Development Level

Tbio 283 | 11,445
Tchem 63 | 1,598
Tclin 35 | 613
Tdark 7 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 31 | 979
abnormal bone structure 9 | 187
preweaning lethality, incomple... 9 | 499
decreased total body fat amoun... 8 | 207
embryonic lethality prior to t... 8 | 278
enlarged heart 8 | 210
embryonic lethality prior to o... 7 | 239
increased circulating alkaline... 7 | 122
decreased vertical activity 6 | 208
increased heart weight 6 | 62
increased startle reflex 6 | 112
abnormal embryo size 5 | 220
abnormal heart morphology 5 | 162
decreased bone mineral content 5 | 151
impaired glucose tolerance 5 | 75
increased bone mineral content 5 | 108
increased lean body mass 5 | 172
short tibia 5 | 97
abnormal retina morphology 4 | 71
decreased body length 4 | 101
decreased body weight 4 | 161
decreased bone mineral density 4 | 126
decreased mean corpuscular vol... 4 | 79
hypoactivity 4 | 132
increased leukocyte cell numbe... 4 | 47
increased neutrophil cell numb... 4 | 46
abnormal behavior 3 | 298
abnormal eye morphology 3 | 68
abnormal kidney morphology 3 | 65
abnormal lens morphology 3 | 81
cataract 3 | 92
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased lean body mass 3 | 135
edema 3 | 59
increased circulating choleste... 3 | 66
increased circulating triglyce... 3 | 42
increased lymphocyte cell numb... 3 | 32
increased total body fat amoun... 3 | 134
microphthalmia 3 | 26
small superior vagus ganglion 3 | 74
abnormal bone mineralization 2 | 38
abnormal femur morphology 2 | 14
abnormal gait 2 | 69
abnormal limb morphology 2 | 13
abnormal lung morphology 2 | 26
abnormal neural tube closure 2 | 46
abnormal seminal vesicle morph... 2 | 114
abnormal skin morphology 2 | 50
cardiovascular system phenotyp... 2 | 36
decreased blood urea nitrogen ... 2 | 51
decreased circulating LDL chol... 2 | 38
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating total pr... 2 | 49
decreased grip strength 2 | 116
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular hem... 2 | 50
decreased mean corpuscular hem... 2 | 31
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
enlarged kidney 2 | 14
enlarged spleen 2 | 41
hemorrhage 2 | 23
improved glucose tolerance 2 | 79
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased circulating amylase ... 2 | 25
increased fasted circulating g... 2 | 76
increased hematocrit 2 | 46
increased hemoglobin content 2 | 45
increased large unstained cell... 2 | 5
increased mean corpuscular hem... 2 | 96
increased or absent threshold ... 2 | 101
male infertility 2 | 123
persistence of hyaloid vascula... 2 | 33
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
thrombocytopenia 2 | 56
abnormal body wall morphology 1 | 9
abnormal craniofacial morpholo... 1 | 33
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal optic disc morphology 1 | 10
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased red blood cell distr... 1 | 41
hydrometra 1 | 53
increased body length 1 | 32
increased circulating iron lev... 1 | 30
increased eosinophil cell numb... 1 | 11
increased red blood cell distr... 1 | 34

