Development Level

Tbio 56 | 11,445
Tchem 40 | 1,598
Tclin 6 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125

IMPC Phenotype

decreased total body fat amoun... 5 | 207
increased heart weight 5 | 62
increased lean body mass 5 | 172
increased startle reflex 5 | 112
preweaning lethality, complete... 5 | 979
preweaning lethality, incomple... 5 | 499
abnormal bone structure 4 | 187
increased circulating alkaline... 3 | 122
increased total body fat amoun... 3 | 134
abnormal embryo size 2 | 220
decreased body weight 2 | 161
decreased circulating HDL chol... 2 | 68
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating magnesiu... 2 | 13
decreased lean body mass 2 | 135
decreased mean platelet volume 2 | 25
embryonic lethality prior to t... 2 | 278
enlarged heart 2 | 210
enlarged spleen 2 | 41
impaired glucose tolerance 2 | 75
increased bone mineral content 2 | 108
increased mean platelet volume 2 | 45
male infertility 2 | 123
small superior vagus ganglion 2 | 74
abnormal bone mineralization 1 | 38
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal gallbladder morpholog... 1 | 1
abnormal glucose homeostasis 1 | 4
abnormal heart left ventricle ... 1 | 16
abnormal heart morphology 1 | 162
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal response to new envir... 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal spleen morphology 1 | 55
abnormal thymus morphology 1 | 7
abnormal vibrissa morphology 1 | 25
abnormal vocalization 1 | 21
absent pinna reflex 1 | 23
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating calcium ... 1 | 36
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged gallbladder 1 | 2
enlarged thymus 1 | 5
hydrometra 1 | 53
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased body length 1 | 32
increased circulating LDL chol... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating calcium ... 1 | 34
increased circulating chloride... 1 | 41
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating sodium l... 1 | 71
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased glycosylated hemoglo... 1 | 1
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
prolonged QT interval 1 | 38
prolonged ST segment 1 | 36
small epididymis 1 | 3
thrombocytosis 1 | 27

