Development Level

Tbio 93 | 11,445
Tchem 36 | 1,598
Tclin 17 | 613
Tdark 2 | 6,588

Collection

GPCR: IDG Consortium (Targets) 1 | 126
Kinase: IDG Consortium (Comple... 1 | 37
RFA-RM-18-021 1 | 328

IMPC Phenotype

preweaning lethality, complete... 20 | 979
abnormal heart morphology 5 | 162
embryonic lethality prior to t... 5 | 278
enlarged heart 5 | 210
abnormal embryo size 4 | 220
cataract 4 | 92
decreased body weight 4 | 161
increased circulating choleste... 4 | 66
increased total body fat amoun... 4 | 134
abnormal bone mineralization 3 | 38
decreased vertical activity 3 | 208
increased startle reflex 3 | 112
prenatal lethality 3 | 28
abnormal body wall morphology 2 | 9
abnormal lens morphology 2 | 81
abnormal retinal vasculature m... 2 | 27
abnormal testis morphology 2 | 43
corneal opacity 2 | 32
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased lean body mass 2 | 135
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
edema 2 | 59
embryonic lethality prior to o... 2 | 239
enlarged lymph nodes 2 | 37
impaired glucose tolerance 2 | 75
impaired pupillary reflex 2 | 26
increased bone mineral density 2 | 72
increased circulating HDL chol... 2 | 80
increased circulating LDL chol... 2 | 13
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
limb grasping 2 | 41
microphthalmia 2 | 26
preweaning lethality, incomple... 2 | 499
short tibia 2 | 97
small testis 2 | 58
abnormal brain morphology 1 | 13
abnormal cornea morphology 1 | 31
abnormal embryo development 1 | 7
abnormal epididymis morphology 1 | 42
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal lung morphology 1 | 26
abnormal optic disc morphology 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal tail morphology 1 | 25
absent startle reflex 1 | 24
anophthalmia 1 | 33
cleft palate 1 | 8
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body length 1 | 101
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased prepulse inhibition 1 | 82
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
fused cornea and lens 1 | 5
hemorrhage 1 | 23
hydroencephaly 1 | 14
hydrometra 1 | 53
impaired righting response 1 | 26
increased B cell number 1 | 9
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating glucose ... 1 | 24
increased monocyte cell number 1 | 63
iris synechia 1 | 3
mammalian phenotype 1 | 17
narrow eye opening 1 | 12
persistence of hyaloid vascula... 1 | 33
polydactyly 1 | 7
prenatal lethality prior to he... 1 | 87
small heart 1 | 10
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
syndactyly 1 | 23
thrombocytosis 1 | 27

