Development Level

Tbio 33 | 11,651
Tchem 31 | 1,388
Tclin 25 | 612
Tdark 1 | 6,593

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
increased startle reflex 5 | 112
preweaning lethality, incomple... 5 | 499
abnormal bone structure 4 | 187
increased heart weight 4 | 62
abnormal behavior 3 | 298
decreased total body fat amoun... 3 | 207
abnormal gait 2 | 69
decreased body weight 2 | 161
enlarged heart 2 | 210
short tibia 2 | 97
abnormal duodenum morphology 1 | 4
abnormal embryo size 1 | 220
abnormal femur morphology 1 | 14
abnormal gallbladder morpholog... 1 | 1
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
cataract 1 | 92
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating phosphat... 1 | 27
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
embryonic lethality prior to t... 1 | 278
enlarged gallbladder 1 | 2
enlarged spleen 1 | 41
hydrometra 1 | 53
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased bone mineral content 1 | 108
increased circulating calcium ... 1 | 34
increased circulating glucose ... 1 | 24
increased fasted circulating g... 1 | 76
increased lean body mass 1 | 172
increased or absent threshold ... 1 | 101
increased total body fat amoun... 1 | 134
male infertility 1 | 123
prenatal lethality 1 | 28
small epididymis 1 | 3
small superior vagus ganglion 1 | 74
vertebral fusion 1 | 23

Disease

Carcinoma 78 | 11,493
ovarian cancer 57 | 8,519
glioblastoma 46 | 5,792
psoriasis 45 | 6,694
osteosarcoma 44 | 7,950
atypical teratoid / rhabdoid tumor 43 | 5,112
medulloblastoma, large-cell 43 | 6,241
lung cancer 39 | 4,740
Kidney cancer 37 | 2,613
ependymoma 37 | 4,679
Breast cancer 34 | 3,577
group 3 medulloblastoma 33 | 4,104
Cancer 32 | 2,499
adult high grade glioma 32 | 3,801
primitive neuroectodermal tumor 31 | 3,035
oligodendroglioma 30 | 2,850
pancreatic cancer 29 | 2,398
Astrocytoma, Pilocytic 28 | 3,081
astrocytic glioma 28 | 2,597
malignant mesothelioma 27 | 3,232
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,988
non-small cell lung cancer 25 | 2,890
lung carcinoma 24 | 2,843
lung adenocarcinoma 22 | 2,716
Schizophrenia 21 | 1,160
colon cancer 21 | 1,478
invasive ductal carcinoma 21 | 2,950
intraductal papillary-mucinous adenoma (IPMA) 20 | 2,954
intraductal papillary-mucinous neoplasm (IPMN) 20 | 3,290
Pick disease 19 | 1,894
interstitial cystitis 19 | 2,312
Depressive disorder 18 | 409
breast carcinoma 18 | 1,637
ulcerative colitis 18 | 1,819
Epilepsy 17 | 792
pituitary cancer 16 | 1,972
subependymal giant cell astrocytoma 16 | 2,287
tuberculosis 16 | 2,010
Intellectual disability 15 | 1,016
Melanoma 15 | 711
group 4 medulloblastoma 15 | 1,855
Autosomal recessive predisposition 14 | 1,442
Major Depressive Disorder 14 | 301
Seizures 14 | 596
Unipolar Depression 14 | 250
Bipolar Disorder 13 | 666
Hypertensive disorder 13 | 57
Muscle hypotonia 13 | 571
Neuroblastoma 13 | 80
Obesity 13 | 678
Short stature 13 | 531
diabetes mellitus 13 | 1,728
juvenile dermatomyositis 13 | 1,187
Cognitive delay 12 | 608
Global developmental delay 12 | 608
Mental and motor retardation 12 | 608
Rhabdomyosarcoma 12 | 39
primary pancreatic ductal adenocarcinoma 12 | 1,108
Blepharoptosis 11 | 231
Breast Neoplasms 11 | 445
Dull intelligence 11 | 645
Dysarthria 11 | 192
Liver cancer 11 | 604
Low intelligence 11 | 645
Mammary Neoplasms 11 | 425
Mental Depression 11 | 333
Mental Retardation 11 | 645
Mental deficiency 11 | 645
Poor school performance 11 | 645
Skin cancer 11 | 469
Stomach Neoplasms 11 | 300
Substance Withdrawal Syndrome 11 | 55
astrocytoma 11 | 1,146
Downward slant of palpebral fissure 10 | 158
Duchenne muscular dystrophy 10 | 601
HER2-positive carcinoma of breast 10 | 21
Hyperreflexia 10 | 209
Hypertensive disease 10 | 292
Ocular hypertension 10 | 42
Open-angle glaucoma 10 | 27
Parkinson's disease 10 | 392
Strabismus 10 | 270
cystic fibrosis 10 | 1,695
dermatomyositis 10 | 966
gastric carcinoma 10 | 807
Adenoma 9 | 167
Alcoholic Intoxication, Chronic 9 | 289
Attention deficit hyperactivity disorder 9 | 278
Kidney disease 9 | 430
Liposarcoma 9 | 20
Liver Cirrhosis, Experimental 9 | 769
Malignant tumor of ovary 9 | 25
Multiple myeloma 9 | 1,332
Nephroblastoma 9 | 51
Rheumatoid arthritis 9 | 1,191
Secondary malignant neoplasm of pancreas 9 | 10
acute quadriplegic myopathy 9 | 1,158
autosomal dominant Emery-Dreifuss muscular dystrophy 9 | 510
pancreatic ductal adenocarcinoma liver metastasis 9 | 1,962
transitional cell carcinoma 9 | 22

Tissue

Endocrine System 86 | 18,159
Female tissues 86 | 17,400
Nervous System 85 | 16,725
Male tissues 84 | 17,142
Liver and Pancreas 82 | 16,750
Skin and soft tissues 82 | 17,230
Urinary Tract 82 | 16,678
Cardiovascular System 81 | 15,192
Digestive Tract 81 | 17,369
Blood and immune system 80 | 16,909
Respiratory system 79 | 16,393

Target Family

Non-IDG 37 | 12,091
Kinase 22 | 634
Enzyme 19 | 4,145
GPCR 9 | 408
Ion Channel 3 | 344

KEGG Pathway

Gap junction 90 | 90
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Neuroendocrine secretory protein 55 GNAS Tbio Non-IDG -2.63356 1389.7 509
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 PLCB1 Tbio Enzyme -2.50444 332.8 190
Mitogen-activated protein kinase 7 MAPK7 Tbio Kinase -2.48754 340.0 422
Platelet-derived growth factor C PDGFC Tbio Non-IDG -2.03910 120.6 226
Tubulin alpha-3C/D chain TUBA3C Tchem Non-IDG -1.55574 5.76 132
5-hydroxytryptamine receptor 2C HTR2C Tclin GPCR -3.08158 1199.3 336
Tubulin beta-3 chain TUBB3 Tclin Non-IDG -2.08746 87.9 594
cAMP-dependent protein kinase catalytic subunit alpha PRKACA Tchem Kinase -1.09531 11.7 331
Pro-epidermal growth factor EGF Tbio Non-IDG -3.75933 4903.2 978
Guanine nucleotide-binding protein G(i) subunit alpha-1 GNAI1 Tbio Non-IDG -0.63224 3.23 220