Development Level

Tbio 37 | 11,445
Tchem 5 | 1,598
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 3 | 278
increased mean corpuscular vol... 2 | 92
abnormal behavioral response t... 1 | 66
abnormal bone mineralization 1 | 38
abnormal gait 1 | 69
abnormal spleen morphology 1 | 55
corneal opacity 1 | 32
decreased circulating glucose ... 1 | 126
decreased red blood cell distr... 1 | 41
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased mean platelet volume 1 | 45
prenatal lethality prior to he... 1 | 87
shortened PQ interval 1 | 7
shortened PR interval 1 | 6
thrombocytosis 1 | 27

Disease

ovarian cancer 29 | 8,520
Carcinoma 28 | 11,493
Breast cancer 22 | 3,578
group 3 medulloblastoma 20 | 4,104
osteosarcoma 20 | 7,950
lung cancer 19 | 4,740
malignant mesothelioma 18 | 3,232
Cancer 17 | 2,499
medulloblastoma, large-cell 15 | 6,241
atypical teratoid / rhabdoid tumor 14 | 5,112
psoriasis 13 | 6,694
Breast Neoplasms 12 | 445
Fanconi anemia 12 | 56
Mammary Neoplasms 12 | 425
Hereditary Breast and Ovarian Cancer Syndrome 11 | 14
glioblastoma 10 | 5,792
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
non-small cell lung cancer 10 | 2,890
Autosomal recessive predisposition 9 | 1,442
Bloom syndrome 9 | 29
Malignant neoplasm of breast 9 | 15
Short stature 9 | 531
ependymoma 9 | 4,679
Ataxia telangiectasia 8 | 34
Chromosome Breakage 8 | 36
Nijmegen breakage syndrome 8 | 24
Small head 8 | 374
lung adenocarcinoma 8 | 2,716
primitive neuroectodermal tumor 8 | 3,035
Dull intelligence 7 | 645
Increased chromosomal breakage 7 | 27
Intellectual disability 7 | 1,016
Kidney cancer 7 | 2,613
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Xeroderma pigmentosum 7 | 43
adult high grade glioma 7 | 3,801
colon cancer 7 | 1,478
ductal carcinoma in situ 7 | 1,745
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 6 | 9
Ovarian Neoplasms 6 | 102
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
invasive ductal carcinoma 6 | 2,951
non primary Sjogren syndrome sicca 6 | 891
ovarian neoplasm 6 | 99
Acquired scoliosis 5 | 281
Anemia 5 | 365
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 5 | 13
BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2 5 | 8
Breast Cancer, Familial 5 | 8
Curvature of spine 5 | 282
Decreased platelet count 5 | 111
Schizophrenia 5 | 1,160
Thrombocytopenia 5 | 197
Waldenstrons macroglobulinemia 5 | 765
Werner syndrome 5 | 29
adrenocortical carcinoma 5 | 1,428
breast carcinoma 5 | 1,638
diabetes mellitus 5 | 1,728
nasopharyngeal carcinoma 5 | 1,058
oligodendroglioma 5 | 2,850
Almond-shaped eyes 4 | 23
Cognitive delay 4 | 608
Esophageal atresia with or without tracheoesophageal fistula 4 | 21
Global developmental delay 4 | 608
Irregular hyperpigmentation 4 | 33
Leukopenia 4 | 72
Liver cancer 4 | 604
Lymphoma 4 | 81
Mental and motor retardation 4 | 608
Microcephaly 4 | 166
Pancreatic Neoplasm 4 | 85
Pancreatic Neoplasms 4 | 85
Prostate cancer 4 | 175
Prostatic Neoplasms 4 | 495
Pyridoxine-responsive sideroblastic anemia 4 | 17
Radial aplasia/hypoplasia 4 | 29
Short palpebral fissure 4 | 38
Tumor Predisposition Syndrome 4 | 6
astrocytic glioma 4 | 2,597
esophageal atresia/tracheoesophageal fistula 4 | 22
hypopigmented skin patch 4 | 59
pancreatic cancer 4 | 2,398
pituitary cancer 4 | 1,972
tuberculosis 4 | 2,010
Astrocytoma, Pilocytic 3 | 3,081
Attention deficit hyperactivity disorder 3 | 278
Chronic Lymphocytic Leukemia 3 | 262
Endometrial cancer 3 | 311
Lymphoma, Non-Hodgkin 3 | 24
Multiple Sclerosis 3 | 540
Multiple myeloma 3 | 1,332
Osteoporosis 3 | 363
dermatomyositis 3 | 966
interstitial cystitis 3 | 2,312
lung carcinoma 3 | 2,843
subependymal giant cell astrocytoma 3 | 2,287

Tissue

Blood and immune system 42 | 16,909
Digestive Tract 42 | 17,369
Endocrine System 42 | 18,159
Female tissues 42 | 17,400
Male tissues 42 | 17,142
Respiratory system 42 | 16,393
Skin and soft tissues 42 | 17,230
Urinary Tract 42 | 16,678
Cardiovascular System 41 | 15,192
Liver and Pancreas 41 | 16,750
Nervous System 41 | 16,725

Target Family

Non-IDG 31 | 12,091
Enzyme 11 | 4,145
Kinase 1 | 634

KEGG Pathway

Homologous recombination 43 | 43
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA topoisomerase 3-beta-1 TOP3B Tbio Enzyme -1.06981 9.54 153
DNA repair and recombination protein RAD54B RAD54B Tbio Non-IDG -1.41173 28.9 153
DNA endonuclease RBBP8 RBBP8 Tbio Enzyme -2.17933 148.4 308
DNA polymerase delta subunit 4 POLD4 Tbio Enzyme -0.84887 7.32 24
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
DNA repair protein XRCC3 XRCC3 Tbio Non-IDG -2.50791 314.0 414
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209
Replication protein A 14 kDa subunit RPA3 Tbio Non-IDG -1.85941 67.1 171
Putative protein SEM1, isoform 2 SEM1 Tbio Non-IDG 0.30 0.49 109