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Development Level

Tbio 181 | 11,445
Tclin 48 | 613
Tchem 34 | 1,598
Tdark 4 | 6,588

IMPC Phenotype

preweaning lethality, complete... 9 | 979
preweaning lethality, incomple... 9 | 499
decreased vertical activity 8 | 208
enlarged heart 8 | 210
abnormal seminal vesicle morph... 6 | 114
increased monocyte cell number 5 | 63
abnormal bone structure 4 | 187
abnormal embryo size 4 | 220
abnormal heart morphology 4 | 162
embryonic lethality prior to o... 4 | 239
embryonic lethality prior to t... 4 | 278
improved glucose tolerance 4 | 79
increased neutrophil cell numb... 4 | 46
decreased blood urea nitrogen ... 3 | 51
decreased circulating insulin ... 3 | 76
decreased fasted circulating g... 3 | 65
decreased lymphocyte cell numb... 3 | 83
female infertility 3 | 60
increased bone mineral density 3 | 72
increased leukocyte cell numbe... 3 | 47
increased lymphocyte cell numb... 3 | 32
increased mean corpuscular vol... 3 | 92
limb grasping 3 | 41
male infertility 3 | 123
small superior vagus ganglion 3 | 74
abnormal behavior 2 | 298
abnormal eye anterior chamber ... 2 | 9
abnormal eye morphology 2 | 68
abnormal gait 2 | 69
decreased bone mineral content 2 | 151
decreased circulating creatini... 2 | 39
decreased circulating glucose ... 2 | 126
decreased erythrocyte cell num... 2 | 62
decreased heart rate 2 | 18
decreased heart weight 2 | 27
decreased lean body mass 2 | 135
decreased leukocyte cell numbe... 2 | 73
decreased startle reflex 2 | 75
decreased total body fat amoun... 2 | 207
enlarged lymph nodes 2 | 37
hydrometra 2 | 53
hypoactivity 2 | 132
increased bone mineral content 2 | 108
increased circulating HDL chol... 2 | 80
increased circulating alkaline... 2 | 122
increased circulating calcium ... 2 | 34
increased circulating total pr... 2 | 28
increased hematocrit 2 | 46
increased or absent threshold ... 2 | 101
prolonged RR interval 2 | 8
thrombocytopenia 2 | 56
tremors 2 | 39
abnormal behavioral response t... 1 | 66
abnormal craniofacial morpholo... 1 | 33
abnormal epididymis morphology 1 | 42
abnormal locomotor behavior 1 | 24
abnormal lung morphology 1 | 26
abnormal neural tube closure 1 | 46
abnormal sleep behavior 1 | 70
abnormal spleen morphology 1 | 55
abnormal testis morphology 1 | 43
abnormal vertebrae morphology 1 | 18
anophthalmia 1 | 33
cardiovascular system phenotyp... 1 | 36
corneal opacity 1 | 32
decreased T cell number 1 | 15
decreased bone mineral density 1 | 126
decreased circulating chloride... 1 | 30
decreased circulating serum al... 1 | 82
decreased circulating triglyce... 1 | 79
decreased eosinophil cell numb... 1 | 24
decreased hematocrit 1 | 46
decreased hemoglobin content 1 | 68
decreased neutrophil cell numb... 1 | 42
decreased total retina thickne... 1 | 17
enlarged uterus 1 | 11
impaired glucose tolerance 1 | 75
impaired righting response 1 | 26
increased circulating aspartat... 1 | 15
increased circulating bilirubi... 1 | 16
increased circulating choleste... 1 | 66
increased circulating creatini... 1 | 38
increased circulating fructosa... 1 | 13
increased circulating iron lev... 1 | 30
increased circulating magnesiu... 1 | 10
increased circulating phosphat... 1 | 26
increased circulating potassiu... 1 | 29
increased circulating serum al... 1 | 22
increased eosinophil cell numb... 1 | 11
increased hemoglobin content 1 | 45
increased large unstained cell... 1 | 5
increased lean body mass 1 | 172
increased mean platelet volume 1 | 45
increased prepulse inhibition 1 | 32
increased startle reflex 1 | 112
increased total body fat amoun... 1 | 134
microphthalmia 1 | 26
small testis 1 | 58
trunk curl 1 | 16
vertebral fusion 1 | 23

