Development Level

Tchem 30 | 1,598
Tbio 24 | 11,445
Tclin 16 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 4 | 161
abnormal lens morphology 3 | 81
cataract 3 | 92
abnormal bone mineralization 2 | 38
abnormal seminal vesicle morph... 2 | 114
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
enlarged heart 2 | 210
increased circulating LDL chol... 2 | 13
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal digit morphology 1 | 10
abnormal embryo size 1 | 220
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal heart morphology 1 | 162
abnormal lung morphology 1 | 26
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
decreased IgG3 level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased total body fat amoun... 1 | 207
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
female infertility 1 | 60
hyperactivity 1 | 148
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
male infertility 1 | 123
microphthalmia 1 | 26
prenatal lethality 1 | 28
short tibia 1 | 97
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Cancer 54 | 2,499
Carcinoma 49 | 11,493
ovarian cancer 49 | 8,520
osteosarcoma 44 | 7,950
glioblastoma 43 | 5,792
lung cancer 38 | 4,740
medulloblastoma, large-cell 38 | 6,241
Breast cancer 35 | 3,578
psoriasis 34 | 6,694
atypical teratoid / rhabdoid tumor 32 | 5,112
group 3 medulloblastoma 31 | 4,104
malignant mesothelioma 26 | 3,232
ependymoma 24 | 4,679
primitive neuroectodermal tumor 24 | 3,035
oligodendroglioma 22 | 2,850
Astrocytoma, Pilocytic 21 | 3,081
adult high grade glioma 21 | 3,801
Breast Neoplasms 20 | 445
Kidney cancer 20 | 2,613
Mammary Neoplasms 20 | 425
astrocytic glioma 20 | 2,597
pancreatic cancer 20 | 2,398
subependymal giant cell astrocytoma 20 | 2,287
Epilepsy 18 | 792
Schizophrenia 18 | 1,160
juvenile dermatomyositis 18 | 1,187
Carcinoma, Hepatocellular 17 | 228
Intellectual disability 17 | 1,016
Liver carcinoma 17 | 240
Lung Neoplasms 17 | 232
Stomach Neoplasms 17 | 300
Hypoplastic mandible condyle 16 | 275
Mandibular hypoplasia 16 | 275
Micrognathism 16 | 275
Prostatic Neoplasms 16 | 495
diabetes mellitus 16 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 16 | 2,955
lung adenocarcinoma 16 | 2,716
Dull intelligence 15 | 645
Low intelligence 15 | 645
Melanoma 15 | 711
Mental Retardation 15 | 645
Mental deficiency 15 | 645
Orbital separation excessive 15 | 244
Poor school performance 15 | 645
Short stature 15 | 531
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
Blepharoptosis 14 | 231
Seizures 14 | 596
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
invasive ductal carcinoma 14 | 2,951
nasopharyngeal carcinoma 14 | 1,058
non-small cell lung cancer 14 | 2,890
Adenoma 13 | 167
Autosomal recessive predisposition 13 | 1,442
Downward slant of palpebral fissure 13 | 158
Rheumatoid arthritis 13 | 1,191
adrenocortical carcinoma 13 | 1,428
tuberculosis 13 | 2,010
Byzanthine arch palate 12 | 194
Cognitive delay 12 | 608
Concave bridge of nose 12 | 195
Depressed nasal bridge 12 | 195
Depressed nasal root/bridge 12 | 195
Global developmental delay 12 | 608
Mental and motor retardation 12 | 608
Muscle hypotonia 12 | 571
Papilloma 12 | 44
Pectus excavatum 12 | 100
Pick disease 12 | 1,894
Vascular disease 12 | 319
breast carcinoma 12 | 1,638
interstitial cystitis 12 | 2,312
pituitary cancer 12 | 1,972
Acquired scoliosis 11 | 281
Big calvaria 11 | 147
Curvature of spine 11 | 282
DOID:2627 11 | 94
Delayed bone age 11 | 136
Hepatomegaly 11 | 285
High forehead 11 | 102
Increased head circumference 11 | 147
Increased size of cranium 11 | 147
Increased size of skull 11 | 147
Multiple myeloma 11 | 1,332
Renal Cell Carcinoma 11 | 214
Squamous cell carcinoma 11 | 129
Strabismus 11 | 270
Tall forehead 11 | 102
Depressive disorder 10 | 409
Endometrial cancer 10 | 311
Frontal bossing 10 | 157
Skin cancer 10 | 469
acute quadriplegic myopathy 10 | 1,158
astrocytoma 10 | 1,146
colon cancer 10 | 1,478
cystic fibrosis 10 | 1,696
lung carcinoma 10 | 2,843
spina bifida 10 | 1,074
ulcerative colitis 10 | 1,819

Tissue

Blood and immune system 71 | 16,909
Digestive Tract 71 | 17,369
Endocrine System 71 | 18,159
Female tissues 71 | 17,400
Liver and Pancreas 71 | 16,750
Male tissues 71 | 17,142
Skin and soft tissues 71 | 17,230
Nervous System 70 | 16,725
Respiratory system 69 | 16,393
Urinary Tract 68 | 16,678
Cardiovascular System 66 | 15,192

Target Family

Kinase 28 | 634
Non-IDG 28 | 12,091
Enzyme 12 | 4,145
Transcription Factor 4 | 1,400

KEGG Pathway

Glioma 72 | 72
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Calmodulin-like protein 5 CALML5 Tbio Non-IDG -1.32968 24.4 111
Calcium/calmodulin-dependent protein kinase type II subunit alpha CAMK2A Tchem Kinase -1.82317 50.9 620