Development Level

Tbio 103 | 11,651
Tchem 46 | 1,388
Tclin 15 | 612
Tdark 4 | 6,593

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 18 | 979
abnormal heart morphology 5 | 162
decreased body weight 5 | 161
cataract 4 | 92
decreased vertical activity 4 | 208
edema 4 | 59
enlarged heart 4 | 210
preweaning lethality, incomple... 4 | 499
abnormal bone mineralization 3 | 38
abnormal embryo size 3 | 220
abnormal lens morphology 3 | 81
decreased circulating LDL chol... 3 | 38
embryonic lethality prior to t... 3 | 278
increased lean body mass 3 | 172
increased total body fat amoun... 3 | 134
microphthalmia 3 | 26
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
abnormal spleen morphology 2 | 55
abnormal testis morphology 2 | 43
decreased bone mineral density 2 | 126
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
increased circulating LDL chol... 2 | 13
increased mean corpuscular hem... 2 | 96
prenatal lethality 2 | 28
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
small superior vagus ganglion 2 | 74
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal brain morphology 1 | 13
abnormal coat appearance 1 | 31
abnormal coat- hair morphology 1 | 19
abnormal coat-hair pigmentatio... 1 | 64
abnormal digit morphology 1 | 10
abnormal embryo development 1 | 7
abnormal epididymis morphology 1 | 42
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal vibrissa morphology 1 | 25
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased mature B cell number 1 | 7
decreased prepulse inhibition 1 | 82
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged spleen 1 | 41
female infertility 1 | 60
hydroencephaly 1 | 14
hydrometra 1 | 53
hyperactivity 1 | 148
impaired glucose tolerance 1 | 75
increased B cell number 1 | 9
increased T cell number 1 | 6
increased blood uric acid leve... 1 | 5
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased monocyte cell number 1 | 63
increased startle reflex 1 | 112
mammalian phenotype 1 | 17
prolonged PR interval 1 | 15
small heart 1 | 10
small seminal vesicle 1 | 10
small testis 1 | 58
syndactyly 1 | 23
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Carcinoma 121 | 11,493
ovarian cancer 104 | 8,520
Cancer 103 | 2,499
osteosarcoma 89 | 7,950
psoriasis 82 | 6,694
glioblastoma 77 | 5,792
medulloblastoma, large-cell 72 | 6,241
lung cancer 69 | 4,740
Breast cancer 66 | 3,578
atypical teratoid / rhabdoid tumor 65 | 5,112
group 3 medulloblastoma 63 | 4,104
ependymoma 58 | 4,679
malignant mesothelioma 47 | 3,232
primitive neuroectodermal tumor 43 | 3,035
Kidney cancer 40 | 2,613
oligodendroglioma 38 | 2,850
Astrocytoma, Pilocytic 36 | 3,081
Prostatic Neoplasms 34 | 495
Intellectual disability 33 | 1,016
Schizophrenia 33 | 1,160
astrocytic glioma 33 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 33 | 2,955
invasive ductal carcinoma 33 | 2,951
Carcinoma, Hepatocellular 32 | 228
Liver carcinoma 32 | 240
adult high grade glioma 31 | 3,801
pancreatic cancer 31 | 2,398
Lung Neoplasms 30 | 232
subependymal giant cell astrocytoma 30 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
diabetes mellitus 28 | 1,728
interstitial cystitis 28 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
lung carcinoma 28 | 2,843
Short stature 27 | 531
adrenocortical carcinoma 27 | 1,428
lung adenocarcinoma 27 | 2,716
non-small cell lung cancer 27 | 2,890
Orbital separation excessive 26 | 244
Stomach Neoplasms 26 | 300
tuberculosis 26 | 2,010
Breast Neoplasms 25 | 445
Dull intelligence 25 | 645
Low intelligence 25 | 645
Mental Retardation 25 | 645
Mental deficiency 25 | 645
Poor school performance 25 | 645
cystic fibrosis 25 | 1,696
pituitary cancer 25 | 1,972
Cognitive delay 24 | 608
Global developmental delay 24 | 608
Hypoplastic mandible condyle 24 | 275
Mammary Neoplasms 24 | 425
Mandibular hypoplasia 24 | 275
Mental and motor retardation 24 | 608
Micrognathism 24 | 275
Vascular disease 24 | 319
astrocytoma 24 | 1,146
Acquired scoliosis 23 | 281
Adenoma 23 | 167
Colorectal Neoplasms 23 | 243
Cryptorchidism 23 | 296
Curvature of spine 23 | 282
breast carcinoma 23 | 1,638
Epilepsy 22 | 792
Multiple myeloma 22 | 1,332
Muscle hypotonia 22 | 571
Pick disease 22 | 1,894
Rheumatoid arthritis 22 | 1,191
pediatric high grade glioma 22 | 1,064
Autosomal recessive predisposition 21 | 1,442
Liver cancer 21 | 604
Seizures 20 | 596
colon cancer 20 | 1,478
ductal carcinoma in situ 20 | 1,745
juvenile dermatomyositis 20 | 1,187
spina bifida 20 | 1,074
Byzanthine arch palate 19 | 194
Melanoma 19 | 711
acute quadriplegic myopathy 19 | 1,158
group 4 medulloblastoma 19 | 1,855
Renal Cell Carcinoma 18 | 214
Squamous cell carcinoma 18 | 129
nasopharyngeal carcinoma 18 | 1,058
non-small cell lung carcinoma 18 | 317
ulcerative colitis 18 | 1,819
Adenocarcinoma 17 | 122
Colonic Neoplasms 17 | 142
Concave bridge of nose 17 | 195
Depressed nasal bridge 17 | 195
Depressed nasal root/bridge 17 | 195
Hypertensive disease 17 | 292
Liver neoplasms 17 | 130
Obesity 17 | 678
Strabismus 17 | 270
acute myeloid leukemia 17 | 783
dermatomyositis 17 | 966
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Endometrial cancer 16 | 311
Liver Cirrhosis, Experimental 16 | 769

Tissue

Endocrine System 163 | 18,159
Digestive Tract 162 | 17,369
Blood and immune system 160 | 16,909
Female tissues 160 | 17,400
Nervous System 160 | 16,725
Skin and soft tissues 159 | 17,230
Male tissues 158 | 17,142
Liver and Pancreas 155 | 16,750
Urinary Tract 154 | 16,678
Respiratory system 152 | 16,393
Cardiovascular System 143 | 15,192

Target Family

Non-IDG 64 | 12,091
Enzyme 37 | 4,145
Kinase 30 | 634
Transcription Factor 18 | 1,400
GPCR 10 | 408
Epigenetic 6 | 242
TF/Epigenetic 3 | 38

KEGG Pathway

Hepatocellular carcinoma 168 | 168
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
SHC-transforming protein 4 SHC4 Tbio Non-IDG -2.45096 295.5 129
Microsomal glutathione S-transferase 2 MGST2 Tbio Enzyme -1.15686 13.6 120
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Protransforming growth factor alpha TGFA Tbio Non-IDG -2.15761 135.3 697
Frizzled-4 FZD4 Tbio GPCR -2.05508 106.8 313
Cyclin-dependent kinase 6 CDK6 Tclin Kinase -2.71197 390.1 730
Hepatocyte growth factor HGF Tchem Enzyme -3.30841 2392.1 724
Glutathione S-transferase theta-2B GSTT2B Tbio Enzyme -1.34935 21.5 93
TGF-beta receptor type-2 TGFBR2 Tchem Kinase -2.84120 665.1 548
Mitogen-activated protein kinase 3 MAPK3 Tchem Kinase -3.66226 3484.0 1440