Targets

Target Filters...

This is where graphics are reside..

Name	Gene	Development Level	Target Family	Log Novelty	Pubmed Score	Antibody Count
Interleukin-9	IL9	Tbio	Non-IDG	-2.46520	301.6	339
Interferon gamma receptor 1	IFNGR1	Tchem	Non-IDG	-2.19638	160.9	450
Vascular endothelial growth factor receptor 1	FLT1	Tclin	Kinase	-3.36387	2061.0	806
CD40 ligand	CD40LG	Tchem	Non-IDG	-4.56976	36580.5	1095
C-X-C chemokine receptor type 1	CXCR1	Tchem	GPCR	-2.45436	257.8	324
Tumor necrosis factor ligand superfamily member 14	TNFSF14	Tchem	Non-IDG	-1.75891	51.5	327
Pro-epidermal growth factor	EGF	Tbio	Non-IDG	-3.74596	4837.7	851
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha	CSF2RA	Tclin	Non-IDG	-2.15518	132.8	381
Hepatocyte growth factor	HGF	Tchem	Enzyme	-3.29371	2317.3	573
Interleukin-7 receptor subunit alpha	IL7R	Tbio	Non-IDG	-2.76199	528.6	688

	Tbio	156 \| 10,625
	Tchem	57 \| 1,890
	Tclin	45 \| 602
	Tdark	4 \| 7,003

	preweaning lethality, complete...	8 \| 633
	preweaning lethality, incomple...	8 \| 260
	enlarged heart	6 \| 111
	decreased lean body mass	4 \| 195
	increased circulating total pr...	4 \| 20
	abnormal embryo size	3 \| 112
	decreased circulating insulin ...	3 \| 75
	decreased fasted circulating g...	3 \| 49
	decreased monocyte cell number	3 \| 28
	decreased total body fat amoun...	3 \| 186
	improved glucose tolerance	3 \| 56
	increased circulating HDL chol...	3 \| 63
	increased circulating alkaline...	3 \| 119
	increased circulating calcium ...	3 \| 32
	increased circulating serum al...	3 \| 25
	increased mean corpuscular vol...	3 \| 91
	abnormal bone structure	2 \| 131
	abnormal gait	2 \| 51
	abnormal seminal vesicle morph...	2 \| 47
	decreased CD8-positive, alpha-...	2 \| 26
	decreased NK T cell number	2 \| 28
	decreased T cell number	2 \| 31
	decreased alpha-beta T cell nu...	2 \| 12
	decreased bone mineral content	2 \| 157
	decreased caudal vertebrae num...	2 \| 49
	decreased circulating free fat...	2 \| 39
	decreased circulating glucose ...	2 \| 121
	decreased erythrocyte cell num...	2 \| 43
	decreased grip strength	2 \| 123
	decreased leukocyte cell numbe...	2 \| 54
	decreased lumbar vertebrae num...	2 \| 62
	enlarged epididymis	2 \| 27
	hypoactivity	2 \| 89
	increased circulating choleste...	2 \| 53
	increased circulating phosphat...	2 \| 24
	increased hematocrit	2 \| 36
