Development Level

Tbio 14 | 11,651
Tchem 5 | 1,388

IMPC Phenotype

abnormal bone structure 3 | 187
decreased total body fat amoun... 3 | 207
increased bone mineral content 3 | 108
decreased circulating serum al... 2 | 82
hypoactivity 2 | 132
increased circulating alkaline... 2 | 122
increased circulating potassiu... 2 | 29
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
abnormal coat appearance 1 | 31
abnormal lung morphology 1 | 26
decreased circulating glucose ... 1 | 126
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
increased blood urea nitrogen ... 1 | 48
increased bone mineral density 1 | 72
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased lean body mass 1 | 172
thrombocytosis 1 | 27

Disease

Carcinoma 18 | 11,493
Mucopolysaccharidosis 15 | 26
Autosomal recessive predisposition 10 | 1,442
Coarse facial features 10 | 108
Thickened facial skin with coarse facial features 10 | 108
ovarian cancer 10 | 8,519
Congenital deafness 9 | 185
Deafness 9 | 198
Hearing Loss, Partial 9 | 185
Hepatomegaly 9 | 285
hearing impairment 9 | 199
Splenomegaly 8 | 190
Intellectual disability 7 | 1,016
Joint stiffness 7 | 84
Pfaundler-Hurler Syndrome 7 | 12
glioblastoma 7 | 5,792
psoriasis 7 | 6,694
subependymal giant cell astrocytoma 7 | 2,287
Cancer 6 | 2,499
Dull intelligence 6 | 645
Heart valve disease 6 | 39
Hernia, Inguinal 6 | 89
Hirsutism 6 | 47
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Poor school performance 6 | 645
Recurrent upper respiratory tract infection 6 | 21
VALVULAR ABNORMALITY 6 | 12
Big calvaria 5 | 147
Epilepsy 5 | 792
Heparan sulfate excretion in urine 5 | 5
Increased head circumference 5 | 147
Increased size of cranium 5 | 147
Increased size of skull 5 | 147
Multiple myeloma 5 | 1,332
ODONTOID HYPOPLASIA 5 | 16
Seizures 5 | 596
Short neck 5 | 140
Short stature 5 | 531
astrocytoma 5 | 1,146
osteosarcoma 5 | 7,950
tuberculosis 5 | 2,010
Acquired scoliosis 4 | 281
Cloudy cornea 4 | 33
Concave bridge of nose 4 | 195
Contracture 4 | 96
Contracture of joint 4 | 93
Corneal stromal opacities 4 | 33
Curvature of spine 4 | 282
Depressed nasal bridge 4 | 195
Depressed nasal root/bridge 4 | 195
Diarrhea 4 | 253
Flexion contracture 4 | 93
Flexion contractures of joints 4 | 93
Gangliosidosis 4 | 20
Hydrocephalus 4 | 152
Hyperkyphosis 4 | 111
Knee joint valgus deformity 4 | 56
Kyphosis deformity of spine 4 | 114
Macroglossia 4 | 65
Metachromatic leukodystrophy 4 | 14
Mucopolysaccharidosis III 4 | 7
Sleep disturbances 4 | 37
Thick rib 4 | 5
Umbilical hernia 4 | 93
atypical teratoid / rhabdoid tumor 4 | 5,112
diabetes mellitus 4 | 1,728
lung cancer 4 | 4,740
malignant mesothelioma 4 | 3,232
medulloblastoma, large-cell 4 | 6,241
Astrocytoma, Pilocytic 3 | 3,081
Asymmetric Septal Hypertrophy 3 | 7
Class III malocclusion 3 | 78
Coarse hair 3 | 31
Corneal Opacity 3 | 53
Frontal bossing 3 | 157
Hyperactive behavior 3 | 91
Hypertrophy of lower jaw 3 | 78
Increased size of mandible 3 | 78
Kluver-Bucy syndrome 3 | 6
Long narrow head 3 | 75
Mandibular hyperplasia 3 | 78
Narrow cranium shape 3 | 75
Narrow head shape 3 | 75
Narrow skull shape 3 | 75
Nerve Degeneration 3 | 121
Neuro-degenerative disease 3 | 43
Neurodegenerative Disorders 3 | 79
Neurodegenerative disease 3 | 414
Osteoporosis 3 | 363
Synophrys 3 | 40
Turridolichocephaly 3 | 75
adult high grade glioma 3 | 3,801
dermatomyositis 3 | 966
group 3 medulloblastoma 3 | 4,104
intraductal papillary-mucinous carcinoma (IPMC) 3 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 3 | 3,290
juvenile dermatomyositis 3 | 1,187
mandibular excess (physical finding) 3 | 78

Tissue

Digestive Tract 19 | 17,369
Endocrine System 19 | 18,159
Female tissues 19 | 17,400
Blood and immune system 18 | 16,909
Liver and Pancreas 18 | 16,750
Male tissues 18 | 17,142
Nervous System 18 | 16,725
Respiratory system 18 | 16,393
Skin and soft tissues 18 | 17,230
Urinary Tract 18 | 16,678
Cardiovascular System 17 | 15,192

Target Family

Enzyme 19 | 4,145

KEGG Pathway

Glycosaminoglycan degradation 19 | 19
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Inactive heparanase-2 HPSE2 Tbio Enzyme -2.52081 326.4 137
Hyaluronidase-1 HYAL1 Tbio Enzyme -1.88328 77.3 220
N-acetylglucosamine-6-sulfatase GNS Tbio Enzyme -2.69362 478.4 159
Hyaluronidase-2 HYAL2 Tbio Enzyme -2.01424 105.1 212
Alpha-N-acetylglucosaminidase NAGLU Tbio Enzyme -2.18649 159.9 64
Hyaluronidase-3 HYAL3 Tbio Enzyme -0.92743 7.88 126
N-sulphoglucosamine sulphohydrolase SGSH Tbio Enzyme -2.17271 151.8 156
Iduronate 2-sulfatase IDS Tbio Enzyme -1.85004 64.1 138
N-acetylgalactosamine-6-sulfatase GALNS Tbio Enzyme -2.43232 272.7 229
Beta-hexosaminidase subunit beta HEXB Tchem Enzyme -2.18934 146.3 132