Disease

Carcinoma 105 | 11,493
Cancer 100 | 2,499
ovarian cancer 83 | 8,520
psoriasis 71 | 6,694
osteosarcoma 69 | 7,950
Breast cancer 60 | 3,578
glioblastoma 59 | 5,792
medulloblastoma, large-cell 56 | 6,241
lung cancer 55 | 4,740
atypical teratoid / rhabdoid tumor 54 | 5,112
group 3 medulloblastoma 48 | 4,104
ependymoma 44 | 4,679
malignant mesothelioma 44 | 3,232
Kidney cancer 40 | 2,613
Breast Neoplasms 32 | 445
oligodendroglioma 32 | 2,850
Mammary Neoplasms 31 | 425
invasive ductal carcinoma 31 | 2,951
primitive neuroectodermal tumor 31 | 3,035
Prostatic Neoplasms 30 | 495
Astrocytoma, Pilocytic 29 | 3,081
interstitial cystitis 28 | 2,312
pancreatic cancer 28 | 2,398
Orbital separation excessive 27 | 244
Schizophrenia 27 | 1,160
Stomach Neoplasms 27 | 300
intraductal papillary-mucinous neoplasm (IPMN) 27 | 3,291
Carcinoma, Hepatocellular 26 | 228
Liver carcinoma 26 | 240
Lung Neoplasms 26 | 232
breast carcinoma 26 | 1,638
non-small cell lung cancer 26 | 2,890
subependymal giant cell astrocytoma 26 | 2,287
Adenoma 25 | 167
Autosomal recessive predisposition 25 | 1,442
intraductal papillary-mucinous adenoma (IPMA) 25 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
lung carcinoma 25 | 2,843
Hypoplastic mandible condyle 24 | 275
Mandibular hypoplasia 24 | 275
Micrognathism 24 | 275
astrocytic glioma 24 | 2,597
ductal carcinoma in situ 24 | 1,745
adult high grade glioma 23 | 3,801
pituitary cancer 23 | 1,972
adrenocortical carcinoma 22 | 1,428
lung adenocarcinoma 22 | 2,716
Cleft Palate 21 | 271
Intellectual disability 21 | 1,016
Short stature 21 | 531
cystic fibrosis 21 | 1,696
diabetes mellitus 21 | 1,728
Colorectal Neoplasms 20 | 243
Adenocarcinoma 19 | 122
Byzanthine arch palate 19 | 194
Dull intelligence 19 | 645
Low intelligence 19 | 645
Mental Retardation 19 | 645
Mental deficiency 19 | 645
Neoplasm Metastasis 19 | 168
Ovarian Neoplasms 19 | 102
Poor school performance 19 | 645
Vascular disease 19 | 319
colon cancer 19 | 1,478
Cognitive delay 18 | 608
Colonic Neoplasms 18 | 142
Cryptorchidism 18 | 296
Epilepsy 18 | 792
Global developmental delay 18 | 608
Mental and motor retardation 18 | 608
ovarian neoplasm 18 | 99
Downward slant of palpebral fissure 17 | 158
Seizures 17 | 596
group 4 medulloblastoma 17 | 1,855
juvenile dermatomyositis 17 | 1,187
pediatric high grade glioma 17 | 1,064
tuberculosis 17 | 2,010
ulcerative colitis 17 | 1,819
Acquired scoliosis 16 | 281
Curvature of spine 16 | 282
Endometrial cancer 16 | 311
Melanoma 16 | 711
Multiple myeloma 16 | 1,332
Muscle hypotonia 16 | 571
Osteoporosis 16 | 363
Rheumatoid arthritis 16 | 1,191
Squamous cell carcinoma 16 | 129
Big calvaria 15 | 147
Bipolar Disorder 15 | 666
Carcinoma, Squamous Cell 15 | 110
Cleft Lip 15 | 141
Depressive disorder 15 | 409
High forehead 15 | 102
Increased head circumference 15 | 147
Increased size of cranium 15 | 147
Increased size of skull 15 | 147
Obesity 15 | 678
Pick disease 15 | 1,894
Tall forehead 15 | 102
astrocytoma 15 | 1,146

Tissue

Endocrine System 143 | 18,159
Digestive Tract 142 | 17,369
Nervous System 140 | 16,725
Female tissues 139 | 17,400
Male tissues 138 | 17,142
Skin and soft tissues 138 | 17,230
Blood and immune system 137 | 16,909
Urinary Tract 136 | 16,678
Liver and Pancreas 135 | 16,750
Respiratory system 129 | 16,393
Cardiovascular System 120 | 15,192

Target Family

Non-IDG 82 | 12,091
Kinase 27 | 634
Transcription Factor 13 | 1,400
Enzyme 11 | 4,145
GPCR 10 | 408
Nuclear Receptor 4 | 48
Transporter 1 | 473

KEGG Pathway

Gastric cancer 148 | 148
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Protein Wnt-6 WNT6 Tbio Non-IDG -1.65830 46.6 186
Fibroblast growth factor 19 FGF19 Tbio Non-IDG -2.54882 334.2 305
Homeobox protein CDX-2 CDX2 Tbio Transcription Factor -2.91273 837.0 699
Mucin-2 MUC2 Tbio Non-IDG -2.89417 752.2 0
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Cadherin-17 CDH17 Tbio Non-IDG -3.38219 2005.5 312
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492