Development Level

Tbio 256 | 11,651
Tchem 26 | 1,388
Tdark 16 | 6,593
Tclin 12 | 612

Collection

Kinase: IDG Consortium (Target... 2 | 125
Kinase: IDG Consortium (Comple... 1 | 37

IMPC Phenotype

preweaning lethality, complete... 26 | 979
preweaning lethality, incomple... 9 | 499
abnormal embryo size 8 | 220
embryonic lethality prior to o... 8 | 239
abnormal behavior 7 | 298
abnormal bone structure 6 | 187
abnormal retina morphology 6 | 71
decreased total body fat amoun... 6 | 207
embryonic lethality prior to t... 6 | 278
decreased bone mineral content 5 | 151
hypoactivity 5 | 132
cataract 4 | 92
decreased bone mineral density 4 | 126
decreased circulating fructosa... 4 | 30
decreased startle reflex 4 | 75
increased circulating alkaline... 4 | 122
increased mean corpuscular vol... 4 | 92
persistence of hyaloid vascula... 4 | 33
abnormal lens morphology 3 | 81
decreased body length 3 | 101
decreased caudal vertebrae num... 3 | 53
decreased circulating glucose ... 3 | 126
decreased circulating serum al... 3 | 82
decreased mean corpuscular hem... 3 | 50
embryonic growth retardation 3 | 106
increased circulating HDL chol... 3 | 80
increased circulating total pr... 3 | 28
increased neutrophil cell numb... 3 | 46
increased or absent threshold ... 3 | 101
increased startle reflex 3 | 112
thrombocytopenia 3 | 56
abnormal body wall morphology 2 | 9
abnormal craniofacial morpholo... 2 | 33
abnormal cranium morphology 2 | 36
abnormal embryo turning 2 | 31
abnormal heart morphology 2 | 162
abnormal iris morphology 2 | 13
abnormal kidney morphology 2 | 65
abnormal neural tube closure 2 | 46
abnormal sleep behavior 2 | 70
abnormal vertebrae morphology 2 | 18
absent pinna reflex 2 | 23
absent startle reflex 2 | 24
corneal opacity 2 | 32
decreased body weight 2 | 161
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased lymphocyte cell numb... 2 | 83
decreased mean corpuscular vol... 2 | 79
decreased prepulse inhibition 2 | 82
decreased vertical activity 2 | 208
edema 2 | 59
enlarged heart 2 | 210
enlarged kidney 2 | 14
enlarged spleen 2 | 41
female infertility 2 | 60
impaired pupillary reflex 2 | 26
improved glucose tolerance 2 | 79
increased body length 2 | 32
increased circulating calcium ... 2 | 34
increased circulating chloride... 2 | 41
increased circulating choleste... 2 | 66
increased circulating free fat... 2 | 20
increased circulating iron lev... 2 | 30
increased circulating phosphat... 2 | 26
increased circulating potassiu... 2 | 29
increased erythrocyte cell num... 2 | 39
increased heart weight 2 | 62
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased leukocyte cell numbe... 2 | 47
increased mean corpuscular hem... 2 | 96
increased red blood cell distr... 2 | 34
increased total body fat amoun... 2 | 134
pallor 2 | 34
prenatal lethality prior to he... 2 | 87
short tibia 2 | 97
abnormal neural tube morpholog... 1 | 12
abnormal optic disc morphology 1 | 10
abnormal retinal inner nuclear... 1 | 8
abnormal tooth morphology 1 | 24
decreased circulating amylase ... 1 | 28
decreased circulating chloride... 1 | 30
decreased circulating triglyce... 1 | 79
decreased grip strength 1 | 116
decreased red blood cell distr... 1 | 41
decreased total retina thickne... 1 | 17
enlarged lymph nodes 1 | 37
hydrometra 1 | 53
increased bone mineral density 1 | 72
increased circulating alanine ... 1 | 13
increased circulating creatini... 1 | 38
increased circulating magnesiu... 1 | 10
increased eosinophil cell numb... 1 | 11
increased exploration in new e... 1 | 8
prenatal lethality 1 | 28
small superior vagus ganglion 1 | 74
tremors 1 | 39
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Carcinoma 194 | 11,493
ovarian cancer 157 | 8,520
psoriasis 139 | 6,694
osteosarcoma 124 | 7,950
Cancer 123 | 2,499
glioblastoma 113 | 5,792
medulloblastoma, large-cell 93 | 6,241
diabetes mellitus 88 | 1,728
atypical teratoid / rhabdoid tumor 86 | 5,112
Ankylosing spondylitis 71 | 140
Behcet's disease 70 | 89
lung cancer 70 | 4,740
ependymoma 68 | 4,679
Astrocytoma, Pilocytic 65 | 3,081
Rheumatoid arthritis 64 | 1,191
adult high grade glioma 64 | 3,801
dermatomyositis 62 | 966
Arthritis 61 | 290
Hypersensitivity reaction type II disease 60 | 253
Juvenile rheumatoid arthritis 60 | 111
tuberculosis 59 | 2,010
Acquired immunodeficiency syndrome 58 | 197
Herpes zoster 56 | 68
Uveitis 56 | 103
Breast cancer 54 | 3,578
Human immunodeficiency virus infectious disease 53 | 138
Stevens-Johnson syndrome 53 | 92
non-small cell lung cancer 52 | 2,890
oligodendroglioma 51 | 2,850
group 3 medulloblastoma 50 | 4,104
Psoriatic arthritis 49 | 86
astrocytic glioma 49 | 2,597
malignant mesothelioma 49 | 3,232
primitive neuroectodermal tumor 49 | 3,035
subependymal giant cell astrocytoma 49 | 2,287
Kidney cancer 47 | 2,613
lung carcinoma 44 | 2,843
intraductal papillary-mucinous neoplasm (IPMN) 43 | 3,291
invasive ductal carcinoma 43 | 2,951
pancreatic cancer 42 | 2,398
Multiple myeloma 41 | 1,332
intraductal papillary-mucinous adenoma (IPMA) 40 | 2,955
Dermatitis 37 | 157
Nephritis 36 | 51
interstitial cystitis 36 | 2,312
Behcet's syndrome 35 | 50
Congenital adrenal hyperplasia 35 | 73
Retinal vasculitis 35 | 36
Spondyloarthropathy, Susceptibility To, 1 35 | 35
Synovitis 35 | 78
Takayasu's arteritis 35 | 53
drug-induced hepatitis 35 | 44
breast carcinoma 34 | 1,638
intraductal papillary-mucinous carcinoma (IPMC) 34 | 2,989
juvenile dermatomyositis 34 | 1,187
Pick disease 33 | 1,894
ulcerative colitis 33 | 1,819
Multiple Sclerosis 32 | 540
lung adenocarcinoma 32 | 2,716
Kidney disease 29 | 430
ductal carcinoma in situ 28 | 1,745
spina bifida 28 | 1,074
cutaneous lupus erythematosus 27 | 1,057
pancreatic ductal adenocarcinoma liver metastasis 27 | 1,962
pituitary cancer 26 | 1,972
Liver disease 25 | 237
Schizophrenia 25 | 1,160
Anemia 24 | 365
astrocytoma 24 | 1,146
Autosomal recessive predisposition 23 | 1,442
Hemochromatosis 23 | 54
Waldenstrons macroglobulinemia 23 | 765
acute quadriplegic myopathy 23 | 1,158
pediatric high grade glioma 23 | 1,064
Primary immunodeficiency disease 22 | 54
Skin disease 22 | 66
esophageal adenocarcinoma 22 | 737
Birdshot chorioretinopathy 21 | 23
Hepatitis B 21 | 108
Leprosy 21 | 73
primary Sjogren syndrome 21 | 735
adrenocortical carcinoma 20 | 1,428
cystic fibrosis 20 | 1,696
primary pancreatic ductal adenocarcinoma 19 | 1,109
Duchenne muscular dystrophy 16 | 601
Neurodegenerative disease 16 | 414
group 4 medulloblastoma 16 | 1,855
Human immunodeficiency virus type 1, susceptibility to 15 | 26
Pre-Eclampsia 15 | 68
active Crohn's disease 15 | 922
gastric carcinoma 15 | 807
Epilepsy 14 | 792
Intellectual disability 14 | 1,016
Psoriasis susceptibility 1 14 | 14
aldosterone-producing adenoma 14 | 665
colon cancer 14 | 1,478
medulloblastoma 14 | 720
Low intelligence 13 | 645
Mental Retardation 13 | 645
Mental deficiency 13 | 645

