Development Level

Tbio 8 | 11,651
Tchem 5 | 1,388
Tdark 2 | 6,593

IMPC Phenotype

cataract 1 | 92
decreased grip strength 1 | 116

Disease

Carcinoma 11 | 11,493
glioblastoma 8 | 5,792
ovarian cancer 8 | 8,520
medulloblastoma, large-cell 7 | 6,241
atypical teratoid / rhabdoid tumor 6 | 5,112
osteosarcoma 6 | 7,950
Breast cancer 5 | 3,578
ependymoma 5 | 4,679
lung cancer 5 | 4,740
non-small cell lung cancer 5 | 2,890
pituitary cancer 5 | 1,972
Autosomal recessive predisposition 4 | 1,442
Neurodegenerative disease 4 | 414
adult high grade glioma 4 | 3,801
group 3 medulloblastoma 4 | 4,104
intraductal papillary-mucinous adenoma (IPMA) 4 | 2,955
primitive neuroectodermal tumor 4 | 3,035
Astrocytoma, Pilocytic 3 | 3,081
Cherry red spot of the macula 3 | 7
Gangliosidosis 3 | 20
Intellectual disability 3 | 1,016
Multiple myeloma 3 | 1,332
Muscle hypotonia 3 | 571
Neurogenic Muscular Atrophy 3 | 139
Neurogenic muscle atrophy, especially in the lower limbs 3 | 139
Paraplegia 3 | 74
Skeletal muscle atrophy 3 | 139
adrenocortical carcinoma 3 | 1,428
astrocytic glioma 3 | 2,597
diabetes mellitus 3 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,291
lung adenocarcinoma 3 | 2,716
malignant mesothelioma 3 | 3,232
muscle degeneration 3 | 139
oligodendroglioma 3 | 2,850
pediatric high grade glioma 3 | 1,064
Absent speech 2 | 43
Blind Vision 2 | 111
Blindness, Legal 2 | 110
Cerebellar Ataxia 2 | 304
Cerebral atrophy 2 | 178
Coarse facial features 2 | 108
Cognitive delay 2 | 608
Congenital deafness 2 | 185
Deafness 2 | 198
Degenerative brain disorder 2 | 100
Epilepsy 2 | 792
Fabry disease 2 | 11
Global developmental delay 2 | 608
Hearing Loss, Partial 2 | 185
Infantile onset 2 | 238
Kidney cancer 2 | 2,613
Krabbe disease 2 | 12
Liver diseases 2 | 87
Lower limb hyperreflexia 2 | 10
Mental and motor retardation 2 | 608
Metachromatic leukodystrophy 2 | 14
Mucopolysaccharidosis 2 | 26
Muscle Weakness 2 | 170
Niemann-Pick disease 2 | 14
Optic Atrophy 2 | 242
Progressive psychomotor deterioration 2 | 2
Supratentorial atrophy 2 | 94
Thickened facial skin with coarse facial features 2 | 108
astrocytoma 2 | 1,146
colon cancer 2 | 1,478
group 4 medulloblastoma 2 | 1,855
hearing impairment 2 | 199
hereditary spastic paraplegia 2 | 318
inclusion-cell disease 2 | 16
interstitial cystitis 2 | 2,312
invasive ductal carcinoma 2 | 2,951
lung carcinoma 2 | 2,843
non primary Sjogren syndrome sicca 2 | 891
nonverbal 2 | 43
pancreatic cancer 2 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 2 | 1,962
posterior fossa group A ependymoma 2 | 468
primary pancreatic ductal adenocarcinoma 2 | 1,109
psoriasis 2 | 6,694
tuberculosis 2 | 2,010
ulcerative colitis 2 | 1,819
Apathy 1 | 16
Blindness, Cortical 1 | 24
CNS hypomyelination 1 | 17
Cortical visual impairment 1 | 24
Erectile dysfunction 1 | 32
Exaggerated startle response 1 | 8
Global brain atrophy 1 | 7
Glycoproteinosis 1 | 12
Hyperexplexia 1 | 8
Hypomyelination 1 | 17
Irritation - emotion 1 | 68
Platyspondyly 1 | 56
Poor head control 1 | 14
Pulmonary aspiration 1 | 8
Sandhoff disease 1 | 3
Tay-Sachs disease 1 | 6
Widely spaced teeth 1 | 31

Tissue

Blood and immune system 15 | 16,909
Cardiovascular System 15 | 15,192
Digestive Tract 15 | 17,369
Endocrine System 15 | 18,159
Female tissues 15 | 17,400
Liver and Pancreas 15 | 16,750
Male tissues 15 | 17,142
Nervous System 15 | 16,725
Skin and soft tissues 15 | 17,230
Urinary Tract 15 | 16,678
Respiratory system 14 | 16,393

Target Family

Enzyme 14 | 4,145
Transporter 1 | 473

KEGG Pathway

Glycosphingolipid biosynthesis... 15 | 15
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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