Development Level

Tbio 27 | 11,651
Tchem 5 | 1,388
Tclin 3 | 612
Tdark 1 | 6,593

IMPC Phenotype

preweaning lethality, complete... 10 | 979
embryonic lethality prior to o... 6 | 239
embryonic lethality prior to t... 3 | 278
abnormal embryo size 2 | 220
embryonic growth retardation 2 | 106
increased mean corpuscular vol... 2 | 92
abnormal embryo turning 1 | 31
abnormal pelvic girdle bone mo... 1 | 12
abnormal pericardium morpholog... 1 | 26
abnormal pharyngeal arch morph... 1 | 8
decreased circulating glucose ... 1 | 126
decreased circulating triglyce... 1 | 79
decreased erythrocyte cell num... 1 | 62
decreased mean corpuscular hem... 1 | 31
increased circulating HDL chol... 1 | 80
increased circulating choleste... 1 | 66
increased grip strength 1 | 41
increased heart weight 1 | 62
increased mean corpuscular hem... 1 | 96
prenatal lethality prior to he... 1 | 87

Disease

group 3 medulloblastoma 26 | 4,104
malignant mesothelioma 23 | 3,232
ovarian cancer 23 | 8,520
lung cancer 20 | 4,740
medulloblastoma, large-cell 20 | 6,241
non-small cell lung cancer 20 | 2,890
Carcinoma 18 | 11,493
osteosarcoma 18 | 7,950
primitive neuroectodermal tumor 18 | 3,035
psoriasis 17 | 6,694
glioblastoma 15 | 5,792
atypical teratoid / rhabdoid tumor 14 | 5,112
adrenocortical carcinoma 12 | 1,428
intraductal papillary-mucinous carcinoma (IPMC) 12 | 2,989
Breast cancer 11 | 3,578
Cancer 10 | 2,499
adult high grade glioma 10 | 3,801
colon cancer 10 | 1,478
intraductal papillary-mucinous neoplasm (IPMN) 10 | 3,291
lung adenocarcinoma 10 | 2,716
nasopharyngeal carcinoma 10 | 1,058
Waldenstrons macroglobulinemia 9 | 765
ependymoma 8 | 4,679
oligodendroglioma 8 | 2,850
Endometriosis 7 | 540
Autosomal recessive predisposition 6 | 1,442
ductal carcinoma in situ 6 | 1,745
invasive ductal carcinoma 6 | 2,951
tuberculosis 6 | 2,010
Kidney cancer 5 | 2,613
pediatric high grade glioma 5 | 1,064
Colorectal Neoplasms 4 | 243
Multiple myeloma 4 | 1,332
Short stature 4 | 531
Xeroderma pigmentosum 4 | 43
astrocytoma 4 | 1,146
diabetes mellitus 4 | 1,728
Acute lymphoid leukemia 3 | 25
Acute myeloid leukemia, disease 3 | 30
Acute promyelocytic leukemia, FAB M3 3 | 11
Adenocarcinoma of pancreas 3 | 14
Aicardi-Goutieres syndrome 3 | 19
Cognitive delay 3 | 608
Colonic Neoplasms 3 | 142
Convex nasal ridge 3 | 37
Dull intelligence 3 | 645
Global developmental delay 3 | 608
Hepatomegaly 3 | 285
Hypoplastic mandible condyle 3 | 275
Intellectual disability 3 | 1,016
Low intelligence 3 | 645
Lymphomatous meningitis 3 | 3
Malignant tumor of ovary 3 | 25
Mandibular hypoplasia 3 | 275
Meningeal Leukemia 3 | 7
Mental Retardation 3 | 645
Mental and motor retardation 3 | 608
Mental deficiency 3 | 645
Metastatic Breast Carcinoma 3 | 21
Micrognathism 3 | 275
Muscle Spasticity 3 | 195
Poor school performance 3 | 645
Seckel syndrome 3 | 34
Small head 3 | 374
acute myeloid leukemia 3 | 783
astrocytic glioma 3 | 2,597
breast carcinoma 3 | 1,638
dermatomyositis 3 | 966
intraductal papillary-mucinous adenoma (IPMA) 3 | 2,955
pituitary cancer 3 | 1,972
primary Sjogren syndrome 3 | 735
Astrocytoma, Pilocytic 2 | 3,081
Atopic dermatitis 2 | 952
Atrophy of cerebellum 2 | 103
Broad forehead 2 | 59
Cerebellar degeneration 2 | 103
Chronic Lymphocytic Leukemia 2 | 262
Chronic progressive external ophthalmoplegia 2 | 26
Cockayne syndrome 2 | 60
Creatine phosphokinase serum increased 2 | 110
Elevated creatine kinase 2 | 110
Elevated hepatic transaminases 2 | 81
Failure to thrive in infancy 2 | 32
Hepatic enzyme increased 2 | 81
Hernia, Inguinal 2 | 89
Infratentorial atrophy 2 | 103
Intrauterine retardation 2 | 176
Liver Dysfunction 2 | 99
Liver enzymes abnormal 2 | 81
Liver function test increased 2 | 81
Liver function tests abnormal finding 2 | 81
Low Vision 2 | 174
Subclinical abnormal liver function tests 2 | 81
Transaminases increased 2 | 81
Visual Impairment 2 | 174
atypical teratoid/rhabdoid tumor 2 | 357
gastric carcinoma 2 | 807
juvenile dermatomyositis 2 | 1,187
posterior fossa group A ependymoma 2 | 468
subependymal giant cell astrocytoma 2 | 2,287

Tissue

Blood and immune system 36 | 16,909
Cardiovascular System 36 | 15,192
Digestive Tract 36 | 17,369
Endocrine System 36 | 18,159
Female tissues 36 | 17,400
Liver and Pancreas 36 | 16,750
Male tissues 36 | 17,142
Nervous System 36 | 16,725
Respiratory system 36 | 16,393
Skin and soft tissues 36 | 17,230
Urinary Tract 36 | 16,678

Target Family

Enzyme 19 | 4,145
Non-IDG 17 | 12,091

KEGG Pathway

DNA replication 36 | 36
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA polymerase delta catalytic subunit POLD1 Tclin Enzyme -2.06760 110.4 225
Flap endonuclease 1 FEN1 Tchem Enzyme -2.79171 617.0 406
DNA polymerase delta subunit 2 POLD2 Tbio Enzyme -0.95222 8.52 115
Replication protein A 70 kDa DNA-binding subunit RPA1 Tchem Non-IDG -2.48277 297.9 350
Replication factor C subunit 4 RFC4 Tbio Non-IDG -1.17661 13.7 195
Replication factor C subunit 5 RFC5 Tbio Non-IDG -1.06074 11.3 79
Proliferating cell nuclear antigen PCNA Tchem Non-IDG -1.13711 11.3 1721
Replication protein A 32 kDa subunit RPA2 Tbio Non-IDG -1.79461 61.4 510
DNA replication licensing factor MCM3 MCM3 Tbio Non-IDG -2.04750 101.5 390
DNA replication ATP-dependent helicase/nuclease DNA2 DNA2 Tbio Enzyme -2.42159 256.1 101