Development Level

Tbio 116 | 11,445
Tchem 51 | 1,598
Tclin 28 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 3 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 14 | 979
preweaning lethality, incomple... 6 | 499
decreased circulating choleste... 4 | 93
enlarged heart 4 | 210
increased circulating triglyce... 4 | 42
abnormal behavior 3 | 298
abnormal bone mineralization 3 | 38
abnormal embryo size 3 | 220
abnormal femur morphology 3 | 14
abnormal retina morphology 3 | 71
decreased body weight 3 | 161
decreased circulating glucose ... 3 | 126
impaired glucose tolerance 3 | 75
increased bone mineral density 3 | 72
increased circulating alkaline... 3 | 122
persistence of hyaloid vascula... 3 | 33
short tibia 3 | 97
abnormal lens morphology 2 | 81
abnormal skin morphology 2 | 50
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased circulating serum al... 2 | 82
decreased circulating total pr... 2 | 49
decreased hematocrit 2 | 46
decreased mean corpuscular vol... 2 | 79
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
edema 2 | 59
embryonic growth retardation 2 | 106
embryonic lethality prior to o... 2 | 239
embryonic lethality prior to t... 2 | 278
increased blood urea nitrogen ... 2 | 48
increased bone mineral content 2 | 108
increased circulating choleste... 2 | 66
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased neutrophil cell numb... 2 | 46
increased startle reflex 2 | 112
increased total body fat amoun... 2 | 134
abnormal behavioral response t... 1 | 66
abnormal coat appearance 1 | 31
abnormal coat-hair pigmentatio... 1 | 64
abnormal cranium morphology 1 | 36
abnormal ear morphology 1 | 9
abnormal eye morphology 1 | 68
abnormal head morphology 1 | 10
abnormal joint morphology 1 | 23
abnormal liver morphology 1 | 17
abnormal lung morphology 1 | 26
abnormal pelvic girdle bone mo... 1 | 12
abnormal seminal vesicle morph... 1 | 114
abnormal startle reflex 1 | 15
abnormal tooth morphology 1 | 24
cataract 1 | 92
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating fructosa... 1 | 30
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased red blood cell distr... 1 | 41
decreased spleen weight 1 | 10
decreased vertical activity 1 | 208
dilated heart left ventricle 1 | 11
enlarged spleen 1 | 41
hemorrhage 1 | 23
hyperactivity 1 | 148
increased body weight 1 | 25
increased circulating HDL chol... 1 | 80
increased circulating amylase ... 1 | 25
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased circulating sodium l... 1 | 71
increased fasted circulating g... 1 | 76
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased spleen weight 1 | 10
pallor 1 | 34
prenatal lethality prior to he... 1 | 87
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39
unresponsive to tactile stimul... 1 | 8