	increased hemoglobin content	2 \| 45
	increased mean corpuscular hem...	2 \| 93
	increased monocyte cell number	2 \| 27
	increased or absent threshold ...	2 \| 128
	limb grasping	2 \| 35
	small superior vagus ganglion	2 \| 20
	small testis	2 \| 37
	thrombocytopenia	2 \| 46
	tremors	2 \| 34
	abnormal behavioral response t...	1 \| 52
	abnormal brain morphology	1 \| 6
	abnormal coat- hair morphology	1 \| 18
	abnormal eye morphology	1 \| 38
	abnormal heart morphology	1 \| 51
	abnormal sleep behavior	1 \| 63
	craniofacial phenotype	1 \| 9
	decreased CD4-positive, CD25-p...	1 \| 24
	decreased CD4-positive, alpha ...	1 \| 19
	decreased blood urea nitrogen ...	1 \| 31
	decreased body length	1 \| 108
	decreased bone mineral density	1 \| 126
	decreased circulating chloride...	1 \| 32
	decreased circulating creatini...	1 \| 31
	decreased circulating serum al...	1 \| 79
	decreased circulating triglyce...	1 \| 83
	decreased eosinophil cell numb...	1 \| 41
	decreased gamma-delta T cell n...	1 \| 18
	decreased heart rate	1 \| 10
	decreased hematocrit	1 \| 25
	decreased hemoglobin content	1 \| 53
	decreased neutrophil cell numb...	1 \| 37
	decreased spleen weight	1 \| 13
	embryonic lethality prior to t...	1 \| 187
	female infertility	1 \| 34
	hydroencephaly	1 \| 6
	hydrometra	1 \| 13
	hydrops fetalis	1 \| 22
	impaired glucose tolerance	1 \| 52
	increased B cell number	1 \| 23
	increased NK cell number	1 \| 19
	increased blood urea nitrogen ...	1 \| 44
	increased bone mineral content	1 \| 92
	increased bone mineral density	1 \| 52
	increased circulating alanine ...	1 \| 11
	increased circulating aspartat...	1 \| 17
	increased circulating creatini...	1 \| 29
	increased circulating fructosa...	1 \| 11
	increased circulating glucose ...	1 \| 16
	increased circulating iron lev...	1 \| 25
	increased circulating potassiu...	1 \| 31
	increased circulating triglyce...	1 \| 24
	increased eosinophil cell numb...	1 \| 9
	increased gamma-delta T cell n...	1 \| 16
	increased grip strength	1 \| 83
	increased lean body mass	1 \| 107
	increased prepulse inhibition	1 \| 21
	increased sacral vertebrae num...	1 \| 62
	increased total body fat amoun...	1 \| 57
	lethargy	1 \| 5
	microphthalmia	1 \| 15
	prolonged RR interval	1 \| 2
	small adrenal glands	1 \| 15
	small seminal vesicle	1 \| 6
	vertebral fusion	1 \| 23

