Development Level

Tchem 32 | 1,598
Tbio 21 | 11,445
Tclin 11 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 8 | 979
decreased body weight 5 | 161
decreased circulating creatini... 4 | 39
increased total body fat amoun... 3 | 134
abnormal bone mineralization 2 | 38
abnormal gait 2 | 69
abnormal lens morphology 2 | 81
cataract 2 | 92
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal digit morphology 1 | 10
abnormal glucose homeostasis 1 | 4
abnormal maxilla morphology 1 | 17
decreased IgG3 level 1 | 1
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating alkaline... 1 | 46
decreased circulating free fat... 1 | 31
decreased erythrocyte cell num... 1 | 62
decreased grip strength 1 | 116
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular vol... 1 | 79
decreased total body fat amoun... 1 | 207
decreased vertical activity 1 | 208
female infertility 1 | 60
increased CD4-positive, alpha ... 1 | 4
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating sodium l... 1 | 71
increased grip strength 1 | 41
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular hem... 1 | 96
increased monocyte cell number 1 | 63
increased neutrophil cell numb... 1 | 46
increased spleen weight 1 | 10
male infertility 1 | 123
prenatal lethality 1 | 28
short tibia 1 | 97
thin ventricular wall 1 | 24
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 48 | 11,493
Cancer 45 | 2,499
ovarian cancer 38 | 8,520
osteosarcoma 36 | 7,950
lung cancer 33 | 4,740
psoriasis 32 | 6,694
glioblastoma 31 | 5,792
medulloblastoma, large-cell 26 | 6,241
invasive ductal carcinoma 22 | 2,951
atypical teratoid / rhabdoid tumor 21 | 5,112
Schizophrenia 20 | 1,160
interstitial cystitis 19 | 2,312
Breast cancer 18 | 3,578
adult high grade glioma 18 | 3,801
group 3 medulloblastoma 18 | 4,104
subependymal giant cell astrocytoma 17 | 2,287
Astrocytoma, Pilocytic 16 | 3,081
Kidney cancer 16 | 2,613
ependymoma 15 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 15 | 2,989
Asthma 14 | 385
lung carcinoma 14 | 2,843
malignant mesothelioma 14 | 3,232
pancreatic cancer 14 | 2,398
intraductal papillary-mucinous adenoma (IPMA) 13 | 2,955
intraductal papillary-mucinous neoplasm (IPMN) 13 | 3,291
ulcerative colitis 13 | 1,819
Arthritis 12 | 290
Melanoma 12 | 711
Orbital separation excessive 12 | 244
diabetes mellitus 12 | 1,728
juvenile dermatomyositis 12 | 1,187
lung adenocarcinoma 12 | 2,716
tuberculosis 12 | 2,010
Allergic hypersensitivity disease 11 | 126
Breast Neoplasms 11 | 445
Epilepsy 11 | 792
Mammary Neoplasms 11 | 425
Stomach Neoplasms 11 | 300
cutaneous lupus erythematosus 11 | 1,057
cystic fibrosis 11 | 1,696
group 4 medulloblastoma 11 | 1,855
non-small cell lung cancer 11 | 2,890
primitive neuroectodermal tumor 11 | 3,035
Blepharoptosis 10 | 231
Byzanthine arch palate 10 | 194
Concave bridge of nose 10 | 195
Depressed nasal bridge 10 | 195
Depressed nasal root/bridge 10 | 195
Downward slant of palpebral fissure 10 | 158
Dull intelligence 10 | 645
High forehead 10 | 102
Hypoplastic mandible condyle 10 | 275
Intellectual disability 10 | 1,016
Low intelligence 10 | 645
Lung Neoplasms 10 | 232
Lung disease 10 | 142
Mandibular hypoplasia 10 | 275
Mental Retardation 10 | 645
Mental deficiency 10 | 645
Micrognathism 10 | 275
Multiple myeloma 10 | 1,332
Poor school performance 10 | 645
Short stature 10 | 531
Tall forehead 10 | 102
Vascular disease 10 | 319
Waldenstrons macroglobulinemia 10 | 765
primary Sjogren syndrome 10 | 735
Acquired scoliosis 9 | 281
Alzheimer's disease 9 | 658
Big calvaria 9 | 147
Cognitive delay 9 | 608
Curvature of spine 9 | 282
Global developmental delay 9 | 608
Increased head circumference 9 | 147
Increased size of cranium 9 | 147
Increased size of skull 9 | 147
Mental and motor retardation 9 | 608
Muscle hypotonia 9 | 571
Neoplasm Metastasis 9 | 168
Noonan syndrome 9 | 34
Pectus excavatum 9 | 100
Rheumatoid arthritis 9 | 1,191
Seizures 9 | 596
astrocytoma 9 | 1,146
colon cancer 9 | 1,478
Allergic rhinitis 8 | 94
Cryptorchidism 8 | 296
Delayed bone age 8 | 136
Liver Cirrhosis, Experimental 8 | 769
Neck webbing 8 | 35
Pick disease 8 | 1,894
Strabismus 8 | 270
acute myeloid leukemia 8 | 783
adrenocortical carcinoma 8 | 1,428
astrocytic glioma 8 | 2,597
breast carcinoma 8 | 1,638
dermatomyositis 8 | 966
ductal carcinoma in situ 8 | 1,745
oligodendroglioma 8 | 2,850

Tissue

Blood and immune system 66 | 16,909
Endocrine System 66 | 18,159
Digestive Tract 65 | 17,369
Male tissues 65 | 17,142
Skin and soft tissues 65 | 17,230
Female tissues 64 | 17,400
Respiratory system 64 | 16,393
Urinary Tract 64 | 16,678
Liver and Pancreas 63 | 16,750
Nervous System 61 | 16,725
Cardiovascular System 59 | 15,192

Target Family

Kinase 29 | 634
Enzyme 19 | 4,145
Non-IDG 18 | 12,091

KEGG Pathway

Fc epsilon RI signaling pathwa... 66 | 66
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Linker for activation of T-cells family member 1 LAT Tbio Non-IDG -2.16291 169.4 667
Cytosolic phospholipase A2 gamma PLA2G4C Tchem Enzyme -1.27690 20.9 63
Cytosolic phospholipase A2 delta PLA2G4D Tbio Enzyme -0.54284 3.41 45
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
Son of sevenless homolog 2 SOS2 Tbio Non-IDG -1.62118 35.9 134
GRB2-associated-binding protein 2 GAB2 Tbio Non-IDG -2.08460 139.8 494