Development Level

Tbio 10 | 10,625
Tchem 5 | 1,890
Tclin 1 | 602

IMPC Term

preweaning lethality, complete... 3 | 633
decreased circulating lipase l... 2 | 2
decreased threshold for audito... 2 | 32
decreased body weight 1 | 174
embryonic lethality prior to o... 1 | 148
embryonic lethality prior to t... 1 | 187

Disease

malignant mesothelioma 7 | 3,162
medulloblastoma, large-cell 7 | 6,234
ovarian cancer 7 | 8,484
lung cancer 6 | 4,466
osteosarcoma 6 | 7,933
glioblastoma 5 | 5,572
non-small cell lung cancer 5 | 2,798
pancreatic ductal adenocarcinoma liver metastasis 5 | 1,795
psoriasis 5 | 6,685
Phenylketonuria 4 | 18
Rheumatoid Arthritis 4 | 1,160
invasive ductal carcinoma 4 | 2,950
lung carcinoma 4 | 2,844
oligodendroglioma 4 | 2,849
Cancer 3 | 2,346
Colorectal Neoplasms 3 | 217
Combined molybdoflavoprotein enzyme deficiency 3 | 3
atypical teratoid / rhabdoid tumor 3 | 4,369
atypical teratoid/rhabdoid tumor 3 | 1,095
ductal carcinoma in situ 3 | 1,745
group 3 medulloblastoma 3 | 2,254
group 4 medulloblastoma 3 | 1,875
pediatric high grade glioma 3 | 2,712
posterior fossa group A ependymoma 3 | 1,511
primitive neuroectodermal tumor 3 | 3,031
sarcoidosis 3 | 358
tuberculosis 3 | 1,557
Breast cancer 2 | 3,094
Drug-Induced Liver Injury 2 | 118
Dystonia 2 | 77
Enamel caries 2 | 8
Endometriosis 2 | 535
Hypophosphatasia 2 | 10
Intellectual disability 2 | 573
Multiple myeloma 2 | 1,327
Obstructive jaundice 2 | 5
Pick disease 2 | 1,893
Spontaneous abortion 2 | 108
Tick infestation 2 | 16
active Crohn's disease 2 | 918
adrenocortical carcinoma 2 | 1,427
adult high grade glioma 2 | 2,148
astrocytic glioma 2 | 2,241
breast carcinoma 2 | 1,614
cystic fibrosis 2 | 1,665
ependymoma 2 | 2,514
hereditary spastic paraplegia 2 | 313
intraductal papillary-mucinous adenoma (IPMA) 2 | 2,956
intraductal papillary-mucinous carcinoma (IPMC) 2 | 2,988
intraductal papillary-mucinous neoplasm (IPMN) 2 | 3,289
lung adenocarcinoma 2 | 2,713
subependymal giant cell astrocytoma 2 | 2,287
tuberculosis and treatment for 6 months 2 | 686
ulcerative colitis 2 | 2,087
Acute lymphoid leukemia 1 | 25
Adverse reaction to drug 1 | 54
Alcoholic Intoxication, Chronic 1 | 41
Alopecia 1 | 55
Anemia 1 | 252
Anemia, Megaloblastic 1 | 4
Bipolar Disorder 1 | 266
Breast fibroadenoma 1 | 8
Burkitt's lymphoma 1 | 15
Calcinosis 1 | 62
Carcinoma of female breast 1 | 20
Cerebral palsy 1 | 28
Constipation 1 | 43
Dentin caries 1 | 4
Diarrhea 1 | 155
Essential tremor 1 | 30
Exanthem 1 | 39
Female infertility 1 | 28
Gestational trophoblastic neoplasia 1 | 14
Hypercalcemia 1 | 37
Hyperphosphatemia 1 | 32
Hypokalemic periodic paralysis 1 | 13
Juvenile rheumatoid arthritis 1 | 104
Lennox-Gastaut syndrome 1 | 34
Liver disease 1 | 219
Liver diseases 1 | 66
Lymphoma, Non-Hodgkin 1 | 22
Malignant tumor of head and/or neck 1 | 15
Mammary Neoplasms 1 | 410
Muscle Rigidity 1 | 5
Mycosis fungoides 1 | 28
Neoplasm Metastasis 1 | 138
Neutropenia 1 | 78
Non-Hodgkin's lymphoma 1 | 22
Osteomalacia 1 | 28
Pain 1 | 70
Parkinson Disease 1 | 102
Rickets 1 | 42
Seminoma 1 | 15
Thrombocytopenia 1 | 105
Tropical sprue 1 | 5
West Syndrome 1 | 23
Wilson disease 1 | 16
active ulcerative colitis 1 | 477
axial spondyloarthropathy 1 | 28
nervous system disorder 1 | 53

Tissue

Digestive Tract 16 | 18,473
Endocrine System 16 | 18,512
Female tissues 16 | 18,647
Liver and Pancreas 16 | 18,136
Nervous System 16 | 18,561
Urinary Tract 16 | 18,444
Male tissues 15 | 17,969
Skin and soft tissues 15 | 18,115
Blood and immune system 14 | 17,995
Respiratory system 14 | 17,484
Cardiovascular System 13 | 17,958

Target Family

Enzyme 14 | 4,146
Non-IDG 2 | 11,971

KEGG Pathway

Folate biosynthesis 16 | 16
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Endocytosis 326 | 326
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Dihydrofolate reductase DHFR Tclin Enzyme -2.97865 960.4 158
Sepiapterin reductase SPR Tbio Enzyme -1.56627 35.3 146
Molybdenum cofactor biosynthesis protein 1 MOCS1 Tbio Non-IDG -1.29163 19.8 117
GTP cyclohydrolase 1 GCH1 Tbio Enzyme -2.76548 613.4 202
Dihydrofolate reductase, mitochondrial DHFR2 Tbio Enzyme -0.37414 2.93 69
Alkaline phosphatase, placental-like ALPPL2 Tchem Enzyme -1.66487 48.0 137
Molybdopterin synthase sulfur carrier subunit MOCS2 Tbio Enzyme -2.27866 193.7 72
Molybdopterin synthase catalytic subunit MOCS2 Tbio Enzyme 193.7 72
Intestinal-type alkaline phosphatase ALPI Tbio Enzyme -2.28789 191.7 276
Gamma-glutamyl hydrolase GGH Tchem Enzyme -2.40280 256.1 190