Development Level

Tbio 248 | 10,625
Tchem 39 | 1,890
Tclin 23 | 602
Tdark 16 | 7,003

Collection

Eligible Kinase Proteins 2 | 134

IMPC Term

preweaning lethality, complete... 19 | 633
decreased lean body mass 9 | 195
decreased total body fat amoun... 8 | 186
abnormal behavior 6 | 226
decreased bone mineral content 6 | 157
decreased circulating fructosa... 5 | 31
embryonic lethality prior to o... 5 | 148
hypoactivity 5 | 89
increased circulating alkaline... 5 | 119
preweaning lethality, incomple... 5 | 260
abnormal bone structure 4 | 131
abnormal retina morphology 4 | 100
decreased circulating glucose ... 4 | 121
decreased grip strength 4 | 123
decreased mean corpuscular vol... 4 | 50
embryonic lethality prior to t... 4 | 187
decreased body length 3 | 108
decreased circulating serum al... 3 | 79
decreased lumbar vertebrae num... 3 | 62
decreased mean corpuscular hem... 3 | 34
increased circulating HDL chol... 3 | 63
increased circulating total pr... 3 | 20
increased mean corpuscular hem... 3 | 93
increased mean corpuscular vol... 3 | 91
increased sacral vertebrae num... 3 | 62
thrombocytopenia 3 | 46
abnormal body wall morphology 2 | 7
abnormal kidney morphology 2 | 30
absent pinna reflex 2 | 21
corneal opacity 2 | 25
decreased NK T cell number 2 | 28
decreased bone mineral density 2 | 126
decreased circulating HDL chol... 2 | 77
decreased circulating choleste... 2 | 85
decreased fasted circulating g... 2 | 49
decreased leukocyte cell numbe... 2 | 54
decreased prepulse inhibition 2 | 52
decreased rib number 2 | 59
decreased startle reflex 2 | 48
improved glucose tolerance 2 | 56
increased circulating LDL chol... 2 | 15
increased circulating calcium ... 2 | 32
increased circulating chloride... 2 | 43
increased circulating phosphat... 2 | 24
increased circulating potassiu... 2 | 31
increased erythrocyte cell num... 2 | 26
increased heart weight 2 | 37
increased lean body mass 2 | 107
increased leukocyte cell numbe... 2 | 37
increased or absent threshold ... 2 | 128
increased total body fat amoun... 2 | 57
persistence of hyaloid vascula... 2 | 22
abnormal QRS complex 1 | 25
abnormal coat appearance 1 | 25
abnormal coping response 1 | 12
abnormal cornea morphology 1 | 24
abnormal cranium morphology 1 | 32
abnormal embryo size 1 | 112
abnormal heart morphology 1 | 51
abnormal lens morphology 1 | 73
abnormal optic disc morphology 1 | 10
abnormal retinal inner nuclear... 1 | 5
abnormal retinal pigmentation 1 | 61
abnormal rib morphology 1 | 28
abnormal skin morphology 1 | 23
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 14
decreased CD8-positive, alpha-... 1 | 26
decreased alpha-beta T cell nu... 1 | 12
decreased blood urea nitrogen ... 1 | 31
decreased caudal vertebrae num... 1 | 49
decreased circulating potassiu... 1 | 17
decreased circulating triglyce... 1 | 83
decreased effector memory CD8-... 1 | 24
decreased eosinophil cell numb... 1 | 41
decreased heart weight 1 | 44
decreased hemoglobin content 1 | 53
decreased total retina thickne... 1 | 20
decreased vertical activity 1 | 22
enlarged heart atrium 1 | 2
enlarged spleen 1 | 26
female infertility 1 | 34
hydrops fetalis 1 | 22
increased CD4-positive, CD25-p... 1 | 18
increased body weight 1 | 42
increased circulating alanine ... 1 | 11
increased circulating aspartat... 1 | 17
increased circulating choleste... 1 | 53
increased circulating creatini... 1 | 29
increased circulating fructosa... 1 | 11
increased circulating iron lev... 1 | 25
increased circulating serum al... 1 | 25
increased fasted circulating g... 1 | 68
increased grip strength 1 | 83
increased rib number 1 | 41
prenatal lethality prior to he... 1 | 64
short tibia 1 | 82
tremors 1 | 34
trunk curl 1 | 15
vertebral fusion 1 | 23

