypoactivity 1 | 132
impaired righting response 1 | 26
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased eosinophil cell numb... 1 | 11
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
limb grasping 1 | 41
microphthalmia 1 | 26
prenatal lethality 1 | 28
short tibia 1 | 97
small kidney 1 | 16
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Cancer 182 | 2,499
Carcinoma 142 | 11,493
psoriasis 138 | 6,694
ovarian cancer 112 | 8,520
diabetes mellitus 97 | 1,728
glioblastoma 93 | 5,792
osteosarcoma 88 | 7,950
Arthritis 87 | 290
lung cancer 84 | 4,740
medulloblastoma, large-cell 76 | 6,241
Hypersensitivity reaction type II disease 74 | 253
Ankylosing spondylitis 73 | 140
Behcet's disease 72 | 89
Rheumatoid arthritis 72 | 1,191
Acquired immunodeficiency syndrome 67 | 197
Juvenile rheumatoid arthritis 63 | 111
Uveitis 60 | 103
dermatomyositis 60 | 966
Herpes zoster 58 | 68
Human immunodeficiency virus infectious disease 58 | 138
atypical teratoid / rhabdoid tumor 58 | 5,112
ependymoma 58 | 4,679
tuberculosis 57 | 2,010
subependymal giant cell astrocytoma 56 | 2,287
Breast cancer 55 | 3,578
Stevens-Johnson syndrome 55 | 92
adult high grade glioma 52 | 3,801
Astrocytoma, Pilocytic 51 | 3,081
Psoriatic arthritis 51 | 86
malignant mesothelioma 51 | 3,232
Schizophrenia 49 | 1,160
Dermatitis 46 | 157
Kidney disease 45 | 430
Multiple Sclerosis 44 | 540
lung carcinoma 44 | 2,843
Synovitis 41 | 78
invasive ductal carcinoma 40 | 2,951
Anemia 39 | 365
group 3 medulloblastoma 39 | 4,104
intraductal papillary-mucinous neoplasm (IPMN) 39 | 3,291
Behcet's syndrome 38 | 50
Kidney cancer 38 | 2,613
Liver disease 38 | 237
Nephritis 37 | 51
Takayasu's arteritis 37 | 53
intraductal papillary-mucinous carcinoma (IPMC) 36 | 2,989
lung adenocarcinoma 36 | 2,716
non-small cell lung cancer 36 | 2,890
pancreatic cancer 36 | 2,398
ulcerative colitis 36 | 1,819
Congenital adrenal hyperplasia 35 | 73
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
drug-induced hepatitis 35 | 44
intraductal papillary-mucinous adenoma (IPMA) 35 | 2,955
Vascular disease 34 | 319
juvenile dermatomyositis 34 | 1,187
oligodendroglioma 33 | 2,850
Hepatitis B 32 | 108
interstitial cystitis 32 | 2,312
primitive neuroectodermal tumor 32 | 3,035
Multiple myeloma 31 | 1,332
cystic fibrosis 30 | 1,696
Breast Neoplasms 29 | 445
Mammary Neoplasms 29 | 425
breast carcinoma 29 | 1,638
group 4 medulloblastoma 29 | 1,855
astrocytic glioma 28 | 2,597
Skin disease 27 | 66
pituitary cancer 27 | 1,972
Pick disease 26 | 1,894
Prostatic Neoplasms 26 | 495
colon cancer 26 | 1,478
cutaneous lupus erythematosus 26 | 1,057
Alzheimer's disease 25 | 658
Primary immunodeficiency disease 25 | 54
astrocytoma 25 | 1,146
primary Sjogren syndrome 25 | 735
Asthma 24 | 385
Carcinoma, Hepatocellular 24 | 228
Epilepsy 24 | 792
Liver carcinoma 24 | 240
Obesity 24 | 678
Bipolar Disorder 23 | 666
Lung Neoplasms 23 | 232
Lung disease 23 | 142
Seizures 23 | 596
Stomach Neoplasms 23 | 300
Depressive disorder 22 | 409
Hemochromatosis 22 | 54
Intellectual disability 22 | 1,016
Birdshot chorioretinopathy 21 | 23
Brain Ischemia 21 | 110
Heart disease 21 | 306
Leprosy 21 | 73
Toxic encephalopathy 21 | 141
nasopharyngeal carcinoma 21 | 1,058
Hypertension 20 | 396
ductal carcinoma in situ 20 | 1,745
gastric carcinoma 19 | 807

Tissue

Blood and immune system 168 | 16,909
Endocrine System 168 | 18,159
Male tissues 167 | 17,142
Digestive Tract 166 | 17,369
Female tissues 165 | 17,400
Liver and Pancreas 164 | 16,750
Skin and soft tissues 164 | 17,230
Respiratory system 163 | 16,393
Urinary Tract 163 | 16,678
Nervous System 161 | 16,725
Cardiovascular System 158 | 15,192

Target Family

Non-IDG 161 | 12,091
Kinase 42 | 634
Transcription Factor 21 | 1,400
Enzyme 18 | 4,145
GPCR 5 | 408
Ion Channel 3 | 344
Epigenetic 2 | 242

KEGG Pathway

Kaposi's sarcoma-associated he... 252 | 252
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Polyubiquitin-B UBB Tbio Non-IDG -1.98860 97.4 427
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 GNG10 Tdark Non-IDG 0.16 0.62 18
HLA class I histocompatibility antigen, A-80 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
Nuclear factor of activated T-cells, cytoplasmic 4 NFATC4 Tbio Transcription Factor -1.93766 88.3 358
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 GNG8 Tdark Non-IDG -2.17483 154.8 34
Beclin-2 BECN2 Tbio Non-IDG 0.00000 87
Nuclear factor of activated T-cells, cytoplasmic 2 NFATC2 Tbio Transcription Factor -2.43207 259.4 365