Development Level

Tchem 44 | 1,598
Tbio 39 | 11,445
Tclin 16 | 613

Collection

Kinase: IDG Consortium (Target... 2 | 125
RFA-RM-18-021 2 | 328

IMPC Phenotype

preweaning lethality, complete... 7 | 979
preweaning lethality, incomple... 6 | 499
abnormal bone structure 4 | 187
decreased body weight 4 | 161
increased heart weight 4 | 62
increased startle reflex 4 | 112
abnormal behavior 3 | 298
abnormal lens morphology 3 | 81
cataract 3 | 92
enlarged heart 3 | 210
abnormal embryo size 2 | 220
abnormal heart morphology 2 | 162
abnormal lung morphology 2 | 26
decreased circulating LDL chol... 2 | 38
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased heart left ventricle... 2 | 28
decreased neutrophil cell numb... 2 | 42
decreased total body fat amoun... 2 | 207
decreased vertical activity 2 | 208
hyperactivity 2 | 148
improved glucose tolerance 2 | 79
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased hemoglobin content 2 | 45
increased lean body mass 2 | 172
increased mean corpuscular hem... 2 | 96
increased monocyte cell number 2 | 63
increased total body fat amoun... 2 | 134
short tibia 2 | 97
thin ventricular wall 2 | 24
abnormal bone mineralization 1 | 38
abnormal eating behavior 1 | 1
abnormal epididymis morphology 1 | 42
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal forced expiratory flo... 1 | 1
abnormal forebrain development 1 | 20
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal kidney morphology 1 | 65
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal seminal vesicle morph... 1 | 114
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal tooth morphology 1 | 24
abnormal vertebrae morphology 1 | 18
abnormal whole-body plethysmog... 1 | 4
altered righting response 1 | 1
decreased CD4-positive, alpha ... 1 | 7
decreased CD8-positive, alpha-... 1 | 8
decreased T cell number 1 | 15
decreased blood urea nitrogen ... 1 | 51
decreased body temperature 1 | 2
decreased bone mineral content 1 | 151
decreased bone mineral density 1 | 126
decreased circulating aspartat... 1 | 34
decreased circulating chloride... 1 | 30
decreased circulating choleste... 1 | 93
decreased circulating creatine... 1 | 4
decreased circulating insulin ... 1 | 76
decreased lean body mass 1 | 135
decreased mean corpuscular vol... 1 | 79
decreased prepulse inhibition 1 | 82
decreased tidal volume 1 | 1
edema 1 | 59
embryonic growth retardation 1 | 106
embryonic lethality prior to o... 1 | 239
embryonic lethality prior to t... 1 | 278
enlarged epididymis 1 | 31
enlarged heart atrium 1 | 4
enlarged kidney 1 | 14
enlarged spleen 1 | 41
enlarged uterus 1 | 11
female infertility 1 | 60
hydrometra 1 | 53
impaired glucose tolerance 1 | 75
increased blood urea nitrogen ... 1 | 48
increased circulating choleste... 1 | 66
increased circulating creatine... 1 | 5
increased circulating glucose ... 1 | 24
increased circulating iron lev... 1 | 30
increased circulating serum al... 1 | 22
increased circulating total pr... 1 | 28
increased erythrocyte cell num... 1 | 39
increased hematocrit 1 | 46
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
male infertility 1 | 123
microphthalmia 1 | 26
pale yolk sac 1 | 25
pallor 1 | 34
persistence of hyaloid vascula... 1 | 33
prenatal lethality 1 | 28
small seminal vesicle 1 | 10
small superior vagus ganglion 1 | 74
small testis 1 | 58
thrombocytosis 1 | 27

