Development Level

Tbio 69 | 11,445
Tchem 35 | 1,598
Tclin 25 | 613
Tdark 6 | 6,588

Collection

Kinase: IDG Consortium (Target... 2 | 125

IMPC Phenotype

abnormal bone structure 7 | 187
preweaning lethality, incomple... 7 | 499
abnormal behavior 6 | 298
increased startle reflex 5 | 112
hyperactivity 4 | 148
increased heart weight 4 | 62
preweaning lethality, complete... 4 | 979
abnormal embryo size 3 | 220
abnormal locomotor behavior 3 | 24
decreased bone mineral content 3 | 151
decreased lean body mass 3 | 135
decreased total body fat amoun... 3 | 207
hypoactivity 3 | 132
increased circulating alkaline... 3 | 122
male infertility 3 | 123
abnormal gait 2 | 69
decreased body length 2 | 101
decreased body weight 2 | 161
decreased fasted circulating g... 2 | 65
decreased grip strength 2 | 116
decreased neutrophil cell numb... 2 | 42
embryonic lethality prior to t... 2 | 278
increased bone mineral content 2 | 108
increased circulating alanine ... 2 | 13
increased circulating choleste... 2 | 66
increased circulating sodium l... 2 | 71
increased circulating triglyce... 2 | 42
increased hematocrit 2 | 46
increased lean body mass 2 | 172
increased total body fat amoun... 2 | 134
small superior vagus ganglion 2 | 74
thrombocytopenia 2 | 56
abnormal bone mineralization 1 | 38
abnormal epididymis morphology 1 | 42
abnormal forebrain development 1 | 20
abnormal gallbladder morpholog... 1 | 1
abnormal glucose homeostasis 1 | 4
abnormal hindbrain development 1 | 16
abnormal neural tube closure 1 | 46
abnormal spleen morphology 1 | 55
abnormal vocalization 1 | 21
cyanosis 1 | 7
decreased bone mineral density 1 | 126
decreased cardiac muscle contr... 1 | 11
decreased circulating LDL chol... 1 | 38
decreased circulating calcium ... 1 | 36
decreased circulating choleste... 1 | 93
decreased circulating fructosa... 1 | 30
decreased circulating glucose ... 1 | 126
decreased circulating glycerol... 1 | 16
decreased circulating insulin ... 1 | 76
decreased circulating iron lev... 1 | 32
decreased circulating magnesiu... 1 | 13
decreased circulating potassiu... 1 | 20
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased heart left ventricle... 1 | 28
decreased heart weight 1 | 27
decreased hemoglobin content 1 | 68
decreased leukocyte cell numbe... 1 | 73
decreased lymphocyte cell numb... 1 | 83
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased mean platelet volume 1 | 25
decreased pulmonary respirator... 1 | 5
decreased respiratory quotient 1 | 16
decreased startle reflex 1 | 75
embryonic growth retardation 1 | 106
enlarged epididymis 1 | 31
enlarged gallbladder 1 | 2
enlarged heart 1 | 210
enlarged spleen 1 | 41
hydrometra 1 | 53
impaired pupillary reflex 1 | 26
impaired righting response 1 | 26
increased cardiac muscle contr... 1 | 8
increased circulating HDL chol... 1 | 80
increased circulating LDL chol... 1 | 13
increased circulating chloride... 1 | 41
increased circulating creatini... 1 | 38
increased circulating phosphat... 1 | 26
increased erythrocyte cell num... 1 | 39
increased fasted circulating g... 1 | 76
increased leukocyte cell numbe... 1 | 47
increased lymphocyte cell numb... 1 | 32
increased mean corpuscular vol... 1 | 92
increased neutrophil cell numb... 1 | 46
increased or absent threshold ... 1 | 101
limb grasping 1 | 41
short tibia 1 | 97
small epididymis 1 | 3
small kidney 1 | 16
thrombocytosis 1 | 27

