Development Level

Tbio 62 | 11,445
Tchem 56 | 1,598
Tclin 12 | 613

IMPC Phenotype

preweaning lethality, complete... 11 | 979
preweaning lethality, incomple... 6 | 499
decreased body weight 3 | 161
enlarged heart 3 | 210
enlarged spleen 3 | 41
abnormal heart morphology 2 | 162
abnormal lens morphology 2 | 81
abnormal spleen morphology 2 | 55
abnormal testis morphology 2 | 43
cataract 2 | 92
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased erythrocyte cell num... 2 | 62
decreased leukocyte cell numbe... 2 | 73
decreased mean platelet volume 2 | 25
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
impaired glucose tolerance 2 | 75
increased circulating alkaline... 2 | 122
increased mean corpuscular hem... 2 | 96
increased mean platelet volume 2 | 45
increased or absent threshold ... 2 | 101
male infertility 2 | 123
abnormal bone mineralization 1 | 38
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal heart left ventricle ... 1 | 16
abnormal lung morphology 1 | 26
abnormal response to new envir... 1 | 10
abnormal retina morphology 1 | 71
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal thymus morphology 1 | 7
anophthalmia 1 | 33
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased startle reflex 1 | 75
decreased vertical activity 1 | 208
edema 1 | 59
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged lymph nodes 1 | 37
enlarged thymus 1 | 5
female infertility 1 | 60
hypoactivity 1 | 132
increased circulating LDL chol... 1 | 13
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased glycosylated hemoglo... 1 | 1
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased lean body mass 1 | 172
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
prenatal lethality 1 | 28
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
urinary bladder obstruction 1 | 4

Disease

Carcinoma 95 | 11,493
Cancer 92 | 2,499
ovarian cancer 85 | 8,520
psoriasis 74 | 6,694
osteosarcoma 73 | 7,950
glioblastoma 67 | 5,792
lung cancer 65 | 4,740
medulloblastoma, large-cell 62 | 6,241
atypical teratoid / rhabdoid tumor 55 | 5,112
Breast cancer 53 | 3,578
ependymoma 46 | 4,679
adult high grade glioma 42 | 3,801
group 3 medulloblastoma 41 | 4,104
diabetes mellitus 39 | 1,728
malignant mesothelioma 39 | 3,232
Astrocytoma, Pilocytic 34 | 3,081
Kidney cancer 34 | 2,613
invasive ductal carcinoma 34 | 2,951
oligodendroglioma 33 | 2,850
pancreatic cancer 32 | 2,398
intraductal papillary-mucinous neoplasm (IPMN) 31 | 3,291
primitive neuroectodermal tumor 31 | 3,035
subependymal giant cell astrocytoma 31 | 2,287
astrocytic glioma 30 | 2,597
Prostatic Neoplasms 29 | 495
Schizophrenia 29 | 1,160
intraductal papillary-mucinous adenoma (IPMA) 29 | 2,955
Obesity 27 | 678
Autosomal recessive predisposition 26 | 1,442
adrenocortical carcinoma 26 | 1,428
breast carcinoma 26 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 25 | 2,989
pituitary cancer 25 | 1,972
Breast Neoplasms 24 | 445
Mammary Neoplasms 24 | 425
Stomach Neoplasms 24 | 300
ductal carcinoma in situ 24 | 1,745
lung adenocarcinoma 24 | 2,716
non-small cell lung cancer 24 | 2,890
Seizures 23 | 596
Short stature 23 | 531
juvenile dermatomyositis 23 | 1,187
Epilepsy 22 | 792
Orbital separation excessive 22 | 244
interstitial cystitis 22 | 2,312
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,962
tuberculosis 22 | 2,010
Byzanthine arch palate 21 | 194
Hyperglycemia 21 | 137
Vascular disease 21 | 319
acute quadriplegic myopathy 21 | 1,158
Acquired scoliosis 20 | 281
Curvature of spine 20 | 282
Dull intelligence 20 | 645
Intellectual disability 20 | 1,016
Liver carcinoma 20 | 240
Low intelligence 20 | 645
Lung Neoplasms 20 | 232
Mental Retardation 20 | 645
Mental deficiency 20 | 645
Poor school performance 20 | 645
Rheumatoid arthritis 20 | 1,191
lung carcinoma 20 | 2,843
ulcerative colitis 20 | 1,819
Carcinoma, Hepatocellular 19 | 228
Liver Cirrhosis, Experimental 19 | 769
Melanoma 19 | 711
Multiple myeloma 19 | 1,332
dermatomyositis 19 | 966
group 4 medulloblastoma 19 | 1,855
Cognitive delay 18 | 608
Global developmental delay 18 | 608
Hypoplastic mandible condyle 18 | 275
Mandibular hypoplasia 18 | 275
Mental and motor retardation 18 | 608
Micrognathism 18 | 275
Squamous cell carcinoma 18 | 129
Alzheimer's disease 17 | 658
Arthritis 17 | 290
Neoplasm Metastasis 17 | 168
cystic fibrosis 17 | 1,696
Bipolar Disorder 16 | 666
Blepharoptosis 16 | 231
Carcinoma, Squamous Cell 16 | 110
Downward slant of palpebral fissure 16 | 158
Endometriosis 16 | 540
Hypertensive disease 16 | 292
Kidney disease 16 | 430
Muscle hypotonia 16 | 571
Ovarian Neoplasms 16 | 102
astrocytoma 16 | 1,146
primary pancreatic ductal adenocarcinoma 16 | 1,109
Depressed nasal bridge 15 | 195
Failure to gain weight 15 | 365
Pectus excavatum 15 | 100
Pediatric failure to thrive 15 | 365
Pick disease 15 | 1,894
Waldenstrons macroglobulinemia 15 | 765
colon cancer 15 | 1,478
hepatocellular carcinoma 15 | 547

Tissue

Endocrine System 130 | 18,159
Digestive Tract 128 | 17,369
Female tissues 127 | 17,400
Male tissues 127 | 17,142
Nervous System 127 | 16,725
Blood and immune system 126 | 16,909
Liver and Pancreas 126 | 16,750
Skin and soft tissues 126 | 17,230
Urinary Tract 126 | 16,678
Cardiovascular System 125 | 15,192
Respiratory system 122 | 16,393

Target Family

Kinase 48 | 634
Non-IDG 39 | 12,091
Enzyme 22 | 4,145
Transcription Factor 11 | 1,400
Epigenetic 6 | 242
GPCR 3 | 408
Transporter 1 | 473

KEGG Pathway

FoxO signaling pathway 130 | 130
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Krueppel-like factor 2 KLF2 Tbio Transcription Factor -2.30630 216.2 308
Glucose-6-phosphatase 3 G6PC3 Tbio Enzyme -1.55249 37.2 54
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Forkhead box protein O6 FOXO6 Tbio Transcription Factor -1.13890 17.2 38
Histone-lysine N-methyltransferase SETD7 SETD7 Tchem Epigenetic -2.13644 139.8 343
Forkhead box protein O1 FOXO1 Tbio Transcription Factor -3.05358 1143.3 1478
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864