Development Level

Tchem 64 | 1,598
Tbio 55 | 11,445
Tclin 16 | 613
Tdark 3 | 6,588

IMPC Phenotype

preweaning lethality, incomple... 6 | 499
embryonic lethality prior to t... 5 | 278
preweaning lethality, complete... 5 | 979
abnormal heart morphology 3 | 162
decreased blood urea nitrogen ... 3 | 51
decreased body weight 3 | 161
decreased circulating creatini... 3 | 39
embryonic lethality prior to o... 3 | 239
enlarged heart 3 | 210
increased circulating alkaline... 3 | 122
abnormal behavior 2 | 298
abnormal bone mineralization 2 | 38
abnormal coat-hair pigmentatio... 2 | 64
abnormal embryo size 2 | 220
abnormal eye morphology 2 | 68
abnormal lens morphology 2 | 81
abnormal seminal vesicle morph... 2 | 114
cataract 2 | 92
decreased circulating amylase ... 2 | 28
decreased circulating triglyce... 2 | 79
decreased lymphocyte cell numb... 2 | 83
decreased total body fat amoun... 2 | 207
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased monocyte cell number 2 | 63
increased neutrophil cell numb... 2 | 46
increased total body fat amoun... 2 | 134
pale yolk sac 2 | 25
pallor 2 | 34
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal craniofacial morpholo... 1 | 33
abnormal femur morphology 1 | 14
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal lung morphology 1 | 26
abnormal skin condition 1 | 6
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
abnormal vibrissa morphology 1 | 25
anophthalmia 1 | 33
decreased circulating LDL chol... 1 | 38
decreased circulating alanine ... 1 | 47
decreased circulating aspartat... 1 | 34
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating insulin ... 1 | 76
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased fasted circulating g... 1 | 65
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased red blood cell distr... 1 | 41
decreased startle reflex 1 | 75
decreased thermal nociceptive ... 1 | 2
decreased vertical activity 1 | 208
embryonic growth retardation 1 | 106
enlarged spleen 1 | 41
impaired righting response 1 | 26
increased basophil cell number 1 | 7
increased body length 1 | 32
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating alanine ... 1 | 13
increased circulating aspartat... 1 | 15
increased circulating choleste... 1 | 66
increased circulating free fat... 1 | 20
increased circulating iron lev... 1 | 30
increased circulating triglyce... 1 | 42
increased eosinophil cell numb... 1 | 11
increased grip strength 1 | 41
increased heart weight 1 | 62
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased mean platelet volume 1 | 45
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
increased thermal nociceptive ... 1 | 9
male infertility 1 | 123
mammalian phenotype 1 | 17
microphthalmia 1 | 26
mydriasis 1 | 6
persistence of hyaloid vascula... 1 | 33
prenatal lethality prior to he... 1 | 87
prolonged PR interval 1 | 15
short tibia 1 | 97
small testis 1 | 58
stereotypic behavior 1 | 3
thrombocytosis 1 | 27
trunk curl 1 | 16

