Development Level

Tbio 26 | 11,445
Tchem 23 | 1,598
Tclin 9 | 613

IMPC Phenotype

preweaning lethality, complete... 10 | 979
decreased body weight 3 | 161
decreased total body fat amoun... 3 | 207
abnormal bone mineralization 2 | 38
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
cataract 2 | 92
decreased circulating creatini... 2 | 39
decreased prepulse inhibition 2 | 82
enlarged heart 2 | 210
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased total body fat amoun... 2 | 134
small testis 2 | 58
abnormal behavior 1 | 298
abnormal behavioral response t... 1 | 66
abnormal body wall morphology 1 | 9
abnormal coat appearance 1 | 31
abnormal embryo development 1 | 7
abnormal epididymis morphology 1 | 42
abnormal eyelid fusion 1 | 3
abnormal facial morphology 1 | 17
abnormal forelimb morphology 1 | 2
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal head morphology 1 | 10
abnormal head shape 1 | 10
abnormal lens morphology 1 | 81
abnormal limb morphology 1 | 13
abnormal lung morphology 1 | 26
abnormal response to tactile s... 1 | 17
abnormal retina morphology 1 | 71
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal startle reflex 1 | 15
abnormal testis morphology 1 | 43
anophthalmia 1 | 33
corneal opacity 1 | 32
decreased CD4-positive, alpha ... 1 | 7
decreased IgG1 level 1 | 8
decreased IgG2b level 1 | 4
decreased T cell number 1 | 15
decreased body length 1 | 101
decreased bone mineral density 1 | 126
decreased circulating LDL chol... 1 | 38
decreased circulating choleste... 1 | 93
decreased circulating insulin ... 1 | 76
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased startle reflex 1 | 75
embryonic lethality prior to o... 1 | 239
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged spleen 1 | 41
hyperactivity 1 | 148
hypoactivity 1 | 132
increased B cell number 1 | 9
increased body weight 1 | 25
increased bone mineral content 1 | 108
increased bone mineral density 1 | 72
increased circulating LDL chol... 1 | 13
increased circulating alkaline... 1 | 122
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased monocyte cell number 1 | 63
increased or absent threshold ... 1 | 101
increased startle reflex 1 | 112
male infertility 1 | 123
mammalian phenotype 1 | 17
microphthalmia 1 | 26
polydactyly 1 | 7
prenatal lethality 1 | 28
preweaning lethality, incomple... 1 | 499
protruding tongue 1 | 3
short tibia 1 | 97
small seminal vesicle 1 | 10
syndactyly 1 | 23
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Carcinoma 47 | 11,493
Cancer 45 | 2,499
ovarian cancer 44 | 8,520
osteosarcoma 35 | 7,950
glioblastoma 33 | 5,792
atypical teratoid / rhabdoid tumor 31 | 5,112
psoriasis 31 | 6,694
medulloblastoma, large-cell 29 | 6,241
lung cancer 26 | 4,740
Breast cancer 24 | 3,578
Kidney cancer 24 | 2,613
Prostatic Neoplasms 22 | 495
ependymoma 22 | 4,679
Stomach Neoplasms 20 | 300
Breast Neoplasms 19 | 445
group 3 medulloblastoma 19 | 4,104
Mammary Neoplasms 18 | 425
oligodendroglioma 18 | 2,850
Lung Neoplasms 17 | 232
Schizophrenia 17 | 1,160
malignant mesothelioma 17 | 3,232
primitive neuroectodermal tumor 17 | 3,035
Adenoma 16 | 167
pancreatic cancer 16 | 2,398
Colonic Neoplasms 15 | 142
Colorectal Neoplasms 15 | 243
