Development Level

Tchem 62 | 1,890
Tbio 61 | 10,625
Tclin 10 | 602
Tdark 5 | 7,003

Collection

Eligible Kinase Proteins 8 | 134

IMPC Term

preweaning lethality, incomple... 5 | 260
abnormal lens morphology 3 | 73
decreased body weight 3 | 174
decreased circulating LDL chol... 3 | 37
preweaning lethality, complete... 3 | 633
decreased circulating choleste... 2 | 85
decreased circulating creatini... 2 | 31
decreased lean body mass 2 | 195
decreased total body fat amoun... 2 | 186
enlarged spleen 2 | 26
increased circulating LDL chol... 2 | 15
increased circulating alkaline... 2 | 119
increased erythrocyte cell num... 2 | 26
increased hematocrit 2 | 36
increased hemoglobin content 2 | 45
increased mean corpuscular hem... 2 | 93
abnormal bone mineralization 1 | 55
abnormal gait 1 | 51
abnormal glucose homeostasis 1 | 5
abnormal locomotor activation 1 | 26
abnormal respiratory quotient 1 | 9
abnormal retina morphology 1 | 100
abnormal retinal blood vessel ... 1 | 18
abnormal retinal vasculature m... 1 | 15
abnormal rib morphology 1 | 28
abnormal spleen morphology 1 | 36
abnormal vibrissa morphology 1 | 17
anophthalmia 1 | 20
cataract 1 | 26
decreased CD5-positive Ly6C-po... 1 | 4
decreased CD8-positive, alpha-... 1 | 26
decreased CD8-positive, naive ... 1 | 5
decreased T cell number 1 | 31
decreased blood urea nitrogen ... 1 | 31
decreased body length 1 | 108
decreased bone mineral density 1 | 126
decreased circulating HDL chol... 1 | 77
decreased circulating alanine ... 1 | 53
decreased circulating amylase ... 1 | 24
decreased circulating glucose ... 1 | 121
decreased circulating glycerol... 1 | 19
decreased circulating iron lev... 1 | 25
decreased circulating magnesiu... 1 | 11
decreased circulating triglyce... 1 | 83
decreased erythrocyte cell num... 1 | 43
decreased fasted circulating g... 1 | 49
decreased grip strength 1 | 123
decreased hematocrit 1 | 25
decreased hemoglobin content 1 | 53
decreased lumbar vertebrae num... 1 | 62
decreased mean corpuscular hem... 1 | 34
decreased mean corpuscular hem... 1 | 19
decreased mean corpuscular vol... 1 | 50
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187
enlarged heart 1 | 111
hypoactivity 1 | 89
immune system phenotype 1 | 17
impaired glucose tolerance 1 | 52
increased bone mineral density 1 | 52
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 32
increased circulating chloride... 1 | 43
increased circulating choleste... 1 | 53
increased circulating iron lev... 1 | 25
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 20
increased effector memory T-he... 1 | 5
increased glycosylated hemoglo... 1 | 1
increased heart rate 1 | 17
increased mean platelet volume 1 | 19
increased memory-marker gamma-... 1 | 2
increased red blood cell distr... 1 | 21
increased spleen weight 1 | 3
shortened RR interval 1 | 19
thrombocytosis 1 | 23

