Development Level

Tbio 62 | 11,445
Tchem 21 | 1,598
Tdark 12 | 6,588
Tclin 1 | 613

IMPC Phenotype

preweaning lethality, complete... 6 | 979
preweaning lethality, incomple... 6 | 499
cataract 2 | 92
decreased bone mineral content 2 | 151
decreased circulating glucose ... 2 | 126
increased red blood cell distr... 2 | 34
abnormal joint morphology 1 | 23
abnormal lens morphology 1 | 81
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
brachydactyly 1 | 19
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating calcium ... 1 | 36
decreased circulating phosphat... 1 | 27
decreased grip strength 1 | 116
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
increased anti-nuclear antigen... 1 | 19
increased body length 1 | 32
increased body weight 1 | 25
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased heart rate variabili... 1 | 7
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
increased total body fat amoun... 1 | 134
male infertility 1 | 123
small seminal vesicle 1 | 10
syndactyly 1 | 23
thrombocytopenia 1 | 56

Disease

Carcinoma 54 | 11,493
osteosarcoma 51 | 7,950
ovarian cancer 44 | 8,520
psoriasis 37 | 6,694
medulloblastoma, large-cell 35 | 6,241
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
invasive ductal carcinoma 26 | 2,951
atypical teratoid / rhabdoid tumor 25 | 5,112
glioblastoma 25 | 5,792
lung cancer 24 | 4,740
ependymoma 23 | 4,679
group 3 medulloblastoma 23 | 4,104
non-small cell lung cancer 23 | 2,890
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
adult high grade glioma 21 | 3,801
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
Breast cancer 20 | 3,578
group 4 medulloblastoma 19 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 18 | 2,989
lung carcinoma 18 | 2,843
Pick disease 17 | 1,894
Astrocytoma, Pilocytic 16 | 3,081
ductal carcinoma in situ 16 | 1,745
malignant mesothelioma 16 | 3,232
pancreatic cancer 16 | 2,398
primitive neuroectodermal tumor 16 | 3,035
oligodendroglioma 15 | 2,850
lung adenocarcinoma 14 | 2,716
breast carcinoma 13 | 1,638
active Crohn's disease 12 | 922
astrocytic glioma 12 | 2,597
subependymal giant cell astrocytoma 12 | 2,287
ulcerative colitis 12 | 1,819
Autosomal recessive predisposition 11 | 1,442
Schizophrenia 11 | 1,160
interstitial cystitis 11 | 2,312
tuberculosis 11 | 2,010
Kidney cancer 10 | 2,613
pituitary cancer 10 | 1,972
Rheumatoid arthritis 9 | 1,191
esophageal adenocarcinoma 9 | 737
Toxic encephalopathy 8 | 141
diabetes mellitus 8 | 1,728
primary pancreatic ductal adenocarcinoma 8 | 1,109
Bipolar Disorder 7 | 666
Intellectual disability 7 | 1,016
Sengers syndrome 7 | 18
active ulcerative colitis 7 | 764
gastric carcinoma 7 | 807
spina bifida 7 | 1,074
Coronary artery disease 6 | 268
Dull intelligence 6 | 645
Liver Cirrhosis, Experimental 6 | 769
Low intelligence 6 | 645
Mental Retardation 6 | 645
Mental deficiency 6 | 645
Multiple myeloma 6 | 1,332
Poor school performance 6 | 645
acute quadriplegic myopathy 6 | 1,158
adrenocortical carcinoma 6 | 1,428
colon cancer 6 | 1,478
cystic fibrosis 6 | 1,696
non primary Sjogren syndrome sicca 6 | 891
Atherosclerosis 5 | 291
Atopic dermatitis 5 | 952
Cancer 5 | 2,499
Down syndrome 5 | 499
Lipodystrophy 5 | 40
dermatomyositis 5 | 966
nasopharyngeal carcinoma 5 | 1,058
pediatric high grade glioma 5 | 1,064
posterior fossa group B ependymoma 5 | 416
Alzheimer's disease 4 | 658
Amyotrophic lateral sclerosis 4 | 451
Depressive disorder 4 | 409
Failure to gain weight 4 | 365
Hepatomegaly 4 | 285
Muscle hypotonia 4 | 571
Newborn respiratory distress syndrome 4 | 10
Obesity 4 | 678
Parkinson's disease 4 | 392
Pediatric failure to thrive 4 | 365
Seizures 4 | 596
Type 2 diabetes mellitus 4 | 272
Waldenstrons macroglobulinemia 4 | 765
juvenile dermatomyositis 4 | 1,187
nephrosclerosis 4 | 333
progressive supranuclear palsy 4 | 676
Arthritis 3 | 290
Duchenne muscular dystrophy 3 | 601
Elevated creatine kinase 3 | 110
Epilepsy 3 | 792
Hypoplastic mandible condyle 3 | 275
aldosterone-producing adenoma 3 | 665
astrocytoma 3 | 1,146
atypical teratoid/rhabdoid tumor 3 | 357
autosomal dominant Emery-Dreifuss muscular dystrophy 3 | 510
cutaneous lupus erythematosus 3 | 1,057
fibroadenoma 3 | 559
pancreatic carcinoma 3 | 562

Tissue

Digestive Tract 95 | 17,369
Endocrine System 94 | 18,159
Skin and soft tissues 94 | 17,230
Female tissues 93 | 17,400
Male tissues 93 | 17,142
Urinary Tract 92 | 16,678
Blood and immune system 91 | 16,909
Liver and Pancreas 91 | 16,750
Nervous System 91 | 16,725
Respiratory system 90 | 16,393
Cardiovascular System 87 | 15,192

Target Family

Enzyme 87 | 4,145
Kinase 7 | 634
Non-IDG 2 | 12,091

KEGG Pathway

Glycerophospholipid metabolism 96 | 96
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Choline O-acetyltransferase CHAT Tchem Enzyme -3.40175 2597.2 436
Glycerol-3-phosphate acyltransferase 1, mitochondrial GPAM Tbio Enzyme -1.93041 83.4 177
Choline-phosphate cytidylyltransferase B PCYT1B Tbio Enzyme -1.46937 28.8 40
Cytosolic phospholipase A2 delta PLA2G4D Tbio Enzyme -0.54284 3.41 45
Diacylglycerol kinase eta DGKH Tbio Kinase -1.45863 29.5 92
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon AGPAT5 Tbio Enzyme -0.79526 4.42 180
Cardiolipin synthase (CMP-forming) CRLS1 Tbio Enzyme -0.87118 6.24 100
Cholinephosphotransferase 1 CHPT1 Tbio Enzyme -1.42313 23.5 80
Lysophospholipid acyltransferase 5 LPCAT3 Tbio Enzyme -2.21771 162.8 32
Cytosolic phospholipase A2 gamma PLA2G4C Tchem Enzyme -1.27690 20.9 63