Development Level

Tbio 47 | 11,445
Tchem 11 | 1,598
Tclin 2 | 613
Tdark 2 | 6,588

IMPC Phenotype

preweaning lethality, complete... 6 | 979
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
abnormal embryo size 2 | 220
decreased bone mineral content 2 | 151
decreased circulating sodium l... 2 | 22
increased circulating free fat... 2 | 20
abnormal behavior 1 | 298
abnormal bone structure 1 | 187
abnormal coat- hair morphology 1 | 19
abnormal cornea morphology 1 | 31
abnormal hair growth 1 | 10
abnormal neural tube closure 1 | 46
abnormal placenta size 1 | 20
abnormal skin condition 1 | 6
absent vibrissae 1 | 12
decreased circulating HDL chol... 1 | 68
decreased circulating amylase ... 1 | 28
decreased circulating choleste... 1 | 93
decreased circulating iron lev... 1 | 32
decreased mean corpuscular hem... 1 | 50
decreased mean corpuscular hem... 1 | 31
decreased mean corpuscular vol... 1 | 79
decreased thermal nociceptive ... 1 | 2
embryonic growth retardation 1 | 106
enlarged lymph nodes 1 | 37
enlarged urinary bladder 1 | 8
female infertility 1 | 60
increased bone mineral content 1 | 108
increased circulating alkaline... 1 | 122
increased circulating iron lev... 1 | 30
increased leukocyte cell numbe... 1 | 47
increased thermal nociceptive ... 1 | 9
pale yolk sac 1 | 25
pallor 1 | 34
preweaning lethality, incomple... 1 | 499

Disease

Carcinoma 26 | 11,493
Cancer 24 | 2,499
ovarian cancer 24 | 8,520
lung cancer 22 | 4,740
psoriasis 22 | 6,694
glioblastoma 17 | 5,792
osteosarcoma 16 | 7,950
Influenza 14 | 142
adult high grade glioma 13 | 3,801
lung carcinoma 13 | 2,843
tuberculosis 13 | 2,010
Arthritis 12 | 290
ependymoma 12 | 4,679
interstitial cystitis 12 | 2,312
lung adenocarcinoma 12 | 2,716
malignant mesothelioma 12 | 3,232
Asthma 11 | 385
Multiple myeloma 11 | 1,332
invasive ductal carcinoma 11 | 2,951
Astrocytoma, Pilocytic 10 | 3,081
Breast cancer 10 | 3,578
Liver Cirrhosis, Experimental 10 | 769
Multiple Sclerosis 10 | 540
cutaneous lupus erythematosus 10 | 1,057
diabetes mellitus 10 | 1,728
non-small cell lung cancer 10 | 2,890
subependymal giant cell astrocytoma 10 | 2,287
ulcerative colitis 10 | 1,819
Inflammatory bowel disease 9 | 151
Kidney cancer 9 | 2,613
Lung disease 9 | 142
cystic fibrosis 9 | 1,696
intraductal papillary-mucinous neoplasm (IPMN) 9 | 3,291
medulloblastoma, large-cell 9 | 6,241
Autosomal recessive predisposition 8 | 1,442
Brain Ischemia 8 | 110
Dermatitis 8 | 157
Hypersensitivity reaction type II disease 8 | 253
Pneumonia 8 | 174
Hepatitis 7 | 67
Hepatitis C 7 | 94
Human immunodeficiency virus infectious disease 7 | 138
Kidney disease 7 | 430
astrocytoma 7 | 1,146
atypical teratoid / rhabdoid tumor 7 | 5,112
breast carcinoma 7 | 1,638
dermatomyositis 7 | 966
pancreatic cancer 7 | 2,398
Atherosclerosis 6 | 291
Breast Neoplasms 6 | 445
Chemical and Drug Induced Liver Injury 6 | 195
Encephalitis 6 | 64
Hepatitis B 6 | 108
Inflammation 6 | 120
Microphthalmia with limb anomalies 6 | 40
Muscle Spasticity 6 | 195
Obesity 6 | 678
Rheumatoid arthritis 6 | 1,191
Schizophrenia 6 | 1,160
juvenile dermatomyositis 6 | 1,187
sarcoidosis 6 | 370
Aicardi-Goutieres syndrome 5 | 19
Cognitive delay 5 | 608
Depressive disorder 5 | 409
Dermatitis, Atopic 5 | 37
Eye disease 5 | 62
Global developmental delay 5 | 608
Glomerulonephritis 5 | 46
Hypersensitivity 5 | 63
Hypertension 5 | 396
Hypodontia 5 | 81
Leukopenia 5 | 72
Major Depressive Disorder 5 | 301
Malaria 5 | 160
Mammary Neoplasms 5 | 425
Melanoma 5 | 711
Mental and motor retardation 5 | 608
Myocardial Ischemia 5 | 169
Seizures 5 | 596
Severe acute respiratory syndrome 5 | 27
Unipolar Depression 5 | 250
Vascular disease 5 | 319
active Crohn's disease 5 | 922
colon cancer 5 | 1,478
ductal carcinoma in situ 5 | 1,745
group 4 medulloblastoma 5 | 1,855
intraductal papillary-mucinous carcinoma (IPMC) 5 | 2,989
non primary Sjogren syndrome sicca 5 | 891
oligodendroglioma 5 | 2,850
primary Sjogren syndrome 5 | 735
Abortion, Spontaneous 4 | 109
Allergic hypersensitivity disease 4 | 126
Anemia 4 | 365
Coronary artery disease 4 | 268
Endometriosis 4 | 540
Hypereosinophilic syndrome 4 | 71
Spontaneous abortion 4 | 113
Strabismus 4 | 270
hepatocellular carcinoma 4 | 547
nasopharyngeal carcinoma 4 | 1,058

Tissue

Blood and immune system 51 | 16,909
Male tissues 50 | 17,142
Nervous System 49 | 16,725
Urinary Tract 49 | 16,678
Cardiovascular System 48 | 15,192
Digestive Tract 48 | 17,369
Endocrine System 48 | 18,159
Female tissues 48 | 17,400
Liver and Pancreas 48 | 16,750
Respiratory system 48 | 16,393
Skin and soft tissues 48 | 17,230

Target Family

Non-IDG 29 | 12,091
Enzyme 22 | 4,145
Kinase 7 | 634
Transcription Factor 4 | 1,400

KEGG Pathway

Cytosolic DNA-sensing pathway 62 | 62
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Cytokine-cytokine receptor int... 267 | 267
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
DNA-directed RNA polymerase III subunit RPC8 POLR3H Tbio Enzyme -1.32118 21.0 104
DNA-directed RNA polymerase III subunit RPC2 POLR3B Tbio Enzyme -1.25377 19.0 105
DNA-directed RNA polymerases I, II, and III subunit RPABC3 POLR2H Tbio Enzyme -1.13403 13.5 180
DNA-directed RNA polymerases I, II, and III subunit RPABC4 POLR2K Tbio Enzyme -0.90716 7.36 65
DNA-directed RNA polymerase III subunit RPC1 POLR3A Tbio Enzyme -2.25632 178.2 99
Interferon-inducible protein AIM2 AIM2 Tbio Non-IDG -2.17906 165.7 439
Double-stranded RNA-specific adenosine deaminase ADAR Tbio Enzyme -2.87338 784.2 197
Protein POLR1D, isoform 2 POLR1D Tbio Non-IDG -1.52326 49.2 0
DNA-directed RNA polymerases I and III subunit RPAC2 POLR1D Tbio Enzyme -1.52326 49.2 0
Interferon alpha-6 IFNA6 Tbio Non-IDG -0.90731 7.40 134