Development Level

Tbio 197 | 11,445
Tchem 64 | 1,598
Tclin 15 | 613
Tdark 4 | 6,588

Collection

Kinase: IDG Consortium (Target... 4 | 125
RFA-RM-18-021 4 | 328
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 20 | 979
embryonic lethality prior to t... 7 | 278
embryonic lethality prior to o... 6 | 239
decreased body weight 4 | 161
decreased circulating choleste... 4 | 93
decreased circulating creatini... 4 | 39
increased erythrocyte cell num... 4 | 39
abnormal heart morphology 3 | 162
decreased circulating sodium l... 3 | 22
decreased lymphocyte cell numb... 3 | 83
enlarged heart 3 | 210
increased neutrophil cell numb... 3 | 46
increased total body fat amoun... 3 | 134
preweaning lethality, incomple... 3 | 499
abnormal bone mineralization 2 | 38
abnormal bone structure 2 | 187
abnormal lens morphology 2 | 81
abnormal lung morphology 2 | 26
abnormal retina morphology 2 | 71
abnormal seminal vesicle morph... 2 | 114
decreased bone mineral density 2 | 126
decreased circulating triglyce... 2 | 79
decreased hemoglobin content 2 | 68
decreased mean corpuscular hem... 2 | 31
enlarged lymph nodes 2 | 37
hypoactivity 2 | 132
impaired glucose tolerance 2 | 75
increased T cell number 2 | 6
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased lymphocyte cell numb... 2 | 32
increased monocyte cell number 2 | 63
short tibia 2 | 97
abnormal behavioral response t... 1 | 66
abnormal cornea morphology 1 | 31
abnormal digit morphology 1 | 10
abnormal epididymis morphology 1 | 42
abnormal gait 1 | 69
abnormal hair growth 1 | 10
abnormal retinal blood vessel ... 1 | 26
abnormal retinal vasculature m... 1 | 27
abnormal skin condition 1 | 6
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
cardiovascular system phenotyp... 1 | 36
cataract 1 | 92
corneal opacity 1 | 32
decreased blood urea nitrogen ... 1 | 51
decreased bone mineral content 1 | 151
decreased caudal vertebrae num... 1 | 53
decreased circulating HDL chol... 1 | 68
decreased circulating LDL chol... 1 | 38
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating free fat... 1 | 31
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased hematocrit 1 | 46
decreased lean body mass 1 | 135
decreased mature B cell number 1 | 7
decreased monocyte cell number 1 | 8
decreased startle reflex 1 | 75
edema 1 | 59
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
enlarged urinary bladder 1 | 8
female infertility 1 | 60
increased blood urea nitrogen ... 1 | 48
increased blood uric acid leve... 1 | 5
increased body length 1 | 32
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased circulating LDL chol... 1 | 13
increased circulating amylase ... 1 | 25
increased circulating glycerol... 1 | 9
increased circulating iron lev... 1 | 30
increased heart rate 1 | 23
increased hematocrit 1 | 46
increased mean corpuscular hem... 1 | 96
increased prepulse inhibition 1 | 32
increased spleen weight 1 | 10
increased startle reflex 1 | 112
prenatal lethality 1 | 28
prenatal lethality prior to he... 1 | 87
shortened RR interval 1 | 17
small seminal vesicle 1 | 10
small testis 1 | 58
thin ventricular wall 1 | 24
thrombocytosis 1 | 27
tremors 1 | 39

