Development Level

Tbio 23 | 11,445
Tchem 5 | 1,598

IMPC Phenotype

preweaning lethality, complete... 5 | 979
abnormal body wall morphology 1 | 9
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
anophthalmia 1 | 33
decreased IgM level 1 | 1
decreased body weight 1 | 161
decreased circulating alkaline... 1 | 46
decreased circulating potassiu... 1 | 20
decreased eosinophil cell numb... 1 | 24
decreased erythrocyte cell num... 1 | 62
embryonic lethality prior to t... 1 | 278
increased basophil cell number 1 | 7
increased body length 1 | 32
increased circulating amylase ... 1 | 25
increased circulating choleste... 1 | 66
increased circulating fructosa... 1 | 13
increased circulating potassiu... 1 | 29
increased mean corpuscular hem... 1 | 96
microphthalmia 1 | 26
prenatal lethality prior to he... 1 | 87

Disease

Carcinoma 21 | 11,493
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
ovarian cancer 16 | 8,520
Autosomal recessive predisposition 13 | 1,442
osteosarcoma 12 | 7,950
psoriasis 12 | 6,694
Seizures 10 | 596
lung cancer 10 | 4,740
Breast cancer 9 | 3,578
Epilepsy 9 | 792
Multiple myeloma 9 | 1,332
adrenocortical carcinoma 9 | 1,428
glioblastoma 9 | 5,792
Muscle hypotonia 8 | 571
Dull intelligence 7 | 645
Intellectual disability 7 | 1,016
Lethargy 7 | 77
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental deficiency 7 | 645
Poor school performance 7 | 645
Hyperglycinemia 6 | 6
atypical teratoid / rhabdoid tumor 6 | 5,112
ependymoma 6 | 4,679
invasive ductal carcinoma 6 | 2,951
medulloblastoma, large-cell 6 | 6,241
Cardiomyopathies 5 | 110
Cognitive delay 5 | 608
Encephalopathies 5 | 43
Global developmental delay 5 | 608
Glycinuria 5 | 10
HYPERGLYCINURIA (disorder) 5 | 12
Mental and motor retardation 5 | 608
Metabolic acidosis 5 | 90
ductal carcinoma in situ 5 | 1,745
group 3 medulloblastoma 5 | 4,104
lung adenocarcinoma 5 | 2,716
pancreatic cancer 5 | 2,398
Astrocytoma, Pilocytic 4 | 3,081
Cerebral atrophy 4 | 178
Dehydration 4 | 40
Dystonia 4 | 164
Dystonic disease 4 | 106
Failure to gain weight 4 | 365
Glycine encephalopathy 4 | 29
Hyperammonemia 4 | 30
Hyperreflexia 4 | 209
Liver Cirrhosis, Experimental 4 | 769
Obesity 4 | 678
Parkinson's disease 4 | 392
Pediatric failure to thrive 4 | 365
Primary hyperoxaluria 4 | 15
Vomiting 4 | 116
astrocytic glioma 4 | 2,597
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
non primary Sjogren syndrome sicca 4 | 891
non-small cell lung cancer 4 | 2,890
oligodendroglioma 4 | 2,850
ulcerative colitis 4 | 1,819
Acidosis, Lactic 3 | 97
Agenesis of corpus callosum 3 | 83
Aggressive behavior 3 | 75
Aggressive reaction 3 | 75
Anemia 3 | 365
Asthma 3 | 385
Atopic dermatitis 3 | 952
Cancer 3 | 2,499
Chemical and Drug Induced Liver Injury 3 | 195
Cholestasis 3 | 155
Comatose 3 | 56
Crohn's disease 3 | 321
Death in early childhood 3 | 82
Death in infancy 3 | 82
Decreased platelet count 3 | 111
Degenerative brain disorder 3 | 100
Hepatomegaly 3 | 285
Hyperactive behavior 3 | 91
Hypoglycemia 3 | 152
Irritation - emotion 3 | 68
Kidney disease 3 | 430
Lactic acidemia 3 | 95
Methylmalonic acidemia 3 | 37
Myoclonus 3 | 74
Nephrocalcinosis 3 | 35
Pancreatitis 3 | 123
Physical aggression 3 | 76
Pick disease 3 | 1,894
Propionic acidemia 3 | 16
Schizophrenia 3 | 1,160
Thrombocytopenia 3 | 197
Waldenstrons macroglobulinemia 3 | 765
diabetes mellitus 3 | 1,728
fibroadenoma 3 | 559
interstitial cystitis 3 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung carcinoma 3 | 2,843
nephrosclerosis 3 | 333
pediatric high grade glioma 3 | 1,064
tuberculosis 3 | 2,010

Tissue

Liver and Pancreas 28 | 16,750
Urinary Tract 28 | 16,678
Blood and immune system 27 | 16,909
Digestive Tract 27 | 17,369
Endocrine System 27 | 18,159
Female tissues 27 | 17,400
Male tissues 27 | 17,142
Skin and soft tissues 27 | 17,230
Nervous System 26 | 16,725
Respiratory system 25 | 16,393
Cardiovascular System 24 | 15,192

Target Family

Enzyme 26 | 4,145
Kinase 1 | 634
Non-IDG 1 | 12,091

KEGG Pathway

Glyoxylate and dicarboxylate m... 28 | 28
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glycerol-3-phosphate phosphatase PGP Tbio Enzyme -1.48294 30.0 90
Aconitate hydratase, mitochondrial ACO2 Tbio Enzyme -2.21106 157.2 307
Methylmalonyl-CoA epimerase, mitochondrial MCEE Tbio Enzyme -1.05059 11.7 115
Malate dehydrogenase, mitochondrial MDH2 Tchem Enzyme -2.25018 186.1 256
Methylmalonyl-CoA mutase, mitochondrial MUT Tbio Enzyme -2.51690 305.3 99
Malate dehydrogenase, cytoplasmic MDH1 Tbio Enzyme -2.64656 428.3 291
Glycine dehydrogenase (decarboxylating), mitochondrial GLDC Tbio Enzyme -1.79392 65.7 131
Glycerate kinase GLYCTK Tbio Kinase -1.31760 20.4 192
Cytoplasmic aconitate hydratase ACO1 Tbio Enzyme -2.59601 396.5 350
Serine--pyruvate aminotransferase AGXT Tbio Enzyme -2.67998 477.5 182