	psoriasis	143 \| 6,685
	Cancer	140 \| 2,346
	lung cancer	106 \| 4,473
	osteosarcoma	101 \| 7,933
	ovarian cancer	101 \| 8,491
	interstitial cystitis	89 \| 2,299
	ulcerative colitis	84 \| 2,087
	glioblastoma	81 \| 5,572
	lung carcinoma	79 \| 2,844
	tuberculosis	78 \| 1,563
	malignant mesothelioma	73 \| 3,163
	medulloblastoma, large-cell	64 \| 6,234
	Asthma	63 \| 349
	Rheumatoid Arthritis	62 \| 1,170
	lung adenocarcinoma	62 \| 2,714
	Breast cancer	61 \| 3,098
	invasive ductal carcinoma	60 \| 2,950
	pilocytic astrocytoma	60 \| 3,086
	non-small cell lung cancer	59 \| 2,798
	Hypersensitivity reaction type II disease	58 \| 235
	pancreatic cancer	58 \| 2,300
	Multiple Sclerosis	56 \| 498
	cutaneous lupus erythematosus	55 \| 1,056
	cystic fibrosis	55 \| 1,670
	Arthritis	46 \| 248
	atypical teratoid / rhabdoid tumor	45 \| 4,369
	intraductal papillary-mucinous neoplasm (IPMN)	44 \| 3,289
	intraductal papillary-mucinous carcinoma (IPMC)	43 \| 2,988
	adult high grade glioma	42 \| 2,148
	diabetes mellitus	42 \| 1,663
	intraductal papillary-mucinous adenoma (IPMA)	42 \| 2,956
	pituitary cancer	42 \| 1,972
	Inflammatory bowel disease	41 \| 142
	Pneumonia	41 \| 133
	Kidney disease	40 \| 397
	Hypersensitivity	38 \| 63
	breast carcinoma	37 \| 1,614
	colon cancer	36 \| 1,475
	posterior fossa group A ependymoma	36 \| 1,511
	Atherosclerosis	32 \| 275
	Lung disease	32 \| 136
	Mammary Neoplasms	32 \| 410
	ductal carcinoma in situ	32 \| 1,745
	primary Sjogren syndrome	32 \| 788
	subependymal giant cell astrocytoma	32 \| 2,287
	Eosinophilia	31 \| 65
	Dermatitis	30 \| 141
	Influenza	30 \| 142
	Atopic dermatitis	29 \| 944
	Allergic hypersensitivity disease	28 \| 123
	nasopharyngeal carcinoma	28 \| 1,056
	periodontitis	28 \| 269
	sarcoidosis	28 \| 368
	active Crohn's disease	27 \| 918
	Liver disease	26 \| 219
	Pulmonary Fibrosis	26 \| 66
	gastric carcinoma	26 \| 832
	hepatocellular carcinoma	26 \| 550
	pediatric high grade glioma	26 \| 2,712
	group 4 medulloblastoma	25 \| 1,875
	oligodendroglioma	25 \| 2,849
	pancreatic ductal adenocarcinoma liver metastasis	25 \| 1,795
	Carcinoma	24 \| 2,147
	Endometriosis	24 \| 535
	Human immunodeficiency virus infectious disease	24 \| 129
	Anemia	23 \| 252
	Coronary artery disease	23 \| 240
	Hepatitis C	23 \| 90
	Prostatic Neoplasms	23 \| 471
	mucosa-associated lymphoid tissue lymphoma	23 \| 480
	non-small cell lung carcinoma	23 \| 413
	primary pancreatic ductal adenocarcinoma	23 \| 1,271
	Crohn's disease	22 \| 304
	Heart disease	22 \| 279
	Inflammation	22 \| 109
	Obesity	22 \| 616
	Allergic rhinitis	21 \| 92
	Hepatitis B	21 \| 103
	juvenile dermatomyositis	21 \| 1,189
	Acquired immunodeficiency syndrome	20 \| 164
	Neoplasm Metastasis	20 \| 138
	Thrombocytopenia	20 \| 105
	Vascular disease	20 \| 281
	group 3 medulloblastoma	20 \| 2,254
	pancreatic carcinoma	20 \| 567
	Dermatitis, Atopic	19 \| 45
	Hypertension	19 \| 293
	adrenocortical carcinoma	19 \| 1,427
	Cerebrovascular disease	18 \| 231
	Diarrhea	18 \| 155
	Drug-Induced Liver Injury	18 \| 118
	Liver Cirrhosis, Experimental	18 \| 108
	Malaria	18 \| 140
	Peripheral Neuropathy	18 \| 303
	Brain Ischemia	17 \| 87
	Leishmaniasis	17 \| 49
	Myocardial Ischemia	17 \| 169
	Spontaneous abortion	17 \| 108
	astrocytoma	17 \| 1,493
	primitive neuroectodermal tumor	17 \| 3,031