Disease

Carcinoma 80 | 11,493
Cancer 71 | 2,499
ovarian cancer 68 | 8,520
glioblastoma 54 | 5,792
osteosarcoma 52 | 7,950
lung cancer 51 | 4,740
psoriasis 51 | 6,694
medulloblastoma, large-cell 47 | 6,241
atypical teratoid / rhabdoid tumor 43 | 5,112
Breast cancer 42 | 3,578
Breast Neoplasms 40 | 445
Kidney cancer 40 | 2,613
Mammary Neoplasms 40 | 425
ependymoma 33 | 4,679
malignant mesothelioma 31 | 3,232
group 3 medulloblastoma 29 | 4,104
Schizophrenia 28 | 1,160
primitive neuroectodermal tumor 28 | 3,035
oligodendroglioma 27 | 2,850
astrocytic glioma 26 | 2,597
Astrocytoma, Pilocytic 25 | 3,081
adult high grade glioma 25 | 3,801
pituitary cancer 24 | 1,972
Liver carcinoma 23 | 240
Lung Neoplasms 23 | 232
diabetes mellitus 23 | 1,728
intraductal papillary-mucinous adenoma (IPMA) 23 | 2,955
pancreatic cancer 23 | 2,398
subependymal giant cell astrocytoma 23 | 2,287
Carcinoma, Hepatocellular 21 | 228
Prostatic Neoplasms 21 | 495
Short stature 21 | 531
Vascular disease 21 | 319
breast carcinoma 21 | 1,638
Adenoma 20 | 167
astrocytoma 20 | 1,146
intraductal papillary-mucinous carcinoma (IPMC) 20 | 2,989
non-small cell lung cancer 20 | 2,890
Alzheimer's disease 19 | 658
Obesity 19 | 678
Stomach Neoplasms 19 | 300
group 4 medulloblastoma 19 | 1,855
invasive ductal carcinoma 19 | 2,951
juvenile dermatomyositis 19 | 1,187
Autosomal recessive predisposition 18 | 1,442
Orbital separation excessive 18 | 244
ductal carcinoma in situ 18 | 1,745
Carcinoma, Squamous Cell 17 | 110
Depressive disorder 17 | 409
Epilepsy 17 | 792
Intellectual disability 17 | 1,016
Kidney disease 17 | 430
interstitial cystitis 17 | 2,312
intraductal papillary-mucinous neoplasm (IPMN) 17 | 3,291
lung adenocarcinoma 17 | 2,716
Dull intelligence 16 | 645
Hypoplastic mandible condyle 16 | 275
Liver cancer 16 | 604
Low intelligence 16 | 645
Mandibular hypoplasia 16 | 275
Melanoma 16 | 711
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Micrognathism 16 | 275
Pick disease 16 | 1,894
Poor school performance 16 | 645
adrenocortical carcinoma 16 | 1,428
lung carcinoma 16 | 2,843
Cell Transformation, Neoplastic 15 | 97
Rheumatoid arthritis 15 | 1,191
ulcerative colitis 15 | 1,819
Blepharoptosis 14 | 231
Endometriosis 14 | 540
Hypertension 14 | 396
Neoplasm Metastasis 14 | 168
Neoplastic Cell Transformation 14 | 89
Osteoporosis 14 | 363
Seizures 14 | 596
Acquired scoliosis 13 | 281
Byzanthine arch palate 13 | 194
Colonic Neoplasms 13 | 142
Colorectal Neoplasms 13 | 243
Concave bridge of nose 13 | 195
Curvature of spine 13 | 282
Depressed nasal bridge 13 | 195
Depressed nasal root/bridge 13 | 195
Downward slant of palpebral fissure 13 | 158
Failure to gain weight 13 | 365
Heart disease 13 | 306
Hypertensive disease 13 | 292
Mammary Neoplasms, Experimental 13 | 154
Muscle hypotonia 13 | 571
Pediatric failure to thrive 13 | 365
Short neck 13 | 140
Squamous cell carcinoma 13 | 129
Stomach cancer 13 | 30
Arthritis 12 | 290
Mental Depression 12 | 333
colon cancer 12 | 1,478
cystic fibrosis 12 | 1,696

Tissue

Endocrine System 95 | 18,159
Blood and immune system 94 | 16,909
Digestive Tract 94 | 17,369
Liver and Pancreas 93 | 16,750
Male tissues 93 | 17,142
Skin and soft tissues 93 | 17,230
Urinary Tract 93 | 16,678
Female tissues 92 | 17,400
Respiratory system 92 | 16,393
Nervous System 91 | 16,725
Cardiovascular System 89 | 15,192

Target Family

Kinase 33 | 634
Non-IDG 29 | 12,091
Enzyme 23 | 4,145
Transcription Factor 8 | 1,400
Epigenetic 2 | 242
Nuclear Receptor 2 | 48
GPCR 1 | 408
Transporter 1 | 473

KEGG Pathway

Endocrine resistance 99 | 99
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
SHC-transforming protein 2 SHC2 Tbio Non-IDG -2.47843 293.4 113
Histone-arginine methyltransferase CARM1 CARM1 Tchem Epigenetic -2.04034 130.8 476
Adenylate cyclase type 8 ADCY8 Tbio Enzyme -2.04645 112.4 147
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
Adenylate cyclase type 6 ADCY6 Tchem Enzyme -2.05332 113.7 111
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
Delta-like protein 3 DLL3 Tbio Non-IDG -1.68978 48.6 214
Adenylate cyclase type 7 ADCY7 Tbio Enzyme -1.68806 49.1 114