Development Level

Tbio 44 | 11,445
Tchem 7 | 1,598
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 3 | 278
anophthalmia 2 | 33
corneal opacity 2 | 32
decreased circulating glucose ... 2 | 126
preweaning lethality, incomple... 2 | 499
abnormal blood vessel morpholo... 1 | 5
abnormal bone structure 1 | 187
abnormal coat-hair pigmentatio... 1 | 64
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal eye morphology 1 | 68
abnormal eye size 1 | 7
abnormal iris transilluminatio... 1 | 2
abnormal lens morphology 1 | 81
abnormal placement of pupils 1 | 6
abnormal spinal cord morpholog... 1 | 9
abnormal spleen morphology 1 | 55
abnormal vitreous body morphol... 1 | 10
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
cornea ulcer 1 | 1
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased fasted circulating g... 1 | 65
decreased heart rate variabili... 1 | 13
fused cornea and lens 1 | 5
hypoactivity 1 | 132
increased bone mineral density 1 | 72
increased circulating sodium l... 1 | 71
increased heart weight 1 | 62
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
iris synechia 1 | 3
male infertility 1 | 123
narrow eye opening 1 | 12
small testis 1 | 58

Disease

Carcinoma 38 | 11,493
ovarian cancer 36 | 8,520
Fanconi anemia 30 | 56
osteosarcoma 29 | 7,950
group 3 medulloblastoma 25 | 4,104
Cancer 22 | 2,499
psoriasis 22 | 6,694
Breast cancer 21 | 3,578
glioblastoma 19 | 5,792
Anemia 18 | 365
medulloblastoma, large-cell 18 | 6,241
Short stature 17 | 531
Small head 17 | 374
lung cancer 17 | 4,740
malignant mesothelioma 17 | 3,232
Autosomal recessive predisposition 16 | 1,442
Chromosome Breakage 16 | 36
Esophageal atresia with or without tracheoesophageal fistula 16 | 21
Intellectual disability 16 | 1,016
esophageal atresia/tracheoesophageal fistula 16 | 22
primitive neuroectodermal tumor 16 | 3,035
Acquired scoliosis 15 | 281
Cognitive delay 15 | 608
Curvature of spine 15 | 282
Dull intelligence 15 | 645
Global developmental delay 15 | 608
Increased chromosomal breakage 15 | 27
Low intelligence 15 | 645
Mental Retardation 15 | 645
Mental and motor retardation 15 | 608
Mental deficiency 15 | 645
Poor school performance 15 | 645
invasive ductal carcinoma 15 | 2,951
Almond-shaped eyes 14 | 23
Decreased platelet count 14 | 111
Irregular hyperpigmentation 14 | 33
Leukopenia 14 | 72
Pyridoxine-responsive sideroblastic anemia 14 | 17
Radial aplasia/hypoplasia 14 | 29
Short palpebral fissure 14 | 38
Thrombocytopenia 14 | 197
atypical teratoid / rhabdoid tumor 14 | 5,112
hypopigmented skin patch 14 | 59
intraductal papillary-mucinous neoplasm (IPMN) 14 | 3,291
Bloom syndrome 13 | 29
Esophageal atresia 12 | 43
Kidney cancer 12 | 2,613
Tracheoesophageal Fistula 12 | 36
lung adenocarcinoma 12 | 2,716
Xeroderma pigmentosum group F 11 | 22
ductal carcinoma in situ 11 | 1,745
ependymoma 11 | 4,679
intraductal papillary-mucinous carcinoma (IPMC) 11 | 2,989
non-small cell lung cancer 11 | 2,890
Xeroderma pigmentosum 10 | 43
adult high grade glioma 10 | 3,801
Fanconi Anemia, Complementation Group a 9 | 9
Birthmark 8 | 35
Cafe-au-Lait Spots 8 | 37
Cryptorchidism 8 | 296
Hematologic Neoplasms 8 | 22
Hemoglobin low 8 | 124
Leukemia 8 | 104
Breast Neoplasms 7 | 445
Mammary Neoplasms 7 | 425
Strabismus 7 | 270
Thumb aplasia 7 | 16
breast carcinoma 7 | 1,638
nasopharyngeal carcinoma 7 | 1,058
Cockayne syndrome 6 | 60
Hereditary Breast and Ovarian Cancer Syndrome 6 | 14
Hypoplasia of thumb 6 | 26
Pancytopenia 6 | 45
adrenocortical carcinoma 6 | 1,428
intraductal papillary-mucinous adenoma (IPMA) 6 | 2,955
ovarian neoplasm 6 | 99
pancreatic cancer 6 | 2,398
Abnormally small eyeball 5 | 97
Absence of radius and ulna 5 | 15
Absent radius 5 | 15
Congenital Heart Defects 5 | 58
Congenital absence of kidney 5 | 31
Congenital deafness 5 | 185
Congenital heart disease 5 | 93
Deafness 5 | 198
Decreased size of eyeball 5 | 97
Epilepsy 5 | 792
Hearing Loss, Partial 5 | 185
Lynch syndrome 5 | 35
Microphthalmos 5 | 100
Muscle hypotonia 5 | 571
Neutrophil count decreased 5 | 47
Ovarian Neoplasms 5 | 102
Pick disease 5 | 1,894
Radial aplasia 5 | 15
Seizures 5 | 596
colon cancer 5 | 1,478
dermatomyositis 5 | 966
hearing impairment 5 | 199
pituitary cancer 5 | 1,972

Tissue

Blood and immune system 52 | 16,909
Digestive Tract 52 | 17,369
Endocrine System 52 | 18,159
Female tissues 52 | 17,400
Male tissues 52 | 17,142
Nervous System 52 | 16,725
Respiratory system 52 | 16,393
Skin and soft tissues 52 | 17,230
Urinary Tract 52 | 16,678
Liver and Pancreas 51 | 16,750
Cardiovascular System 50 | 15,192

Target Family

Non-IDG 33 | 12,091
Enzyme 17 | 4,145
Kinase 1 | 634
Transcription Factor 1 | 1,400

KEGG Pathway

Fanconi anemia pathway 52 | 52
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA topoisomerase 3-beta-1 TOP3B Tbio Enzyme -1.06981 9.54 153
E3 ubiquitin-protein ligase FANCL FANCL Tbio Enzyme -2.46302 286.2 146
Fanconi-associated nuclease 1 FAN1 Tbio Enzyme -2.06970 115.9 85
Serine/threonine-protein kinase ATR ATR Tchem Kinase -2.80362 549.6 376
DNA topoisomerase 3-alpha TOP3A Tbio Enzyme -2.77897 560.7 45
Fanconi anemia group C protein FANCC Tbio Non-IDG -2.85516 703.4 348
DNA polymerase iota POLI Tbio Enzyme -3.24008 1701.9 333
Fanconi anemia group J protein BRIP1 Tbio Non-IDG -1.81875 78.3 223
Telomere length regulation protein TEL2 homolog TELO2 Tbio Non-IDG -0.93554 9.48 94
Breast cancer type 2 susceptibility protein BRCA2 Tbio Non-IDG -3.46139 2647.6 209