Development Level

Tbio 111 | 11,178
Tclin 44 | 612
Tchem 20 | 1,885
Tdark 19 | 6,569

IMPC Phenotype

preweaning lethality, complete... 25 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
abnormal embryo size 5 | 220
cataract 5 | 92
abnormal lens morphology 4 | 81
pallor 4 | 34
abnormal behavior 3 | 298
embryonic growth retardation 3 | 106
hyperactivity 3 | 148
hypoactivity 3 | 132
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
increased hemoglobin content 3 | 45
increased lean body mass 3 | 172
preweaning lethality, incomple... 3 | 499
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal placenta size 2 | 20
abnormal skin coloration 2 | 25
cardiovascular system phenotyp... 2 | 36
decreased bone mineral content 2 | 151
decreased circulating chloride... 2 | 30
decreased circulating insulin ... 2 | 76
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
hydrometra 2 | 53
increased circulating calcium ... 2 | 34
increased circulating free fat... 2 | 20
increased circulating sodium l... 2 | 71
increased heart weight 2 | 62
increased mean corpuscular hem... 2 | 96
increased mean corpuscular hem... 2 | 36
prenatal lethality 2 | 28
small superior vagus ganglion 2 | 74
abnormal allantois morphology 1 | 8
abnormal cecum morphology 1 | 7
abnormal chorioallantoic fusio... 1 | 8
abnormal coat appearance 1 | 31
abnormal embryo turning 1 | 31
abnormal embryonic autopod pla... 1 | 2
abnormal epididymis morphology 1 | 42
abnormal hindbrain development 1 | 16
abnormal limb bud morphology 1 | 17
abnormal liver size 1 | 5
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal neural tube closure 1 | 46
abnormal neural tube morpholog... 1 | 12
abnormal placenta morphology 1 | 5
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal tail movements 1 | 12
abnormal testis morphology 1 | 43
abnormal visceral yolk sac mor... 1 | 6
abnormal vitelline vasculature... 1 | 6
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
decreased body length 1 | 101
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating creatini... 1 | 39
decreased circulating iron lev... 1 | 32
decreased circulating phosphat... 1 | 27
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased exploration in new e... 1 | 11
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased heart rate 1 | 18
decreased lean body mass 1 | 135
decreased mean platelet volume 1 | 25
decreased threshold for audito... 1 | 26
decreased total retina thickne... 1 | 17
edema 1 | 59
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
hemorrhage 1 | 23
increased blood urea nitrogen ... 1 | 48
increased circulating HDL chol... 1 | 80
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating phosphat... 1 | 26
increased fasted circulating g... 1 | 76
increased mean corpuscular vol... 1 | 92
increased startle reflex 1 | 112
long tibia 1 | 25
pale liver 1 | 6
polycystic kidney 1 | 15
prenatal lethality prior to he... 1 | 87
short tibia 1 | 97
small testis 1 | 58
thin ventricular wall 1 | 24
tremors 1 | 39