Disease

Cancer 166 | 2,499
Carcinoma 158 | 11,493
psoriasis 132 | 6,694
ovarian cancer 119 | 8,520
diabetes mellitus 100 | 1,728
lung cancer 92 | 4,740
osteosarcoma 90 | 7,950
Rheumatoid arthritis 86 | 1,191
glioblastoma 81 | 5,792
Hypersensitivity reaction type II disease 74 | 253
Arthritis 72 | 290
Ankylosing spondylitis 70 | 140
Behcet's disease 70 | 89
Juvenile rheumatoid arthritis 67 | 111
dermatomyositis 64 | 966
Acquired immunodeficiency syndrome 61 | 197
Uveitis 61 | 103
Herpes zoster 60 | 68
tuberculosis 58 | 2,010
medulloblastoma, large-cell 57 | 6,241
Human immunodeficiency virus infectious disease 55 | 138
Stevens-Johnson syndrome 55 | 92
atypical teratoid / rhabdoid tumor 55 | 5,112
Psoriatic arthritis 53 | 86
adult high grade glioma 49 | 3,801
Multiple myeloma 48 | 1,332
Multiple Sclerosis 46 | 540
ependymoma 46 | 4,679
subependymal giant cell astrocytoma 44 | 2,287
Dermatitis 41 | 157
Astrocytoma, Pilocytic 38 | 3,081
Schizophrenia 37 | 1,160
malignant mesothelioma 37 | 3,232
Behcet's syndrome 36 | 50
Synovitis 36 | 78
Congenital adrenal hyperplasia 35 | 73
Kidney cancer 35 | 2,613
Nephritis 35 | 51
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Takayasu's arteritis 35 | 53
drug-induced hepatitis 35 | 44
intraductal papillary-mucinous neoplasm (IPMN) 35 | 3,291
intraductal papillary-mucinous carcinoma (IPMC) 33 | 2,989
Anemia 32 | 365
Breast cancer 32 | 3,578
Kidney disease 32 | 430
Liver disease 32 | 237
interstitial cystitis 32 | 2,312
Hepatitis B 31 | 108
group 3 medulloblastoma 31 | 4,104
invasive ductal carcinoma 31 | 2,951
pancreatic cancer 31 | 2,398
astrocytoma 30 | 1,146
lung carcinoma 30 | 2,843
oligodendroglioma 28 | 2,850
ulcerative colitis 28 | 1,819
Primary immunodeficiency disease 27 | 54
juvenile dermatomyositis 27 | 1,187
Leprosy 26 | 73
Skin disease 26 | 66
Waldenstrons macroglobulinemia 26 | 765
group 4 medulloblastoma 26 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
lung adenocarcinoma 26 | 2,716
primitive neuroectodermal tumor 26 | 3,035
non-small cell lung cancer 25 | 2,890
Systemic lupus erythematosus 23 | 194
pancreatic ductal adenocarcinoma liver metastasis 23 | 1,962
primary Sjogren syndrome 23 | 735
Hemochromatosis 22 | 54
astrocytic glioma 22 | 2,597
breast carcinoma 22 | 1,638
Birdshot chorioretinopathy 21 | 23
colon cancer 21 | 1,478
Asthma 20 | 385
Bipolar Disorder 20 | 666
Vascular disease 20 | 319
Autosomal recessive predisposition 19 | 1,442
Prostatic Neoplasms 19 | 495
acute quadriplegic myopathy 19 | 1,158
cutaneous lupus erythematosus 19 | 1,057
Breast Neoplasms 18 | 445
Mammary Neoplasms 18 | 425
pituitary cancer 18 | 1,972
sarcoidosis 18 | 370
Intellectual disability 17 | 1,016
cystic fibrosis 17 | 1,696
follicular lymphoma 17 | 20
HIV Infections 16 | 102
Human immunodeficiency virus type 1, susceptibility to 16 | 26
Liver Cirrhosis, Experimental 16 | 769
Narcolepsy 16 | 72
Pre-Eclampsia 16 | 68
adrenocortical carcinoma 16 | 1,428
primary pancreatic ductal adenocarcinoma 16 | 1,109
Carcinoma, Squamous Cell 15 | 110
Lung Neoplasms 15 | 232
acute myeloid leukemia 15 | 783
nasopharyngeal carcinoma 15 | 1,058

Tissue

Endocrine System 194 | 18,159
Digestive Tract 193 | 17,369
Respiratory system 193 | 16,393
Skin and soft tissues 193 | 17,230
Female tissues 192 | 17,400
Liver and Pancreas 192 | 16,750
Male tissues 192 | 17,142
Blood and immune system 191 | 16,909
Urinary Tract 191 | 16,678
Nervous System 188 | 16,725
Cardiovascular System 187 | 15,192

Target Family

Non-IDG 151 | 12,091
Enzyme 61 | 4,145
Kinase 47 | 634
Transcription Factor 14 | 1,400
Epigenetic 7 | 242

KEGG Pathway

Epstein-Barr virus infection 280 | 280
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.13403 13.5 180
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 CD38 Tclin Enzyme -3.44680 2663.1 1493
HLA class I histocompatibility antigen, A-80 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
Transcription factor PU.1 SPI1 Tbio Transcription Factor -3.05079 1139.0 397
DNA-directed RNA polymerase III subunit RPC8 POLR3H Tbio Enzyme -1.32118 21.0 104
DNA-directed RNA polymerase III subunit RPC2 POLR3B Tbio Enzyme -1.25377 19.0 105
DNA-directed RNA polymerase II subunit RPB2 POLR2B Tbio Enzyme -2.49730 299.8 149
Staphylococcal nuclease domain-containing protein 1 SND1 Tbio Epigenetic -2.35812 225.9 175
14-3-3 protein theta YWHAQ Tchem Non-IDG -2.43493 235.4 358
Heat shock-related 70 kDa protein 2 HSPA2 Tbio Non-IDG -1.98655 104.3 162