Development Level

Tbio 56 | 11,178
Tchem 27 | 1,885
Tdark 12 | 6,569
Tclin 1 | 612

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 6 | 499
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
increased red blood cell distr... 2 | 34
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
brachydactyly 1 | 19
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating phosphat... 1 | 27
decreased grip strength 1 | 116
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased body weight 1 | 25
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart rate variabili... 1 | 7
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
male infertility 1 | 123
small seminal vesicle 1 | 10
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

Carcinoma 54 | 11,192
osteosarcoma 51 | 7,766
ovarian cancer 44 | 8,297
psoriasis 37 | 6,514
medulloblastoma, large-cell 35 | 6,086
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,204
invasive ductal carcinoma 26 | 2,867
atypical teratoid / rhabdoid tumor 25 | 4,971
glioblastoma 25 | 5,635
lung cancer 24 | 4,607
ependymoma 23 | 4,559
group 3 medulloblastoma 23 | 4,002
non-small cell lung cancer 23 | 2,799
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,911
adult high grade glioma 21 | 3,701
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,872
Breast cancer 20 | 3,469
group 4 medulloblastoma 19 | 1,806
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,902
lung carcinoma 18 | 2,755
Pick disease 17 | 1,856
Astrocytoma, Pilocytic 16 | 3,006
ductal carcinoma in situ 16 | 1,686
malignant mesothelioma 16 | 3,135
pancreatic cancer 16 | 2,322
primitive neuroectodermal tumor 16 | 2,957
oligodendroglioma 15 | 2,768
lung adenocarcinoma 14 | 2,627
breast carcinoma 13 | 1,589
active Crohn's disease 12 | 882
astrocytic glioma 12 | 2,530
subependymal giant cell astrocytoma 12 | 2,230
ulcerative colitis 12 | 1,765
Autosomal recessive predisposition 11 | 1,407
Schizophrenia 11 | 1,136
interstitial cystitis 11 | 2,237
tuberculosis 11 | 1,963
Kidney cancer 10 | 2,548
pituitary cancer 10 | 1,915
Rheumatoid arthritis 9 | 1,156
esophageal adenocarcinoma 9 | 696
Toxic encephalopathy 8 | 139
diabetes mellitus 8 | 1,683
primary pancreatic ductal adenocarcinoma 8 | 1,071
Bipolar Disorder 7 | 646
Intellectual disability 7 | 998
Sengers syndrome 7 | 18
active ulcerative colitis 7 | 736
gastric carcinoma 7 | 781
spina bifida 7 | 1,053
Coronary artery disease 6 | 253
Dull intelligence 6 | 634
Liver Cirrhosis, Experimental 6 | 733
Low intelligence 6 | 634
Mental Retardation 6 | 634
Mental deficiency 6 | 634
Multiple myeloma 6 | 1,296
Poor school performance 6 | 634
acute quadriplegic myopathy 6 | 1,133
adrenocortical carcinoma 6 | 1,385
colon cancer 6 | 1,428
cystic fibrosis 6 | 1,629
non primary Sjogren syndrome sicca 6 | 861
Atherosclerosis 5 | 276
Atopic dermatitis 5 | 915
Cancer 5 | 2,388
Down syndrome 5 | 480
Lipodystrophy 5 | 37
dermatomyositis 5 | 941
nasopharyngeal carcinoma 5 | 1,024
pediatric high grade glioma 5 | 1,035
posterior fossa group B ependymoma 5 | 406
Alzheimer's disease 4 | 640
Amyotrophic lateral sclerosis 4 | 437
Depressive disorder 4 | 401
Failure to gain weight 4 | 359
Hepatomegaly 4 | 280
Muscle hypotonia 4 | 562
Newborn respiratory distress syndrome 4 | 10
Obesity 4 | 655
Parkinson's disease 4 | 378
Pediatric failure to thrive 4 | 359
Seizures 4 | 584
Type 2 diabetes mellitus 4 | 268
Waldenstrons macroglobulinemia 4 | 742
juvenile dermatomyositis 4 | 1,147
nephrosclerosis 4 | 314
progressive supranuclear palsy 4 | 656
Arthritis 3 | 276
Creatine phosphokinase serum increased 3 | 110
Duchenne muscular dystrophy 3 | 587
Elevated creatine kinase 3 | 110
Epilepsy 3 | 775
Hypoplastic mandible condyle 3 | 273
aldosterone-producing adenoma 3 | 646
astrocytoma 3 | 1,113
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 492
cutaneous lupus erythematosus 3 | 1,016
fibroadenoma 3 | 538
pancreatic carcinoma 3 | 555

Tissue

Digestive Tract 95 | 17,369
Endocrine System 94 | 18,159
Skin and soft tissues 94 | 17,230
Female tissues 93 | 17,400
Male tissues 93 | 17,142
Urinary Tract 92 | 16,678
Blood and immune system 91 | 16,909
Liver and Pancreas 91 | 16,750
Nervous System 91 | 16,725
Respiratory system 90 | 16,393
Cardiovascular System 87 | 15,192

Target Family

Enzyme 87 | 4,145
Kinase 7 | 634
Non-IDG 2 | 12,091

KEGG Pathway

Glycerophospholipid metabolism 96 | 96
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Cytosolic phospholipase A2 beta JMJD7-PLA2G4B Tchem Enzyme -0.60640 3.75 104
Diacylglycerol kinase delta DGKD Tbio Enzyme -1.41858 27.5 133
Phosphatidylethanolamine N-methyltransferase PEMT Tbio Enzyme -1.90213 89.9 149
Phospholipase D1 PLD1 Tchem Enzyme -1.51188 30.9 203
Phosphatidate phosphatase LPIN1 LPIN1 Tbio Enzyme -2.13963 149.5 280
Phosphatidylcholine-sterol acyltransferase LCAT Tchem Enzyme -2.52851 336.6 270
Phosphatidylserine decarboxylase proenzyme, mitochondrial PISD Tbio Enzyme -1.98575 94.1 143
Cytosolic phospholipase A2 zeta PLA2G4F Tdark Enzyme 0.59 0.40 38
Glycerophosphocholine phosphodiesterase GPCPD1 GPCPD1 Tdark Enzyme -1.71900 49.0 17
Glycerol-3-phosphate dehydrogenase 1-like protein GPD1L Tbio Enzyme -1.31283 20.2 132