Disease

Cancer 151 | 2,499
psoriasis 149 | 6,694
Carcinoma 125 | 11,493
lung cancer 109 | 4,740
osteosarcoma 103 | 7,950
ovarian cancer 101 | 8,520
malignant mesothelioma 92 | 3,232
interstitial cystitis 89 | 2,312
tuberculosis 89 | 2,010
glioblastoma 86 | 5,792
lung carcinoma 79 | 2,843
ulcerative colitis 77 | 1,819
Breast cancer 67 | 3,578
Rheumatoid arthritis 66 | 1,191
medulloblastoma, large-cell 66 | 6,241
Asthma 65 | 385
lung adenocarcinoma 62 | 2,716
non-small cell lung cancer 62 | 2,890
invasive ductal carcinoma 61 | 2,951
Astrocytoma, Pilocytic 60 | 3,081
Hypersensitivity reaction type II disease 60 | 253
pancreatic cancer 60 | 2,398
Multiple Sclerosis 58 | 540
adult high grade glioma 58 | 3,801
cutaneous lupus erythematosus 55 | 1,057
cystic fibrosis 55 | 1,696
atypical teratoid / rhabdoid tumor 53 | 5,112
Arthritis 50 | 290
ependymoma 47 | 4,679
Pneumonia 46 | 174
Inflammatory bowel disease 45 | 151
Schizophrenia 44 | 1,160
diabetes mellitus 44 | 1,728
intraductal papillary-mucinous carcinoma (IPMC) 44 | 2,989
intraductal papillary-mucinous neoplasm (IPMN) 44 | 3,291
intraductal papillary-mucinous adenoma (IPMA) 43 | 2,955
pituitary cancer 43 | 1,972
Liver Cirrhosis, Experimental 40 | 769
Hypersensitivity 39 | 63
Kidney disease 38 | 430
breast carcinoma 38 | 1,638
Dermatitis 37 | 157
colon cancer 36 | 1,478
Atherosclerosis 33 | 291
Autosomal recessive predisposition 33 | 1,442
Breast Neoplasms 33 | 445
Lung disease 33 | 142
Mammary Neoplasms 33 | 425
ductal carcinoma in situ 33 | 1,745
subependymal giant cell astrocytoma 33 | 2,287
Influenza 32 | 142
group 3 medulloblastoma 31 | 4,104
Atopic dermatitis 30 | 952
Hypereosinophilic syndrome 30 | 71
pancreatic ductal adenocarcinoma liver metastasis 30 | 1,962
Anemia 29 | 365
periodontitis 29 | 293
primary Sjogren syndrome 29 | 735
sarcoidosis 29 | 370
Allergic hypersensitivity disease 28 | 126
Pulmonary Fibrosis 28 | 106
nasopharyngeal carcinoma 28 | 1,058
Arthritis, Rheumatoid 27 | 174
Coronary artery disease 27 | 268
Human immunodeficiency virus infectious disease 27 | 138
active Crohn's disease 27 | 922
hepatocellular carcinoma 26 | 547
Liver disease 25 | 237
Melanoma 25 | 711
Mesothelioma, Malignant 25 | 105
oligodendroglioma 25 | 2,850
Endometriosis 24 | 540
Inflammation 24 | 120
Major Depressive Disorder 24 | 301
Prostatic Neoplasms 24 | 495
gastric carcinoma 24 | 807
group 4 medulloblastoma 24 | 1,855
Brain Injuries 23 | 65
Hepatitis C 23 | 94
mucosa-associated lymphoid tissue lymphoma 23 | 484
Crohn's disease 22 | 321
Depressive disorder 22 | 409
Heart disease 22 | 306
Hypertension 22 | 396
Malaria 22 | 160
Vascular disease 22 | 319
active ulcerative colitis 22 | 764
juvenile dermatomyositis 22 | 1,187
Allergic rhinitis 21 | 94
Kidney cancer 21 | 2,613
Neoplasm Metastasis 21 | 168
Obesity 21 | 678
Thrombocytopenia 21 | 197
Acquired immunodeficiency syndrome 20 | 197
Fever 20 | 138
Hepatitis B 20 | 108
Unipolar Depression 20 | 250
Vasculitis 19 | 80
adrenocortical carcinoma 19 | 1,428
pancreatic carcinoma 19 | 562

Tissue

Blood and immune system 248 | 16,909
Endocrine System 248 | 18,159
Digestive Tract 245 | 17,369
Skin and soft tissues 243 | 17,230
Urinary Tract 242 | 16,678
Male tissues 241 | 17,142
Liver and Pancreas 240 | 16,750
Female tissues 239 | 17,400
Respiratory system 233 | 16,393
Nervous System 217 | 16,725
Cardiovascular System 196 | 15,192

