Development Level

Tchem 32 | 1,598
Tbio 30 | 11,445
Tclin 4 | 613
Tdark 2 | 6,588

Collection

Kinase: IDG Consortium (Target... 1 | 125

IMPC Phenotype

preweaning lethality, complete... 7 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 6 | 278
preweaning lethality, incomple... 5 | 499
abnormal behavior 3 | 298
decreased hemoglobin content 3 | 68
increased circulating alkaline... 3 | 122
abnormal retina morphology 2 | 71
decreased leukocyte cell numbe... 2 | 73
increased blood urea nitrogen ... 2 | 48
increased erythrocyte cell num... 2 | 39
increased neutrophil cell numb... 2 | 46
increased spleen weight 2 | 10
short tibia 2 | 97
abnormal bone mineralization 1 | 38
abnormal bone structure 1 | 187
abnormal cornea morphology 1 | 31
abnormal cranium morphology 1 | 36
abnormal digit morphology 1 | 10
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal kidney morphology 1 | 65
abnormal maxilla morphology 1 | 17
abnormal seminal vesicle morph... 1 | 114
abnormal skin condition 1 | 6
abnormal vibrissa morphology 1 | 25
brachydactyly 1 | 19
cardiovascular system phenotyp... 1 | 36
decreased IgG3 level 1 | 1
decreased body weight 1 | 161
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased caudal vertebrae num... 1 | 53
decreased circulating alkaline... 1 | 46
decreased circulating amylase ... 1 | 28
decreased circulating bilirubi... 1 | 19
decreased circulating choleste... 1 | 93
decreased circulating free fat... 1 | 31
decreased circulating serum al... 1 | 82
decreased circulating sodium l... 1 | 22
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased fasted circulating g... 1 | 65
decreased hematocrit 1 | 46
decreased large unstained cell... 1 | 11
decreased lymphocyte cell numb... 1 | 83
decreased mature B cell number 1 | 7
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased neutrophil cell numb... 1 | 42
decreased prepulse inhibition 1 | 82
decreased spleen weight 1 | 10
decreased thermal nociceptive ... 1 | 2
decreased total body fat amoun... 1 | 207
enlarged kidney 1 | 14
hyperactivity 1 | 148
hypoactivity 1 | 132
improved glucose tolerance 1 | 79
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased bone mineral content 1 | 108
increased circulating calcium ... 1 | 34
increased circulating creatini... 1 | 38
increased circulating free fat... 1 | 20
increased circulating magnesiu... 1 | 10
increased circulating total pr... 1 | 28
increased circulating triglyce... 1 | 42
increased heart rate variabili... 1 | 7
increased hematocrit 1 | 46
increased lean body mass 1 | 172
increased leukocyte cell numbe... 1 | 47
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased thermal nociceptive ... 1 | 9
increased total body fat amoun... 1 | 134
male infertility 1 | 123
small adrenal glands 1 | 16
small lymph nodes 1 | 1
syndactyly 1 | 23
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 48 | 11,493
ovarian cancer 39 | 8,520
glioblastoma 37 | 5,792
Cancer 33 | 2,499
osteosarcoma 31 | 7,950
psoriasis 31 | 6,694
lung cancer 28 | 4,740
atypical teratoid / rhabdoid tumor 27 | 5,112
medulloblastoma, large-cell 27 | 6,241
ependymoma 25 | 4,679
oligodendroglioma 22 | 2,850
Astrocytoma, Pilocytic 21 | 3,081
lung carcinoma 21 | 2,843
adult high grade glioma 20 | 3,801
subependymal giant cell astrocytoma 19 | 2,287
Pick disease 18 | 1,894
astrocytic glioma 18 | 2,597
group 3 medulloblastoma 18 | 4,104
primitive neuroectodermal tumor 17 | 3,035
malignant mesothelioma 16 | 3,232
intraductal papillary-mucinous neoplasm (IPMN) 15 | 3,291
Breast cancer 14 | 3,578
diabetes mellitus 14 | 1,728
tuberculosis 14 | 2,010
Kidney cancer 13 | 2,613
colon cancer 13 | 1,478
invasive ductal carcinoma 13 | 2,951
non-small cell lung cancer 13 | 2,890
Multiple myeloma 12 | 1,332
cystic fibrosis 12 | 1,696
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
pancreatic cancer 12 | 2,398
Arthritis 11 | 290
group 4 medulloblastoma 11 | 1,855
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
ulcerative colitis 11 | 1,819
Inflammatory bowel disease 10 | 151
breast carcinoma 10 | 1,638
interstitial cystitis 10 | 2,312
lung adenocarcinoma 10 | 2,716
pituitary cancer 10 | 1,972
Asthma 9 | 385
Lung disease 9 | 142
Schizophrenia 9 | 1,160
astrocytoma 9 | 1,146
Alzheimer's disease 8 | 658
Autosomal recessive predisposition 8 | 1,442
Breast Neoplasms 8 | 445
Kidney disease 8 | 430
Mammary Neoplasms 8 | 425
Reperfusion Injury 8 | 86
Stomach Neoplasms 8 | 300
Vascular disease 8 | 319
hepatocellular carcinoma 8 | 547
pediatric high grade glioma 8 | 1,064
Cell Transformation, Neoplastic 7 | 97
Osteopetrosis 7 | 43
Parkinson's disease 7 | 392
Waldenstrons macroglobulinemia 7 | 765
acute myeloid leukemia 7 | 783
dermatomyositis 7 | 966
esophageal adenocarcinoma 7 | 737
mucosa-associated lymphoid tissue lymphoma 7 | 484
pancreatic ductal adenocarcinoma liver metastasis 7 | 1,962
Brain Ischemia 6 | 110
Carcinoma, Hepatocellular 6 | 228
Hypertension 6 | 396
Liver Cirrhosis, Experimental 6 | 769
Liver carcinoma 6 | 240
Multiple Sclerosis 6 | 540
Neoplastic Cell Transformation 6 | 89
Obesity 6 | 678
Rheumatoid arthritis 6 | 1,191
acute quadriplegic myopathy 6 | 1,158
sarcoidosis 6 | 370
Adenocarcinoma 5 | 122
Brain disease 5 | 96
Cholestasis 5 | 155
Colitis, Ulcerative 5 | 59
Colonic Neoplasms 5 | 142
Endometriosis 5 | 540
Failure to gain weight 5 | 365
Gaucher disease type 1 5 | 180
Heart disease 5 | 306
Liver disease 5 | 237
Lung Neoplasms 5 | 232
Neoplasm Invasiveness 5 | 161
Pediatric failure to thrive 5 | 365
adrenocortical carcinoma 5 | 1,428
cutaneous lupus erythematosus 5 | 1,057
gastric cancer 5 | 459
medulloblastoma 5 | 720
nasopharyngeal carcinoma 5 | 1,058
non-small cell lung carcinoma 5 | 317
spina bifida 5 | 1,074
Down syndrome 4 | 499
Juvenile arthritis 4 | 126
Mental Depression 4 | 333
juvenile dermatomyositis 4 | 1,187
pancreatic carcinoma 4 | 562