Disease

Carcinoma 94 | 11,493
glioblastoma 78 | 5,792
medulloblastoma, large-cell 73 | 6,241
ovarian cancer 69 | 8,520
atypical teratoid / rhabdoid tumor 67 | 5,112
ependymoma 63 | 4,679
psoriasis 63 | 6,694
osteosarcoma 60 | 7,950
adult high grade glioma 59 | 3,801
group 3 medulloblastoma 51 | 4,104
Astrocytoma, Pilocytic 50 | 3,081
Schizophrenia 48 | 1,160
primitive neuroectodermal tumor 47 | 3,035
lung cancer 44 | 4,740
Breast cancer 41 | 3,578
Bipolar Disorder 40 | 666
oligodendroglioma 39 | 2,850
subependymal giant cell astrocytoma 39 | 2,287
Depressive disorder 38 | 409
lung carcinoma 37 | 2,843
astrocytic glioma 35 | 2,597
Pick disease 33 | 1,894
Mental Depression 32 | 333
Kidney cancer 31 | 2,613
Cancer 29 | 2,499
pituitary cancer 29 | 1,972
intraductal papillary-mucinous carcinoma (IPMC) 28 | 2,989
Epilepsy 27 | 792
intraductal papillary-mucinous adenoma (IPMA) 26 | 2,955
Parkinson's disease 25 | 392
group 4 medulloblastoma 25 | 1,855
Major Depressive Disorder 24 | 301
diabetes mellitus 24 | 1,728
intraductal papillary-mucinous neoplasm (IPMN) 24 | 3,291
invasive ductal carcinoma 24 | 2,951
lung adenocarcinoma 24 | 2,716
non-small cell lung cancer 23 | 2,890
Intellectual disability 22 | 1,016
malignant mesothelioma 22 | 3,232
Alcoholic Intoxication, Chronic 19 | 289
Rheumatoid arthritis 19 | 1,191
Unipolar Depression 19 | 250
pancreatic cancer 19 | 2,398
ulcerative colitis 19 | 1,819
Alzheimer's disease 18 | 658
Mood Disorders 18 | 184
Obesity 18 | 678
colon cancer 18 | 1,478
Attention deficit hyperactivity disorder 17 | 278
Toxic encephalopathy 17 | 141
Seizures 16 | 596
breast carcinoma 16 | 1,638
interstitial cystitis 15 | 2,312
tuberculosis 15 | 2,010
Autistic Disorder 14 | 364
Hypertension 14 | 396
Alcohol dependence 13 | 107
Cognitive delay 13 | 608
Global developmental delay 13 | 608
Liver cancer 13 | 604
Mental and motor retardation 13 | 608
Waldenstrons macroglobulinemia 13 | 765
ductal carcinoma in situ 13 | 1,745
Dull intelligence 12 | 645
Low intelligence 12 | 645
Mental Retardation 12 | 645
Mental deficiency 12 | 645
Poor school performance 12 | 645
Substance Withdrawal Syndrome 12 | 55
astrocytoma 12 | 1,146
pancreatic ductal adenocarcinoma liver metastasis 12 | 1,962
Autosomal recessive predisposition 11 | 1,442
Cocaine-Related Disorders 11 | 92
Multiple myeloma 11 | 1,332
Cocaine Dependence 10 | 51
Hyperactive behavior 10 | 91
Hypertensive disease 10 | 292
Substance abuse 10 | 59
Amphetamine-Related Disorders 9 | 74
Neurodegenerative disease 9 | 414
Vascular disease 9 | 319
adrenocortical carcinoma 9 | 1,428
aldosterone-producing adenoma 9 | 665
cutaneous lupus erythematosus 9 | 1,057
juvenile dermatomyositis 9 | 1,187
spina bifida 9 | 1,074
Acromegaly 8 | 51
Adenoma 8 | 167
Dementia 8 | 175
Dystonia 8 | 164
Endometrial cancer 8 | 311
Heart disease 8 | 306
Melanoma 8 | 711
Pain agnosia 8 | 104
Prostatic Neoplasms 8 | 495
Psychotic Disorders 8 | 151
Skin cancer 8 | 469
cystic fibrosis 8 | 1,696
non primary Sjogren syndrome sicca 8 | 891
substance-related disorder 8 | 162

Tissue

Endocrine System 131 | 18,159
Digestive Tract 126 | 17,369
Female tissues 125 | 17,400
Nervous System 124 | 16,725
Skin and soft tissues 124 | 17,230
Blood and immune system 123 | 16,909
Male tissues 123 | 17,142
Liver and Pancreas 120 | 16,750
Respiratory system 116 | 16,393
Urinary Tract 113 | 16,678
Cardiovascular System 108 | 15,192

Target Family

Non-IDG 40 | 12,091
Enzyme 34 | 4,145
Kinase 22 | 634
Ion Channel 18 | 344
Transcription Factor 12 | 1,400
GPCR 5 | 408
Transporter 3 | 473
TF/Epigenetic 1 | 38

KEGG Pathway

Dopaminergic synapse 135 | 135
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

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