Development Level

Tbio 19 | 11,178
Tdark 6 | 6,569

IMPC Phenotype

preweaning lethality, complete... 8 | 979
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
abnormal heart morphology 1 | 162
abnormal joint morphology 1 | 23
abnormal kidney morphology 1 | 65
abnormal seminal vesicle morph... 1 | 114
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased eosinophil cell numb... 1 | 24
decreased lean body mass 1 | 135
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
enlarged kidney 1 | 14
hydroencephaly 1 | 14
impaired glucose tolerance 1 | 75
increased circulating alkaline... 1 | 122
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased total body fat amoun... 1 | 134
prenatal lethality prior to he... 1 | 87
small testis 1 | 58
syndactyly 1 | 23

Disease

Carcinoma 13 | 11,192
ovarian cancer 13 | 8,297
osteosarcoma 12 | 7,766
lung cancer 9 | 4,607
medulloblastoma, large-cell 9 | 6,086
Intellectual disability 8 | 998
psoriasis 8 | 6,514
Epilepsy 7 | 775
glioblastoma 7 | 5,635
atypical teratoid / rhabdoid tumor 6 | 4,971
Autosomal recessive predisposition 5 | 1,407
Breast cancer 5 | 3,469
Iridogoniodysgenesis syndrome 5 | 9
Seizures 5 | 584
ependymoma 5 | 4,559
tuberculosis 5 | 1,963
Cerebral atrophy 4 | 175
Concave bridge of nose 4 | 191
Depressed nasal bridge 4 | 191
Depressed nasal root/bridge 4 | 191
Hyperphosphatasia with Mental Retardation 4 | 5
Paroxysmal nocturnal hemoglobinuria 4 | 10
astrocytic glioma 4 | 2,530
primitive neuroectodermal tumor 4 | 2,957
Big calvaria 3 | 147
Byzanthine arch palate 3 | 194
Cerebellar Hypoplasia 3 | 61
Cognitive delay 3 | 596
Global developmental delay 3 | 596
Hypoplastic mandible condyle 3 | 273
Increased head circumference 3 | 147
Increased size of cranium 3 | 147
Increased size of skull 3 | 147
Large for gestational age 3 | 11
Mandibular hypoplasia 3 | 273
Mental and motor retardation 3 | 596
Micrognathism 3 | 273
Multiple myeloma 3 | 1,296
Muscle hypotonia 3 | 562
Overfolded helix 3 | 22
cutaneous lupus erythematosus 3 | 1,016
diabetes mellitus 3 | 1,683
group 3 medulloblastoma 3 | 4,002
interstitial cystitis 3 | 2,237
lung carcinoma 3 | 2,755
malignant mesothelioma 3 | 3,135
oligodendroglioma 3 | 2,768
subependymal giant cell astrocytoma 3 | 2,230
Absent speech 2 | 43
Acquired scoliosis 2 | 274
Anteverted nostril 2 | 186
Astrocytoma, Pilocytic 2 | 3,006
Bilateral fifth finger clinodactyly 2 | 109
Brachycephaly 2 | 86
Broad cranium shape 2 | 86
Broad flat nasal bridge 2 | 232
Coarse facial features 2 | 103
Congenital Epicanthus 2 | 175
Congenital muscular dystrophy 2 | 29
Curvature of little finger 2 | 109
Curvature of spine 2 | 275
Death in early childhood 2 | 82
Death in infancy 2 | 82
Degenerative brain disorder 2 | 98
Dull intelligence 2 | 634
Hydronephrosis 2 | 87
Hyperreflexia 2 | 208
Inverted V-shaped upper lip 2 | 19
Long philtrum 2 | 137
Malar flattening 2 | 129
Mental deficiency 2 | 634
Narrow forehead 2 | 34
Nasal bridge wide 2 | 232
Pick disease 2 | 1,856
Poor school performance 2 | 634
Prenatal onset 2 | 137
Proteinuria 2 | 143
Short nose 2 | 127
Short philtrum 2 | 51
Small nose 2 | 127
Somatic mutation 2 | 61
Strabismus 2 | 265
Supratentorial atrophy 2 | 93
Tented mouth 2 | 19
Tented upper lip 2 | 19
Thickened facial skin with coarse facial features 2 | 103
Upward slant of palpebral fissure 2 | 74
Uranostaphyloschisis 2 | 162
West Syndrome 2 | 28
Wide skull shape 2 | 86
acute myeloid leukemia 2 | 760
adult high grade glioma 2 | 3,701
aldosterone-producing adenoma 2 | 646
hepatocellular carcinoma 2 | 536
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,872
medulloblastoma 2 | 702
nonverbal 2 | 43
pediatric high grade glioma 2 | 1,035
pituitary cancer 2 | 1,915
ulcerative colitis 2 | 1,765

Tissue

Digestive Tract 25 | 17,369
Blood and immune system 24 | 16,909
Cardiovascular System 24 | 15,192
Endocrine System 24 | 18,159
Female tissues 24 | 17,400
Liver and Pancreas 24 | 16,750
Male tissues 24 | 17,142
Nervous System 24 | 16,725
Respiratory system 24 | 16,393
Skin and soft tissues 24 | 17,230
Urinary Tract 24 | 16,678

Target Family

Enzyme 19 | 4,145
Non-IDG 6 | 12,091

KEGG Pathway

Glycosylphosphatidylinositol (... 25 | 25
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Phosphatidylinositol-glycan-specific phospholipase D GPLD1 Tbio Enzyme -2.08209 126.8 222
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase PIGL Tbio Enzyme -2.19025 150.5 95
GPI ethanolamine phosphate transferase 2 PIGG Tbio Enzyme -1.77555 59.4 7
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H PIGH Tbio Enzyme -1.19063 13.0 116
GPI inositol-deacylase PGAP1 Tbio Enzyme -1.11041 12.5 25
Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y PIGY Tdark Enzyme -0.25795 2.85 56
GPI mannosyltransferase 2 PIGV Tbio Enzyme -1.07565 13.4 71
GPI transamidase component PIG-S PIGS Tdark Enzyme -0.42822 1.54 84
GPI mannosyltransferase 3 PIGB Tbio Enzyme -1.30392 19.1 79
Phosphatidylinositol N-acetylglucosaminyltransferase subunit C PIGC Tbio Enzyme -1.62741 41.3 50