Development Level

Tbio 241 | 11,445
Tchem 69 | 1,598
Tclin 23 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 21 | 979
preweaning lethality, incomple... 11 | 499
embryonic lethality prior to t... 10 | 278
embryonic lethality prior to o... 9 | 239
decreased vertical activity 8 | 208
enlarged heart 7 | 210
abnormal embryo size 6 | 220
abnormal heart morphology 6 | 162
increased circulating alkaline... 5 | 122
abnormal bone mineralization 4 | 38
abnormal seminal vesicle morph... 4 | 114
decreased bone mineral density 4 | 126
edema 4 | 59
male infertility 4 | 123
abnormal bone structure 3 | 187
abnormal cornea morphology 3 | 31
abnormal neural tube closure 3 | 46
decreased body weight 3 | 161
decreased circulating chloride... 3 | 30
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating sodium l... 3 | 22
decreased circulating triglyce... 3 | 79
female infertility 3 | 60
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased bone mineral density 3 | 72
increased leukocyte cell numbe... 3 | 47
increased lymphocyte cell numb... 3 | 32
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal hindbrain development 2 | 16
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
abnormal spleen morphology 2 | 55
abnormal startle reflex 2 | 15
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased T cell number 2 | 15
decreased bone mineral content 2 | 151
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased lymphocyte cell numb... 2 | 83
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased circulating glucose ... 2 | 24
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
microphthalmia 2 | 26
prenatal lethality 2 | 28
small testis 2 | 58
abnormal craniofacial morpholo... 1 | 33
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal lung morphology 1 | 26
abnormal vertebrae morphology 1 | 18
brachydactyly 1 | 19
decreased IgG1 level 1 | 8
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased circulating alanine ... 1 | 13
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased lactate dehydrogenas... 1 | 3
increased startle reflex 1 | 112
limb grasping 1 | 41
small kidney 1 | 16
small spleen 1 | 19
small superior vagus ganglion 1 | 74
syndactyly 1 | 23
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Cancer 218 | 2,499
Carcinoma 204 | 11,493
psoriasis 162 | 6,694
ovarian cancer 152 | 8,520
osteosarcoma 127 | 7,950
lung cancer 115 | 4,740
glioblastoma 112 | 5,792
diabetes mellitus 110 | 1,728
medulloblastoma, large-cell 97 | 6,241
Breast cancer 92 | 3,578
Rheumatoid arthritis 91 | 1,191
malignant mesothelioma 80 | 3,232
atypical teratoid / rhabdoid tumor 79 | 5,112
ependymoma 78 | 4,679
Hypersensitivity reaction type II disease 76 | 253
Ankylosing spondylitis 75 | 140
Arthritis 73 | 290
group 3 medulloblastoma 71 | 4,104
Behcet's disease 70 | 89
Juvenile rheumatoid arthritis 68 | 111
Acquired immunodeficiency syndrome 67 | 197
tuberculosis 67 | 2,010
adult high grade glioma 65 | 3,801
dermatomyositis 63 | 966
Uveitis 62 | 103
invasive ductal carcinoma 62 | 2,951
non-small cell lung cancer 62 | 2,890
Astrocytoma, Pilocytic 61 | 3,081
lung carcinoma 60 | 2,843
Herpes zoster 57 | 68
lung adenocarcinoma 56 | 2,716
Human immunodeficiency virus infectious disease 55 | 138
Schizophrenia 55 | 1,160
oligodendroglioma 55 | 2,850
Psoriatic arthritis 54 | 86
pancreatic cancer 54 | 2,398
Stevens-Johnson syndrome 53 | 92
intraductal papillary-mucinous carcinoma (IPMC) 53 | 2,989
primitive neuroectodermal tumor 53 | 3,035
interstitial cystitis 51 | 2,312
subependymal giant cell astrocytoma 51 | 2,287
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,291
breast carcinoma 48 | 1,638
Multiple Sclerosis 47 | 540
intraductal papillary-mucinous adenoma (IPMA) 47 | 2,955
Dermatitis 45 | 157
Kidney cancer 45 | 2,613
ulcerative colitis 45 | 1,819
astrocytoma 43 | 1,146
astrocytic glioma 42 | 2,597
adrenocortical carcinoma 41 | 1,428
ductal carcinoma in situ 41 | 1,745
Kidney disease 39 | 430
Synovitis 39 | 78
Anemia 37 | 365
Takayasu's arteritis 37 | 53
colon cancer 37 | 1,478
Behcet's syndrome 36 | 50
Liver disease 36 | 237
group 4 medulloblastoma 36 | 1,855
Congenital adrenal hyperplasia 35 | 73
Nephritis 35 | 51
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
cystic fibrosis 35 | 1,696
drug-induced hepatitis 35 | 44
juvenile dermatomyositis 35 | 1,187
pituitary cancer 33 | 1,972
Breast Neoplasms 32 | 445
Mammary Neoplasms 32 | 425
Autosomal recessive predisposition 31 | 1,442
Hepatitis B 31 | 108
Multiple myeloma 31 | 1,332
Prostatic Neoplasms 31 | 495
cutaneous lupus erythematosus 31 | 1,057
acute quadriplegic myopathy 30 | 1,158
Lung Neoplasms 29 | 232
Waldenstrons macroglobulinemia 29 | 765
Bipolar Disorder 28 | 666
Epilepsy 28 | 792
Leprosy 27 | 73
Vascular disease 27 | 319
acute myeloid leukemia 26 | 783
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,962
Seizures 25 | 596
Skin disease 25 | 66
Stomach Neoplasms 25 | 300
primary Sjogren syndrome 25 | 735
Asthma 24 | 385
Carcinoma, Hepatocellular 24 | 228
Liver carcinoma 24 | 240
Primary immunodeficiency disease 24 | 54
nasopharyngeal carcinoma 24 | 1,058
primary pancreatic ductal adenocarcinoma 24 | 1,109
Depressive disorder 23 | 409
Endometriosis 23 | 540
Hemochromatosis 23 | 54
Liver Cirrhosis, Experimental 23 | 769
non primary Sjogren syndrome sicca 23 | 891
sarcoidosis 23 | 370

Tissue

Endocrine System 247 | 18,159
Digestive Tract 245 | 17,369
Blood and immune system 244 | 16,909
Female tissues 244 | 17,400
Male tissues 242 | 17,142
Skin and soft tissues 242 | 17,230
Liver and Pancreas 240 | 16,750
Urinary Tract 239 | 16,678
Nervous System 238 | 16,725
Respiratory system 238 | 16,393
Cardiovascular System 226 | 15,192

Target Family

Non-IDG 196 | 12,091
Enzyme 46 | 4,145
Transcription Factor 42 | 1,400
Kinase 32 | 634
GPCR 10 | 408
Epigenetic 5 | 242
Transporter 5 | 473

KEGG Pathway

HTLV-I infection 336 | 336
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
X-box-binding protein 1 XBP1 Tchem Transcription Factor -2.90444 780.2 514
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Tumor necrosis factor receptor superfamily member 13C TNFRSF13C Tbio Non-IDG -2.48953 288.2 437
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Nuclear factor of activated T-cells, cytoplasmic 4 NFATC4 Tbio Transcription Factor -1.93766 88.3 358
HLA class I histocompatibility antigen, B-35 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Talin-2 TLN2 Tbio Non-IDG -1.36153 20.0 101
Putative peripheral benzodiazepine receptor-related protein TSPO Tchem Non-IDG -3.08695 2284.2 212