Disease

ovarian cancer 166 | 8,484
psoriasis 149 | 6,685
Cancer 136 | 2,346
osteosarcoma 134 | 7,933
glioblastoma 122 | 5,572
medulloblastoma, large-cell 103 | 6,234
diabetes mellitus 94 | 1,663
atypical teratoid / rhabdoid tumor 84 | 4,369
lung cancer 75 | 4,466
pilocytic astrocytoma 73 | 3,086
Ankylosing spondylitis 71 | 138
Rheumatoid Arthritis 65 | 1,160
Arthritis 62 | 248
Hypersensitivity reaction type II disease 61 | 235
non-small cell lung cancer 61 | 2,798
Breast cancer 59 | 3,094
Juvenile rheumatoid arthritis 59 | 104
pediatric high grade glioma 59 | 2,712
Acquired immunodeficiency syndrome 58 | 164
Behcet's disease 56 | 74
Uveitis 56 | 103
oligodendroglioma 54 | 2,849
primitive neuroectodermal tumor 53 | 3,031
subependymal giant cell astrocytoma 53 | 2,287
lung carcinoma 51 | 2,844
malignant mesothelioma 51 | 3,162
intraductal papillary-mucinous neoplasm (IPMN) 50 | 3,289
invasive ductal carcinoma 50 | 2,950
Psoriatic arthritis 49 | 83
pancreatic cancer 47 | 2,300
astrocytoma 46 | 1,493
intraductal papillary-mucinous adenoma (IPMA) 46 | 2,956
Carcinoma 42 | 2,147
Multiple myeloma 41 | 1,327
interstitial cystitis 41 | 2,299
lung adenocarcinoma 41 | 2,713
ulcerative colitis 41 | 2,087
Stevens-Johnson syndrome 40 | 78
intraductal papillary-mucinous carcinoma (IPMC) 39 | 2,988
ependymoma 38 | 2,514
adult high grade glioma 37 | 2,148
breast carcinoma 36 | 1,614
Congenital adrenal hyperplasia 35 | 74
Multiple Sclerosis 35 | 498
Retinal vasculitis 35 | 36
Takayasu's arteritis 35 | 52
tuberculosis 35 | 1,557
Pick disease 34 | 1,893
astrocytic glioma 34 | 2,241
juvenile dermatomyositis 34 | 1,189
Kidney disease 33 | 396
ductal carcinoma in situ 32 | 1,745
pituitary cancer 31 | 1,972
cutaneous lupus erythematosus 30 | 1,056
primary pancreatic ductal adenocarcinoma 29 | 1,271
dermatomyositis 28 | 933
medulloblastoma 28 | 1,524
Liver disease 27 | 219
spina bifida 27 | 1,064
cystic fibrosis 26 | 1,665
group 3 medulloblastoma 26 | 2,254
posterior fossa group A ependymoma 26 | 1,511
Anemia 24 | 252
Waldenstrons macroglobulinemia 24 | 765
esophageal adenocarcinoma 24 | 737
Hemochromatosis 23 | 55
acute quadriplegic myopathy 23 | 1,157
adrenocortical carcinoma 23 | 1,427
posterior fossa group B ependymoma 23 | 1,530
primary Sjogren syndrome 23 | 789
Hepatitis B 22 | 103
Primary immunodeficiency disease 22 | 52
Skin disease 22 | 65
group 4 medulloblastoma 22 | 1,875
pancreatic ductal adenocarcinoma liver metastasis 22 | 1,795
sonic hedgehog group medulloblastoma 22 | 1,482
Leprosy 21 | 77
Duchenne muscular dystrophy 18 | 602
Human immunodeficiency virus infectious disease 18 | 92
gastric carcinoma 18 | 832
Neurodegenerative disease 17 | 383
colon cancer 17 | 1,475
pre-eclampsia 17 | 67
active Crohn's disease 16 | 918
Mammary Neoplasms 15 | 410
aldosterone-producing adenoma 15 | 664
atypical teratoid/rhabdoid tumor 15 | 1,095
Alzheimer's disease 13 | 644
Hypertension 13 | 287
IGA Glomerulonephritis 13 | 454
acute myeloid leukemia 13 | 780
pancreatic carcinoma 13 | 567
progressive supranuclear palsy 13 | 674
Obesity 12 | 616
Schizophrenia 12 | 501
Stomach Neoplasms 12 | 282
hereditary spastic paraplegia 12 | 313
interstitial lung disease 12 | 291
tuberculosis and treatment for 6 months 12 | 686
Asthma 11 | 349