Disease

Cancer 94 | 2,499
Carcinoma 85 | 11,493
ovarian cancer 83 | 8,520
psoriasis 77 | 6,694
glioblastoma 72 | 5,792
osteosarcoma 65 | 7,950
lung cancer 61 | 4,740
Breast cancer 53 | 3,578
medulloblastoma, large-cell 52 | 6,241
diabetes mellitus 51 | 1,728
atypical teratoid / rhabdoid tumor 46 | 5,112
ependymoma 44 | 4,679
malignant mesothelioma 44 | 3,232
Schizophrenia 41 | 1,160
adult high grade glioma 41 | 3,801
pancreatic cancer 40 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 38 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 38 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 38 | 3,291
Hypertension 37 | 396
non-small cell lung cancer 37 | 2,890
lung carcinoma 36 | 2,843
ulcerative colitis 36 | 1,819
Astrocytoma, Pilocytic 34 | 3,081
Kidney disease 34 | 430
invasive ductal carcinoma 34 | 2,951
lung adenocarcinoma 33 | 2,716
interstitial cystitis 32 | 2,312
Heart disease 31 | 306
tuberculosis 31 | 2,010
group 3 medulloblastoma 30 | 4,104
cystic fibrosis 29 | 1,696
Breast Neoplasms 28 | 445
Mammary Neoplasms 28 | 425
Prostatic Neoplasms 28 | 495
Rheumatoid arthritis 28 | 1,191
subependymal giant cell astrocytoma 27 | 2,287
Atherosclerosis 26 | 291
group 4 medulloblastoma 26 | 1,855
oligodendroglioma 26 | 2,850
Liver Cirrhosis, Experimental 25 | 769
Arthritis 24 | 290
Vascular disease 24 | 319
primitive neuroectodermal tumor 24 | 3,035
Asthma 23 | 385
Hypertensive disease 23 | 292
Lung disease 23 | 142
Alzheimer's disease 22 | 658
Cerebrovascular disease 22 | 238
Kidney cancer 22 | 2,613
cutaneous lupus erythematosus 22 | 1,057
pituitary cancer 22 | 1,972
breast carcinoma 21 | 1,638
nasopharyngeal carcinoma 21 | 1,058
Coronary artery disease 20 | 268
Diabetes Mellitus, Experimental 20 | 108
colon cancer 20 | 1,478
pancreatic ductal adenocarcinoma liver metastasis 20 | 1,962
Autosomal recessive predisposition 19 | 1,442
Endometriosis 19 | 540
Lung Neoplasms 19 | 232
Obesity 19 | 678
adrenocortical carcinoma 19 | 1,428
astrocytic glioma 19 | 2,597
primary pancreatic ductal adenocarcinoma 19 | 1,109
Chemical and Drug Induced Liver Injury 18 | 195
Depressive disorder 18 | 409
Myocardial Ischemia 18 | 169
Reperfusion Injury 18 | 86
acute quadriplegic myopathy 18 | 1,158
ductal carcinoma in situ 18 | 1,745
pancreatic carcinoma 18 | 562
Multiple myeloma 17 | 1,332
Stomach Neoplasms 17 | 300
juvenile dermatomyositis 17 | 1,187
Bipolar Disorder 16 | 666
Brain Ischemia 16 | 110
Carcinoma, Hepatocellular 16 | 228
Colonic Neoplasms 16 | 142
Epilepsy 16 | 792
Hyperglycemia 16 | 137
Inflammatory bowel disease 16 | 151
Liver carcinoma 16 | 240
Liver disease 16 | 237
Waldenstrons macroglobulinemia 16 | 765
dermatomyositis 16 | 966
periodontitis 15 | 293
Colorectal Neoplasms 14 | 243
Heart failure 14 | 162
Hypersensitivity reaction type II disease 14 | 253
Intellectual disability 14 | 1,016
Mental Depression 14 | 333
Multiple Sclerosis 14 | 540
Neoplasm Invasiveness 14 | 161
Parkinson's disease 14 | 392
Toxic encephalopathy 14 | 141
astrocytoma 14 | 1,146
Diabetes Mellitus, Non-Insulin-Dependent 13 | 145
autosomal dominant Emery-Dreifuss muscular dystrophy 13 | 510
spina bifida 13 | 1,074

Tissue

Endocrine System 134 | 18,159
Blood and immune system 133 | 16,909
Digestive Tract 133 | 17,369
Female tissues 133 | 17,400
Male tissues 133 | 17,142
Skin and soft tissues 133 | 17,230
Respiratory system 132 | 16,393
Liver and Pancreas 131 | 16,750
Urinary Tract 130 | 16,678
Nervous System 129 | 16,725
Cardiovascular System 124 | 15,192

Target Family

Non-IDG 56 | 12,091
Kinase 36 | 634
Enzyme 35 | 4,145
Transcription Factor 10 | 1,400
Ion Channel 1 | 344

KEGG Pathway

Fluid shear stress and atheros... 138 | 138
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Krueppel-like factor 2 KLF2 Tbio Transcription Factor -2.30630 216.2 308
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Transient receptor potential cation channel subfamily V member 4 TRPV4 Tchem Ion Channel -2.86016 747.3 258
Dual specificity protein phosphatase 1 DUSP1 Tchem Enzyme -2.88260 810.9 388
Glutathione S-transferase theta-2 GSTT2 Tbio Enzyme -1.25193 16.8 0
Actin, cytoplasmic 2 ACTG1 Tbio Non-IDG -2.50312 297.3 225
NAD(P)H dehydrogenase [quinone] 1 NQO1 Tchem Enzyme -3.12097 1326.4 550
Bone morphogenetic protein receptor type-2 BMPR2 Tchem Kinase -2.66587 458.1 390
Calmodulin-like protein 5 CALML5 Tbio Non-IDG -1.32968 24.4 111
C-C motif chemokine 2 CCL2 Tchem Non-IDG -3.84820 7088.3 1260