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Development Level

Tbio 71 | 11,651
Tchem 57 | 1,388
Tclin 13 | 612
Tdark 2 | 6,593

IMPC Phenotype

preweaning lethality, incomple... 8 | 499
preweaning lethality, complete... 7 | 979
edema 4 | 59
abnormal embryo size 3 | 220
decreased body weight 3 | 161
enlarged lymph nodes 3 | 37
increased circulating alkaline... 3 | 122
short tibia 3 | 97
small superior vagus ganglion 3 | 74
abnormal gait 2 | 69
abnormal heart morphology 2 | 162
abnormal neural tube closure 2 | 46
abnormal retina morphology 2 | 71
abnormal testis morphology 2 | 43
decreased circulating creatini... 2 | 39
decreased circulating sodium l... 2 | 22
decreased mean corpuscular vol... 2 | 79
embryonic lethality prior to t... 2 | 278
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased neutrophil cell numb... 2 | 46
abnormal behavior 1 | 298
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal glucose homeostasis 1 | 4
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal midbrain development 1 | 20
abnormal pericardium morpholog... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin coloration 1 | 25
abnormal skin condition 1 | 6
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal vibrissa morphology 1 | 25
cataract 1 | 92
decreased bone mineral content 1 | 151
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
enlarged heart 1 | 210
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
enlarged uterus 1 | 11
female infertility 1 | 60
hyperactivity 1 | 148
impaired righting response 1 | 26
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating glucose ... 1 | 24
increased eosinophil cell numb... 1 | 11
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality 1 | 28
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Cancer 103 | 2,499
Carcinoma 97 | 11,493
ovarian cancer 89 | 8,520
osteosarcoma 72 | 7,950
glioblastoma 71 | 5,792
psoriasis 69 | 6,694
lung cancer 66 | 4,740
medulloblastoma, large-cell 65 | 6,241
atypical teratoid / rhabdoid tumor 58 | 5,112
Breast cancer 52 | 3,578
ependymoma 47 | 4,679
malignant mesothelioma 43 | 3,232
adult high grade glioma 41 | 3,801
group 3 medulloblastoma 39 | 4,104
Astrocytoma, Pilocytic 38 | 3,081
Kidney cancer 37 | 2,613
Schizophrenia 34 | 1,160
Breast Neoplasms 32 | 445
Mammary Neoplasms 32 | 425
intraductal papillary-mucinous neoplasm (IPMN) 32 | 3,291
invasive ductal carcinoma 32 | 2,951
primitive neuroectodermal tumor 32 | 3,035
lung adenocarcinoma 31 | 2,716
subependymal giant cell astrocytoma 31 | 2,287
tuberculosis 31 | 2,010
diabetes mellitus 30 | 1,728
oligodendroglioma 30 | 2,850
Arthritis 27 | 290
Lung Neoplasms 27 | 232
Stomach Neoplasms 27 | 300
group 4 medulloblastoma 27 | 1,855
lung carcinoma 27 | 2,843
pancreatic cancer 27 | 2,398
Carcinoma, Hepatocellular 26 | 228
Liver carcinoma 26 | 240
Rheumatoid arthritis 26 | 1,191
juvenile dermatomyositis 26 | 1,187
Vascular disease 25 | 319
astrocytoma 25 | 1,146
Asthma 24 | 385
Melanoma 24 | 711
Prostatic Neoplasms 24 | 495
ulcerative colitis 24 | 1,819
intraductal papillary-mucinous carcinoma (IPMC) 23 | 2,989
Intellectual disability 22 | 1,016
Multiple myeloma 22 | 1,332
Short stature 22 | 531
breast carcinoma 22 | 1,638
cystic fibrosis 22 | 1,696
ductal carcinoma in situ 22 | 1,745
non-small cell lung cancer 22 | 2,890
Hypersensitivity reaction type II disease 21 | 253
astrocytic glioma 21 | 2,597
Colorectal Neoplasms 20 | 243
Dull intelligence 20 | 645
Low intelligence 20 | 645
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Multiple Sclerosis 20 | 540
Obesity 20 | 678
Poor school performance 20 | 645
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,955
Bipolar Disorder 19 | 666
Epilepsy 19 | 792
Inflammatory bowel disease 19 | 151
Kidney disease 19 | 430
Reperfusion Injury 19 | 86
Seizures 19 | 596
Squamous cell carcinoma 19 | 129
dermatomyositis 19 | 966
interstitial cystitis 19 | 2,312
Autosomal recessive predisposition 18 | 1,442
Carcinoma, Squamous Cell 18 | 110
Cell Transformation, Neoplastic 18 | 97
Depressive disorder 18 | 409
Heart disease 18 | 306
Influenza 18 | 142
Pick disease 18 | 1,894
adrenocortical carcinoma 18 | 1,428
colon cancer 18 | 1,478
cutaneous lupus erythematosus 18 | 1,057
nasopharyngeal carcinoma 18 | 1,058
pituitary cancer 18 | 1,972
Acquired scoliosis 17 | 281
Alzheimer's disease 17 | 658
Brain Ischemia 17 | 110
Byzanthine arch palate 17 | 194
Curvature of spine 17 | 282
Hypertensive disease 17 | 292
Liver Cirrhosis, Experimental 17 | 769
Neoplasm Metastasis 17 | 168
Orbital separation excessive 17 | 244
Adenocarcinoma 16 | 122
Colonic Neoplasms 16 | 142
Endometriosis 16 | 540
Liver disease 16 | 237
Neoplastic Cell Transformation 16 | 89
Parkinson's disease 16 | 392
pancreatic ductal adenocarcinoma liver metastasis 15 | 1,962
primary Sjogren syndrome 15 | 735

Tissue

Blood and immune system 132 | 16,909
Male tissues 130 | 17,142
Nervous System 130 | 16,725
Digestive Tract 129 | 17,369
Endocrine System 129 | 18,159
Female tissues 129 | 17,400
Liver and Pancreas 129 | 16,750
Skin and soft tissues 129 | 17,230
Urinary Tract 129 | 16,678
Respiratory system 127 | 16,393
Cardiovascular System 125 | 15,192

Target Family

Non-IDG 52 | 12,091
Transcription Factor 37 | 1,400
Kinase 32 | 634
Enzyme 20 | 4,145
Epigenetic 2 | 242

KEGG Pathway

Hepatitis B 143 | 143
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive caspase-12 CASP12 Tbio Enzyme -2.64252 415.1 429
Interleukin-6 IL6 Tclin Non-IDG -4.50976 30968.8 2075
NF-kappa-B essential modulator IKBKG Tbio Kinase -3.07452 1188.4 879
Cyclic AMP-dependent transcription factor ATF-2 ATF2 Tbio Transcription Factor -2.23104 170.7 1819
Cyclic AMP-dependent transcription factor ATF-6 beta ATF6B Tbio Transcription Factor -1.03459 8.22 6
Cyclic AMP-responsive element-binding protein 5 CREB5 Tbio Transcription Factor -0.88055 7.80 164
14-3-3 protein beta/alpha YWHAB Tchem Non-IDG -2.06798 109.1 482
Myeloid differentiation primary response protein MyD88 MYD88 Tbio Non-IDG -3.26747 1795.4 672
Transforming growth factor beta-1 TGFB1 Tchem Non-IDG -3.84680 5672.0 1222
Signal transducer and activator of transcription 3 STAT3 Tchem Transcription Factor -3.81500 6459.7 1749