Development Level

Tbio 230 | 11,178
Tchem 80 | 1,885
Tclin 23 | 612
Tdark 3 | 6,569

Collection

Kinase: IDG Consortium (Target... 3 | 125
GPCR: IDG Consortium (Targets) 1 | 126

IMPC Phenotype

preweaning lethality, complete... 21 | 979
preweaning lethality, incomple... 11 | 499
embryonic lethality prior to t... 10 | 278
embryonic lethality prior to o... 9 | 239
decreased vertical activity 8 | 208
enlarged heart 7 | 210
abnormal embryo size 6 | 220
abnormal heart morphology 6 | 162
increased circulating alkaline... 5 | 122
abnormal bone mineralization 4 | 38
abnormal seminal vesicle morph... 4 | 114
decreased bone mineral density 4 | 126
edema 4 | 59
male infertility 4 | 123
abnormal bone structure 3 | 187
abnormal cornea morphology 3 | 31
abnormal neural tube closure 3 | 46
decreased body weight 3 | 161
decreased circulating chloride... 3 | 30
decreased circulating choleste... 3 | 93
decreased circulating glucose ... 3 | 126
decreased circulating sodium l... 3 | 22
decreased circulating triglyce... 3 | 79
female infertility 3 | 60
impaired glucose tolerance 3 | 75
improved glucose tolerance 3 | 79
increased bone mineral density 3 | 72
increased leukocyte cell numbe... 3 | 47
increased lymphocyte cell numb... 3 | 32
prenatal lethality prior to he... 3 | 87
short tibia 3 | 97
abnormal behavior 2 | 298
abnormal eye morphology 2 | 68
abnormal forebrain development 2 | 20
abnormal hindbrain development 2 | 16
abnormal lens morphology 2 | 81
abnormal retina morphology 2 | 71
abnormal spleen morphology 2 | 55
abnormal startle reflex 2 | 15
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased T cell number 2 | 15
decreased bone mineral content 2 | 151
decreased circulating amylase ... 2 | 28
decreased circulating creatini... 2 | 39
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased lymphocyte cell numb... 2 | 83
decreased startle reflex 2 | 75
embryonic growth retardation 2 | 106
enlarged lymph nodes 2 | 37
hyperactivity 2 | 148
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased circulating glucose ... 2 | 24
increased heart weight 2 | 62
increased lean body mass 2 | 172
increased mean corpuscular vol... 2 | 92
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased or absent threshold ... 2 | 101
increased total body fat amoun... 2 | 134
microphthalmia 2 | 26
prenatal lethality 2 | 28
small testis 2 | 58
abnormal craniofacial morpholo... 1 | 33
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal lung morphology 1 | 26
abnormal vertebrae morphology 1 | 18
brachydactyly 1 | 19
decreased IgG1 level 1 | 8
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased circulating calcium ... 1 | 36
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
decreased lean body mass 1 | 135
decreased mean corpuscular hem... 1 | 31
decreased red blood cell distr... 1 | 41
enlarged spleen 1 | 41
hydrometra 1 | 53
increased blood urea nitrogen ... 1 | 48
increased circulating alanine ... 1 | 13
increased circulating magnesiu... 1 | 10
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased lactate dehydrogenas... 1 | 3
increased startle reflex 1 | 112
limb grasping 1 | 41
small kidney 1 | 16
small spleen 1 | 19
small superior vagus ganglion 1 | 74
syndactyly 1 | 23
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Cancer 213 | 2,388
Carcinoma 202 | 11,192
psoriasis 158 | 6,514
ovarian cancer 148 | 8,297
osteosarcoma 124 | 7,766
lung cancer 113 | 4,607
glioblastoma 110 | 5,635
diabetes mellitus 109 | 1,683
medulloblastoma, large-cell 96 | 6,086
Rheumatoid arthritis 90 | 1,156
Breast cancer 89 | 3,469
atypical teratoid / rhabdoid tumor 78 | 4,971
ependymoma 78 | 4,559
malignant mesothelioma 78 | 3,135
Hypersensitivity reaction type II disease 76 | 245
Ankylosing spondylitis 75 | 134
Arthritis 72 | 276
group 3 medulloblastoma 71 | 4,002
Behcet's disease 70 | 87
Juvenile rheumatoid arthritis 68 | 110
Acquired immunodeficiency syndrome 67 | 192
tuberculosis 66 | 1,963
adult high grade glioma 65 | 3,701
dermatomyositis 63 | 941
Uveitis 62 | 102
Astrocytoma, Pilocytic 61 | 3,006
invasive ductal carcinoma 61 | 2,867
non-small cell lung cancer 60 | 2,799
lung carcinoma 58 | 2,755
Herpes zoster 57 | 68
Human immunodeficiency virus infectious disease 55 | 136
oligodendroglioma 55 | 2,768
Psoriatic arthritis 54 | 84
Schizophrenia 54 | 1,136
lung adenocarcinoma 54 | 2,627
pancreatic cancer 54 | 2,322
Stevens-Johnson syndrome 53 | 92
intraductal papillary-mucinous carcinoma (IPMC) 53 | 2,902
primitive neuroectodermal tumor 53 | 2,957
subependymal giant cell astrocytoma 51 | 2,230
interstitial cystitis 50 | 2,237
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,204
Multiple Sclerosis 47 | 527
intraductal papillary-mucinous adenoma (IPMA) 47 | 2,872
breast carcinoma 46 | 1,589
Dermatitis 45 | 154
Kidney cancer 45 | 2,548
ulcerative colitis 43 | 1,765
astrocytic glioma 42 | 2,530
astrocytoma 42 | 1,113
ductal carcinoma in situ 41 | 1,686
Synovitis 39 | 75
adrenocortical carcinoma 39 | 1,385
Kidney disease 38 | 411
Anemia 37 | 353
Takayasu's arteritis 37 | 53
Behcet's syndrome 36 | 49
Liver disease 36 | 227
colon cancer 36 | 1,428
Congenital adrenal hyperplasia 35 | 71
Nephritis 35 | 51
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
drug-induced hepatitis 35 | 44
juvenile dermatomyositis 35 | 1,147
cystic fibrosis 34 | 1,629
group 4 medulloblastoma 33 | 1,806
Autosomal recessive predisposition 31 | 1,407
Breast Neoplasms 31 | 423
Hepatitis B 31 | 105
Mammary Neoplasms 31 | 403
cutaneous lupus erythematosus 31 | 1,016
pituitary cancer 31 | 1,915
Multiple myeloma 30 | 1,296
Prostatic Neoplasms 30 | 472
acute quadriplegic myopathy 30 | 1,133
Lung Neoplasms 28 | 217
Waldenstrons macroglobulinemia 28 | 742
Bipolar Disorder 27 | 646
Epilepsy 27 | 775
Leprosy 27 | 72
pancreatic ductal adenocarcinoma liver metastasis 26 | 1,911
Skin disease 25 | 64
Stomach Neoplasms 25 | 287
Vascular disease 25 | 294
primary Sjogren syndrome 25 | 710
Asthma 24 | 370
Primary immunodeficiency disease 24 | 54
Seizures 24 | 584
acute myeloid leukemia 24 | 760
nasopharyngeal carcinoma 24 | 1,024
primary pancreatic ductal adenocarcinoma 24 | 1,071
Carcinoma, Hepatocellular 23 | 217
Hemochromatosis 23 | 52
Liver carcinoma 23 | 229
sarcoidosis 23 | 357
Hypoplastic mandible condyle 22 | 273
Mandibular hypoplasia 22 | 273
Micrognathism 22 | 273
non primary Sjogren syndrome sicca 22 | 861

