Development Level

Tchem 41 | 1,598
Tbio 30 | 11,445
Tclin 13 | 613

Collection

Kinase: IDG Consortium (Target... 3 | 125

IMPC Phenotype

preweaning lethality, complete... 5 | 979
decreased body weight 4 | 161
decreased circulating creatini... 3 | 39
preweaning lethality, incomple... 3 | 499
abnormal bone mineralization 2 | 38
abnormal heart morphology 2 | 162
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating triglyce... 2 | 79
enlarged heart 2 | 210
increased circulating LDL chol... 2 | 13
increased erythrocyte cell num... 2 | 39
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat appearance 1 | 31
abnormal digit morphology 1 | 10
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal lung morphology 1 | 26
abnormal seminal vesicle morph... 1 | 114
abnormal skin morphology 1 | 50
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating alkaline... 1 | 46
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased erythrocyte cell num... 1 | 62
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased neutrophil cell numb... 1 | 42
decreased total body fat amoun... 1 | 207
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased blood urea nitrogen ... 1 | 48
increased caudal vertebrae num... 1 | 7
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased circulating triglyce... 1 | 42
increased heart left ventricle... 1 | 4
increased hematocrit 1 | 46
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
prenatal lethality 1 | 28
short tibia 1 | 97
small seminal vesicle 1 | 10
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Carcinoma 68 | 11,493
ovarian cancer 59 | 8,520
Cancer 58 | 2,499
osteosarcoma 50 | 7,950
glioblastoma 48 | 5,792
medulloblastoma, large-cell 45 | 6,241
atypical teratoid / rhabdoid tumor 42 | 5,112
psoriasis 41 | 6,694
lung cancer 39 | 4,740
Breast cancer 37 | 3,578
Kidney cancer 33 | 2,613
ependymoma 33 | 4,679
group 3 medulloblastoma 29 | 4,104
adult high grade glioma 26 | 3,801
subependymal giant cell astrocytoma 26 | 2,287
Astrocytoma, Pilocytic 24 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
oligodendroglioma 23 | 2,850
Schizophrenia 22 | 1,160
intraductal papillary-mucinous neoplasm (IPMN) 22 | 3,291
primitive neuroectodermal tumor 22 | 3,035
Breast Neoplasms 21 | 445
Mammary Neoplasms 21 | 425
astrocytic glioma 21 | 2,597
pancreatic cancer 21 | 2,398
tuberculosis 20 | 2,010
Stomach Neoplasms 19 | 300
intraductal papillary-mucinous carcinoma (IPMC) 19 | 2,989
Lung Neoplasms 18 | 232
malignant mesothelioma 18 | 3,232
Pick disease 17 | 1,894
group 4 medulloblastoma 17 | 1,855
interstitial cystitis 17 | 2,312
invasive ductal carcinoma 17 | 2,951
pituitary cancer 17 | 1,972
Prostatic Neoplasms 16 | 495
Intellectual disability 15 | 1,016
Vascular disease 15 | 319
diabetes mellitus 15 | 1,728
juvenile dermatomyositis 15 | 1,187
lung adenocarcinoma 15 | 2,716
lung carcinoma 15 | 2,843
ulcerative colitis 15 | 1,819
Orbital separation excessive 14 | 244
Rheumatoid arthritis 14 | 1,191
non-small cell lung cancer 14 | 2,890
spina bifida 14 | 1,074
Dull intelligence 13 | 645
Epilepsy 13 | 792
Hypoplastic mandible condyle 13 | 275
Low intelligence 13 | 645
Mandibular hypoplasia 13 | 275
Mental Retardation 13 | 645
Mental deficiency 13 | 645
Micrognathism 13 | 275
Poor school performance 13 | 645
Blepharoptosis 12 | 231
Byzanthine arch palate 12 | 194
Carcinoma, Hepatocellular 12 | 228
Cognitive delay 12 | 608
Concave bridge of nose 12 | 195
Depressed nasal bridge 12 | 195
Depressed nasal root/bridge 12 | 195
Downward slant of palpebral fissure 12 | 158
Global developmental delay 12 | 608
Liver carcinoma 12 | 240
Mental and motor retardation 12 | 608
Noonan syndrome 12 | 34
Ovarian Neoplasms 12 | 102
astrocytoma 12 | 1,146
High forehead 11 | 102
Melanoma 11 | 711
Muscle hypotonia 11 | 571
Pectus excavatum 11 | 100
Renal Cell Carcinoma 11 | 214
Seizures 11 | 596
Short stature 11 | 531
Tall forehead 11 | 102
cystic fibrosis 11 | 1,696
ovarian neoplasm 11 | 99
primary pancreatic ductal adenocarcinoma 11 | 1,109
Acquired scoliosis 10 | 281
Adenoma 10 | 167
Big calvaria 10 | 147
Bipolar Disorder 10 | 666
Carcinoma, Squamous Cell 10 | 110
Cryptorchidism 10 | 296
Curvature of spine 10 | 282
Depressive disorder 10 | 409
Disease Models, Animal 10 | 155
Frontal bossing 10 | 157
Heart disease 10 | 306
Increased head circumference 10 | 147
Increased size of cranium 10 | 147
Increased size of skull 10 | 147
Neck webbing 10 | 35
Neoplasm Metastasis 10 | 168
Squamous cell carcinoma 10 | 129
colon cancer 10 | 1,478
nasopharyngeal carcinoma 10 | 1,058

Tissue

Digestive Tract 84 | 17,369
Endocrine System 84 | 18,159
Female tissues 84 | 17,400
Liver and Pancreas 84 | 16,750
Male tissues 84 | 17,142
Nervous System 84 | 16,725
Skin and soft tissues 84 | 17,230
Blood and immune system 83 | 16,909
Respiratory system 83 | 16,393
Urinary Tract 83 | 16,678
Cardiovascular System 82 | 15,192

Target Family

Kinase 44 | 634
Non-IDG 24 | 12,091
Enzyme 11 | 4,145
Transcription Factor 5 | 1,400

KEGG Pathway

ErbB signaling pathway 84 | 84
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Pro-neuregulin-4, membrane-bound isoform NRG4 Tbio Non-IDG -1.33564 24.6 137
Abelson tyrosine-protein kinase 2 ABL2 Tchem Kinase -1.86293 71.2 358
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Calcium/calmodulin-dependent protein kinase type II subunit gamma CAMK2G Tchem Kinase -0.94556 7.03 308
Calcium/calmodulin-dependent protein kinase type II subunit beta CAMK2B Tchem Kinase -1.14550 13.6 344
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328