Development Level

Tbio 64 | 11,445
Tchem 45 | 1,598
Tclin 13 | 613
Tdark 8 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 8 | 979
increased circulating choleste... 3 | 66
increased leukocyte cell numbe... 3 | 47
increased lymphocyte cell numb... 3 | 32
preweaning lethality, incomple... 3 | 499
abnormal seminal vesicle morph... 2 | 114
decreased body weight 2 | 161
decreased cardiac muscle contr... 2 | 11
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased leukocyte cell numbe... 2 | 73
decreased mean corpuscular vol... 2 | 79
decreased vertical activity 2 | 208
enlarged heart 2 | 210
enlarged spleen 2 | 41
increased circulating alkaline... 2 | 122
increased neutrophil cell numb... 2 | 46
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal skin condition 1 | 6
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating potassiu... 1 | 20
decreased circulating sodium l... 1 | 22
decreased circulating unsatura... 1 | 2
decreased heart rate 1 | 18
decreased heart weight 1 | 27
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased neutrophil cell numb... 1 | 42
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
hypoactivity 1 | 132
impaired righting response 1 | 26
increased basophil cell number 1 | 7
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating free fat... 1 | 20
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality 1 | 28
prolonged PQ interval 1 | 5
prolonged QT interval 1 | 38
short tibia 1 | 97
shortened PR interval 1 | 6
shortened RR interval 1 | 17
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 85 | 11,493
ovarian cancer 79 | 8,520
Cancer 75 | 2,499
psoriasis 65 | 6,694
osteosarcoma 62 | 7,950
glioblastoma 57 | 5,792
atypical teratoid / rhabdoid tumor 48 | 5,112
medulloblastoma, large-cell 47 | 6,241
lung cancer 46 | 4,740
Breast cancer 36 | 3,578
ependymoma 35 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
pancreatic cancer 31 | 2,398
adult high grade glioma 30 | 3,801
invasive ductal carcinoma 30 | 2,951
subependymal giant cell astrocytoma 27 | 2,287
Astrocytoma, Pilocytic 26 | 3,081
lung adenocarcinoma 26 | 2,716
Schizophrenia 25 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
Kidney cancer 24 | 2,613
juvenile dermatomyositis 24 | 1,187
malignant mesothelioma 24 | 3,232
cystic fibrosis 23 | 1,696
interstitial cystitis 23 | 2,312
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
ductal carcinoma in situ 22 | 1,745
group 4 medulloblastoma 22 | 1,855
Multiple Sclerosis 21 | 540
Rheumatoid arthritis 21 | 1,191
group 3 medulloblastoma 21 | 4,104
Autosomal recessive predisposition 20 | 1,442
Breast Neoplasms 20 | 445
Mammary Neoplasms 20 | 425
Prostatic Neoplasms 20 | 495
diabetes mellitus 20 | 1,728
breast carcinoma 19 | 1,638
oligodendroglioma 19 | 2,850
tuberculosis 19 | 2,010
Influenza 18 | 142
lung carcinoma 18 | 2,843
non-small cell lung cancer 18 | 2,890
pituitary cancer 18 | 1,972
Multiple myeloma 17 | 1,332
Stomach Neoplasms 17 | 300
Vascular disease 17 | 319
Arthritis 16 | 290
Hepatitis C 16 | 94
Lung Neoplasms 16 | 232
cutaneous lupus erythematosus 16 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
astrocytic glioma 15 | 2,597
dermatomyositis 15 | 966
Depressive disorder 14 | 409
Diarrhea 14 | 253
Epilepsy 14 | 792
Inflammatory bowel disease 14 | 151
Microphthalmia with limb anomalies 14 | 40
Orbital separation excessive 14 | 244
Seizures 14 | 596
astrocytoma 14 | 1,146
primary pancreatic ductal adenocarcinoma 14 | 1,109
primitive neuroectodermal tumor 14 | 3,035
Asthma 13 | 385
Lung disease 13 | 142
Obesity 13 | 678
Pick disease 13 | 1,894
Splenomegaly 13 | 190
ulcerative colitis 13 | 1,819
Atopic dermatitis 12 | 952
Carcinoma, Hepatocellular 12 | 228
Dull intelligence 12 | 645
Intellectual disability 12 | 1,016
Liver carcinoma 12 | 240
Liver disease 12 | 237
Low intelligence 12 | 645
Melanoma 12 | 711
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
Renal Cell Carcinoma 12 | 214
Short stature 12 | 531
active Crohn's disease 12 | 922
nasopharyngeal carcinoma 12 | 1,058
pancreatic carcinoma 12 | 562
Brain Ischemia 11 | 110
Byzanthine arch palate 11 | 194
Carcinoma, Squamous Cell 11 | 110
Cell Transformation, Neoplastic 11 | 97
Hepatitis 11 | 67
Kidney disease 11 | 430
Neoplasm Metastasis 11 | 168
Neoplastic Cell Transformation 11 | 89
Squamous cell carcinoma 11 | 129
active ulcerative colitis 11 | 764
hepatocellular carcinoma 11 | 547
primary Sjogren syndrome 11 | 735
Endometriosis 10 | 540
Hypersensitivity reaction type II disease 10 | 253
adrenocortical carcinoma 10 | 1,428

Tissue

Digestive Tract 115 | 17,369
Female tissues 115 | 17,400
Blood and immune system 114 | 16,909
Endocrine System 114 | 18,159
Urinary Tract 114 | 16,678
Male tissues 113 | 17,142
Skin and soft tissues 113 | 17,230
Liver and Pancreas 111 | 16,750
Nervous System 111 | 16,725
Respiratory system 110 | 16,393
Cardiovascular System 104 | 15,192

Target Family

Non-IDG 63 | 12,091
Kinase 35 | 634
Enzyme 18 | 4,145
Transcription Factor 11 | 1,400
Nuclear Receptor 3 | 48

KEGG Pathway

Hepatitis C 130 | 130
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
2'-5'-oligoadenylate synthase 3 OAS3 Tbio Enzyme -1.30083 17.8 141
Claudin-16 CLDN16 Tbio Non-IDG -1.98248 102.4 138
Scavenger receptor class B member 1 SCARB1 Tchem Non-IDG -2.93920 915.7 378
Claudin-1 CLDN1 Tbio Non-IDG -2.07626 126.7 593
Interferon alpha-1/13 IFNA13 Tbio Non-IDG -3.87160 7663.4 500
Interferon alpha-17 IFNA17 Tbio Non-IDG -2.39299 231.1 56
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Claudin-3 CLDN3 Tbio Non-IDG -2.37681 227.3 358