Development Level

Tbio 73 | 11,445
Tchem 37 | 1,598
Tclin 19 | 613
Tdark 10 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

preweaning lethality, incomple... 9 | 499
abnormal behavior 5 | 298
decreased total body fat amoun... 5 | 207
preweaning lethality, complete... 5 | 979
abnormal bone structure 4 | 187
hyperactivity 4 | 148
increased heart weight 4 | 62
increased lean body mass 4 | 172
increased startle reflex 4 | 112
decreased body weight 3 | 161
decreased bone mineral content 3 | 151
embryonic lethality prior to t... 3 | 278
increased bone mineral content 3 | 108
increased circulating alkaline... 3 | 122
abnormal embryo size 2 | 220
abnormal gait 2 | 69
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating insulin ... 2 | 76
decreased circulating triglyce... 2 | 79
decreased fasted circulating g... 2 | 65
decreased vertical activity 2 | 208
increased hemoglobin content 2 | 45
increased total body fat amoun... 2 | 134
male infertility 2 | 123
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
thrombocytosis 2 | 27
abnormal bone mineralization 1 | 38
abnormal epididymis morphology 1 | 42
abnormal femur morphology 1 | 14
abnormal forebrain development 1 | 20
abnormal gallbladder morpholog... 1 | 1
abnormal glucose homeostasis 1 | 4
abnormal hindbrain development 1 | 16
abnormal lens morphology 1 | 81
abnormal locomotor behavior 1 | 24
abnormal neural tube closure 1 | 46
abnormal snout morphology 1 | 23
abnormal spleen morphology 1 | 55
abnormal tooth morphology 1 | 24
abnormal vocalization 1 | 21
cataract 1 | 92
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased circulating LDL chol... 1 | 38
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating creatine... 1 | 4
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating iron lev... 1 | 32
decreased circulating serum al... 1 | 82
decreased heart left ventricle... 1 | 28
decreased lean body mass 1 | 135
decreased leukocyte cell numbe... 1 | 73
decreased neutrophil cell numb... 1 | 42
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
hydrometra 1 | 53
hypoactivity 1 | 132
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
improved glucose tolerance 1 | 79
increased IgG2b level 1 | 1
increased circulating LDL chol... 1 | 13
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating creatini... 1 | 38
increased circulating glucose ... 1 | 24
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased grip strength 1 | 41
increased mean corpuscular hem... 1 | 96
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
limb grasping 1 | 41
persistence of hyaloid vascula... 1 | 33
premature death 1 | 5
prenatal lethality 1 | 28
small epididymis 1 | 3
small superior vagus ganglion 1 | 74
thin ventricular wall 1 | 24