Target Family

Non-IDG 226 | 12,091
Kinase 20 | 634
GPCR 19 | 408
Enzyme 2 | 4,145

KEGG Pathway

Cytokine-cytokine receptor int... 267 | 267
Metabolic pathways 1,263 | 1,263
Pathways in cancer 530 | 530
Olfactory transduction 414 | 414
Human papillomavirus infection 388 | 388
PI3K-Akt signaling pathway 349 | 349
HTLV-I infection 336 | 336
Endocytosis 310 | 310
MAPK signaling pathway 295 | 295
Epstein-Barr virus infection 280 | 280
Neuroactive ligand-receptor in... 276 | 276
Herpes simplex infection 262 | 262
Kaposi's sarcoma-associated he... 252 | 252
Viral carcinogenesis 251 | 251
Thermogenesis 232 | 232
Ras signaling pathway 230 | 230
Phagosome 229 | 229
Cellular senescence 228 | 228
Cell adhesion molecules (CAMs) 225 | 225
Rap1 signaling pathway 209 | 209
Regulation of actin cytoskelet... 207 | 207
cAMP signaling pathway 201 | 201
Focal adhesion 198 | 198
Proteoglycans in cancer 198 | 198
Natural killer cell mediated c... 197 | 197
Huntington's disease 194 | 194
Tuberculosis 189 | 189
Calcium signaling pathway 183 | 183
Chemokine signaling pathway 183 | 183
Influenza A 182 | 182
Axon guidance 174 | 174
Purine metabolism 172 | 172
Alzheimer's disease 171 | 171
Transcriptional misregulation ... 171 | 171
Tight junction 169 | 169
Hepatocellular carcinoma 168 | 168
NOD-like receptor signaling pa... 166 | 166
Protein processing in endoplas... 164 | 164
RNA transport 163 | 163
cGMP-PKG signaling pathway 162 | 162
Jak-STAT signaling pathway 161 | 161
Cushing's syndrome 158 | 158
Antigen processing and present... 156 | 156
Hippo signaling pathway 154 | 154
Necroptosis 154 | 154
Oxytocin signaling pathway 154 | 154
MicroRNAs in cancer 150 | 150
mTOR signaling pathway 150 | 150
Non-alcoholic fatty liver dise... 149 | 149
Gastric cancer 148 | 148
Retrograde endocannabinoid sig... 148 | 148
Adrenergic signaling in cardio... 147 | 147
Alcoholism 147 | 147
Breast cancer 147 | 147
Phospholipase D signaling path... 147 | 147
Wnt signaling pathway 145 | 145
Hepatitis B 143 | 143
Parkinson's disease 142 | 142
Estrogen signaling pathway 139 | 139
Apoptosis 138 | 138
Fluid shear stress and atheros... 138 | 138
Signaling pathways regulating ... 138 | 138
Insulin signaling pathway 137 | 137
Ubiquitin mediated proteolysis 137 | 137
Viral myocarditis 137 | 137
Apelin signaling pathway 136 | 136
Dopaminergic synapse 135 | 135
Ribosome 134 | 134
Measles 133 | 133
Oxidative phosphorylation 133 | 133
Relaxin signaling pathway 133 | 133
Spliceosome 132 | 132
Autoimmune thyroid disease 130 | 130
FoxO signaling pathway 130 | 130
Hepatitis C 130 | 130
Autophagy - animal 128 | 128
Osteoclast differentiation 127 | 127
Cell cycle 125 | 125
Platelet activation 125 | 125
Toxoplasmosis 125 | 125
Lysosome 123 | 123
Vascular smooth muscle contrac... 123 | 123
Type I diabetes mellitus 122 | 122
Oocyte meiosis 121 | 121
AMPK signaling pathway 120 | 120
Graft-versus-host disease 120 | 120
Neurotrophin signaling pathway 119 | 119
Th17 cell differentiation 119 | 119
Sphingolipid signaling pathway 118 | 118
Allograft rejection 116 | 116
Carbon metabolism 116 | 116
Glutamatergic synapse 116 | 116
Thyroid hormone signaling path... 116 | 116
Serotonergic synapse 114 | 114
Leukocyte transendothelial mig... 112 | 112
Cholinergic synapse 111 | 111
Hematopoietic cell lineage 108 | 108
Systemic lupus erythematosus 108 | 108
TNF signaling pathway 108 | 108
Insulin resistance 107 | 107

This is where graphics are reside..
Name Gene Development Level Target Family Log Novelty  Pubmed Score  Antibody Count  Knowledge Availability 
Leukemia inhibitory factor LIF Tbio Non-IDG -2.86943 538.7 413
Activin receptor type-2A ACVR2A Tchem Kinase -2.08745 108.0 315
Thrombopoietin THPO Tbio Non-IDG -3.23551 1632.3 440
Tumor necrosis factor receptor superfamily member 11A TNFRSF11A Tbio Non-IDG -3.26478 1689.0 464
Tumor necrosis factor receptor superfamily member 13C TNFRSF13C Tbio Non-IDG -2.48953 288.2 437
C-C motif chemokine 3-like 1 CCL3L1 Tbio Non-IDG -1.80717 51.3 142
Vascular endothelial growth factor receptor 1 FLT1 Tclin Kinase -3.38913 2189.4 953
CD40 ligand CD40LG Tbio Non-IDG -4.58203 37578.3 1461
Leukemia inhibitory factor receptor LIFR Tbio Non-IDG -2.35146 221.3 249
C-C motif chemokine 13 CCL13 Tbio Non-IDG -2.02640 99.2 264