Tissue

Blood and immune system 68 | 16,909
Male tissues 68 | 17,142
Urinary Tract 68 | 16,678
Digestive Tract 67 | 17,369
Endocrine System 67 | 18,159
Female tissues 67 | 17,400
Nervous System 67 | 16,725
Respiratory system 67 | 16,393
Skin and soft tissues 67 | 17,230
Cardiovascular System 66 | 15,192
Liver and Pancreas 66 | 16,750

Target Family

Enzyme 34 | 4,145
Kinase 18 | 634
Non-IDG 11 | 12,091
Transcription Factor 3 | 1,400
GPCR 2 | 408

KEGG Pathway

Epithelial cell signaling in H... 68 | 68
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Junctional adhesion molecule A F11R Tbio Non-IDG -2.56739 380.0 394
ARF GTPase-activating protein GIT1 GIT1 Tbio Enzyme -1.84352 75.7 358
V-type proton ATPase 116 kDa subunit a isoform 4 ATP6V0A4 Tbio Enzyme -2.84949 692.2 90
C-X-C chemokine receptor type 2 CXCR2 Tchem GPCR -2.87313 723.9 643
C-X-C chemokine receptor type 1 CXCR1 Tchem GPCR -2.48051 278.1 378
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
V-type proton ATPase subunit E 1 ATP6V1E1 Tbio Enzyme -1.04091 10.7 137
V-type proton ATPase catalytic subunit A ATP6V1A Tbio Enzyme -1.83801 66.4 144
V-type proton ATPase subunit E 2 ATP6V1E2 Tbio Enzyme -0.78312 6.53 60
Junctional adhesion molecule B JAM2 Tbio Non-IDG -1.72934 50.6 302