Orbital separation excessive 15 | 244
breast carcinoma 15 | 1,638
invasive ductal carcinoma 15 | 2,951
subependymal giant cell astrocytoma 15 | 2,287
Epilepsy 14 | 792
Intellectual disability 14 | 1,016
Muscle hypotonia 14 | 571
Neoplasm Metastasis 14 | 168
Vascular disease 14 | 319
adult high grade glioma 14 | 3,801
juvenile dermatomyositis 14 | 1,187
Byzanthine arch palate 13 | 194
Carcinoma, Hepatocellular 13 | 228
Cognitive delay 13 | 608
Downward slant of palpebral fissure 13 | 158
Dull intelligence 13 | 645
Familial adenomatous polyposis 13 | 32
Global developmental delay 13 | 608
Hypoplastic mandible condyle 13 | 275
Liver carcinoma 13 | 240
Low intelligence 13 | 645
Mandibular hypoplasia 13 | 275
Melanoma 13 | 711
Mental Retardation 13 | 645
Mental and motor retardation 13 | 608
Mental deficiency 13 | 645
Micrognathism 13 | 275
Ovarian Neoplasms 13 | 102
Poor school performance 13 | 645
Seizures 13 | 596
astrocytic glioma 13 | 2,597
Adenocarcinoma 12 | 122
Astrocytoma, Pilocytic 12 | 3,081
Autosomal recessive predisposition 12 | 1,442
Big calvaria 12 | 147
Concave bridge of nose 12 | 195
Depressed nasal bridge 12 | 195
Depressed nasal root/bridge 12 | 195
Endometrial cancer 12 | 311
High forehead 12 | 102
Increased head circumference 12 | 147
Increased size of cranium 12 | 147
Increased size of skull 12 | 147
Renal Cell Carcinoma 12 | 214
Rheumatoid arthritis 12 | 1,191
Squamous cell carcinoma 12 | 129
Strabismus 12 | 270
Tall forehead 12 | 102
diabetes mellitus 12 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 12 | 3,291
ovarian neoplasm 12 | 99
Acquired scoliosis 11 | 281
Blepharoptosis 11 | 231
Carcinoma, Squamous Cell 11 | 110
Curvature of spine 11 | 282
Frontal bossing 11 | 157
Lymphoid leukemia 11 | 160
Multiple myeloma 11 | 1,332
Pectus excavatum 11 | 100
Short stature 11 | 531
Stomach cancer 11 | 30
intraductal papillary-mucinous adenoma (IPMA) 11 | 2,955
Carcinoma of colon 10 | 32
Immune system cancer 10 | 140
Liver Neoplasms, Experimental 10 | 59
Papilloma 10 | 44
Pick disease 10 | 1,894
Skin cancer 10 | 469
adrenocortical carcinoma 10 | 1,428
astrocytoma 10 | 1,146
ductal carcinoma in situ 10 | 1,745
interstitial cystitis 10 | 2,312
intraductal papillary-mucinous carcinoma (IPMC) 10 | 2,989
tuberculosis 10 | 2,010

Tissue

Blood and immune system 57 | 16,909
Digestive Tract 57 | 17,369
Endocrine System 57 | 18,159
Female tissues 57 | 17,400
Liver and Pancreas 57 | 16,750
Male tissues 57 | 17,142
Nervous System 57 | 16,725
Skin and soft tissues 57 | 17,230
Urinary Tract 57 | 16,678
Respiratory system 56 | 16,393
Cardiovascular System 55 | 15,192

Target Family

Non-IDG 22 | 12,091
Kinase 19 | 634
Enzyme 9 | 4,145
Transcription Factor 8 | 1,400

KEGG Pathway

Endometrial cancer 58 | 58
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Adenomatous polyposis coli protein 2 APC2 Tbio Non-IDG -1.50271 33.3 93
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
Son of sevenless homolog 2 SOS2 Tbio Non-IDG -1.62118 35.9 134
Caspase-9 CASP9 Tchem Enzyme -3.44725 2332.0 1313
ETS domain-containing protein Elk-1 ELK1 Tbio Transcription Factor -0.51976 3.02 941
DNA polymerase kappa POLK Tbio Enzyme -2.42142 256.3 224