Development Level

Tbio 34 | 11,178
Tchem 4 | 1,885
Tclin 2 | 612

IMPC Phenotype

preweaning lethality, complete... 4 | 979
abnormal behavior 3 | 298
hypoactivity 3 | 132
decreased circulating alkaline... 2 | 46
male infertility 2 | 123
thrombocytopenia 2 | 56
abnormal craniofacial morpholo... 1 | 33
abnormal embryo size 1 | 220
abnormal eye morphology 1 | 68
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal retina morphology 1 | 71
anophthalmia 1 | 33
brachydactyly 1 | 19
cataract 1 | 92
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating phosphat... 1 | 27
decreased circulating serum al... 1 | 82
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased food intake 1 | 13
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased leukocyte cell numbe... 1 | 73
decreased prepulse inhibition 1 | 82
decreased red blood cell distr... 1 | 41
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
edema 1 | 59
female infertility 1 | 60
increased basophil cell number 1 | 7
increased bone mineral content 1 | 108
increased circulating bilirubi... 1 | 16
increased circulating potassiu... 1 | 29
increased lean body mass 1 | 172
increased mean corpuscular hem... 1 | 96
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
small adrenal glands 1 | 16
syndactyly 1 | 23
thin ventricular wall 1 | 24

Disease

Carcinoma 27 | 11,192
pancreatic ductal adenocarcinoma liver metastasis 19 | 1,911
psoriasis 19 | 6,514
Autosomal recessive predisposition 18 | 1,407
osteosarcoma 16 | 7,766
ovarian cancer 14 | 8,297
pancreatic cancer 12 | 2,322
lung cancer 11 | 4,607
Epilepsy 10 | 775
Intellectual disability 10 | 998
atypical teratoid / rhabdoid tumor 10 | 4,971
group 3 medulloblastoma 10 | 4,002
Dull intelligence 9 | 634
Low intelligence 9 | 634
Mental Retardation 9 | 634
Mental deficiency 9 | 634
Poor school performance 9 | 634
Seizures 9 | 584
ependymoma 9 | 4,559
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,902
medulloblastoma, large-cell 9 | 6,086
non-small cell lung cancer 9 | 2,799
Breast cancer 8 | 3,469
Cancer 8 | 2,388
Schizophrenia 8 | 1,136
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,872
lung adenocarcinoma 8 | 2,627
malignant mesothelioma 8 | 3,135
pituitary cancer 8 | 1,915
glioblastoma 7 | 5,635
intraductal papillary-mucinous neoplasm (IPMN) 7 | 3,204
Astrocytoma, Pilocytic 6 | 3,006
Cognitive delay 6 | 596
Global developmental delay 6 | 596
Mental and motor retardation 6 | 596
adrenocortical carcinoma 6 | 1,385
adult high grade glioma 6 | 3,701
breast carcinoma 6 | 1,589
colon cancer 6 | 1,428
invasive ductal carcinoma 6 | 2,867
spina bifida 6 | 1,053
Bipolar Disorder 5 | 646
Depressive disorder 5 | 401
Hyperhomocysteinemia 5 | 36
Muscle hypotonia 5 | 562
ductal carcinoma in situ 5 | 1,686
group 4 medulloblastoma 5 | 1,806
interstitial cystitis 5 | 2,237
nephrosclerosis 5 | 314
oligodendroglioma 5 | 2,768
Agenesis of corpus callosum 4 | 79
Atherosclerosis 4 | 276
Autistic Disorder 4 | 358
Carcinoma, Non-Small-Cell Lung 4 | 97
Cleft Palate 4 | 265
Dementia 4 | 172
Down syndrome 4 | 480
Encephalopathies 4 | 43
Fetal Growth Retardation 4 | 186
Glycine encephalopathy 4 | 29
Homocystinuria 4 | 21
Hypermethioninemia 4 | 11
Hyperreflexia 4 | 208
Hypertension 4 | 372
Lethargy 4 | 77
Liver Cirrhosis, Experimental 4 | 733
Multiple myeloma 4 | 1,296
Myoclonus 4 | 71
Prostatic Neoplasms 4 | 472
aldosterone-producing adenoma 4 | 646
cystic fibrosis 4 | 1,629
lung carcinoma 4 | 2,755
nasopharyngeal carcinoma 4 | 1,024
non primary Sjogren syndrome sicca 4 | 861
non-small cell lung carcinoma 4 | 302
subependymal giant cell astrocytoma 4 | 2,230
tuberculosis 4 | 1,963
Aggressive behavior 3 | 75
Aggressive reaction 3 | 75
Alcoholic Intoxication, Chronic 3 | 283
Delayed speech and language development 3 | 110
Dystonia 3 | 163
Infantile onset 3 | 236
Kidney disease 3 | 411
Language Delay 3 | 110
Melanoma 3 | 689
Mood Disorders 3 | 181
Physical aggression 3 | 76
Primary hyperoxaluria 3 | 15
Speech Delay 3 | 110
Speech impairment 3 | 110
acute myeloid leukemia 3 | 760
dermatomyositis 3 | 941
diabetes mellitus 3 | 1,683
fibroadenoma 3 | 538
gastric carcinoma 3 | 781
pancreatic carcinoma 3 | 555
pediatric high grade glioma 3 | 1,035
primary pancreatic ductal adenocarcinoma 3 | 1,071
ulcerative colitis 3 | 1,765

Tissue

Digestive Tract 40 | 17,369
Female tissues 40 | 17,400
Skin and soft tissues 40 | 17,230
Urinary Tract 40 | 16,678
Liver and Pancreas 39 | 16,750
Blood and immune system 38 | 16,909
Endocrine System 38 | 18,159
Nervous System 38 | 16,725
Male tissues 37 | 17,142
Respiratory system 36 | 16,393
Cardiovascular System 33 | 15,192

Target Family

Enzyme 37 | 4,145
Non-IDG 2 | 12,091
Kinase 1 | 634

KEGG Pathway

Glycine, serine and threonine ... 40 | 40
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Serine dehydratase-like SDSL Tbio Enzyme -2.81127 638.6 190
Glyoxylate reductase/hydroxypyruvate reductase GRHPR Tbio Enzyme -1.91645 81.8 157
Phosphoserine phosphatase PSPH Tbio Enzyme -1.56433 55.8 252
D-3-phosphoglycerate dehydrogenase PHGDH Tbio Enzyme -3.17330 1408.2 293
Amine oxidase [flavin-containing] B MAOB Tclin Enzyme -3.40865 2530.3 252
Probable phosphoglycerate mutase 4 PGAM4 Tbio Enzyme -1.19846 14.5 75
Phosphoglycerate mutase 1 PGAM1 Tbio Enzyme -1.80675 62.6 193
Dimethylglycine dehydrogenase, mitochondrial DMGDH Tbio Enzyme -1.39556 25.3 115
Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 Tbio Enzyme -1.47858 32.0 77
Glycine N-methyltransferase GNMT Tbio Enzyme -1.56517 40.8 216