Disease

Carcinoma 164 | 11,493
ovarian cancer 133 | 8,520
glioblastoma 112 | 5,792
Cancer 103 | 2,499
osteosarcoma 103 | 7,950
psoriasis 94 | 6,694
Breast cancer 90 | 3,578
lung cancer 89 | 4,740
medulloblastoma, large-cell 87 | 6,241
atypical teratoid / rhabdoid tumor 86 | 5,112
Kidney cancer 80 | 2,613
ependymoma 75 | 4,679
invasive ductal carcinoma 70 | 2,951
pancreatic cancer 69 | 2,398
Astrocytoma, Pilocytic 67 | 3,081
malignant mesothelioma 66 | 3,232
adult high grade glioma 65 | 3,801
intraductal papillary-mucinous neoplasm (IPMN) 62 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 61 | 2,989
lung carcinoma 59 | 2,843
intraductal papillary-mucinous adenoma (IPMA) 56 | 2,955
non-small cell lung cancer 56 | 2,890
lung adenocarcinoma 54 | 2,716
oligodendroglioma 52 | 2,850
interstitial cystitis 51 | 2,312
primitive neuroectodermal tumor 48 | 3,035
cystic fibrosis 47 | 1,696
group 3 medulloblastoma 47 | 4,104
Autosomal recessive predisposition 45 | 1,442
breast carcinoma 42 | 1,638
tuberculosis 42 | 2,010
group 4 medulloblastoma 41 | 1,855
colon cancer 39 | 1,478
diabetes mellitus 39 | 1,728
ductal carcinoma in situ 38 | 1,745
pituitary cancer 38 | 1,972
subependymal giant cell astrocytoma 38 | 2,287
astrocytic glioma 37 | 2,597
Schizophrenia 36 | 1,160
juvenile dermatomyositis 36 | 1,187
ulcerative colitis 36 | 1,819
pancreatic ductal adenocarcinoma liver metastasis 34 | 1,962
primary pancreatic ductal adenocarcinoma 34 | 1,109
Breast Neoplasms 31 | 445
Liver cancer 30 | 604
Mammary Neoplasms 30 | 425
gastric carcinoma 30 | 807
Duchenne muscular dystrophy 29 | 601
Liver Cirrhosis, Experimental 29 | 769
autosomal dominant Emery-Dreifuss muscular dystrophy 28 | 510
Intellectual disability 27 | 1,016
Melanoma 27 | 711
acute quadriplegic myopathy 27 | 1,158
Kidney disease 26 | 430
Short stature 26 | 531
Skin cancer 26 | 469
adrenocortical carcinoma 26 | 1,428
astrocytoma 25 | 1,146
Epilepsy 24 | 792
Pick disease 24 | 1,894
Prostatic Neoplasms 24 | 495
dermatomyositis 24 | 966
nasopharyngeal carcinoma 24 | 1,058
Rheumatoid arthritis 23 | 1,191
Acquired scoliosis 22 | 281
Curvature of spine 22 | 282
Dull intelligence 22 | 645
Low intelligence 22 | 645
Mental Retardation 22 | 645
Mental deficiency 22 | 645
Muscle hypotonia 22 | 571
Poor school performance 22 | 645
Vascular disease 22 | 319
Heart disease 21 | 306
Myopia 21 | 176
Neoplasm Invasiveness 21 | 161
Neoplasm Metastasis 21 | 168
Renal Cell Carcinoma 21 | 214
Seizures 21 | 596
Stomach Neoplasms 21 | 300
Hypertension 20 | 396
Hypoplastic mandible condyle 20 | 275
Mandibular hypoplasia 20 | 275
Micrognathism 20 | 275
spina bifida 20 | 1,074
fibroadenoma 19 | 559
pediatric high grade glioma 19 | 1,064
Lung Neoplasms 18 | 232
Orbital separation excessive 18 | 244
interstitial lung disease 18 | 298
Alzheimer's disease 17 | 658
Failure to gain weight 17 | 365
Joint hyperflexibility 17 | 78
Multiple myeloma 17 | 1,332
Pediatric failure to thrive 17 | 365
cutaneous lupus erythematosus 17 | 1,057
esophageal adenocarcinoma 17 | 737
Cognitive delay 16 | 608
Global developmental delay 16 | 608
Mental and motor retardation 16 | 608

Tissue

Digestive Tract 197 | 17,369
Endocrine System 197 | 18,159
Female tissues 197 | 17,400
Skin and soft tissues 197 | 17,230
Liver and Pancreas 196 | 16,750
Male tissues 196 | 17,142
Blood and immune system 195 | 16,909
Nervous System 193 | 16,725
Urinary Tract 193 | 16,678
Respiratory system 190 | 16,393
Cardiovascular System 188 | 15,192

Target Family

Non-IDG 128 | 12,091
Kinase 46 | 634
Enzyme 21 | 4,145
Transcription Factor 3 | 1,400

KEGG Pathway

Focal adhesion 198 | 198
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Integrin alpha-11 ITGA11 Tbio Non-IDG -1.13736 14.3 76
Talin-2 TLN2 Tbio Non-IDG -1.36153 20.0 101
Myosin regulatory light chain 2, atrial isoform MYL7 Tbio Non-IDG -0.85198 5.20 169
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Reelin RELN Tbio Non-IDG -2.78255 645.2 121
Fibronectin FN1 Tchem Non-IDG -3.09873 1208.8 1583
Collagen alpha-1(VI) chain COL6A1 Tbio Non-IDG -2.03348 104.7 204
Collagen alpha-2(VI) chain COL6A2 Tbio Non-IDG -1.80531 59.2 151
Ras-related protein Rap-1b RAP1B Tbio Enzyme -2.38904 417.6 114