Development Level

Tchem 53 | 1,598
Tbio 43 | 11,445
Tclin 9 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125
RFA-RM-18-021 1 | 328

IMPC Phenotype

increased circulating alkaline... 5 | 122
preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 4 | 499
decreased body weight 3 | 161
decreased circulating LDL chol... 3 | 38
increased mean corpuscular hem... 3 | 96
decreased circulating amylase ... 2 | 28
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular hem... 2 | 31
decreased mean platelet volume 2 | 25
decreased vertical activity 2 | 208
enlarged spleen 2 | 41
increased circulating LDL chol... 2 | 13
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased mean platelet volume 2 | 45
increased total body fat amoun... 2 | 134
male infertility 2 | 123
abnormal bone mineralization 1 | 38
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal thymus morphology 1 | 7
abnormal tooth morphology 1 | 24
abnormal vibrissa morphology 1 | 25
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to t... 1 | 278
enlarged heart 1 | 210
enlarged thymus 1 | 5
impaired glucose tolerance 1 | 75
increased basophil cell number 1 | 7
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased glycosylated hemoglo... 1 | 1
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Carcinoma 87 | 11,493
osteosarcoma 62 | 7,950
ovarian cancer 62 | 8,520
psoriasis 58 | 6,694
glioblastoma 50 | 5,792
medulloblastoma, large-cell 50 | 6,241
Cancer 48 | 2,499
diabetes mellitus 45 | 1,728
lung cancer 41 | 4,740
Obesity 40 | 678
atypical teratoid / rhabdoid tumor 38 | 5,112
ependymoma 37 | 4,679
Hyperglycemia 33 | 137
adult high grade glioma 31 | 3,801
group 3 medulloblastoma 31 | 4,104
Breast cancer 30 | 3,578
invasive ductal carcinoma 30 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
lung adenocarcinoma 25 | 2,716
subependymal giant cell astrocytoma 25 | 2,287
intraductal papillary-mucinous carcinoma (IPMC) 24 | 2,989
Astrocytoma, Pilocytic 23 | 3,081
intraductal papillary-mucinous neoplasm (IPMN) 23 | 3,291
malignant mesothelioma 23 | 3,232
oligodendroglioma 23 | 2,850
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
pituitary cancer 22 | 1,972
tuberculosis 22 | 2,010
Autosomal recessive predisposition 21 | 1,442
Schizophrenia 21 | 1,160
group 4 medulloblastoma 21 | 1,855
non-small cell lung cancer 21 | 2,890
primitive neuroectodermal tumor 21 | 3,035
Diabetes Mellitus, Non-Insulin-Dependent 20 | 145
interstitial cystitis 20 | 2,312
Insulin Resistance 19 | 72
Kidney cancer 19 | 2,613
astrocytic glioma 19 | 2,597
breast carcinoma 19 | 1,638
ductal carcinoma in situ 19 | 1,745
Diabetes Mellitus, Experimental 18 | 108
Diabetes Mellitus, Type 2 18 | 142
Hyperinsulinism 18 | 133
Hypertension 18 | 396
Liver carcinoma 18 | 240
astrocytoma 18 | 1,146
lung carcinoma 18 | 2,843
Carcinoma, Hepatocellular 17 | 228
colon cancer 17 | 1,478
Breast Neoplasms 16 | 445
Epilepsy 16 | 792
Fatty liver disease 16 | 103
Liver Cirrhosis, Experimental 16 | 769
Mammary Neoplasms 16 | 425
Pick disease 16 | 1,894
adrenocortical carcinoma 16 | 1,428
cystic fibrosis 16 | 1,696
pancreatic cancer 16 | 2,398
ulcerative colitis 16 | 1,819
Alzheimer's disease 15 | 658
Seizures 15 | 596
Hypertensive disease 14 | 292
Hypoglycemia 14 | 152
Rheumatoid arthritis 14 | 1,191
Bipolar Disorder 13 | 666
Cardiomegaly 13 | 116
Prostatic Neoplasms 13 | 495
Stomach Neoplasms 13 | 300
Vascular disease 13 | 319
Kidney disease 12 | 430
Lipid metabolism disorder 12 | 114
Parkinson's disease 12 | 392
Polycystic ovary syndrome 12 | 360
Arthritis 11 | 290
Atherosclerosis 11 | 291
Depressive disorder 11 | 409
dermatomyositis 11 | 966
juvenile dermatomyositis 11 | 1,187
Asthma 10 | 385
Glycogen storage disease 10 | 39
Heart disease 10 | 306
Heart failure 10 | 162
Intellectual disability 10 | 1,016
Liver disease 10 | 237
Mental Depression 10 | 333
Reperfusion Injury 10 | 86
acute quadriplegic myopathy 10 | 1,158
Brain Ischemia 9 | 110
Cognitive delay 9 | 608
Coronary artery disease 9 | 268
Global developmental delay 9 | 608
Hepatomegaly 9 | 285
Inflammatory bowel disease 9 | 151
Mental and motor retardation 9 | 608
Multiple myeloma 9 | 1,332
Myocardial Ischemia 9 | 169
Orbital separation excessive 9 | 244
Renal Cell Carcinoma 9 | 214
Short stature 9 | 531
acute myeloid leukemia 9 | 783

Tissue

Digestive Tract 107 | 17,369
Endocrine System 106 | 18,159
Skin and soft tissues 106 | 17,230
Liver and Pancreas 105 | 16,750
Female tissues 104 | 17,400
Urinary Tract 104 | 16,678
Blood and immune system 103 | 16,909
Nervous System 103 | 16,725
Male tissues 102 | 17,142
Cardiovascular System 101 | 15,192
Respiratory system 99 | 16,393

Target Family

Enzyme 34 | 4,145
Kinase 33 | 634
Transcription Factor 15 | 1,400
Non-IDG 13 | 12,091
Transporter 9 | 473
Nuclear Receptor 3 | 48

KEGG Pathway

Insulin resistance 107 | 107
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glucose-6-phosphatase 3 G6PC3 Tbio Enzyme -1.55249 37.2 54
Ribosomal protein S6 kinase alpha-6 RPS6KA6 Tchem Kinase -1.26563 21.6 158
Bile acyl-CoA synthetase SLC27A5 Tbio Transporter -2.32176 196.8 181
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Protein O-GlcNAcase MGEA5 Tchem Enzyme -3.38049 2167.6 123
Protein phosphatase 1 regulatory subunit 3A PPP1R3A Tbio Enzyme -1.36272 22.6 88
Carbohydrate-responsive element-binding protein MLXIPL Tbio Transcription Factor -2.29554 206.7 235
Acetyl-CoA carboxylase 2 ACACB Tchem Enzyme -2.25387 171.9 125
Cyclic AMP-responsive element-binding protein 3-like protein 4 CREB3L4 Tbio Transcription Factor -1.64875 47.6 188