Tissue

Blood and immune system 264 | 17,995
Cardiovascular System 264 | 17,958
Digestive Tract 264 | 18,473
Endocrine System 264 | 18,512
Female tissues 264 | 18,647
Liver and Pancreas 264 | 18,136
Male tissues 264 | 17,969
Nervous System 264 | 18,561
Urinary Tract 264 | 18,444
Respiratory system 262 | 17,484
Skin and soft tissues 258 | 18,115

Target Family

Non-IDG 239 | 11,971
Enzyme 47 | 4,146
Kinase 30 | 634
GPCR 8 | 406
Transcription Factor 2 | 1,400

KEGG Pathway

Endocytosis 326 | 326
Metabolic pathways 1,254 | 1,254
Olfactory transduction 412 | 412
Pathways in cancer 402 | 402
HTLV-I infection 339 | 339
PI3K-Akt signaling pathway 338 | 338
Epstein-Barr virus infection 279 | 279
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 262 | 262
Herpes simplex infection 262 | 262
MAPK signaling pathway 255 | 255
Viral carcinogenesis 253 | 253
Phagosome 231 | 231
Cell adhesion molecules (CAMs) 225 | 225
Ras signaling pathway 225 | 225
Rap1 signaling pathway 213 | 213
Regulation of actin cytoskelet... 213 | 213
Proteoglycans in cancer 202 | 202
cAMP signaling pathway 201 | 201
Focal adhesion 200 | 200
Natural killer cell mediated c... 199 | 199
Huntington's disease 194 | 194
Tuberculosis 187 | 187
Influenza A 184 | 184
Chemokine signaling pathway 182 | 182
Calcium signaling pathway 181 | 181
Axon guidance 176 | 176
Purine metabolism 171 | 171
Alzheimer's disease 169 | 169
Tight junction 169 | 169
NOD-like receptor signaling pa... 168 | 168
Protein processing in endoplas... 165 | 165
Transcriptional misregulation ... 165 | 165
cGMP-PKG signaling pathway 165 | 165
RNA transport 164 | 164
Oxytocin signaling pathway 158 | 158
Jak-STAT signaling pathway 157 | 157
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
mTOR signaling pathway 153 | 153
Non-alcoholic fatty liver dise... 151 | 151
Adrenergic signaling in cardio... 150 | 150
MicroRNAs in cancer 150 | 150
Breast cancer 146 | 146
Alcoholism 145 | 145
Hepatitis B 145 | 145
Phospholipase D signaling path... 145 | 145
Parkinson's disease 142 | 142
Wnt signaling pathway 142 | 142
Signaling pathways regulating ... 141 | 141
Apoptosis 140 | 140
Insulin signaling pathway 138 | 138
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Measles 135 | 135
Ribosome 134 | 134
Oxidative phosphorylation 133 | 133
FoxO signaling pathway 132 | 132
Hepatitis C 132 | 132
Spliceosome 132 | 132
Dopaminergic synapse 131 | 131
Osteoclast differentiation 131 | 131
Autoimmune thyroid disease 130 | 130
Toxoplasmosis 130 | 130
Cell cycle 125 | 125
Platelet activation 124 | 124
AMPK signaling pathway 123 | 123
Lysosome 123 | 123
Type I diabetes mellitus 122 | 122
Vascular smooth muscle contrac... 121 | 121
Graft-versus-host disease 120 | 120
Sphingolipid signaling pathway 120 | 120
Neurotrophin signaling pathway 119 | 119
Oocyte meiosis 119 | 119
Th17 cell differentiation 119 | 119
Thyroid hormone signaling path... 118 | 118
Allograft rejection 116 | 116
Glutamatergic synapse 116 | 116
Leukocyte transendothelial mig... 116 | 116
Carbon metabolism 114 | 114
Serotonergic synapse 114 | 114
Cholinergic synapse 110 | 110
TNF signaling pathway 110 | 110
Insulin resistance 109 | 109
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
Chagas disease (American trypa... 106 | 106
T cell receptor signaling path... 104 | 104
Th1 and Th2 cell differentiati... 104 | 104
Glucagon signaling pathway 103 | 103
HIF-1 signaling pathway 103 | 103
Toll-like receptor signaling p... 103 | 103
Melanogenesis 102 | 102
Pyrimidine metabolism 102 | 102
AGE-RAGE signaling pathway in ... 101 | 101
Endocrine resistance 101 | 101
Estrogen signaling pathway 101 | 101
Retrograde endocannabinoid sig... 101 | 101
Amoebiasis 100 | 100
Rheumatoid arthritis 100 | 100

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