Disease

Carcinoma 284 | 11,493
Cancer 226 | 2,499
psoriasis 205 | 6,694
ovarian cancer 189 | 8,520
glioblastoma 154 | 5,792
osteosarcoma 147 | 7,950
lung cancer 129 | 4,740
medulloblastoma, large-cell 129 | 6,241
atypical teratoid / rhabdoid tumor 117 | 5,112
Breast cancer 114 | 3,578
ependymoma 112 | 4,679
Kidney cancer 100 | 2,613
diabetes mellitus 97 | 1,728
Astrocytoma, Pilocytic 91 | 3,081
adult high grade glioma 88 | 3,801
malignant mesothelioma 86 | 3,232
group 3 medulloblastoma 85 | 4,104
pancreatic cancer 80 | 2,398
invasive ductal carcinoma 76 | 2,951
Arthritis 75 | 290
interstitial cystitis 75 | 2,312
Ankylosing spondylitis 73 | 140
dermatomyositis 73 | 966
Rheumatoid arthritis 72 | 1,191
tuberculosis 72 | 2,010
Hypersensitivity reaction type II disease 71 | 253
non-small cell lung cancer 71 | 2,890
Behcet's disease 70 | 89
intraductal papillary-mucinous adenoma (IPMA) 69 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 69 | 3,291
lung adenocarcinoma 69 | 2,716
intraductal papillary-mucinous carcinoma (IPMC) 68 | 2,989
lung carcinoma 67 | 2,843
Schizophrenia 65 | 1,160
oligodendroglioma 64 | 2,850
primitive neuroectodermal tumor 64 | 3,035
subependymal giant cell astrocytoma 64 | 2,287
Acquired immunodeficiency syndrome 61 | 197
Juvenile rheumatoid arthritis 61 | 111
breast carcinoma 61 | 1,638
Autosomal recessive predisposition 60 | 1,442
Uveitis 59 | 103
Herpes zoster 58 | 68
Stevens-Johnson syndrome 56 | 92
Human immunodeficiency virus infectious disease 54 | 138
cystic fibrosis 54 | 1,696
Psoriatic arthritis 51 | 86
astrocytic glioma 51 | 2,597
ductal carcinoma in situ 51 | 1,745
Kidney disease 50 | 430
juvenile dermatomyositis 49 | 1,187
Multiple Sclerosis 48 | 540
pituitary cancer 47 | 1,972
ulcerative colitis 47 | 1,819
Anemia 44 | 365
Breast Neoplasms 44 | 445
Intellectual disability 43 | 1,016
Mammary Neoplasms 43 | 425
Melanoma 42 | 711
group 4 medulloblastoma 42 | 1,855
Dermatitis 41 | 157
Epilepsy 41 | 792
Multiple myeloma 41 | 1,332
Synovitis 41 | 78
astrocytoma 41 | 1,146
Seizures 40 | 596
Short stature 40 | 531
cutaneous lupus erythematosus 40 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 40 | 1,962
Nephritis 39 | 51
Pick disease 39 | 1,894
Behcet's syndrome 37 | 50
Liver cancer 37 | 604
Prostatic Neoplasms 37 | 495
gastric carcinoma 37 | 807
primary pancreatic ductal adenocarcinoma 37 | 1,109
Congenital adrenal hyperplasia 36 | 73
Takayasu's arteritis 36 | 53
adrenocortical carcinoma 36 | 1,428
colon cancer 36 | 1,478
Dull intelligence 35 | 645
Low intelligence 35 | 645
Mental Retardation 35 | 645
Mental deficiency 35 | 645
Poor school performance 35 | 645
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
drug-induced hepatitis 35 | 44
Liver disease 34 | 237
Lung Neoplasms 33 | 232
nasopharyngeal carcinoma 32 | 1,058
Cognitive delay 30 | 608
Global developmental delay 30 | 608
Hypoplastic mandible condyle 30 | 275
Mandibular hypoplasia 30 | 275
Mental and motor retardation 30 | 608
Micrognathism 30 | 275
Muscle hypotonia 30 | 571
Obesity 30 | 678
pediatric high grade glioma 30 | 1,064

Tissue

Endocrine System 302 | 18,159
Digestive Tract 300 | 17,369
Blood and immune system 299 | 16,909
Female tissues 298 | 17,400
Male tissues 296 | 17,142
Skin and soft tissues 296 | 17,230
Nervous System 294 | 16,725
Urinary Tract 293 | 16,678
Liver and Pancreas 292 | 16,750
Respiratory system 288 | 16,393
Cardiovascular System 276 | 15,192

Target Family

Non-IDG 244 | 12,091
Enzyme 44 | 4,145
Kinase 40 | 634
Transcription Factor 34 | 1,400
Epigenetic 14 | 242
GPCR 11 | 408
Transporter 1 | 473

KEGG Pathway

Human papillomavirus infection 388 | 388
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Beta-1,3-N-acetylglucosaminyltransferase radical fringe RFNG Tdark Enzyme -0.37913 1.57 92
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Histone deacetylase 9 HDAC9 Tclin Epigenetic -2.27309 185.2 431
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 MAGI1 Tbio Enzyme -1.08587 12.0 153
Transcription factor HES-2 HES2 Tdark Transcription Factor -0.19957 1.87 213
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Hairy/enhancer-of-split related with YRPW motif protein 1 HEY1 Tbio Transcription Factor -2.28398 163.4 335
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Chromodomain-helicase-DNA-binding protein 4 CHD4 Tbio Epigenetic -2.22229 159.7 203