Development Level

Tbio 31 | 11,445
Tchem 10 | 1,598

IMPC Phenotype

preweaning lethality, complete... 4 | 979
embryonic lethality prior to t... 3 | 278
preweaning lethality, incomple... 3 | 499
abnormal bone structure 2 | 187
decreased bone mineral content 2 | 151
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
hydrometra 2 | 53
abnormal behavior 1 | 298
abnormal heart morphology 1 | 162
abnormal lens morphology 1 | 81
abnormal optic disc morphology 1 | 10
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal tibia morphology 1 | 14
abnormal vitreous body morphol... 1 | 10
corneal opacity 1 | 32
decreased body length 1 | 101
decreased body weight 1 | 161
decreased circulating HDL chol... 1 | 68
decreased circulating choleste... 1 | 93
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased circulating triglyce... 1 | 79
decreased heart weight 1 | 27
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lean body mass 1 | 135
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased vertical activity 1 | 208
hyperactivity 1 | 148
increased circulating bilirubi... 1 | 16
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased heart weight 1 | 62
increased lean body mass 1 | 172
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
increased spleen weight 1 | 10
long tibia 1 | 25
small superior vagus ganglion 1 | 74
thrombocytopenia 1 | 56

Disease

Carcinoma 27 | 11,493
ovarian cancer 26 | 8,520
medulloblastoma, large-cell 21 | 6,241
lung cancer 20 | 4,740
osteosarcoma 19 | 7,950
Cancer 18 | 2,499
atypical teratoid / rhabdoid tumor 17 | 5,112
glioblastoma 17 | 5,792
psoriasis 16 | 6,694
pancreatic cancer 14 | 2,398
Breast cancer 13 | 3,578
ependymoma 13 | 4,679
lung carcinoma 13 | 2,843
non-small cell lung cancer 13 | 2,890
Anemia 12 | 365
Schizophrenia 11 | 1,160
cystic fibrosis 11 | 1,696
pancreatic ductal adenocarcinoma liver metastasis 11 | 1,962
tuberculosis 11 | 2,010
adult high grade glioma 10 | 3,801
group 3 medulloblastoma 10 | 4,104
interstitial cystitis 10 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
invasive ductal carcinoma 10 | 2,951
malignant mesothelioma 10 | 3,232
subependymal giant cell astrocytoma 10 | 2,287
Astrocytoma, Pilocytic 9 | 3,081
Autosomal recessive predisposition 9 | 1,442
intraductal papillary-mucinous carcinoma (IPMC) 9 | 2,989
ulcerative colitis 9 | 1,819
Neurodegenerative disease 8 | 414
Toxic encephalopathy 8 | 141
active Crohn's disease 8 | 922
intraductal papillary-mucinous adenoma (IPMA) 8 | 2,955
lung adenocarcinoma 8 | 2,716
pituitary cancer 8 | 1,972
primitive neuroectodermal tumor 8 | 3,035
Alzheimer's disease 7 | 658
Hemochromatosis 7 | 54
Multiple myeloma 7 | 1,332
Pick disease 7 | 1,894
Rheumatoid arthritis 7 | 1,191
Vascular disease 7 | 319
diabetes mellitus 7 | 1,728
ductal carcinoma in situ 7 | 1,745
Chemical and Drug Induced Liver Injury 6 | 195
Depressive disorder 6 | 409
Hypertension 6 | 396
Liver Cirrhosis, Experimental 6 | 769
Obesity 6 | 678
astrocytoma 6 | 1,146
colon cancer 6 | 1,478
hepatocellular carcinoma 6 | 547
primary pancreatic ductal adenocarcinoma 6 | 1,109
Aceruloplasminemia 5 | 16
Brain disease 5 | 96
Contact Dermatitis 5 | 81
Dermatitis, Contact 5 | 71
Duchenne muscular dystrophy 5 | 601
Hemoglobin low 5 | 124
Hyperferritinaemia 5 | 14
Hypertensive disease 5 | 292
Increased ferritin 5 | 14
Kidney disease 5 | 430
Lung Neoplasms 5 | 232
Serum ferritin increased 5 | 14
Waldenstrons macroglobulinemia 5 | 765
active ulcerative colitis 5 | 764
acute quadriplegic myopathy 5 | 1,158
gastric cancer 5 | 459
nasopharyngeal carcinoma 5 | 1,058
non primary Sjogren syndrome sicca 5 | 891
oligodendroglioma 5 | 2,850
Abnormality of metabolism/homeostasis 4 | 134
Atopic dermatitis 4 | 952
Cerebellar Ataxia 4 | 304
Chronic Lymphocytic Leukemia 4 | 262
Coronary artery disease 4 | 268
Dementia 4 | 175
Dysarthria 4 | 192
Endometriosis 4 | 540
Heart failure 4 | 162
Hepatomegaly 4 | 285
Kidney cancer 4 | 2,613
Liver neoplasms 4 | 130
Mammary Neoplasms 4 | 425
Neoplasm Invasiveness 4 | 161
Neoplasm Metastasis 4 | 168
Osteoarthritis 4 | 184
Prostatic Neoplasms 4 | 495
Psychotic Disorders 4 | 151
adrenocortical carcinoma 4 | 1,428
aldosterone-producing adenoma 4 | 665
astrocytic glioma 4 | 2,597
dermatomyositis 4 | 966
esophageal adenocarcinoma 4 | 737
juvenile dermatomyositis 4 | 1,187
mucosa-associated lymphoid tissue lymphoma 4 | 484
pancreatic carcinoma 4 | 562
progressive supranuclear palsy 4 | 676

Tissue

Endocrine System 40 | 18,159
Blood and immune system 39 | 16,909
Cardiovascular System 39 | 15,192
Digestive Tract 39 | 17,369
Female tissues 39 | 17,400
Liver and Pancreas 39 | 16,750
Male tissues 39 | 17,142
Nervous System 39 | 16,725
Respiratory system 39 | 16,393
Skin and soft tissues 39 | 17,230
Urinary Tract 39 | 16,678

Target Family

Non-IDG 18 | 12,091
Enzyme 15 | 4,145
Transporter 6 | 473
Ion Channel 1 | 344
Transcription Factor 1 | 1,400

KEGG Pathway

Ferroptosis 41 | 41
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Long-chain-fatty-acid--CoA ligase 5 ACSL5 Tbio Enzyme -1.98202 97.3 170
Serotransferrin TF Tbio Non-IDG -4.15070 13447.9 1168
Transferrin receptor protein 1 TFRC Tbio Non-IDG -3.43851 2558.3 1677
Ferritin light chain FTL Tbio Non-IDG -2.36162 227.3 549
Lysophospholipid acyltransferase 5 LPCAT3 Tbio Enzyme -2.21771 162.8 32
Cytochrome b-245 heavy chain CYBB Tchem Ion Channel -3.09698 1276.8 315
Alternative prion protein PRNP Tbio Non-IDG -3.45326 5611.1 0
Long-chain-fatty-acid--CoA ligase 6 ACSL6 Tbio Enzyme -1.86749 73.8 139
Glutathione synthetase GSS Tbio Enzyme -2.78139 592.8 229
Natural resistance-associated macrophage protein 2 SLC11A2 Tchem Transporter -2.53965 373.5 250