Disease

ovarian cancer 81 | 8,492
osteosarcoma 71 | 7,933
psoriasis 69 | 6,685
medulloblastoma, large-cell 63 | 6,234
Cancer 56 | 2,346
glioblastoma 55 | 5,572
atypical teratoid / rhabdoid tumor 45 | 4,369
lung cancer 39 | 4,473
subependymal giant cell astrocytoma 38 | 2,287
diabetes mellitus 34 | 1,663
Carcinoma 32 | 2,147
Breast cancer 31 | 3,099
ependymoma 31 | 2,514
intraductal papillary-mucinous adenoma (IPMA) 30 | 2,956
Obesity 29 | 616
intraductal papillary-mucinous carcinoma (IPMC) 29 | 2,988
pediatric high grade glioma 29 | 2,712
group 4 medulloblastoma 28 | 1,875
invasive ductal carcinoma 28 | 2,950
pilocytic astrocytoma 28 | 3,086
primitive neuroectodermal tumor 27 | 3,031
malignant mesothelioma 26 | 3,163
oligodendroglioma 26 | 2,849
astrocytoma 25 | 1,493
intraductal papillary-mucinous neoplasm (IPMN) 25 | 3,289
lung adenocarcinoma 25 | 2,714
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,795
adult high grade glioma 22 | 2,148
pituitary cancer 21 | 1,972
ulcerative colitis 21 | 2,087
astrocytic glioma 20 | 2,241
non-small cell lung cancer 20 | 2,798
pancreatic cancer 20 | 2,300
Pick disease 19 | 1,893
group 3 medulloblastoma 19 | 2,254
interstitial cystitis 18 | 2,299
tuberculosis 18 | 1,563
juvenile dermatomyositis 17 | 1,189
lung carcinoma 17 | 2,844
Hyperglycemia 16 | 120
Metabolic syndrome X 16 | 155
colon cancer 16 | 1,475
ductal carcinoma in situ 16 | 1,745
medulloblastoma 16 | 1,524
Liver carcinoma 15 | 217
acute quadriplegic myopathy 15 | 1,157
adrenocortical carcinoma 15 | 1,427
Glycogen storage disease 14 | 37
breast carcinoma 13 | 1,614
dermatomyositis 13 | 967
primary pancreatic ductal adenocarcinoma 13 | 1,271
Diabetes Mellitus, Non-Insulin-Dependent 12 | 161
Multiple myeloma 12 | 1,328
Parkinson's disease 12 | 364
Stomach Neoplasms 12 | 282
Vascular disease 12 | 281
cystic fibrosis 12 | 1,670
posterior fossa group A ependymoma 12 | 1,511
spina bifida 12 | 1,064
Alzheimer's disease 11 | 644
Fatty liver disease 11 | 86
Insulin Resistance 11 | 50
Intellectual disability 11 | 573
Hyperinsulinism 10 | 63
Mammary Neoplasms 10 | 410
Noonan Syndrome 10 | 33
Prostatic Neoplasms 10 | 471
Renal Cell Carcinoma 10 | 199
Rheumatoid Arthritis 10 | 1,171
Schizophrenia 10 | 503
autosomal dominant Emery-Dreifuss muscular dystrophy 10 | 499
esophageal adenocarcinoma 10 | 737
non-small cell lung carcinoma 10 | 413
posterior fossa group B ependymoma 10 | 1,530
Diabetes Mellitus, Experimental 9 | 106
Waldenstrons macroglobulinemia 9 | 765
atypical teratoid/rhabdoid tumor 9 | 1,095
sonic hedgehog group medulloblastoma 9 | 1,482
Adenoma 8 | 165
Amyotrophic Lateral Sclerosis 8 | 432
Duchenne muscular dystrophy 8 | 602
Heart disease 8 | 279
Lung Neoplasms 8 | 171
Squamous cell carcinoma 8 | 96
cutaneous lupus erythematosus 8 | 1,056
nasopharyngeal carcinoma 8 | 1,056
ovarian neoplasm 8 | 97
pancreatic carcinoma 8 | 567
Arthritis 7 | 248
Atopic dermatitis 7 | 944
Cardiomyopathy 7 | 110
Diabetes Mellitus, Noninsulin-Dependent 7 | 31
Epilepsy 7 | 346
Kidney cancer 7 | 121
Kidney disease 7 | 397
Polycystic Ovary Syndrome 7 | 335
fibroadenoma 7 | 557
gastric carcinoma 6 | 832
nephrosclerosis 6 | 329
primary Sjogren syndrome 6 | 789

Tissue

Blood and immune system 138 | 17,995
Female tissues 138 | 18,647
Liver and Pancreas 138 | 18,136
Nervous System 138 | 18,561
Digestive Tract 137 | 18,473
Endocrine System 137 | 18,512
Cardiovascular System 136 | 17,958
Male tissues 136 | 17,969
Urinary Tract 136 | 18,444
Skin and soft tissues 135 | 18,115
Respiratory system 134 | 17,484

Target Family

Kinase 48 | 634
Enzyme 47 | 4,146
Non-IDG 39 | 11,969
Transcription Factor 3 | 1,400
Transporter 1 | 473

KEGG Pathway

Insulin signaling pathway 138 | 138
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.02404 9.59 274
5'-AMP-activated protein kinase subunit beta-1 PRKAB1 Tbio Kinase -1.47950 28.8 495
Insulin receptor substrate 2 IRS2 Tbio Non-IDG -2.62322 398.1 207
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.04744 808.6 1868
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -2.99634 1000.8 1343
Hexokinase-2 HK2 Tchem Kinase -2.60415 391.1 373
GTPase HRas HRAS Tchem Enzyme -3.99319 9497.9 312
GTPase NRas NRAS Tchem Enzyme -2.98048 880.4 265
SHC-transforming protein 2 SHC2 Tchem Non-IDG -2.45636 272.6 97
Hexokinase-3 HK3 Tbio Kinase -1.70703 47.9 299