Development Level

Tbio 69 | 11,445
Tchem 50 | 1,598
Tclin 13 | 613
Tdark 5 | 6,588

Collection

Kinase: IDG Consortium (Target... 5 | 125
RFA-RM-18-021 5 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 7 | 499
decreased body weight 4 | 161
decreased circulating LDL chol... 3 | 38
increased circulating alkaline... 3 | 122
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal retinal vasculature m... 2 | 27
cataract 2 | 92
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased mean platelet volume 2 | 25
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
enlarged spleen 2 | 41
increased circulating LDL chol... 2 | 13
increased erythrocyte cell num... 2 | 39
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
increased total body fat amoun... 2 | 134
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal vibrissa morphology 1 | 25
anophthalmia 1 | 33
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged thymus 1 | 5
impaired glucose tolerance 1 | 75
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased glycosylated hemoglo... 1 | 1
increased heart left ventricle... 1 | 4
increased heart weight 1 | 62
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
male infertility 1 | 123
prenatal lethality 1 | 28
short tibia 1 | 97
thrombocytosis 1 | 27

Disease

Carcinoma 103 | 11,493
ovarian cancer 81 | 8,520
osteosarcoma 70 | 7,950
psoriasis 70 | 6,694
medulloblastoma, large-cell 64 | 6,241
glioblastoma 60 | 5,792
Cancer 58 | 2,499
atypical teratoid / rhabdoid tumor 54 | 5,112
ependymoma 45 | 4,679
lung cancer 43 | 4,740
group 3 medulloblastoma 39 | 4,104
adult high grade glioma 38 | 3,801
diabetes mellitus 38 | 1,728
subependymal giant cell astrocytoma 37 | 2,287
Breast cancer 36 | 3,578
Kidney cancer 33 | 2,613
Obesity 30 | 678
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,989
malignant mesothelioma 28 | 3,232
primitive neuroectodermal tumor 28 | 3,035
Autosomal recessive predisposition 27 | 1,442
astrocytic glioma 27 | 2,597
group 4 medulloblastoma 27 | 1,855
oligodendroglioma 27 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
invasive ductal carcinoma 26 | 2,951
Astrocytoma, Pilocytic 25 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,291
lung adenocarcinoma 24 | 2,716
Schizophrenia 23 | 1,160
tuberculosis 23 | 2,010
Epilepsy 22 | 792
Hyperglycemia 21 | 137
pituitary cancer 21 | 1,972
Pick disease 20 | 1,894
pancreatic cancer 20 | 2,398
Cognitive delay 19 | 608
Global developmental delay 19 | 608
Intellectual disability 19 | 1,016
Mental and motor retardation 19 | 608
astrocytoma 19 | 1,146
non-small cell lung cancer 19 | 2,890
Liver carcinoma 17 | 240
Orbital separation excessive 17 | 244
Seizures 17 | 596
Short stature 17 | 531
juvenile dermatomyositis 17 | 1,187
Carcinoma, Hepatocellular 16 | 228
Dull intelligence 16 | 645
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Muscle hypotonia 16 | 571
Poor school performance 16 | 645
breast carcinoma 16 | 1,638
colon cancer 16 | 1,478
ductal carcinoma in situ 16 | 1,745
Concave bridge of nose 15 | 195
Depressed nasal bridge 15 | 195
Depressed nasal root/bridge 15 | 195
Insulin Resistance 15 | 72
acute quadriplegic myopathy 15 | 1,158
adrenocortical carcinoma 15 | 1,428
interstitial cystitis 15 | 2,312
lung carcinoma 15 | 2,843
ulcerative colitis 15 | 1,819
Blepharoptosis 14 | 231
Glycogen storage disease 14 | 39
Hepatomegaly 14 | 285
Liver Cirrhosis, Experimental 14 | 769
Stomach Neoplasms 14 | 300
Alzheimer's disease 13 | 658
Multiple myeloma 13 | 1,332
Muscle Weakness 13 | 170
Parkinson's disease 13 | 392
Renal Cell Carcinoma 13 | 214
dermatomyositis 13 | 966
Byzanthine arch palate 12 | 194
Cryptorchidism 12 | 296
Diabetes Mellitus, Non-Insulin-Dependent 12 | 145
Diabetes Mellitus, Type 2 12 | 142
Downward slant of palpebral fissure 12 | 158
Fatty liver disease 12 | 103
Hyperinsulinism 12 | 133
Hypertension 12 | 396
Hypoglycemia 12 | 152
cystic fibrosis 12 | 1,696
pediatric high grade glioma 12 | 1,064
Acquired scoliosis 11 | 281
Curvature of spine 11 | 282
Hypoplastic mandible condyle 11 | 275
Mandibular hypoplasia 11 | 275
Micrognathism 11 | 275
Pectus excavatum 11 | 100
Prostatic Neoplasms 11 | 495
Rheumatoid arthritis 11 | 1,191
Vascular disease 11 | 319
primary pancreatic ductal adenocarcinoma 11 | 1,109
spina bifida 11 | 1,074

Tissue

Endocrine System 136 | 18,159
Digestive Tract 134 | 17,369
Male tissues 133 | 17,142
Skin and soft tissues 133 | 17,230
Female tissues 131 | 17,400
Liver and Pancreas 131 | 16,750
Blood and immune system 130 | 16,909
Nervous System 130 | 16,725
Urinary Tract 128 | 16,678
Cardiovascular System 126 | 15,192
Respiratory system 125 | 16,393

Target Family

Kinase 47 | 634
Enzyme 45 | 4,145
Non-IDG 41 | 12,091
Transcription Factor 3 | 1,400
Transporter 1 | 473

KEGG Pathway

Insulin signaling pathway 137 | 137
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Suppressor of cytokine signaling 4 SOCS4 Tbio Non-IDG -1.22763 14.8 224
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Glucose-6-phosphatase 3 G6PC3 Tbio Enzyme -1.55249 37.2 54
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574