Disease

Carcinoma 79 | 11,493
ovarian cancer 56 | 8,520
osteosarcoma 55 | 7,950
psoriasis 45 | 6,694
medulloblastoma, large-cell 43 | 6,241
lung cancer 38 | 4,740
glioblastoma 37 | 5,792
Cancer 32 | 2,499
atypical teratoid / rhabdoid tumor 31 | 5,112
group 3 medulloblastoma 30 | 4,104
Obesity 29 | 678
diabetes mellitus 29 | 1,728
ependymoma 29 | 4,679
Breast cancer 27 | 3,578
adult high grade glioma 27 | 3,801
Kidney cancer 26 | 2,613
Autosomal recessive predisposition 24 | 1,442
Astrocytoma, Pilocytic 22 | 3,081
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
invasive ductal carcinoma 22 | 2,951
intraductal papillary-mucinous adenoma (IPMA) 21 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 21 | 3,291
malignant mesothelioma 21 | 3,232
Epilepsy 20 | 792
primitive neuroectodermal tumor 20 | 3,035
Schizophrenia 19 | 1,160
subependymal giant cell astrocytoma 19 | 2,287
Pick disease 18 | 1,894
astrocytic glioma 18 | 2,597
ductal carcinoma in situ 18 | 1,745
group 4 medulloblastoma 18 | 1,855
lung carcinoma 18 | 2,843
Glycogen storage disease 17 | 39
oligodendroglioma 17 | 2,850
pancreatic cancer 17 | 2,398
pancreatic ductal adenocarcinoma liver metastasis 17 | 1,962
Bipolar Disorder 16 | 666
lung adenocarcinoma 16 | 2,716
pituitary cancer 16 | 1,972
Hyperglycemia 15 | 137
colon cancer 15 | 1,478
ulcerative colitis 15 | 1,819
Hypoglycemia 14 | 152
Seizures 14 | 596
breast carcinoma 14 | 1,638
non-small cell lung cancer 14 | 2,890
Hepatomegaly 11 | 285
Liver cancer 11 | 604
Prostatic Neoplasms 11 | 495
Diabetes Mellitus, Non-Insulin-Dependent 10 | 145
Diabetes Mellitus, Type 2 10 | 142
Dull intelligence 10 | 645
Fatty liver disease 10 | 103
Intellectual disability 10 | 1,016
Low intelligence 10 | 645
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Poor school performance 10 | 645
Rheumatoid arthritis 10 | 1,191
tuberculosis 10 | 2,010
Breast Neoplasms 9 | 445
Mammary Neoplasms 9 | 425
Muscle hypotonia 9 | 571
Polycystic ovary syndrome 9 | 360
interstitial cystitis 9 | 2,312
Cognitive delay 8 | 608
Depressive disorder 8 | 409
Diabetes Mellitus, Experimental 8 | 108
Global developmental delay 8 | 608
Heart disease 8 | 306
Hyperinsulinism 8 | 133
Insulin Resistance 8 | 72
Kidney disease 8 | 430
Liver carcinoma 8 | 240
Mental and motor retardation 8 | 608
Renal Cell Carcinoma 8 | 214
Short stature 8 | 531
Adenoma 7 | 167
Alzheimer's disease 7 | 658
Carcinoma, Hepatocellular 7 | 228
Cardiomegaly 7 | 116
Liver Cirrhosis, Experimental 7 | 769
Multiple Endocrine Neoplasia Type 1 7 | 29
Multiple myeloma 7 | 1,332
Parkinson's disease 7 | 392
Stomach Neoplasms 7 | 300
adrenocortical carcinoma 7 | 1,428
astrocytoma 7 | 1,146
cutaneous lupus erythematosus 7 | 1,057
cystic fibrosis 7 | 1,696
dermatomyositis 7 | 966
esophageal adenocarcinoma 7 | 737
Endometrial cancer 6 | 311
Hypertension 6 | 396
Mental Depression 6 | 333
Vascular disease 6 | 319
Waldenstrons macroglobulinemia 6 | 765
acute quadriplegic myopathy 6 | 1,158
juvenile dermatomyositis 6 | 1,187
nephrosclerosis 6 | 333

Tissue

Endocrine System 101 | 18,159
Digestive Tract 99 | 17,369
Skin and soft tissues 98 | 17,230
Liver and Pancreas 97 | 16,750
Blood and immune system 96 | 16,909
Female tissues 96 | 17,400
Urinary Tract 95 | 16,678
Male tissues 94 | 17,142
Nervous System 93 | 16,725
Cardiovascular System 89 | 15,192
Respiratory system 88 | 16,393

Target Family

Enzyme 41 | 4,145
Kinase 26 | 634
Non-IDG 17 | 12,091
Transcription Factor 10 | 1,400
Epigenetic 4 | 242
Ion Channel 3 | 344
Transporter 2 | 473
GPCR 1 | 408
Nuclear Receptor 1 | 48

KEGG Pathway

Glucagon signaling pathway 105 | 105
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Glucose-6-phosphatase 3 G6PC3 Tbio Enzyme -1.55249 37.2 54
Serine/threonine-protein phosphatase 4 regulatory subunit 3B PPP4R3B Tbio Enzyme -1.46618 28.8 121
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform PPP3CB Tbio Enzyme -1.53531 28.2 147
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
Guanine nucleotide-binding protein G(q) subunit alpha GNAQ Tbio Non-IDG -2.73429 514.5 206
Calmodulin-like protein 5 CALML5 Tbio Non-IDG -1.32968 24.4 111
Calcineurin subunit B type 1 PPP3R1 Tbio Non-IDG -2.60752 391.4 125
Cyclic AMP-responsive element-binding protein 3-like protein 2 CREB3L2 Tbio Transcription Factor -2.52262 324.1 178