Development Level

Tchem 46 | 1,598
Tbio 37 | 11,445
Tclin 15 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Comple... 1 | 37
Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 4 | 161
abnormal bone mineralization 2 | 38
abnormal heart morphology 2 | 162
abnormal lung morphology 2 | 26
abnormal seminal vesicle morph... 2 | 114
abnormal testis morphology 2 | 43
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating alkaline... 2 | 46
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased lymphocyte cell numb... 2 | 83
decreased total body fat amoun... 2 | 207
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
small testis 2 | 58
abnormal QT variability 1 | 10
abnormal bone structure 1 | 187
abnormal cecum morphology 1 | 7
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal humerus morphology 1 | 11
abnormal pericardium morpholog... 1 | 26
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
decreased IgG3 level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating alanine ... 1 | 47
decreased circulating amylase ... 1 | 28
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating sodium l... 1 | 22
decreased erythrocyte cell num... 1 | 62
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 31
decreased thermal nociceptive ... 1 | 2
embryonic lethality prior to o... 1 | 239
enlarged cecum 1 | 5
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
enlarged uterus 1 | 11
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased body temperature 1 | 9
increased bone mineral content 1 | 108
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased eosinophil cell numb... 1 | 11
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased spleen weight 1 | 10
increased thermal nociceptive ... 1 | 9
preweaning lethality, incomple... 1 | 499
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
thrombocytosis 1 | 27

Disease

Carcinoma 73 | 11,493
Cancer 72 | 2,499
ovarian cancer 69 | 8,520
osteosarcoma 55 | 7,950
glioblastoma 54 | 5,792
psoriasis 48 | 6,694
lung cancer 46 | 4,740
medulloblastoma, large-cell 40 | 6,241
atypical teratoid / rhabdoid tumor 39 | 5,112
diabetes mellitus 39 | 1,728
Breast cancer 33 | 3,578
ependymoma 33 | 4,679
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
pancreatic cancer 30 | 2,398
adult high grade glioma 29 | 3,801
malignant mesothelioma 29 | 3,232
invasive ductal carcinoma 28 | 2,951
group 3 medulloblastoma 27 | 4,104
Breast Neoplasms 26 | 445
Mammary Neoplasms 26 | 425
Schizophrenia 26 | 1,160
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
Kidney cancer 24 | 2,613
Obesity 24 | 678
intraductal papillary-mucinous adenoma (IPMA) 24 | 2,955
lung adenocarcinoma 24 | 2,716
non-small cell lung cancer 24 | 2,890
tuberculosis 24 | 2,010
Astrocytoma, Pilocytic 23 | 3,081
Prostatic Neoplasms 23 | 495
lung carcinoma 23 | 2,843
Autosomal recessive predisposition 22 | 1,442
Hypertension 22 | 396
astrocytic glioma 22 | 2,597
subependymal giant cell astrocytoma 22 | 2,287
ulcerative colitis 22 | 1,819
Heart disease 21 | 306
Kidney disease 21 | 430
Multiple myeloma 21 | 1,332
primitive neuroectodermal tumor 21 | 3,035
Hypertensive disease 20 | 292
interstitial cystitis 20 | 2,312
oligodendroglioma 20 | 2,850
Bipolar Disorder 19 | 666
Stomach Neoplasms 19 | 300
Vascular disease 19 | 319
primary pancreatic ductal adenocarcinoma 19 | 1,109
ductal carcinoma in situ 18 | 1,745
Diabetes Mellitus, Non-Insulin-Dependent 17 | 145
Hyperglycemia 17 | 137
Liver Cirrhosis, Experimental 17 | 769
Renal Cell Carcinoma 17 | 214
acute quadriplegic myopathy 17 | 1,158
pituitary cancer 17 | 1,972
Alzheimer's disease 16 | 658
Diabetes Mellitus, Experimental 16 | 108
Lung Neoplasms 16 | 232
Neoplasm Invasiveness 16 | 161
Pick disease 16 | 1,894
pancreatic ductal adenocarcinoma liver metastasis 16 | 1,962
Arthritis 15 | 290
Inflammation 15 | 120
Intellectual disability 15 | 1,016
Major Depressive Disorder 15 | 301
Myocardial Ischemia 15 | 169
Neoplasm Metastasis 15 | 168
adrenocortical carcinoma 15 | 1,428
cystic fibrosis 15 | 1,696
Cerebrovascular disease 14 | 238
Coronary artery disease 14 | 268
Diabetes Mellitus, Type 2 14 | 142
Disease Models, Animal 14 | 155
Heart failure 14 | 162
Lung disease 14 | 142
Seizures 14 | 596
Unipolar Depression 14 | 250
astrocytoma 14 | 1,146
dermatomyositis 14 | 966
Anemia 13 | 365
Asthma 13 | 385
Atherosclerosis 13 | 291
Autistic Disorder 13 | 364
Carcinoma, Hepatocellular 13 | 228
Depressive disorder 13 | 409
Diabetic retinopathy 13 | 56
Dull intelligence 13 | 645
Epilepsy 13 | 792
Liver carcinoma 13 | 240
Low intelligence 13 | 645
Melanoma 13 | 711
Mental Depression 13 | 333
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Poor school performance 13 | 645
breast carcinoma 13 | 1,638
juvenile dermatomyositis 13 | 1,187
Adenoma 12 | 167
Reperfusion Injury 12 | 86
Rheumatoid arthritis 12 | 1,191
colon cancer 12 | 1,478

Tissue

Endocrine System 100 | 18,159
Blood and immune system 98 | 16,909
Digestive Tract 98 | 17,369
Female tissues 98 | 17,400
Liver and Pancreas 98 | 16,750
Male tissues 98 | 17,142
Nervous System 98 | 16,725
Skin and soft tissues 98 | 17,230
Respiratory system 97 | 16,393
Urinary Tract 97 | 16,678
Cardiovascular System 93 | 15,192

Target Family

Kinase 37 | 634
Non-IDG 32 | 12,091
Enzyme 22 | 4,145
Transcription Factor 5 | 1,400
Epigenetic 2 | 242
Ion Channel 1 | 344
Transporter 1 | 473

KEGG Pathway

HIF-1 signaling pathway 100 | 100
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 Tchem Kinase -1.71576 46.7 408
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
MAP kinase-interacting serine/threonine-protein kinase 2 MKNK2 Tchem Kinase -1.32729 19.5 234
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Serotransferrin TF Tbio Non-IDG -4.15070 13447.9 1168
Transferrin receptor protein 1 TFRC Tbio Non-IDG -3.43851 2558.3 1677
Hexokinase-2 HK2 Tchem Kinase -2.64934 432.5 446
Cytochrome b-245 heavy chain CYBB Tchem Ion Channel -3.09698 1276.8 315