	Digestive Tract	253 \| 18,472
	Nervous System	251 \| 18,560
	Female tissues	250 \| 18,646
	Urinary Tract	247 \| 18,443
	Blood and immune system	245 \| 17,994
	Skin and soft tissues	245 \| 18,114
	Endocrine System	244 \| 18,511
	Liver and Pancreas	239 \| 18,135
	Cardiovascular System	237 \| 17,957
	Respiratory system	236 \| 17,483
	Male tissues	229 \| 17,968

	Cytokine-cytokine receptor int...	262 \| 262
	Metabolic pathways	1,254 \| 1,254
	Olfactory transduction	412 \| 412
	Pathways in cancer	402 \| 402
	HTLV-I infection	339 \| 339
	PI3K-Akt signaling pathway	338 \| 338
	Endocytosis	326 \| 326
	Epstein-Barr virus infection	279 \| 279
	Neuroactive ligand-receptor in...	276 \| 276
	Herpes simplex infection	262 \| 262
	MAPK signaling pathway	255 \| 255
	Viral carcinogenesis	253 \| 253
	Phagosome	231 \| 231
	Cell adhesion molecules (CAMs)	225 \| 225
	Ras signaling pathway	225 \| 225
	Rap1 signaling pathway	213 \| 213
	Regulation of actin cytoskelet...	213 \| 213
	Proteoglycans in cancer	202 \| 202
	cAMP signaling pathway	201 \| 201
	Focal adhesion	200 \| 200
	Natural killer cell mediated c...	199 \| 199
	Huntington's disease	194 \| 194
	Tuberculosis	187 \| 187
	Influenza A	184 \| 184
	Chemokine signaling pathway	182 \| 182
	Calcium signaling pathway	181 \| 181
	Axon guidance	176 \| 176
	Purine metabolism	171 \| 171
	Alzheimer's disease	169 \| 169
	Tight junction	169 \| 169
	NOD-like receptor signaling pa...	168 \| 168
	Protein processing in endoplas...	165 \| 165
	Transcriptional misregulation ...	165 \| 165
	cGMP-PKG signaling pathway	165 \| 165
	RNA transport	164 \| 164
	Oxytocin signaling pathway	158 \| 158
	Jak-STAT signaling pathway	157 \| 157
	Antigen processing and present...	156 \| 156
	Hippo signaling pathway	154 \| 154
	mTOR signaling pathway	153 \| 153
	Non-alcoholic fatty liver dise...	151 \| 151
	Adrenergic signaling in cardio...	150 \| 150
	MicroRNAs in cancer	150 \| 150
	Breast cancer	146 \| 146
	Alcoholism	145 \| 145
	Hepatitis B	145 \| 145
	Phospholipase D signaling path...	145 \| 145
	Parkinson's disease	142 \| 142
	Wnt signaling pathway	142 \| 142
	Signaling pathways regulating ...	141 \| 141
	Apoptosis	140 \| 140
	Insulin signaling pathway	138 \| 138
	Ubiquitin mediated proteolysis	137 \| 137
	Viral myocarditis	137 \| 137
	Measles	135 \| 135
	Ribosome	134 \| 134
	Oxidative phosphorylation	133 \| 133
	FoxO signaling pathway	132 \| 132
	Hepatitis C	132 \| 132
	Spliceosome	132 \| 132
	Dopaminergic synapse	131 \| 131
	Osteoclast differentiation	131 \| 131
	Autoimmune thyroid disease	130 \| 130
	Toxoplasmosis	130 \| 130
	Cell cycle	125 \| 125
	Platelet activation	124 \| 124
	AMPK signaling pathway	123 \| 123
	Lysosome	123 \| 123
	Type I diabetes mellitus	122 \| 122
	Vascular smooth muscle contrac...	121 \| 121
	Graft-versus-host disease	120 \| 120
	Sphingolipid signaling pathway	120 \| 120
	Neurotrophin signaling pathway	119 \| 119
	Oocyte meiosis	119 \| 119
	Th17 cell differentiation	119 \| 119
	Thyroid hormone signaling path...	118 \| 118
	Allograft rejection	116 \| 116
	Glutamatergic synapse	116 \| 116
	Leukocyte transendothelial mig...	116 \| 116
	Carbon metabolism	114 \| 114
	Serotonergic synapse	114 \| 114
	Cholinergic synapse	110 \| 110
	TNF signaling pathway	110 \| 110
	Insulin resistance	109 \| 109
	Hematopoietic cell lineage	108 \| 108
	Systemic lupus erythematosus	108 \| 108
	Chagas disease (American trypa...	106 \| 106
	T cell receptor signaling path...	104 \| 104
	Th1 and Th2 cell differentiati...	104 \| 104
	Glucagon signaling pathway	103 \| 103
	HIF-1 signaling pathway	103 \| 103
	Toll-like receptor signaling p...	103 \| 103
	Melanogenesis	102 \| 102
	Pyrimidine metabolism	102 \| 102
	AGE-RAGE signaling pathway in ...	101 \| 101
	Endocrine resistance	101 \| 101
	Estrogen signaling pathway	101 \| 101
	Retrograde endocannabinoid sig...	101 \| 101
	Amoebiasis	100 \| 100
	Rheumatoid arthritis	100 \| 100

Development Level

IMPC Phenotype

Disease

Tissue

Target Family

KEGG Pathway

Drug Target Ontology

Target Development Level

Target Family

PANTHER Protein Ontology

Ligand

GTEx Tissue

HPA RNA Tissue

HPA Protein Tissue

HPM Tissue

JAX/MGI Phenotype

OMIM Phenotype

GWAS Trait

GO Component

UniProt Keywords

Grant Funding IC

Grant Activity

Data Source

	Non-IDG	221 \| 11,969
	Kinase	20 \| 634
	GPCR	19 \| 408
	Enzyme	2 \| 4,146