Development Level

Tbio 47 | 11,445
Tchem 15 | 1,598
Tclin 4 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
abnormal behavior 3 | 298
decreased bone mineral density 3 | 126
decreased total body fat amoun... 3 | 207
increased lean body mass 3 | 172
preweaning lethality, incomple... 3 | 499
abnormal QT variability 2 | 10
decreased circulating HDL chol... 2 | 68
decreased circulating alkaline... 2 | 46
abnormal bone mineralization 1 | 38
abnormal kidney morphology 1 | 65
abnormal lens morphology 1 | 81
abnormal response to tactile s... 1 | 17
abnormal retinal vasculature m... 1 | 27
abnormal skin morphology 1 | 50
abnormal startle reflex 1 | 15
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
hyperactivity 1 | 148
hypoactivity 1 | 132
increased body temperature 1 | 9
increased bone mineral density 1 | 72
increased circulating alkaline... 1 | 122
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134

Disease

Carcinoma 45 | 11,493
ovarian cancer 33 | 8,520
psoriasis 27 | 6,694
lung cancer 23 | 4,740
osteosarcoma 23 | 7,950
Autosomal recessive predisposition 21 | 1,442
Cancer 19 | 2,499
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,962
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
non-small cell lung cancer 17 | 2,890
invasive ductal carcinoma 16 | 2,951
lung adenocarcinoma 16 | 2,716
ductal carcinoma in situ 15 | 1,745
glioblastoma 15 | 5,792
pancreatic cancer 15 | 2,398
intraductal papillary-mucinous carcinoma (IPMC) 14 | 2,989
medulloblastoma, large-cell 14 | 6,241
Breast cancer 12 | 3,578
adrenocortical carcinoma 12 | 1,428
ependymoma 12 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 12 | 2,955
malignant mesothelioma 12 | 3,232
Alcoholic Intoxication, Chronic 11 | 289
Multiple myeloma 11 | 1,332
atypical teratoid / rhabdoid tumor 11 | 5,112
breast carcinoma 11 | 1,638
lung carcinoma 11 | 2,843
Glycogen storage disease 10 | 39
Liver Cirrhosis, Experimental 10 | 769
acute quadriplegic myopathy 10 | 1,158
group 3 medulloblastoma 10 | 4,104
Alcohol dependence 9 | 107
Epilepsy 9 | 792
Schizophrenia 9 | 1,160
diabetes mellitus 9 | 1,728
Icterus 8 | 82
Seizures 8 | 596
cystic fibrosis 8 | 1,696
esophageal adenocarcinoma 8 | 737
nasopharyngeal carcinoma 8 | 1,058
primary pancreatic ductal adenocarcinoma 8 | 1,109
subependymal giant cell astrocytoma 8 | 2,287
Adenocarcinoma of lung 7 | 142
Alcohol abuse 7 | 50
Cognitive delay 7 | 608
Dull intelligence 7 | 645
Global developmental delay 7 | 608
Hypoglycemia 7 | 152
Intellectual disability 7 | 1,016
Liver carcinoma 7 | 240
Low intelligence 7 | 645
Mental Retardation 7 | 645
Mental and motor retardation 7 | 608
Mental deficiency 7 | 645
Mouth Neoplasms 7 | 55
Myocardial Ischemia 7 | 169
Obesity 7 | 678
Osteoporosis 7 | 363
Poor school performance 7 | 645
Stomach Neoplasms 7 | 300
Waldenstrons macroglobulinemia 7 | 765
acute myeloid leukemia 7 | 783
adult high grade glioma 7 | 3,801
astrocytic glioma 7 | 2,597
colon cancer 7 | 1,478
dermatomyositis 7 | 966
group 4 medulloblastoma 7 | 1,855
pituitary cancer 7 | 1,972
ulcerative colitis 7 | 1,819
Acidosis, Lactic 6 | 97
Carcinoma, Hepatocellular 6 | 228
Cholecystitis 6 | 18
Cholelithiasis 6 | 33
Congenital hemolytic anemia 6 | 32
Disease Models, Animal 6 | 155
Kidney cancer 6 | 2,613
Lactic acidosis 6 | 51
Male infertility 6 | 206
Splenomegaly 6 | 190
Succinic semialdehyde dehydrogenase deficiency 6 | 16
nephrosclerosis 6 | 333
tuberculosis 6 | 2,010
Astrocytoma, Pilocytic 5 | 3,081
Breast Neoplasms 5 | 445
Diabetes Mellitus, Experimental 5 | 108
Esophageal Neoplasms 5 | 69
Impaired exercise tolerance 5 | 42
Lactic acidemia 5 | 95
Liver disease 5 | 237
Mammary Neoplasms 5 | 425
Muscle hypotonia 5 | 571
Pancreatitis 5 | 123
Pick disease 5 | 1,894
fibroadenoma 5 | 559
non-small cell lung carcinoma 5 | 317
oligodendroglioma 5 | 2,850
Bipolar Disorder 4 | 666
astrocytoma 4 | 1,146
gastric carcinoma 4 | 807
primitive neuroectodermal tumor 4 | 3,035

Tissue

Endocrine System 67 | 18,159
Digestive Tract 66 | 17,369
Blood and immune system 65 | 16,909
Female tissues 65 | 17,400
Liver and Pancreas 65 | 16,750
Skin and soft tissues 65 | 17,230
Urinary Tract 65 | 16,678
Male tissues 64 | 17,142
Nervous System 62 | 16,725
Respiratory system 60 | 16,393
Cardiovascular System 55 | 15,192

Target Family

Enzyme 53 | 4,145
Kinase 15 | 634

KEGG Pathway

Glycolysis / Gluconeogenesis 68 | 68
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glucose-6-phosphatase 3 G6PC3 Tbio Enzyme -1.55249 37.2 54
Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 Tbio Enzyme -1.48800 26.8 73
Hexokinase-2 HK2 Tchem Kinase -2.64934 432.5 446
4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 Tbio Enzyme -1.43954 27.0 162
Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 Tbio Enzyme -3.14670 1303.9 150
Alcohol dehydrogenase class 4 mu/sigma chain ADH7 Tchem Enzyme -2.18765 159.0 243
Pyruvate kinase PKLR PKLR Tbio Kinase -2.37549 231.1 391
Alcohol dehydrogenase 6 ADH6 Tbio Enzyme -1.84121 71.7 117
Phosphoglycerate kinase 1 PGK1 Tchem Kinase -2.79738 602.5 340
Pyruvate kinase PKM PKM Tchem Kinase -3.15332 1424.2 749