Tissue

Endocrine System 247 | 18,159
Digestive Tract 245 | 17,369
Blood and immune system 244 | 16,909
Female tissues 244 | 17,400
Male tissues 242 | 17,142
Skin and soft tissues 242 | 17,230
Liver and Pancreas 240 | 16,750
Urinary Tract 239 | 16,678
Nervous System 238 | 16,725
Respiratory system 238 | 16,393
Cardiovascular System 226 | 15,192

Target Family

Non-IDG 196 | 12,091
Enzyme 46 | 4,145
Transcription Factor 42 | 1,400
Kinase 32 | 634
GPCR 10 | 408
Epigenetic 5 | 242
Transporter 5 | 473

KEGG Pathway

HTLV-I infection 336 | 336
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
HLA class I histocompatibility antigen, B-67 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 362
Adenylate cyclase type 3 ADCY3 Tbio Enzyme -2.31593 204.4 82
HLA class I histocompatibility antigen, Cw-16 alpha chain HLA-C Tbio Non-IDG -1.90661 830.5 0
HLA class I histocompatibility antigen, B-59 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
HLA class II histocompatibility antigen, DRB1-16 beta chain HLA-DRB1 Tbio Non-IDG -2.84258 1665.5 489
Dual specificity mitogen-activated protein kinase kinase 4 MAP2K4 Tchem Kinase -2.43646 236.7 998
HLA class I histocompatibility antigen, Cw-6 alpha chain HLA-C Tbio Non-IDG -1.90661 830.5 0
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
Protein Wnt-10a WNT10A Tbio Non-IDG -2.66153 436.3 118
ADP/ATP translocase 2 SLC25A5 Tbio Transporter -1.98936 91.6 65