Development Level

Tchem 31 | 1,598
Tclin 24 | 613
Tbio 23 | 11,445
Tdark 1 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
decreased body weight 4 | 161
increased mean corpuscular hem... 3 | 96
abnormal bone mineralization 2 | 38
abnormal retina morphology 2 | 71
decreased bone mineral density 2 | 126
decreased circulating LDL chol... 2 | 38
decreased circulating choleste... 2 | 93
decreased circulating creatini... 2 | 39
decreased circulating triglyce... 2 | 79
decreased erythrocyte cell num... 2 | 62
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
enlarged heart 2 | 210
increased circulating LDL chol... 2 | 13
increased circulating alkaline... 2 | 122
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
preweaning lethality, incomple... 2 | 499
abnormal behavior 1 | 298
abnormal digit morphology 1 | 10
abnormal eye morphology 1 | 68
abnormal femur morphology 1 | 14
abnormal gait 1 | 69
abnormal glucose homeostasis 1 | 4
abnormal lens morphology 1 | 81
abnormal seminal vesicle morph... 1 | 114
abnormal sleep behavior 1 | 70
cataract 1 | 92
decreased IgG3 level 1 | 1
decreased blood urea nitrogen ... 1 | 51
decreased circulating alanine ... 1 | 47
decreased circulating alkaline... 1 | 46
decreased circulating aspartat... 1 | 34
decreased circulating free fat... 1 | 31
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased lactate dehydrogenas... 1 | 16
decreased leukocyte cell numbe... 1 | 73
decreased mature B cell number 1 | 7
decreased prepulse inhibition 1 | 82
decreased vertical activity 1 | 208
hypoactivity 1 | 132
increased IgG1 level 1 | 1
increased IgM level 1 | 1
increased T cell number 1 | 6
increased circulating choleste... 1 | 66
increased circulating glucose ... 1 | 24
increased erythrocyte cell num... 1 | 39
increased hemoglobin content 1 | 45
increased mean corpuscular vol... 1 | 92
increased or absent threshold ... 1 | 101
limb grasping 1 | 41
prenatal lethality 1 | 28
short tibia 1 | 97
thrombocytopenia 1 | 56
thrombocytosis 1 | 27