Disease

Carcinoma 111 | 11,493
psoriasis 80 | 6,694
ovarian cancer 75 | 8,520
Cancer 66 | 2,499
medulloblastoma, large-cell 59 | 6,241
osteosarcoma 58 | 7,950
glioblastoma 57 | 5,792
lung cancer 57 | 4,740
atypical teratoid / rhabdoid tumor 49 | 5,112
Breast cancer 47 | 3,578
Kidney cancer 38 | 2,613
ependymoma 38 | 4,679
adult high grade glioma 36 | 3,801
group 3 medulloblastoma 36 | 4,104
Schizophrenia 32 | 1,160
Astrocytoma, Pilocytic 31 | 3,081
subependymal giant cell astrocytoma 31 | 2,287
oligodendroglioma 29 | 2,850
pancreatic cancer 29 | 2,398
primitive neuroectodermal tumor 29 | 3,035
Breast Neoplasms 27 | 445
Mammary Neoplasms 27 | 425
interstitial cystitis 27 | 2,312
malignant mesothelioma 27 | 3,232
non-small cell lung cancer 27 | 2,890
pituitary cancer 27 | 1,972
astrocytic glioma 26 | 2,597
intraductal papillary-mucinous carcinoma (IPMC) 26 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 26 | 3,291
ulcerative colitis 25 | 1,819
diabetes mellitus 23 | 1,728
invasive ductal carcinoma 23 | 2,951
lung adenocarcinoma 23 | 2,716
lung carcinoma 23 | 2,843
Epilepsy 22 | 792
Pick disease 22 | 1,894
breast carcinoma 22 | 1,638
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
cystic fibrosis 21 | 1,696
Autosomal recessive predisposition 20 | 1,442
Prostatic Neoplasms 20 | 495
Rheumatoid arthritis 20 | 1,191
colon cancer 20 | 1,478
Depressive disorder 19 | 409
Obesity 19 | 678
group 4 medulloblastoma 19 | 1,855
Bipolar Disorder 17 | 666
Alzheimer's disease 16 | 658
Mental Depression 16 | 333
astrocytoma 16 | 1,146
ductal carcinoma in situ 16 | 1,745
juvenile dermatomyositis 16 | 1,187
Intellectual disability 15 | 1,016
Stomach Neoplasms 15 | 300
Unipolar Depression 15 | 250
esophageal adenocarcinoma 15 | 737
Adenoma 14 | 167
Dull intelligence 14 | 645
Low intelligence 14 | 645
Major Depressive Disorder 14 | 301
Mental Retardation 14 | 645
Mental deficiency 14 | 645
Poor school performance 14 | 645
Seizures 14 | 596
Short stature 14 | 531
Vascular disease 14 | 319
tuberculosis 14 | 2,010
Endometriosis 13 | 540
Heart disease 13 | 306
Hypertension 13 | 396
Hypoplastic mandible condyle 13 | 275
Mandibular hypoplasia 13 | 275
Melanoma 13 | 711
Micrognathism 13 | 275
Multiple myeloma 13 | 1,332
Orbital separation excessive 13 | 244
Substance Withdrawal Syndrome 13 | 55
cutaneous lupus erythematosus 13 | 1,057
spina bifida 13 | 1,074
Alcoholic Intoxication, Chronic 12 | 289
Blepharoptosis 12 | 231
Carcinoma, Hepatocellular 12 | 228
Carcinoma, Squamous Cell 12 | 110
Cognitive delay 12 | 608
Global developmental delay 12 | 608
Hypertensive disease 12 | 292
Kidney disease 12 | 430
Liver carcinoma 12 | 240
Lung Neoplasms 12 | 232
Mammary Neoplasms, Experimental 12 | 154
Mental and motor retardation 12 | 608
Muscle hypotonia 12 | 571
Squamous cell carcinoma 12 | 129
Waldenstrons macroglobulinemia 12 | 765
Byzanthine arch palate 11 | 194
Concave bridge of nose 11 | 195
Depressed nasal bridge 11 | 195
Depressed nasal root/bridge 11 | 195
Parkinson's disease 11 | 392
nasopharyngeal carcinoma 11 | 1,058

Tissue

Endocrine System 132 | 18,159
Digestive Tract 128 | 17,369
Female tissues 128 | 17,400
Skin and soft tissues 128 | 17,230
Blood and immune system 122 | 16,909
Male tissues 120 | 17,142
Nervous System 117 | 16,725
Liver and Pancreas 116 | 16,750
Respiratory system 113 | 16,393
Urinary Tract 113 | 16,678
Cardiovascular System 105 | 15,192

Target Family

Non-IDG 66 | 12,091
Enzyme 24 | 4,145
Kinase 18 | 634
Transcription Factor 13 | 1,400
Ion Channel 7 | 344
GPCR 5 | 408
Nuclear Receptor 4 | 48
Epigenetic 2 | 242

KEGG Pathway

Estrogen signaling pathway 139 | 139
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Heat shock-related 70 kDa protein 2 HSPA2 Tbio Non-IDG -1.98655 104.3 162
Keratin, type I cytoskeletal 18 KRT18 Tbio Non-IDG -3.05211 1057.8 1953
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Heat shock 70 kDa protein 1A HSPA1B Tchem Non-IDG -3.10995 0.00000 1174
Heat shock 70 kDa protein 1B HSPA1B Tbio Non-IDG -1.61862 0.00000 60
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328