Development Level

Tbio 48 | 11,445
Tchem 31 | 1,598
Tclin 7 | 613
Tdark 3 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 10 | 979
decreased body weight 4 | 161
decreased circulating creatini... 3 | 39
embryonic lethality prior to t... 3 | 278
increased neutrophil cell numb... 3 | 46
increased total body fat amoun... 3 | 134
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal coat-hair pigmentatio... 2 | 64
abnormal digit morphology 2 | 10
abnormal retina morphology 2 | 71
decreased circulating choleste... 2 | 93
decreased circulating fructosa... 2 | 30
decreased circulating serum al... 2 | 82
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased total body fat amoun... 2 | 207
embryonic lethality prior to o... 2 | 239
increased blood urea nitrogen ... 2 | 48
increased circulating alkaline... 2 | 122
increased lean body mass 2 | 172
increased monocyte cell number 2 | 63
increased spleen weight 2 | 10
persistence of hyaloid vascula... 2 | 33
preweaning lethality, incomple... 2 | 499
abnormal coat appearance 1 | 31
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal embryo size 1 | 220
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal hair texture 1 | 4
abnormal lens morphology 1 | 81
abnormal locomotor activation 1 | 16
abnormal maxilla morphology 1 | 17
abnormal stomach morphology 1 | 10
cataract 1 | 92
corneal opacity 1 | 32
decreased IgG3 level 1 | 1
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating free fat... 1 | 31
decreased circulating iron lev... 1 | 32
decreased circulating total pr... 1 | 49
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased neutrophil cell numb... 1 | 42
decreased spleen weight 1 | 10
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged kidney 1 | 14
fused cornea and lens 1 | 5
fused phalanges 1 | 1
fusion of vertebral arches 1 | 7
impaired pupillary reflex 1 | 26
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating sodium l... 1 | 71
increased circulating triglyce... 1 | 42
increased erythrocyte cell num... 1 | 39
increased grip strength 1 | 41
increased hemoglobin content 1 | 45
increased leukocyte cell numbe... 1 | 47
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
increased red blood cell distr... 1 | 34
increased startle reflex 1 | 112
long tibia 1 | 25
male infertility 1 | 123
short tibia 1 | 97
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
thrombocytosis 1 | 27
vertebral fusion 1 | 23

Disease

Carcinoma 64 | 11,493
osteosarcoma 55 | 7,950
ovarian cancer 55 | 8,520
Cancer 46 | 2,499
psoriasis 42 | 6,694
glioblastoma 37 | 5,792
lung cancer 35 | 4,740
medulloblastoma, large-cell 34 | 6,241
intraductal papillary-mucinous neoplasm (IPMN) 29 | 3,291
ependymoma 28 | 4,679
intraductal papillary-mucinous adenoma (IPMA) 28 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
invasive ductal carcinoma 28 | 2,951
Breast cancer 25 | 3,578
atypical teratoid / rhabdoid tumor 25 | 5,112
group 3 medulloblastoma 23 | 4,104
lung carcinoma 23 | 2,843
subependymal giant cell astrocytoma 23 | 2,287
Astrocytoma, Pilocytic 22 | 3,081
interstitial cystitis 22 | 2,312
pancreatic cancer 22 | 2,398
tuberculosis 21 | 2,010
adult high grade glioma 20 | 3,801
Kidney cancer 19 | 2,613
colon cancer 18 | 1,478
oligodendroglioma 18 | 2,850
diabetes mellitus 17 | 1,728
malignant mesothelioma 17 | 3,232
non-small cell lung cancer 17 | 2,890
primitive neuroectodermal tumor 17 | 3,035
ulcerative colitis 17 | 1,819
Liver Cirrhosis, Experimental 16 | 769
breast carcinoma 16 | 1,638
cystic fibrosis 16 | 1,696
ductal carcinoma in situ 16 | 1,745
lung adenocarcinoma 16 | 2,716
Waldenstrons macroglobulinemia 15 | 765
astrocytic glioma 15 | 2,597
Rheumatoid arthritis 14 | 1,191
juvenile dermatomyositis 14 | 1,187
Autosomal recessive predisposition 13 | 1,442
Schizophrenia 13 | 1,160
group 4 medulloblastoma 13 | 1,855
cutaneous lupus erythematosus 12 | 1,057
esophageal adenocarcinoma 12 | 737
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
astrocytoma 11 | 1,146
pituitary cancer 11 | 1,972
primary Sjogren syndrome 11 | 735
spina bifida 11 | 1,074
Intellectual disability 10 | 1,016
Multiple myeloma 10 | 1,332
Pick disease 10 | 1,894
Arthritis 9 | 290
Bipolar Disorder 9 | 666
Kidney disease 9 | 430
Melanoma 9 | 711
Multiple Sclerosis 9 | 540
active ulcerative colitis 9 | 764
adrenocortical carcinoma 9 | 1,428
Breast Neoplasms 8 | 445
Cognitive delay 8 | 608
Dull intelligence 8 | 645
Epilepsy 8 | 792
Global developmental delay 8 | 608
Liver cancer 8 | 604
Low intelligence 8 | 645
Mammary Neoplasms 8 | 425
Mental Retardation 8 | 645
Mental and motor retardation 8 | 608
Mental deficiency 8 | 645
Muscle hypotonia 8 | 571
Obesity 8 | 678
Poor school performance 8 | 645
Seizures 8 | 596
Alzheimer's disease 7 | 658
Atopic dermatitis 7 | 952
Concave bridge of nose 7 | 195
Depressed nasal bridge 7 | 195
Depressed nasal root/bridge 7 | 195
Depressive disorder 7 | 409
Duchenne muscular dystrophy 7 | 601
Hypoplastic mandible condyle 7 | 275
Immunologic Deficiency Syndromes 7 | 113
Mandibular hypoplasia 7 | 275
Micrognathism 7 | 275
Orbital separation excessive 7 | 244
Wiskott-Aldrich syndrome 7 | 30
gastric carcinoma 7 | 807
nasopharyngeal carcinoma 7 | 1,058
pediatric high grade glioma 7 | 1,064
periodontitis 7 | 293
primary pancreatic ductal adenocarcinoma 7 | 1,109
Heart disease 6 | 306
Hypertension 6 | 396
Vascular disease 6 | 319
active Crohn's disease 6 | 922
dermatomyositis 6 | 966
fibroadenoma 6 | 559
mucosa-associated lymphoid tissue lymphoma 6 | 484

Tissue

Blood and immune system 89 | 16,909
Digestive Tract 89 | 17,369
Endocrine System 89 | 18,159
Female tissues 89 | 17,400
Skin and soft tissues 89 | 17,230
Male tissues 88 | 17,142
Liver and Pancreas 87 | 16,750
Nervous System 87 | 16,725
Respiratory system 87 | 16,393
Urinary Tract 87 | 16,678
Cardiovascular System 86 | 15,192

Target Family

Non-IDG 38 | 12,091
Kinase 29 | 634
Enzyme 22 | 4,145

KEGG Pathway

Fc gamma R-mediated phagocytos... 89 | 89
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 ASAP2 Tbio Non-IDG -1.14527 15.1 71
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 ASAP1 Tbio Non-IDG -1.76454 62.6 183
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Unconventional myosin-X MYO10 Tbio Non-IDG -1.49855 36.4 47
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
Adseverin SCIN Tbio Non-IDG -1.90989 89.8 72
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Wiskott-Aldrich syndrome protein family member 2 WASF2 Tbio Non-IDG -2.90666 762.6 254
Cytosolic phospholipase A2 delta PLA2G4D Tbio Enzyme -0.54284 3.41 45