Disease

ovarian cancer 107 | 8,297
Carcinoma 82 | 11,192
osteosarcoma 69 | 7,766
Multiple myeloma 63 | 1,296
psoriasis 60 | 6,514
lung cancer 57 | 4,607
ependymoma 51 | 4,559
glioblastoma 47 | 5,635
medulloblastoma, large-cell 43 | 6,086
Breast cancer 42 | 3,469
Diabetes mellitus type 2 40 | 69
Treatment Refractory Type 2 Diabetes Mellitus 40 | 53
atypical teratoid / rhabdoid tumor 39 | 4,971
Autosomal recessive predisposition 38 | 1,407
Epilepsy 38 | 775
adult high grade glioma 33 | 3,701
diabetes mellitus 31 | 1,683
Cancer 30 | 2,388
Schizophrenia 30 | 1,136
Seizures 30 | 584
astrocytic glioma 30 | 2,530
Cerebellar Ataxia 27 | 302
Kidney cancer 27 | 2,548
Cognitive delay 26 | 596
Global developmental delay 26 | 596
Mental and motor retardation 26 | 596
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,204
oligodendroglioma 26 | 2,768
Intellectual disability 25 | 998
Leigh disease 25 | 100
pancreatic ductal adenocarcinoma liver metastasis 25 | 1,911
Blepharoptosis 24 | 229
Muscle hypotonia 24 | 562
group 3 medulloblastoma 24 | 4,002
Acidosis, Lactic 23 | 97
Hyperreflexia 23 | 208
Lactic acidemia 23 | 95
lung adenocarcinoma 23 | 2,627
primitive neuroectodermal tumor 23 | 2,957
Dull intelligence 22 | 634
Low intelligence 22 | 634
Mental Retardation 22 | 634
Mental deficiency 22 | 634
Mitochondrial complex I deficiency 22 | 46
Nystagmus 22 | 309
Poor school performance 22 | 634
Waldenstrons macroglobulinemia 22 | 742
Astrocytoma, Pilocytic 21 | 3,006
Failure to gain weight 21 | 359
Muscle Spasticity 21 | 192
Pediatric failure to thrive 21 | 359
Strabismus 21 | 265
lung carcinoma 21 | 2,755
Bipolar Disorder 20 | 646
malignant mesothelioma 20 | 3,135
Parkinson's disease 19 | 378
Sensorineural Hearing Loss (disorder) 19 | 281
subependymal giant cell astrocytoma 19 | 2,230
Alzheimer's disease 18 | 640
Highly variable clinical phenotype 18 | 147
Highly variable phenotype and severity 18 | 147
Highly variable phenotype, even within families 18 | 147
Liver cancer 18 | 589
Obesity 18 | 655
Phenotypic variability 18 | 147
Pick disease 18 | 1,856
Respiratory Failure 18 | 101
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,902
Developmental regression 17 | 94
Hypertrophic Cardiomyopathy 17 | 115
Loss of developmental milestones 17 | 94
Melanoma 17 | 689
Mental deterioration in childhood 17 | 94
Neurodevelopmental regression 17 | 94
Psychomotor regression 17 | 94
Psychomotor regression beginning in infancy 17 | 94
Psychomotor regression in infants 17 | 94
Psychomotor regression, progressive 17 | 94
breast carcinoma 17 | 1,589
group 4 medulloblastoma 17 | 1,806
intraductal papillary-mucinous adenoma (IPMA) 17 | 2,872
CSF lactate increased 16 | 33
Muscle Weakness 16 | 168
astrocytoma 16 | 1,113
Increased serum lactate 15 | 60
Mitochondrial Complex 1 Deficiency 15 | 28
pancreatic cancer 15 | 2,322
ulcerative colitis 15 | 1,765
Depressive disorder 14 | 401
Huntington's disease 14 | 75
Impaired exercise tolerance 14 | 42
Neurogenic Muscular Atrophy 14 | 136
Neurogenic muscle atrophy, especially in the lower limbs 14 | 136
Optic Atrophy 14 | 239
Skeletal muscle atrophy 14 | 136
Toxic encephalopathy 14 | 139
muscle degeneration 14 | 136
nasopharyngeal carcinoma 14 | 1,024
non-small cell lung cancer 14 | 2,799
pituitary cancer 14 | 1,915

Tissue

Endocrine System 193 | 18,159
Skin and soft tissues 191 | 17,230
Female tissues 190 | 17,400
Digestive Tract 189 | 17,369
Nervous System 187 | 16,725
Liver and Pancreas 186 | 16,750
Respiratory system 186 | 16,393
Male tissues 185 | 17,142
Urinary Tract 185 | 16,678
Blood and immune system 184 | 16,909
Cardiovascular System 176 | 15,192

Target Family

Enzyme 106 | 4,145
Non-IDG 62 | 12,091
Transcription Factor 13 | 1,400
Epigenetic 4 | 242
Transporter 4 | 473
Ion Channel 3 | 344
GPCR 1 | 408
Nuclear Receptor 1 | 48

KEGG Pathway

Huntington's disease 194 | 194
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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