Tissue

Endocrine System 242 | 18,159
Digestive Tract 241 | 17,369
Female tissues 240 | 17,400
Skin and soft tissues 240 | 17,230
Blood and immune system 239 | 16,909
Male tissues 239 | 17,142
Urinary Tract 239 | 16,678
Liver and Pancreas 238 | 16,750
Respiratory system 237 | 16,393
Nervous System 235 | 16,725
Cardiovascular System 232 | 15,192

Target Family

Non-IDG 236 | 12,091
Enzyme 47 | 4,145
Kinase 21 | 634
GPCR 4 | 408
Transcription Factor 2 | 1,400

KEGG Pathway

Endocytosis 310 | 310
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Ras-related protein Rab-22A RAB22A Tbio Enzyme -1.40824 19.7 123
HLA class I histocompatibility antigen, A-25 alpha chain HLA-A Tbio Non-IDG -2.41667 4123.8 0
HLA class I histocompatibility antigen, B-51 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
F-actin-capping protein subunit alpha-3 CAPZA3 Tdark Non-IDG -0.56455 3.20 78
E3 ubiquitin-protein ligase CBL-B CBLB Tbio Enzyme -0.82313 6.58 193
ADP-ribosylation factor GTPase-activating protein 2 ARFGAP2 Tbio Enzyme -0.97596 10.1 144
Epsin-1 EPN1 Tbio Non-IDG -1.52389 32.5 163
HLA class I histocompatibility antigen, B-37 alpha chain HLA-B Tbio Non-IDG -1.88752 1613.5 0
Vacuolar protein sorting-associated protein 37D VPS37D Tdark Non-IDG 0.51 0.16 8
Sorting nexin-32 SNX32 Tdark Non-IDG 0.35 0.28 89