Disease

Cancer 64 | 2,499
Carcinoma 61 | 11,493
ovarian cancer 60 | 8,520
osteosarcoma 49 | 7,950
lung cancer 48 | 4,740
glioblastoma 47 | 5,792
Breast cancer 43 | 3,578
medulloblastoma, large-cell 43 | 6,241
psoriasis 43 | 6,694
atypical teratoid / rhabdoid tumor 39 | 5,112
Kidney cancer 31 | 2,613
group 3 medulloblastoma 30 | 4,104
ependymoma 28 | 4,679
invasive ductal carcinoma 27 | 2,951
malignant mesothelioma 27 | 3,232
Breast Neoplasms 25 | 445
Mammary Neoplasms 25 | 425
oligodendroglioma 25 | 2,850
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
Schizophrenia 23 | 1,160
pancreatic cancer 23 | 2,398
Astrocytoma, Pilocytic 22 | 3,081
intraductal papillary-mucinous adenoma (IPMA) 22 | 2,955
intraductal papillary-mucinous carcinoma (IPMC) 22 | 2,989
lung adenocarcinoma 22 | 2,716
non-small cell lung cancer 22 | 2,890
ulcerative colitis 22 | 1,819
Prostatic Neoplasms 21 | 495
Stomach Neoplasms 21 | 300
interstitial cystitis 21 | 2,312
tuberculosis 21 | 2,010
Renal Cell Carcinoma 19 | 214
adult high grade glioma 19 | 3,801
astrocytic glioma 19 | 2,597
diabetes mellitus 19 | 1,728
subependymal giant cell astrocytoma 19 | 2,287
Intellectual disability 18 | 1,016
Lung Neoplasms 18 | 232
Orbital separation excessive 18 | 244
Depressive disorder 17 | 409
Hypoplastic mandible condyle 17 | 275
Mandibular hypoplasia 17 | 275
Micrognathism 17 | 275
Seizures 17 | 596
Short stature 17 | 531
group 4 medulloblastoma 17 | 1,855
lung carcinoma 17 | 2,843
Autosomal recessive predisposition 16 | 1,442
Blepharoptosis 16 | 231
Carcinoma, Hepatocellular 16 | 228
Downward slant of palpebral fissure 16 | 158
Dull intelligence 16 | 645
Epilepsy 16 | 792
Liver carcinoma 16 | 240
Low intelligence 16 | 645
Mental Retardation 16 | 645
Mental deficiency 16 | 645
Neoplasm Metastasis 16 | 168
Poor school performance 16 | 645
Vascular disease 16 | 319
Byzanthine arch palate 15 | 194
Concave bridge of nose 15 | 195
Depressed nasal bridge 15 | 195
Depressed nasal root/bridge 15 | 195
Multiple myeloma 15 | 1,332
Obesity 15 | 678
adrenocortical carcinoma 15 | 1,428
breast carcinoma 15 | 1,638
cystic fibrosis 15 | 1,696
pituitary cancer 15 | 1,972
primitive neuroectodermal tumor 15 | 3,035
spina bifida 15 | 1,074
Acquired scoliosis 14 | 281
Adenoma 14 | 167
Big calvaria 14 | 147
Cognitive delay 14 | 608
Cryptorchidism 14 | 296
Curvature of spine 14 | 282
Global developmental delay 14 | 608
Heart disease 14 | 306
Increased head circumference 14 | 147
Increased size of cranium 14 | 147
Increased size of skull 14 | 147
Kidney disease 14 | 430
Mental and motor retardation 14 | 608
Neoplasm Invasiveness 14 | 161
Rheumatoid arthritis 14 | 1,191
astrocytoma 14 | 1,146
Bipolar Disorder 13 | 666
Frontal bossing 13 | 157
High forehead 13 | 102
Liver Neoplasms, Experimental 13 | 59
Pectus excavatum 13 | 100
Squamous cell carcinoma 13 | 129
Tall forehead 13 | 102
colon cancer 13 | 1,478
Muscle hypotonia 12 | 571
Pick disease 12 | 1,894
juvenile dermatomyositis 12 | 1,187
primary pancreatic ductal adenocarcinoma 12 | 1,109

Tissue

Endocrine System 79 | 18,159
Male tissues 79 | 17,142
Nervous System 79 | 16,725
Blood and immune system 78 | 16,909
Digestive Tract 78 | 17,369
Female tissues 78 | 17,400
Liver and Pancreas 78 | 16,750
Skin and soft tissues 78 | 17,230
Cardiovascular System 77 | 15,192
Respiratory system 77 | 16,393
Urinary Tract 77 | 16,678

Target Family

Kinase 35 | 634
Non-IDG 33 | 12,091
Enzyme 9 | 4,145
Transcription Factor 2 | 1,400

KEGG Pathway

EGFR tyrosine kinase inhibitor... 79 | 79
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Protein kinase C beta type PRKCB Tchem Kinase -2.00437 93.5 598
GRB2-associated-binding protein 1 GAB1 Tbio Non-IDG -1.55563 50.4 268
Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 Tclin Kinase -3.07197 862.4 2448
GTPase KRas KRAS Tchem Enzyme -3.80300 6069.9 574
GTPase HRas HRAS Tchem Enzyme -4.01300 9975.8 492
GTPase NRas NRAS Tchem Enzyme -3.01534 959.1 328
Forkhead box protein O3 FOXO3 Tbio Transcription Factor -2.94477 863.9 864
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 PLCG2 Tchem Enzyme -2.41628 245.1 733
SHC-transforming protein 2 SHC2 Tbio Non-IDG -2.47843 293.4 113
SHC-transforming protein 3 SHC3 Tbio Non-IDG -1.97665 99.4 137